Splitting the Bill: Estimating Personal Consumption in Case of Wrongful Death

In cases of wrongful death, the decedent’s survivors may sue alleged responsible parties for lost financial support. Forensic experts estimate a deceased individual’s personal consumption rate in order to separate the portion of the decedent’s income spent on him- or herself from the amount available as financial support for dependents. This paper enhances the prevailing estimation process by regressing consumption rates over individual households surveyed by the United States Bureau of Labor Statistics in its annual Consumer Expenditure Survey. We contend that this method improves the precision of estimates by accounting for the inherent heterogeneity in consumption among households with otherwise similar characteristics while furthering the methods and purpose which have guided personal consumption estimation for over two decades. In a structure reminiscent of those used by Krueger (2015) and by Patton, Nelson and Lierman (1998), we regress a natural-log-on-natural-log model of personal consumption rate on household income, as well as on the number of dependent children living in the household. The estimated personal consumption rates produced in this analysis are distinctly flatter with respect to income than those of past research using BLS CE microdata. Additionally, the number of children in a household is shown to have greater effect on personal consumption than previously exhibited

Spatial mapping of splicing factor complexes involved in exon and intron definition

We have analyzed the interaction between serine/arginine-rich (SR) proteins and splicing components that recognize either the 5′ or 3′ splice site. Previously, these interactions have been extensively characterized biochemically and are critical for both intron and exon definition. We use fluorescence resonance energy transfer (FRET) microscopy to identify interactions of individual SR proteins with the U1 small nuclear ribonucleoprotein (snRNP)–associated 70-kD protein (U1 70K) and with the small subunit of the U2 snRNP auxiliary factor (U2AF35) in live-cell nuclei. We find that these interactions occur in the presence of RNA polymerase II inhibitors, demonstrating that they are not exclusively cotranscriptional. Using FRET imaging by means of fluorescence lifetime imaging microscopy (FLIM), we map these interactions to specific sites in the nucleus. The FLIM data also reveal a previously unknown interaction between HCC1, a factor related to U2AF65, with both subunits of U2AF. Spatial mapping using FLIM-FRET reveals differences in splicing factors interactions within complexes located in separate subnuclear domains

Dynamical Formation of Horizons in Recoiling D Branes

A toy calculation of string/D-particle interactions within a world-sheet approach indicates that quantum recoil effects - reflecting the gravitational back-reaction on space-time foam due to the propagation of energetic particles - induces the appearance of a microscopic event horizon, or `bubble', inside which stable matter can exist. The scattering event causes this horizon to expand, but we expect quantum effects to cause it to contract again, in a `bounce' solution. Within such `bubbles', massless matter propagates with an effective velocity that is less than the velocity of light in vacuo, which may lead to observable violations of Lorentz symmetry that may be tested experimentally. The conformal invariance conditions in the interior geometry of the bubbles select preferentially three for the number of the spatial dimensions, corresponding to a consistent formulation of the interaction of D3 branes with recoiling D particles, which are allowed to fluctuate independently only on the D3-brane hypersurface.Comment: 25 pages LaTeX, 4 eps figures include

Quantum-Gravitational Diffusion and Stochastic Fluctuations in the Velocity of Light

We argue that quantum-gravitational fluctuations in the space-time background give the vacuum non-trivial optical properties that include diffusion and consequent uncertainties in the arrival times of photons, causing stochastic fluctuations in the velocity of light ``in vacuo''. Our proposal is motivated within a Liouville string formulation of quantum gravity that also suggests a frequency-dependent refractive index of the particle vacuum. We construct an explicit realization by treating photon propagation through quantum excitations of $D$-brane fluctuations in the space-time foam. These are described by higher-genus string effects, that lead to stochastic fluctuations in couplings, and hence in the velocity of light. We discuss the possibilities of constraining or measuring photon diffusion ``in vacuo'' via $\gamma$-ray observations of distant astrophysical sources.Comment: 17 pages LATEX, uses axodraw style fil

