A fresh look at the predictors of naming accuracy and errors in Alzheimer's disease

In recent years, a considerable number of studies have tried to establish which characteristics of objects and their names predict the responses of patients with Alzheimer's disease (AD) in the picture‐naming task. The frequency of use of words and their age of acquisition (AoA) have been implicated as two of the most influential variables, with naming being best preserved for objects with high‐frequency, early‐acquired names. The present study takes a fresh look at the predictors of naming success in Spanish and English AD patients using a range of measures of word frequency and AoA along with visual complexity, imageability, and word length as predictors. Analyses using generalized linear mixed modelling found that naming accuracy was better predicted by AoA ratings taken from older adults than conventional ratings from young adults. Older frequency measures based on written language samples predicted accuracy better than more modern measures based on the frequencies of words in film subtitles. Replacing adult frequency with an estimate of cumulative (lifespan) frequency did not reduce the impact of AoA. Semantic error rates were predicted by both written word frequency and senior AoA while null response errors were only predicted by frequency. Visual complexity, imageability, and word length did not predict naming accuracy or errors

Non-perturbative structure of the polarized nucleon sea

We investigate the flavour and quark-antiquark structure of the polarized nucleon by calculating the parton distribution functions of the nucleon sea using the meson cloud model. We find that the SU(2) flavor symmetry in the light antiquark sea and quark-antiquark symmetry in the strange quark sea are broken, {\it i.e.} \Delta\ubar < \Delta \dbar and \Delta s < \Delta \sbar. The polarization of the strange sea is found to be positive, which is in contradiction to previous analyses. We predict a much larger quark-antiquark asymmetry in the polarized strange quark sea than that in the unpolarized strange quark sea. Our results for both polarized light quark sea and polarized strange quark sea are consistent with the recent HERMES data.Comment: RevTex, 17 pages plus 8 PS figure

Galactic-Centre Gamma Rays in CMSSM Dark Matter Scenarios

We study the production of gamma rays via LSP annihilations in the core of the Galaxy as a possible experimental signature of the constrained minimal supersymmetric extension of the Standard Model (CMSSM), in which supersymmetry-breaking parameters are assumed to be universal at the GUT scale, assuming also that the LSP is the lightest neutralino chi. The part of the CMSSM parameter space that is compatible with the measured astrophysical density of cold dark matter is known to include a stau_1 - chi coannihilation strip, a focus-point strip where chi has an enhanced Higgsino component, and a funnel at large tanb where the annihilation rate is enhanced by the poles of nearby heavy MSSM Higgs bosons, A/H. We calculate the total annihilation rates, the fractions of annihilations into different Standard Model final states and the resulting fluxes of gamma rays for CMSSM scenarios along these strips. We observe that typical annihilation rates are much smaller in the coannihilation strip for tanb = 10 than along the focus-point strip or for tanb = 55, and that the annihilation branching ratios differ greatly between the different dark matter strips. Whereas the current Fermi-LAT data are not sensitive to any of the CMSSM scenarios studied, and the calculated gamma-ray fluxes are probably unobservably low along the coannihilation strip for tanb = 10, we find that substantial portions of the focus-point strips and rapid-annihilation funnel regions could be pressured by several more years of Fermi-LAT data, if understanding of the astrophysical background and/or systematic uncertainties can be improved in parallel.Comment: 33 pages, 12 figures, comments and references added, version to appear in JCA

Recent results on nucleon sigma terms in lattice QCD

It has proven a significant challenge to experiment and phenomenology to extract precise values of the nucleon sigma terms. This difficulty opens the window for lattice QCD simulations to lead the field in resolving this aspect of nucleon structure. Here we report on recent advances in the extraction of nucleon sigma terms in lattice QCD. In particular, the strangeness component is now being resolved to a precision that far surpasses best phenomenological estimates.Comment: 6 pages, 1 figure; prepared for Proc. 4th Int Symposium on Symmetries in Subatomic Physics (SSP2009), Taipei, Taiwan, June 2-5 200

Mapping the x dependence of the axial anomaly in polarised deep inelastic scattering

We discuss the role of the U(1) axial anomaly in the spin structure functions of the nucleon, with particular emphasis on how one might determine its x dependence in present and future deep inelastic scattering experiments. We focus on the C-odd spin structure function g3 and also the deuteron structure function g1^d.Comment: 11pages Latex, 6 Figs. appended as .ps files after main text, Cavendish preprint HEP-93/

Understanding person acquisition using an interactive activation and competition network

Face perception is one of the most developed visual skills that humans display, and recent work has attempted to examine the mechanisms involved in face perception through noting how neural networks achieve the same performance. The purpose of the present paper is to extend this approach to look not just at human face recognition, but also at human face acquisition. Experiment 1 presents empirical data to describe the acquisition over time of appropriate representations for newly encountered faces. These results are compared with those of Simulation 1, in which a modified IAC network capable of modelling the acquisition process is generated. Experiment 2 and Simulation 2 explore the mechanisms of learning further, and it is demonstrated that the acquisition of a set of associated new facts is easier than the acquisition of individual facts in isolation of one another. This is explained in terms of the advantage gained from additional inputs and mutual reinforcement of developing links within an interactive neural network system. <br/

