Telesis 2020

Front Matter: This edition of Telesis, the University of Oklahoma Gibbs College of Architecture student journal, explores the theme of "Metamedia."Editorial: The Telesis Team introduces Telesis: Metamedia.Conversation: Emily Hays and Evan Sack discuss the history of Telesis and its revitalization in 2018 with Telesis: Design Against.Renegade: Luca Guido re-imagines two famous, outlandish Bruce Goff designs as Cold War hideouts for necessary military operations.Impermanent: Elaheh Houshmanidpanah and Ben DeCuyper discuss the agency the general public has in affecting their built surroundings through place attachment.Nuclear: Caroline Simon investigates the results of the United States' fallout shelter program.Literature: Marilyn Anthony compares, and shares the mutual inspiration between, literature and architecture.Black: Ryan Godfrey questions why designers, especially architects, wear black.Headspace: Humans of Gould documents the daily activities and habits of students within The University of Oklahoma's College of Architecture.Sketching: Students translate, through sketching, various pieces of music spanning time and genre.Cycle: Anthony Andrade discusses the inevitability of self-driving cars and their potential effects on urbanism.Pervious: Ben DeCuyper discusses potential flood mitigation techniques for cities and buildings.Action: Conor McMichael discusses how improving our built environments can reduce social isolation.N

By Popular Demand: Building a Consortial Demand‐Driven Program

The Orbis Cascade Alliance set out to create an e‐book program for its 36 member libraries. Unlike the single-library patron‐driven acquisition programs that we have seen in the past, this ambitious pilot needed to take into account the different discovery options and workflow requirements of 36 libraries and their varying size and technical capabilities. We will discuss the ideal makeup of an implementation team for a program of this size, how to assess the technical hurdles and what training must be provided, how to work with vendors effectively in this setting, and how to evaluate the success of a patron‐driven program, both during the program and afterward. We will include lessons learned that are applicable both to individual libraries considering patron‐driven programs and to consortia looking to provide a similar service to their libraries

Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau−/− mice

Microtubule associated protein tau (MAPT) is involved in the pathogenesis of Alzheimer's disease and many forms of frontotemporal dementia (FTD). We recently reported that Aβ-mediated inhibition of hippocampal long-term potentiation (LTP) in mice requires tau. Here, we asked whether expression of human MAPT can restore Aβ-mediated inhibition on a mouse Tau−/− background and whether human tau with an FTD-causing mutation (N296H) can interfere with Aβ-mediated inhibition of LTP. We used transgenic mouse lines each expressing the full human MAPT locus using bacterial artificial chromosome technology. These lines expressed all six human tau protein isoforms on a Tau−/− background. We found that the human wild-type MAPT H1 locus was able to restore Aβ42-mediated impairment of LTP. In contrast, Aβ42 did not reduce LTP in slices in two independently generated transgenic lines expressing tau protein with the mutation N296H associated with frontotemporal dementia (FTD). Basal phosphorylation of tau measured as the ratio of AT8/Tau5 immunoreactivity was significantly reduced in N296H mutant hippocampal slices. Our data show that human MAPT is able to restore Aβ42-mediated inhibition of LTP in Tau−/− mice. These results provide further evidence that tau protein is central to Aβ-induced LTP impairment and provide a valuable tool for further analysis of the links between Aβ, human tau and impairment of synaptic function