Time-Dependent Vacuum Energy Induced by D-Particle Recoil

We consider cosmology in the framework of a `material reference system' of D particles, including the effects of quantum recoil induced by closed-string probe particles. We find a time-dependent contribution to the cosmological vacuum energy, which relaxes to zero as $\sim 1/ t^2$ for large times $t$. If this energy density is dominant, the Universe expands with a scale factor $R(t) \sim t^2$. We show that this possibility is compatible with recent observational constraints from high-redshift supernovae, and may also respect other phenomenological bounds on time variation in the vacuum energy imposed by early cosmology.Comment: 14 pages LATEX, no figure

Non-Critical Liouville String Escapes Constraints on Generic Models of Quantum Gravity

It has recently been pointed out that generic models of quantum gravity must contend with severe phenomenological constraints imposed by gravitational Cerenkov radiation, neutrino oscillations and the cosmic microwave background radiation. We show how the non-critical Liouville-string model of quantum gravity we have proposed escapes these constraints. It gives energetic particles subluminal velocities, obviating the danger of gravitational Cerenkov radiation. The effect on neutrino propagation is naturally flavour-independent, obviating any impact on oscillation phenomenology. Deviations from the expected black-body spectrum and the effects of time delays and stochastic fluctuations in the propagation of cosmic microwave background photons are negligible, as are their effects on observable spectral lines from high-redshift astrophysical objects.Comment: 15 pages LaTeX, 2 eps figures include

Illuminating disease and enlightening biomedicine:Raman spectroscopy as a diagnostic tool

The discovery of the Raman effect in 1928 not only aided fundamental understanding about the quantum nature of light and matter but also opened up a completely novel area of optics and spectroscopic research that is accelerating at a greater rate during the last decade than at any time since its inception. This introductory overview focuses on some of the most recent developments within this exciting field and how this has enabled and enhanced disease diagnosis and biomedical applications. We highlight a small number of stimulating high-impact studies in imaging, endoscopy, stem cell research, and other recent developments such as spatially offset Raman scattering amongst others. We hope this stimulates further interest in this already exciting field, by 'illuminating' some of the current research being undertaken by the latest in a very long line of dedicated experimentalists interested in the properties and potential beneficial applications of light

Antiplane elastic wave propagation in pre-stressed periodic structures; tuning, band gap switching and invariance

The effect of nonlinear elastic pre-stress on antiplane elastic wave propagation in a two-dimensional periodic structure is investigated. The medium consists of cylindrical annuli embedded on a periodic square lattice in a uniform host material. An identical inhomogeneous deformation is imposed in each annulus and the theory of small-on-large is used to find the incremental wave equation governing subsequent small-amplitude antiplane waves. The plane-wave-expansion method is employed in order to determine the permissable eigenfrequencies. It is found that pre-stress significantly affects the band gap structure for Mooney–Rivlin and Fung type materials, allowing stop bands to be switched on and off. However, it is also shown that for a specific class of materials, their phononic properties remain invariant under nonlinear deformation, permitting some rather interesting behaviour and leading to the possibility of phononic cloaks

A flavour of omics approaches for the detection of food fraud

Food fraud has been identified as an increasing problem on a global scale with wide-ranging economic, social, health and environmental impacts. Omics and their related techniques, approaches, and bioanalytical platforms incorporate a significant number of scientific areas which have the potential to be applied to and significantly reduce food fraud and its negative impacts. In this overview we consider a selected number of very recent studies where omics techniques were applied to detect food authenticity and could be implemented to ensure food integrity. We postulate that significant reductions in food fraud, with the assistance of omics technologies and other approaches, will result in less food waste, decreases in energy use as well as greenhouse gas emissions, and as a direct consequence of this, increases in quality, productivity, yields, and the ability of food systems to be more resilient and able to withstand future food shocks

From genomes to systems

A report on the 2nd Conference of the Consortium for Post-Genome Science (CPGS) 'Genomes to Systems', Manchester, UK, 1-3 September 2004