Expression in the human brain of retinoic acid induced 1, a protein associated with neurobehavioural disorders

Acknowledgements Funding was provided by the Wellcome Trust and Tenovus Scotland. Prof Fragoso is the recipient of a Post Doctoral Science without Borders grant from the Brazilian National Council for Scientific and Technological Development (CNPq, 37450/2012- 7). We also thank Aberdeen Proteomics for assistance with the western blots as well as the Microscopy and Histology Core Facility at the University of Aberdeen for confocal microscopy.Peer reviewedPublisher PD

Production and characterization of CSSI003 (2961) human induced pluripotent stem cells (iPSCs) carrying a novel puntiform mutation in RAI1 gene, Causative of Smith–Magenis syndrome

Smith-Magenis syndrome (SMS) is a complex genetic disorder characterized by developmental delay, behavioural problems and circadian rhythm dysregulation. About 90% of SMS cases are due to a 17p11.2 deletion containing retinoic acid induced1 (RAI1) gene, 10% are due to heterozygousmutations affecting RAI1 coding region. Little is known about RAI1 role

Study to minimize hydrogen embrittlement of ultrahigh-strength steels

Hydrogen-stress cracking in high-strength steels is influenced by hydrogen content of the material and its hydrogen absorption tendency. Non-embrittling cleaning, pickling, and electroplating processes are being studied. Protection from this hydrogen embrittlement is important to the aerospace and aircraft industries

The Arab-Israeli Conflict and Civil Litigation against Terrorism

The Arab-Israeli conflict has been a testing ground for the involvement of U.S. courts in foreign conflicts and for the concept of civil litigation against terrorists. Plaintiffs on both sides of the dispute have sought to recover damages in U.S. courts, embroiling the courts in one of the world\u27s most contentious political disputes. Plaintiffs bringing claims against the Palestine Liberation Organization, the Palestinian Authority, material supporters of terrorism, and the Islamic Republic of Iran have been aided by congressional statutes passed precisely to enhance their ability to bring such lawsuits, whereas plaintiffs bringing suit against Israel or Israeli leaders have not had the benefit of such laws. Although the courts have sought to give effect to the congressional authorization embodied in these statutes, they have faced the resistance at times half-hearted of the executive branch, which regards such legislative and judicial involvement as an intrusion on its foreign policy prerogatives. Though these lawsuits have been subject to criticism and have not fully achieved the goals attributed to them, U.S. courts have largely acted within the authority given them by Congress and the executive branch in hearing the suits, and there is at least some evidence that such lawsuits constitute an effective tool in the fight against terrorism

Literature review on pickling inhibitors and cadmium electroplating processes

Because introduction of hydrogen during bright-cadmium electroplating of high strength steels causes hydrogen-stress cracking, a program was undertaken to evaluate various processes and materials. Report describes effectiveness of inhibitors for reducing hydrogen absorption by steels

Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function.

Normal synapse formation is fundamental to brain function. We show here that an apical-basal polarity (A-BP) protein, Lgl1, is present in the postsynaptic density and negatively regulates glutamatergic synapse numbers by antagonizing the atypical protein kinase Cs (aPKCs). A planar cell polarity protein, Vangl2, which inhibits synapse formation, was decreased in synaptosome fractions of cultured cortical neurons from Lgl1 knockout embryos. Conditional knockout of Lgl1 in pyramidal neurons led to reduction of AMPA/NMDA ratio and impaired plasticity. Lgl1 is frequently deleted in Smith-Magenis syndrome (SMS). Lgl1 conditional knockout led to increased locomotion, impaired novel object recognition and social interaction. Lgl1+/- animals also showed increased synapse numbers, defects in open field and social interaction, as well as stereotyped repetitive behavior. Social interaction in Lgl1+/- could be rescued by NMDA antagonists. Our findings reveal a role of apical-basal polarity proteins in glutamatergic synapse development and function and also suggest a potential treatment for SMS patients with Lgl1 deletion

A study of hydrogen embrittlement of various alloys Annual summary report, 24 Jun. 1965 - 23 Jun. 1966

Hydrogen embrittlement of alloy cathodically charged and notched tensile metal

A review of the literature on pickling inhibitors and cadmium electroplating processes to minimize hydrogen absorption by ultrahigh-strength steels

Literature review on pickling inhibitors and cadmium electroplating processes to minimize hydrogen absorption by ultrahigh strength steel

Gender, consent, and hermaphroditic legibility in James Joyce\u27s Ulysses and Finnegans Wake

It is difficult to imagine a more elusive, polemical author than James Joyce. He is often spoken of as both a cosmopolitan and a nationalist, syphilitic madman and genius, and misogynist and writer of écriture feminine. This final paradoxical view of Joyce is one that I find most compelling. However, this is not a project in feminist historiography attempting to reclaim Joyce for feminism, but rather a demonstration of the pulsing bodies that already exist between the texts. When exploring this idea of écriture feminine in Joyce’s Ulysses, one might be surprised that Hélène Cixous refers to Joyce’s treatment of Molly in Ulysses as “carrying [it] off beyond any book and toward the new writing” (Laugh of the Medusa). Throughout the text she is fetishized for her foreign identity, objectified, and taken whether willingly or not by, what seems like, the majority of Dublin. However, the accounts of these events are all given to the reader by the men of Dublin, and it is not until the final chapter that we finally hear (and feel) the voice of Molly. In this final chapter Molly fondly recounts many of her sexual exploits; however, this is not a defense or even an apology, but rather a celebration of the female body. In a similar style to Tom Phillips’s work A Humument, I took the final chapter of Ulysses and created a new text through a form of textual violence. By marking out the majority of Molly’s monologue, I was surprised when I discovered all that was left was the language of the body: her body. Her language pulses through the final chapter, and this pulsing is brought to center stage when it is extracted from the surrounding text. However, this work with Ulysses, and Joyce’s other early works, acts as a stepping-stone that leads to Finnegans Wake. The Wake is one of the most famous and infamous texts in the literature, because of its near impossibility to read, let alone analyze. And yet with the use of écriture feminine we begin to see a text that is “a female story which appropriates the textual authority of the male master narrative, thereby deconstructing the linguistic codes which underpin western patriarchal culture” (Henke). The subjects of bodies, gender, and identity flow freely through the text, much in the same way we now understand they do in the social sphere. And just as real bodies are determined, or more accurately overdetermined, by lived situations, so too are the characters of Joyce’s works. For this portion of the project I will rely heavily on Marxist theory to unravel the complexities of daily lives, which are always, already defined by and limited by capitalism. These forces work to inscribe ideology on the bodies of the characters, some of which resist (Stephen and Molly), while others seem blissfully unaware to their submission to a system that works against them (Mr. Dedalus). Through the work of écriture feminine and Marxist analysis, the works of Joyce become liberating and visceral