THE IMPACT OF MARKET REFORMS ON SPATIAL VOLATILITY OF MAIZE PRICE IN TANZANIA

The impacts of market reforms on prices volatility in developing countries are not well understood because analysts have not been able to predict the impacts. This study investigates whether the reforms have exacerbated the degree of spatial volatility of maize price in Tanzania using ARCH-M model. Results indicate that developed regions might have experienced less volatile prices than less developed regions. Infrastructure development to increase the volume of trade between the regions is recommended.Demand and Price Analysis,

Design and evaluation of a DASH-compliant second screen video player for live events in mobile scenarios

The huge diffusion of mobile devices is rapidly changing the way multimedia content is consumed. Mobile devices are often used as a second screen, providing complementary information on the content shown on the primary screen, as different camera angles in case of a sport event. The introduction of multiple camera angles poses many challenges with respect to guaranteeing a high Quality of Experience to the end user, especially when the live aspect, different devices and highly variable network conditions typical of mobile environments come into play. Due to the ability of HTTP Adaptive Streaming (HAS) protocols to dynamically adapt to bandwidth fluctuations, they are especially suited for the delivery of multimedia content in mobile environments. In HAS, each video is temporally segmented and stored in different quality levels. Rate adaptation heuristics, deployed at the video player, allow the most appropriate quality level to be dynamically requested, based on the current network conditions. Recently, a standardized solution has been proposed by the MPEG consortium, called Dynamic Adaptive Streaming over HTTP (DASH). We present in this paper a DASH-compliant iOS video player designed to support research on rate adaptation heuristics for live second screen scenarios in mobile environments. The video player allows to monitor the battery consumption and CPU usage of the mobile device and to provide this information to the heuristic. Live and Video-on-Demand streaming scenarios and real-time multi-video switching are supported as well. Quantitative results based on real 3G traces are reported on how the developed prototype has been used to benchmark two existing heuristics and to analyse the main aspects affecting battery lifetime in mobile video streaming

Influence of polar co-solutes and salt on the hydration of lipid membranes

The influence of the co-solutes TMAO, urea, and NaCl on the hydration repulsion between lipid membranes is investigated in a combined experimental/simulation approach. Pressure–hydration curves obtained via sorption experiments reveal that the repulsion significantly increases when the membranes are loaded with co-solutes, most strongly for TMAO. As a result, the co-solutes retain additional water molecules and therefore provide membranes with a fluid and more physiological environment. The experimental data are quantitatively reproduced in complementary solvent-explicit atomistic molecular dynamics simulations, which yield the chemical potential of water. Simulation analysis reveals that the additional repulsion arises from the osmotic pressure generated by the co-solutes, an effect which is maximal for TMAO, due to its unfavorable interactions with the lipid headgroup layer and its extraordinarily high osmotic coefficient