Q2Q^2--Dependence of the Gerasimov-Drell-Hearn Sum Rule

We test the Gerasimov-Drell-Hearn (GDH) sum rule numerically by calculating the total photon absorption cross sections $\sigma_{1/2}$ and $\sigma_{3/2}$ on the nucleon via photon excitation of baryon resonances in the constituent quark model. A total of seventeen, low-lying, non-strange baryon resonances are included in this calculation. The transverse and longitudinal interference cross section, $\sigma_{1/2}^{TL}$, is found to play an important role in the study of the $Q^2$ variation of the sum rule. The results show that the GDH sum rule is saturated by these resonances at a confidence level of 94%. In particular, the $P_{33}(1232)$ excitation largely saturates the sum rule at $Q^2 = 0$, and dominates at small $Q^2$. The GDH integral has a strong $Q^2$-dependence below $Q^2= 1.0 {GeV}^2$ and changes its sign around $Q^2= 0.3 {GeV}^2$. It becomes weakly $Q^2$-dependent for $Q^2 > 1.0 {GeV}^2$ because of the quick decline of the resonance contributions. We point out that the $Q^2$ variation of the GDH sum rule is very important for understanding the nucleon spin structure in the non-perturbative QCD region.Comment: revtex, 17 pages, 3 ps figs include

Combined Ex Vivo 9.4T MRI and Quantitative Histopathological Study in Normal and Pathological Neocortical Resections in Focal Epilepsy

High-resolution magnetic resonance imaging (MRI) may improve the preoperative diagnosis of focal cortical dysplasia (FCD) in epilepsy. Quantitative 9.4T MRI was carried out (T1, T2, T2* and magnetization transfer ratio) on 13 cortical resections, representing pathologically confirmed FCD (five cases) and normal cortex. Quantitative immunohistochemistry for myelination (myelin basic protein/SMI94), neuronal populations [microtubule-associated protein 2 (MAP2), neurofilament (SMI31, SMI32), synaptophysin, NeuN, calbindin], reactive glia (GFAP), microglia (CD68) and blood–brain barrier permeability (albumin) was carried out in 43 regions of interest (ROI) from normal and abnormal white matter and cortex. MRI was spatially aligned and quantitative analysis carried out on corresponding ROI. Line profile analysis (LPA) of intensity gradients through the cortex was carried out on MRI and immunostained sections. An inverse correlation was noted between myelin/SMI94 and T1, T2 (P < 0.005) and T2* (P < 0.05; Spearman's correlation) and a positive correlation between neuronal MAP2 and T1 (P < 0.005) and T2* (P < 0.05) over all ROI. Similar pathology–MRI correlations were observed for histologically unremarkable white matter ROI only. LPA showed altered gradient contours in regions of FCD, reflecting abnormal cortical lamination and myelo-architecture, including a preoperatively undetected FCD case. This study demonstrates the ability of quantitative 9.4T MRI to detect subtle differences in neuronal numbers and myelination in histologically normal appearing white matter and LPA in the evaluation of cortical dyslamination. These methods may be translatable to the in vivo detection of mild cortical malformations

Optically opaque color-flavor locked phase inside compact stars

The contribution of thermally excited electron-positron pairs to the bulk properties of the color-flavor locked quark phase inside compact stars is examined. The presence of these pairs causes the photon mean free path to be much smaller than a typical core radius ($R_0 \simeq 1$ km) for all temperatures above 25 keV so that the photon contribution to the thermal conductivity is much smaller than that of the Nambu-Goldstone bosons. We also find that the electrons and positrons dominate the electrical conductivity, while their contributions to the total thermal energy is negligible.Comment: 3 pages, 2 figures. Published versio

Deep Inelastic Scattering from off-Shell Nucleons

We derive the general structure of the hadronic tensor required to describe deep-inelastic scattering from an off-shell nucleon within a covariant formalism. Of the large number of possible off-shell structure functions we find that only three contribute in the Bjorken limit. In our approach the usual ambiguities encountered when discussing problems related to off-shellness in deep-inelastic scattering are not present. The formulation therefore provides a clear framework within which one can discuss the various approximations and assumptions which have been used in earlier work. As examples, we investigate scattering from the deuteron, nuclear matter and dressed nucleons. The results of the full calculation are compared with those where various aspects of the off-shell structure are neglected, as well as with those of the convolution model.Comment: 36 pages RevTeX, 9 figures (available upon request), ADP-93-210/T128, PSI-PR-93-13, accepted for publication in Physical Review