Giardia lamblia and respiratory allergies: a study of children from an urban area with a high incidence of protozoan infections

OBJECTIVES: There is a high incidence of intestinal parasite infection in urban areas in the Northeast of Brazil. Giardia lamblia infections have been associated with increased prevalence of cutaneous allergies and gastrointestinal disorders. However, little is known about the relationship between giardiasis and allergic diseases of the airways. The present study aimed to investigate the possible association between respiratory allergic diseases and infections by G. lamblia in children from urban areas. METHODS: This study recruited 110 patients of both sexes aged 5-15 years. Patients were administered a questionnaire evaluating clinical symptoms and were given skin tests, parasite tests and serum tests. RESULTS: A high incidence of G. lamblia was observed (45%, 50/110). Infections by this protozoan were not associated with increased risk of respiratory allergy (p = 0.075), high total IgE levels (p = 0.701), positive specific IgE tests (p = 0.250), or positive skin tests for a range of environmental allergens (p = 0.239). CONCLUSION: This study demonstrated that symptoms of asthma, skin allergy and serum markers were not associated with G. lamblia infections in this sample of children from urban areas.OBJETIVO: Uma elevada incidência de enteroparasitoses é encontrada em regiões urbanas do nordeste brasileiro. As infecções por Giardia lamblia têm sido relacionadas com aumento da prevalência de alergias cutâneas e gastrointestinais. Contudo, ainda existe pouca informação sobre a associação entre a giardíase e doenças alérgicas das vias aéreas. Diante disso, o presente estudo se propôs a verificar a relação entre a infecção por G. lamblia em crianças de área urbana e reatividade alérgica respiratória. MÉTODOS: O estudo incluiu 110 pacientes, de ambos os sexos e idades, entre 5 e 15 anos. Os pacientes foram submetidos a questionários de avaliação dos sintomas clínicos, testes cutâneos de leitura imediata e exames coproparasitológicos e sorológicos. RESULTADOS: Foi verificada uma frequência elevada de crianças infectadas por G. lamblia (45%, 50/110). A infecção pelo protozoário não foi associada com maior risco de alergias respiratórias (p = 0,075), elevação de IgE total (p = 0,701), IgE específica (p = 0,250) ou teste cutâneo positivo para diferentes alérgenos ambientais (p = 0,239). CONCLUSÃO: O estudo demonstrou que a presença dos sintomas de asma, atopia cutânea e marcadores sorológicos não foram associados com a presença de infecção pela G. lamblia nessa amostra de crianças.Ministério da Saúde (Governo Federal do Brasil)Ministério da Ciência e e Tecnologia (Governo Federal do Brasil)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de Pernambuco Laboratório de Imunopatologia Keizo AsamiUFPE Laboratório de Imunopatologia Keizo AsamiUFPE Hospital das Cínicas ImunologiaUFPE Hospital das Clínicas ImunologiaUFPE Hospital das ClínicasUniversidade Federal de São Paulo (UNIFESP) Pediatria e Ciências AplicadasUNIFESP Imunologia Clínica e Reumatologia Pediatria e Ciências Aplicadas PediatriaUFPEUFPE Programa de Pós-graduação em Ciências da SaúdeUNIFESP, Pediatria e Ciências AplicadasUNIFESP, Imunologia Clínica e Reumatologia Pediatria e Ciências Aplicadas PediatriaCNPq: 402666/2005-4SciEL

Prevalência de doenças negligenciadas em escolares: filariose linfática e parasitoses intestinais

