3,351 research outputs found
Conducting rigorous research with subgroups of at-risk youth: lessons learned from a teen pregnancy prevention project in Alaska
In 2010, Alaska Department of Health and Social Services (DHSS) received federal funding to test an
evidence-based teen pregnancy prevention program. The grant required a major modification to an existing
program and a randomized control trial (RCT) to test its effectiveness. As the major modifications, Alaska
used peer educators instead of adults to deliver the program to youth aged 1419 instead of the original
curriculum intended age range of 1214. Cultural and approach adaptations were included as well. After
4 years of implementation and data collection, the sample was too small to provide statistically significant
results. The lack of findings gave no information about the modification, nor any explanation of how the
curriculum was received, or reasons for the small sample. This paper reports on a case study follow-up to
the RCT to better understand outcome and implementation results. For this study, researchers reviewed
project documents and interviewed peer educators, state and local staff, and evaluators. Three themes
emerged from the data: (a) the professional growth of peer educators and development of peer education, (b)
difficulties resulting from curriculum content, especially for subpopulations of sexually active youth, youth
identified as lesbian, gay, bisexual, transgender, queer, intersex and/or asexual, pregnant, and parenting
youth and (c) the appropriateness of an RCT with subpopulations of at-risk youth. Three recommendations
emerged from the case study. First, including as many stakeholders as possible in the program and
evaluation design phases is essential, and must be supported by appropriate funding streams and training.
Second, there must be recognition of the multiple small subpopulations found in Alaska when adapting
programs designed for a larger and more homogeneous population. Third, RCTs may not be appropriate
for all population subgroups.Ye
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Paediatric gastroenterology evaluation of overweight and obese children referred from primary care for suspected non-alcoholic fatty liver disease.
BackgroundScreening overweight and obese children for non-alcoholic fatty liver disease (NAFLD) is recommended by paediatric and endocrinology societies. However, gastroenterology societies have called for more data before making a formal recommendation.AimTo determine whether the detection of suspected NAFLD in overweight and obese children through screening in primary care and referral to paediatric gastroenterology resulted in a correct diagnosis of NAFLD.MethodsInformation generated in the clinical evaluation of 347 children identified with suspected NAFLD through screening in primary care and referral to paediatric gastroenterology was captured prospectively. Diagnostic outcomes were reported. The diagnostic performance of two times the upper limit of normal (ULN) for alanine aminotransferase (ALT) was assessed.ResultsNon-alcoholic fatty liver disease was diagnosed in 55% of children identified by screening and referral. Liver disease other than NAFLD was present in 18% of those referred. Autoimmune hepatitis was the most common alternative diagnosis. Children with NAFLD had significantly (P < 0.05) higher screening ALT (98 ± 95) than children with liver disease other than NAFLD (86 ± 74). Advanced fibrosis was present in 11% of children. For the diagnosis of NAFLD, screening ALT two times the clinical ULN had a sensitivity of 57% and a specificity of 71%.ConclusionsScreening of overweight and obese children in primary care for NAFLD with referral to paediatric gastroenterology has the potential to identify clinically relevant liver pathology. Consensus is needed on how to value the risk and rewards of screening and referral, to identify children with liver disease in the most appropriate manner
The effect of Mg location on Co-Mg-Ru/Îł-Al2O3 FischerâTropsch catalysts
© 2016 The Author(s) Published by the Royal Society. All rights reserved.The effectiveness of Mg as a promoter of Co-Ru/γ-Al2O3 Fischer-Tropsch catalysts depends on how and when the Mg is added. When the Mg is impregnated into the support before the Co and Ru addition, some Mg is incorporated into the support in the form of MgxAl2O3+x if the material is calcined at 550°C or 800°C after the impregnation, while the remainder is present as amorphous MgO/MgCO3 phases. After subsequent Co-Ru impregnation MgxCo3-xO4 is formed which decomposes on reduction, leading to Co(0) particles intimately mixed with Mg, as shown by high-resolution transmission electron microscopy. The process of impregnating Co into an Mg-modified support results in dissolution of the amorphous Mg, and it is this Mg which is then incorporated into MgxCo3-xO4. Acid washing or higher temperature calcination after Mg impregnation can remove most of this amorphous Mg, resulting in lower values of x in MgxCo3-xO4. Catalytic testing of these materials reveals that Mg incorporation into the Co oxide phase is severely detrimental to the site-Time yield, while Mg incorporation into the support may provide some enhancement of activity at high temperature
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Medium-term seed storage of 50 genera of forage legumes and evidence-based genebank monitoring intervals
Genebanks maintaining seeds for long-term genetic resources conservation monitor seed lots to detect early loss in viability. Monitoring is costly and depletes valuable seed. Three decades of genebank seed germination test results of diverse forage species from 50 legume genera in the International Livestock Research Instituteâs medium-term store (circa 8° C with 5 % moisture content) were analysed to determine whether advice on seed monitoring intervals could be derived. Cumulative normal distributions were fitted by probit analysis for each seed lot and compared within each genus. Six patterns of within-genus variation were identified: no detectable trend in germination test results during storage (4 genera); detectable trends, but variable (positive to negative) amongst lots (5); consistent slope of loss in viability amongst lots (17); consistent slope of increase in ability to germinate amongst lots (21); common loss in viability amongst lots (2); common increase in ability to germinate amongst lots (1). Seed lot monitoring intervals for the medium-term store were derived for each of 19 genera with consistent loss in viability across seed lots: three genera provided comparatively rapid deterioration, five met the general expectations for a medium-term store (2-10 yearsâ maintenance of high viability), whilst 11 provided much better survival. Moreover, 26 further genera provided no evidence as yet of seed deterioration; of these, 22 improved in ability to germinate during storage indicating confounding of hardseededness with viability in germination tests