Superconducting wireless power transfer for electric vehicles

Electric vehicles (EVs) are an important pillar for the transition towards a cleaner and more sustainable future as renewable energy can penetrate into the transportation section and act as energy storage to cope with the intermittent supply of such energy sources. EVs have recently been significantly developed in terms of both performance and drive range. Various models are already commercially available, and the number of EVs on roads increases rapidly. Rather than being limited by physical cable connections, the wireless (inductive) link creates the opportunity of dynamic charging – charging while driving. Once realised, EVs will no longer be limited by their achievable range and the requirement for battery capacity will be greatly reduced. However, wireless charging systems are limited in their transfer distance and power density. Such drawbacks can be alleviated through high-temperature superconductors (HTS) and their increased current carrying capacity, which can substitute conventionally used copper coils in the charging pads. This thesis investigates the effectiveness of wireless power transfer (WPT) systems as a whole and when HTS coils are used as well as HTS performance at operating frequencies commonly used in WPT-systems. Initially, the fundamentals of superconductivity are outlined to give some background on how such conductors can help tackle problems occurring in WPT-systems and how their behaviour can be simulated. Subsequently, key technical components of wireless charging are summarised and compared, such as compensation topologies, coil design and communication. In addition, health and safety concerns regarding wireless charging are addressed, as well as their relevant standards. Economically, the costs of a wide range of wireless charging systems has also been summarised and compared. To explore the benefits of WPT-system for EVs, a force-based vehicle model is coupled with an extended battery model to simulate the impact of wireless charging on the state of charge of the accumulator sub-system. In total, three different scenarios, i.e. urban, highway and combined driving are presented. The trade-off between having a standalone charging option versus combined dynamic (or on-road charging) and quasi-dynamic (stationary charging in a dynamic environment) wireless charging is outlined and minimum system requirements, such as charging power levels and road coverage, for unlimited range are established. Furthermore, the effects of external factors such as ambient temperature, battery age and wireless transfer efficiency are investigated. It is shown that employing combined charging at medium power levels is sufficient to achieve unlimited range compared to high power requirements for standalone charging. HTS coils show great potential to enhance the WPT-system performance with high current-carrying capability and extremely low losses under certain conditions. However, HTS coils exhibit highly nonlinear loss characteristics, especially at high frequencies (above 1 kHz), which negatively influence the overall system performance. To investigate the improvements, copper, HTS and hybrid wireless charging systems in the frequency range of 11-85 kHz are experimentally tested. Results are compared with finite element analysis (FEA) simulations, which have been combined with electrical circuit models for performance analysis. The measurements and modelling results show good agreement for the WPT-system and HTS charging systems have a much higher transfer efficiency than copper at frequencies below 50 kHz. As the operating frequency increases towards 100 kHz, the performance of HTS systems deteriorates and becomes comparable to copper systems. Similar results are obtained from hybrid systems with a mixture of HTS and copper coils, either as transmitting or receiving coils. Nevertheless, it has been demonstrated that HTS significantly improves the transfer efficiency of wireless charging within a certain range of frequencies. The AC losses occurring in HTS coils, particularly transport current loss, magnetisation loss and combined loss, at high frequencies are studied further. A multilayer 2D axisymmetric coil model based on H-formulation is proposed and validated by experimental results as the HTS film layer is inapplicable at such frequencies. Three of the most commonly employed coil configurations, namely: double pancake, solenoid and circular spiral are examined. While spiral coils experience the highest transport current loss, solenoid coils are subject to the highest magnetisation loss due to the overall distribution of the turns. Furthermore, a transition frequency is defined for each coil when losses in the copper layer exceed the HTS losses. It is much lower for coils due to the interactions between the different turns compared to single HTS tapes. At higher frequencies, the range of magnetic field densities, causing a shift where the highest losses occur, decreases until losses in the copper stabilisers always dominate. In addition, case studies investigating the suitability of HTS-WPT are proposed. Lastly, methods to reduce AC losses of HTS coils are investigated with particular focus on flux diverters, which have been used for low frequency superconducting applications but their effectiveness at high frequencies is unexplored. Therefore, the impact of flux diverters on HTS double pancake coils operating at high frequencies up to 85 kHz is researched. Various geometric characteristics of the flux diverter are investigated such as air gap between diverter and coil, width and thickness. An FEA-model was used to examine the coil and diverter losses at such frequencies and different load factors between 0.1 and 0.8. It is demonstrated that flux diverters are a viable option to reduce the coil losses even at high frequencies and the width of the coil has the biggest impact on the loss reduction. In general, flux diverters are more suitable for applications using high load factors. Lastly, the impact of the diverter in terms of magnetic field distribution above the coil and overall loss distribution in the HTS coil was examined

Assessing sedimentary records of paleohurricane activity using modeled hurricane climatology

Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 9 (2008): Q09V10, doi:10.1029/2008GC002043.Patterns of overwash deposition observed within back-barrier sediment archives can indicate past changes in tropical cyclone activity; however, it is necessary to evaluate the significance of observed trends in the context of the full range of variability under modern climate conditions. Here we present a method for assessing the statistical significance of patterns observed within a sedimentary hurricane-overwash reconstruction. To alleviate restrictions associated with the limited number of historical hurricanes affecting a specific site, we apply a recently published technique for generating a large number of synthetic storms using a coupled ocean-atmosphere hurricane model set to simulate modern climatology. Thousands of overwash records are generated for a site using a random draw of these synthetic hurricanes, a prescribed threshold for overwash, and a specified temporal resolution based on sedimentation rates observed at a particular site. As a test case we apply this Monte Carlo technique to a hurricane-induced overwash reconstruction developed from Laguna Playa Grande (LPG), a coastal lagoon located on the island of Vieques, Puerto Rico in the northeastern Caribbean. Apparent overwash rates in the LPG overwash record are observed to be four times lower between 2500 and 1000 years B.P. when compared to apparent overwash rates during the last 300 years. However, probability distributions based on Monte Carlo simulations indicate that as much as 65% of this drop can be explained by a reduction in the temporal resolution for older sediments due to a decrease in sedimentation rates. Periods of no apparent overwash activity at LPG between 2500 and 3600 years B.P. and 500–1000 years B.P. are exceptionally long and are unlikely to occur (above 99% confidence) under the current climate conditions. In addition, breaks in activity are difficult to produce even when the hurricane model is forced to a constant El Niño state. Results from this study continue to support the interpretation that the western North Atlantic has exhibited significant changes in hurricane climatology over the last 5500 years.Funding for this research was provided by the Earth Systems History Program of the National Science Foundation, Risk Prediction Initiative, National Geographic Society, Coastal Ocean Institute at WHOI, and the Andrew W. Mellon Foundation Endowed Fund for Innovative Research

Revisorns framtid - Ett arbete i förändring

Den rådande forskningen kring IT-utvecklingens påverkan på revisorns arbete i framtiden, pekar på en mängd olika IT-tekniker som kan utveckla dagens IT- verktyg och göra revisorns arbete mer effektivt. Forskningen pekar även på att IT kan utveckla löpande revision till att bli mer effektivt och billigare att implementera. Vilket har stor möjlighet att påverka revisorns arbete i framtiden

Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns

A diverse group of genes are involved in the tooth development of mammals. Several studies, focused mainly on mice and rats, have provided a detailed depiction of the processes coordinating tooth formation and shape. Here we surveyed 236 tooth-associated genes in 39 mammalian genomes and tested for signatures of selection to assess patterns of molecular adaptation in genes regulating mammalian dentition. Of the 236 genes, 31 (∼13.1%) showed strong signatures of positive selection that may be responsible for the phenotypic diversity observed in mammalian dentition. Mammalian-specific tooth-associated genes had accelerated mutation rates compared with older genes found across all vertebrates. More recently evolved genes had fewer interactions (either genetic or physical), were associated with fewer Gene Ontology terms and had faster evolutionary rates compared with older genes. The introns of these positively selected genes also exhibited accelerated evolutionary rates, which may reflect additional adaptive pressure in the intronic regions that are associated with regulatory processes that influence tooth-gene networks. The positively selected genes were mainly involved in processes like mineralization and structural organization of tooth specific tissues such as enamel and dentin. Of the 236 analyzed genes, 12 mammalian-specific genes (younger genes) provided insights on diversification of mammalian teeth as they have higher evolutionary rates and exhibit different expression profiles compared with older genes. Our results suggest that the evolution and development of mammalian dentition occurred in part through positive selection acting on genes that previously had other functions

22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion disorder, estimated to result mainly from de novo non-homologous meiotic recombination events occurring in approximately 1 in every 1,000 fetuses. The first description in the English language of the constellation of findings now known to be due to this chromosomal difference was made in the 1960s in children with DiGeorge syndrome, who presented with the clinical triad of immunodeficiency, hypoparathyroidism and congenital heart disease. The syndrome is now known to have a heterogeneous presentation that includes multiple additional congenital anomalies and later-onset conditions, such as palatal, gastrointestinal and renal abnormalities, autoimmune disease, variable cognitive delays, behavioural phenotypes and psychiatric illness - all far extending the original description of DiGeorge syndrome. Management requires a multidisciplinary approach involving paediatrics, general medicine, surgery, psychiatry, psychology, interventional therapies (physical, occupational, speech, language and behavioural) and genetic counselling. Although common, lack of recognition of the condition and/or lack of familiarity with genetic testing methods, together with the wide variability of clinical presentation, delays diagnosis. Early diagnosis, preferably prenatally or neonatally, could improve outcomes, thus stressing the importance of universal screening. Equally important, 22q11.2DS has become a model for understanding rare and frequent congenital anomalies, medical conditions, psychiatric and developmental disorders, and may provide a platform to better understand these disorders while affording opportunities for translational strategies across the lifespan for both patients with 22q11.2DS and those with these associated features in the general population

Addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas and risk of hypoglycaemia: systematic review and meta-analysis

OBJECTIVE: To quantify the risk of hypoglycaemia associated with the concomitant use of dipeptidyl peptidase-4 (DPP-4) inhibitors and sulphonylureas compared with placebo and sulphonylureas. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Medline, ISI Web of Science, SCOPUS, Cochrane Central Register of Controlled Trials, and clinicaltrial.gov were searched without any language restriction. STUDY SELECTION: Placebo controlled randomised trials comprising at least 50 participants with type 2 diabetes treated with DPP-4 inhibitors and sulphonylureas. REVIEW METHODS: Risk of bias in each trial was assessed using the Cochrane Collaboration tool. The risk ratio of hypoglycaemia with 95% confidence intervals was computed for each study and then pooled using fixed effect models (Mantel Haenszel method) or random effect models, when appropriate. Subgroup analyses were also performed (eg, dose of DPP-4 inhibitors). The number needed to harm (NNH) was estimated according to treatment duration. RESULTS: 10 studies were included, representing a total of 6546 participants (4020 received DPP-4 inhibitors plus sulphonylureas, 2526 placebo plus sulphonylureas). The risk ratio of hypoglycaemia was 1.52 (95% confidence interval 1.29 to 1.80). The NNH was 17 (95% confidence interval 11 to 30) for a treatment duration of six months or less, 15 (9 to 26) for 6.1 to 12 months, and 8 (5 to 15) for more than one year. In subgroup analysis, no difference was found between full and low doses of DPP-4 inhibitors: the risk ratio related to full dose DPP-4 inhibitors was 1.66 (1.34 to 2.06), whereas the increased risk ratio related to low dose DPP-4 inhibitors did not reach statistical significance (1.33, 0.92 to 1.94). CONCLUSIONS: Addition of DPP-4 inhibitors to sulphonylurea to treat people with type 2 diabetes is associated with a 50% increased risk of hypoglycaemia and to one excess case of hypoglycaemia for every 17 patients in the first six months of treatment. This highlights the need to respect recommendations for a decrease in sulphonylureas dose when initiating DPP-4 inhibitors and to assess the effectiveness of this risk minimisation strategy