Submitted by Kamylla Nascimento ([email protected]) on 2017-12-13T12:48:59Z No. of bitstreams: 2 art. Epidemiological assessment - santos.pdf: 507527 bytes, checksum: 0eae68621fde891ca47e42097925d1e2 (MD5) art. Epidemiological assessment - santos port.pdf: 197861 bytes, checksum: ae7f512e1dd970137a2cc2e654b70b63 (MD5)Approved for entry into archive by Kamylla Nascimento ([email protected]) on 2017-12-13T13:09:49Z (GMT) No. of bitstreams: 2 art. Epidemiological assessment - santos.pdf: 507527 bytes, checksum: 0eae68621fde891ca47e42097925d1e2 (MD5) art. Epidemiological assessment - santos port.pdf: 197861 bytes, checksum: ae7f512e1dd970137a2cc2e654b70b63 (MD5)Made available in DSpace on 2017-12-13T13:09:49Z (GMT). No. of bitstreams: 2 art. Epidemiological assessment - santos.pdf: 507527 bytes, checksum: 0eae68621fde891ca47e42097925d1e2 (MD5) art. Epidemiological assessment - santos port.pdf: 197861 bytes, checksum: ae7f512e1dd970137a2cc2e654b70b63 (MD5) Previous issue date: 2013Conselho Nacional de Desenvolvimento Científico e Tecnológico (processo nº: 476336 / 2008-2).Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Hospital Barão de Lucena (SUS). Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco (UPE). Recife, PE, Brasil.Fundação Joaquim Nabuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco (UPE). Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Secretária de Saúde do Município de Olinda. Olinda, PE, Brasil.Secretária de Saúde do Município de Olinda. Olinda, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Programa de Pós-graduação em Ciências da Saúde. Recife, PE, Brasil.Descrever a prevalência de infecção filarial e de parasitoses intestinais em escolares numa área endêmica de filariose e refletir sobre a opção terapêutica utilizada no Brasil no tratamento coletivo para filariose.To report the prevalence of lymphatic filariasis and intestinal parasitic infections in school-aged children living in a filariasis endemic area and discuss about the therapeutic regimen adopted in Brazil for the large-scale treatment of filariasis

Pediatric allergy and immunology in Brazil

The subspecialty of pediatric allergy and immunology in Brazil is in its early years and progressing steadily. This review highlights the research developed in the past years aiming to show the characteristics of allergic and immunologic diseases in this vast country. Epidemiologic studies demonstrated the high prevalence of asthma in infants, children, and adolescents. Mortality rates and average annual variation of asthma hospitalization have reduced in all pediatric age groups. Indoor aeroallergen exposure is excessively high and contributes to the high rates of allergy sensitization. Prevalence of food allergy has increased to epidemic levels. Foods (35%), insect stings (30%), and drugs (23%) are the main etiological agents of anaphylaxis in children and adolescents. Molecular diagnosis of primary immunodeficiencies (PID) showed a high incidence of fungal infections including paracoccidioidomycosis in X-linked hyper-IgM syndrome, and the occurrence of BCG adverse reactions or other mycobacterial infections in patients with chronic granulomatous disease. Education in pediatric allergy and immunology is deficient for medical students, but residency programs are effective in training internists and pediatricians for the practice of allergy. the field of PID requires further training. Last, this review is a tribute to Prof. Dr. Charles Naspitz, one of the pioneers of our specialty in Brazil.Univ Fed Parana, Dept Pediat, BR-80060900 Curitiba, Parana, BrazilUniv São Paulo, Dept Pediat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, São Paulo, BrazilUniv São Paulo, Dept Immunol, Inst Biomed Sci, São Paulo, BrazilUniv São Paulo, Dept Med, Sch Med Ribeirao Preto, São Paulo, BrazilUniv São Paulo, São Paulo, BrazilUniv Fed Pernambuco, Dept Pediat, Recife, PE, BrazilUniversidade Federal de São Paulo, Dept Pediat, São Paulo, BrazilWeb of Scienc

Allergic sensitization pattern of patients in Brazil

Objective: Allergic sensitization is one of the key components for the development of allergies. Polysensitization seems to be related to the persistence and severity of allergic diseases. Furthermore, allergic sensitization has a predictive role in the development of allergies. The aim of this study was to characterize the pattern of sensitization of atopic patients treated at different pediatric allergy referral centers in Brazil. Methods: A nation-wide transversal multicenter study collected data on patients attended in Brazil. Peripheral blood samples were collected to determine the serum levels of allergen-specific IgE. If allergen-specific IgE was higher than 0.1 kUA/L, the following specific components were quantified. Results: A total of 470 individuals were enrolled in the study. Mite sensitization was the most frequent kind in all participants. A high frequency of sensitization to furry animals and grasses featured in the respiratory allergies. Regarding components, there was a predominance of sensitization to Der p 1 and Der p 2. It has been verified that having a food allergy, atopic dermatitis, or multimorbidity are risk factors for the development of more severe allergic disease. Conclusion: Studies on the pattern of allergic sensitization to a specific population offer tools for the more effectual prevention, diagnosis, and treatment of allergic diseases. Sensitization to dust mites house was the most prevalent in the evaluated sample. High rates of sensitization to furry animals also stand out. Patients with food allergy, atopic dermatitis, or multimorbidity appear to be at greater risk for developing more severe allergic diseases