Discovery of a recent, natural whale fall on the continental slope off Anvers Island, western Antarctic Peninsula
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Whale falls provide a substantial, nutrient-rich resource for species in areas of the ocean that may otherwise be largely devoid of food. We report the discovery of a natural whale fall at 1430 m depth in the cold waters of the continental slope off the western Antarctic Peninsula. This is the highest-latitude whale fall reported to date. The section of the carcass we observedâthe tail flukeâwas more complete than any previously reported natural whale fall from the deep sea and in the early stages of decomposition. We estimate the entire cetacean to measure 5â8 m in length. The flesh remained almost intact on the carcass but the skin was missing from the entire section except for the end of the fluke, clearly exposing blubber and soft tissue. The absence of skin indicates rapid and Homogeneous loss. The dominant macrofauna present were crustaceans, including most prominently the lithodid crab Paralomis birsteini, and zoarcid fish typical of the âmobile-scavengerâ successional stage. The density of mobile macrofauna was greatest on the carcass and declined to background levels within 100 m, indicating that they were attracted to the whale fall. This whale fall offers an important opportunity to examine the decomposition of a carcass under deep-sea conditions at polar latitudes.We are grateful to the captain and crew of the RV Nathaniel B. Palmer, and to the US Antarctic Support Contractor, Lockheed Martin, for their assistance at sea. We thank J.T. Eastman and two anonymous reviewers for helpful comments on the manuscript. Funding was provided by grants from the U.S. National Science Foundation: ANT-1141877 to R.B.A. and ANT-1141896 to J.B.M. This is contribution 122 from the Institute for Research on Global Climate Change at the Florida Institute of Technology
On the Numerical Evaluation of Loop Integrals With Mellin-Barnes Representations
An improved method is presented for the numerical evaluation of multi-loop
integrals in dimensional regularization. The technique is based on
Mellin-Barnes representations, which have been used earlier to develop
algorithms for the extraction of ultraviolet and infrared divergencies. The
coefficients of these singularities and the non-singular part can be integrated
numerically. However, the numerical integration often does not converge for
diagrams with massive propagators and physical branch cuts. In this work,
several steps are proposed which substantially improve the behavior of the
numerical integrals. The efficacy of the method is demonstrated by calculating
several two-loop examples, some of which have not been known before.Comment: 13 pp. LaTe
How classical is the quantum universe?
We discuss two topics that are usually considered to be exclusively
"quantum": the Schroedinger equation, and the uncertainty principle. We show
(or rather recall) that the Schroedinger equation can be derived from
Hamilton's equations using the metaplectic representation. We also show that
the uncertainty principle, stated in the form of the
Robertson-Schroedinger-Heisenberg inequalities can be formulated in perfectly
classical terms using the topological notion of symplectic capacity
Supernova 2007bi as a pair-instability explosion
Stars with initial masses 10 M_{solar} < M_{initial} < 100 M_{solar} fuse
progressively heavier elements in their centres, up to inert iron. The core
then gravitationally collapses to a neutron star or a black hole, leading to an
explosion -- an iron-core-collapse supernova (SN). In contrast, extremely
massive stars (M_{initial} > 140 M_{solar}), if such exist, have oxygen cores
which exceed M_{core} = 50 M_{solar}. There, high temperatures are reached at
relatively low densities. Conversion of energetic, pressure-supporting photons
into electron-positron pairs occurs prior to oxygen ignition, and leads to a
violent contraction that triggers a catastrophic nuclear explosion. Tremendous
energies (>~ 10^{52} erg) are released, completely unbinding the star in a
pair-instability SN (PISN), with no compact remnant. Transitional objects with
100 M_{solar} < M_{initial} < 140 M_{solar}, which end up as iron-core-collapse
supernovae following violent mass ejections, perhaps due to short instances of
the pair instability, may have been identified. However, genuine PISNe, perhaps
common in the early Universe, have not been observed to date. Here, we present
our discovery of SN 2007bi, a luminous, slowly evolving supernova located
within a dwarf galaxy (~1% the size of the Milky Way). We measure the exploding
core mass to be likely ~100 M_{solar}, in which case theory unambiguously
predicts a PISN outcome. We show that >3 M_{solar} of radioactive 56Ni were
synthesized, and that our observations are well fit by PISN models. A PISN
explosion in the local Universe indicates that nearby dwarf galaxies probably
host extremely massive stars, above the apparent Galactic limit, perhaps
resulting from star formation processes similar to those that created the first
stars in the Universe.Comment: Accepted version of the paper appearing in Nature, 462, 624 (2009),
including all supplementary informatio
Next-to-leading order QCD corrections to Higgs boson production in association with a photon via weak-boson fusion at the LHC
Higgs boson production in association with a hard central photon and two
forward tagging jets is expected to provide valuable information on Higgs boson
couplings in a range where it is difficult to disentangle weak-boson fusion
processes from large QCD backgrounds. We present next-to-leading order QCD
corrections to Higgs production in association with a photon via weak-boson
fusion at a hadron collider in the form of a flexible parton-level Monte Carlo
program. The QCD corrections to integrated cross sections are found to be small
for experimentally relevant selection cuts, while the shape of kinematic
distributions can be distorted by up to 20% in some regions of phase space.
Residual scale uncertainties at next-to-leading order are at the few-percent
level.Comment: 17 pages, 7 figures, 1 tabl
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