Disposal Alternatives for Intermittent Sand Filter Scrapings Utilization and Sand Recovery

A three phase study is used to develop disposal alternatives and cost analysis for algae laden sand scrapings removed from intermittent sand filters used to polish wastewater lagoon effluent. Phase I, Irrigation Technique, explores the feasibility of supplying sufficient water to sand scrapings to leach out entrapped material. Details of removal with amount of water applied are presented. Phase II, Soil Application, tests with lysimeters soil response to application of the algae laden sand material. Physical and chemical parameters are not markedly altered where algae laden sand is applied to the soil surface. Phase III, Plant Bioassays, grew tall fescue on lysimeters which had algae laden sand scrapings applied and compared this growth response with lysimeters having no additives to a clay soil and lysimeters having ammonium nitrate added as fertilizer. Results indicate that all three disposal alternatives are viable recourses for sewage sand filter sand deposition and utilization. Cost analyses indicate that an irrigation technique may be less expensive

Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions.

BACKGROUND:Chronic lesion activity driven by smoldering inflammation is a pathological hallmark of progressive forms of multiple sclerosis (MS). OBJECTIVE:To develop a method for automatic detection of slowly expanding/evolving lesions (SELs) on conventional brain magnetic resonance imaging (MRI) and characterize such SELs in primary progressive MS (PPMS) and relapsing MS (RMS) populations. METHODS:We defined SELs as contiguous regions of existing T2 lesions showing local expansion assessed by the Jacobian determinant of the deformation between reference and follow-up scans. SEL candidates were assigned a heuristic score based on concentricity and constancy of change in T2- and T1-weighted MRIs. SELs were examined in 1334 RMS patients and 555 PPMS patients. RESULTS:Compared with RMS patients, PPMS patients had higher numbers of SELs (p = 0.002) and higher T2 volumes of SELs (p < 0.001). SELs were devoid of gadolinium enhancement. Compared with areas of T2 lesions not classified as SEL, SELs had significantly lower T1 intensity at baseline and larger decrease in T1 intensity over time. CONCLUSION:We suggest that SELs reflect chronic tissue loss in the absence of ongoing acute inflammation. SELs may represent a conventional brain MRI correlate of chronic active MS lesions and a candidate biomarker for smoldering inflammation in MS

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis.

Chronic active and slowly expanding lesions with smouldering inflammation are neuropathological correlates of progressive multiple sclerosis pathology. T1 hypointense volume and signal intensity on T1-weighted MRI reflect brain tissue damage that may develop within newly formed acute focal inflammatory lesions or in chronic pre-existing lesions without signs of acute inflammation. Using a recently developed method to identify slowly expanding/evolving lesions in vivo from longitudinal conventional T2- and T1-weighted brain MRI scans, we measured the relative amount of chronic lesion activity as measured by change in T1 volume and intensity within slowly expanding/evolving lesions and non-slowly expanding/evolving lesion areas of baseline pre-existing T2 lesions, and assessed the effect of ocrelizumab on this outcome in patients with primary progressive multiple sclerosis participating in the phase III, randomized, placebo-controlled, double-blind ORATORIO study (n = 732, NCT01194570). We also assessed the predictive value of T1-weighted measures of chronic lesion activity for clinical multiple sclerosis progression as reflected by a composite disability measure including the Expanded Disability Status Scale, Timed 25-Foot Walk and 9-Hole Peg Test. We observed in this clinical trial population that most of total brain non-enhancing T1 hypointense lesion volume accumulation was derived from chronic lesion activity within pre-existing T2 lesions rather than new T2 lesion formation. There was a larger decrease in mean normalized T1 signal intensity and greater relative accumulation of T1 hypointense volume in slowly expanding/evolving lesions compared with non-slowly expanding/evolving lesions. Chronic white matter lesion activity measured by longitudinal T1 hypointense lesion volume accumulation in slowly expanding/evolving lesions and in non-slowly expanding/evolving lesion areas of pre-existing lesions predicted subsequent composite disability progression with consistent trends on all components of the composite. In contrast, whole brain volume loss and acute lesion activity measured by longitudinal T1 hypointense lesion volume accumulation in new focal T2 lesions did not predict subsequent composite disability progression in this trial at the population level. Ocrelizumab reduced longitudinal measures of chronic lesion activity such as T1 hypointense lesion volume accumulation and mean normalized T1 signal intensity decrease both within regions of pre-existing T2 lesions identified as slowly expanding/evolving and in non-slowly expanding/evolving lesions. Using conventional brain MRI, T1-weighted intensity-based measures of chronic white matter lesion activity predict clinical progression in primary progressive multiple sclerosis and may qualify as a longitudinal in vivo neuroimaging correlate of smouldering demyelination and axonal loss in chronic active lesions due to CNS-resident inflammation and/or secondary neurodegeneration across the multiple sclerosis disease continuum

Elastic-Plastic Nonlinear Response of a Space Shuttle External Tank Stringer

Elastic-plastic, large-deflection nonlinear thermo-mechanical stress analyses are performed for the Space Shuttle external tank s intertank stringers. Detailed threedimensional finite element models are developed and used to investigate the stringer s elastic-plastic response for different thermal and mechanical loading events from assembly through flight. Assembly strains caused by initial installation on an intertank panel are accounted for in the analyses. Thermal loading due to tanking was determined to be the bounding loading event. The cryogenic shrinkage caused by tanking resulted in a rotation of the intertank chord flange towards the center of the intertank, which in turn loaded the intertank stringer feet. The analyses suggest that the strain levels near the first three fasteners remain sufficiently high that a failure may occur. The analyses also confirmed that the installation of radius blocks on the stringer feet ends results in an increase in the stringer capability

The Role of Databases in Areawide Pest Management

The simplest definition of the term \u27database\u27 is given in Webster\u27s dictionary as \u27a comprehensive collection of related data organized for convenient access, generally in a computer\u27 (Random House, 1996). This term appeared in the late 1960s because of the evolution of computer software and the need to distinguish the specialized computer systems for the storage and manipulation of data, called database management systems (DBMS) (Neufeld and Cornog, 1986). Today, the acronym \u27DBMS\u27 is universally understood within Information Technology (IT), just like the acronym \u27Bt\u27 for \u27Bacillus thuringiensis\u27 is in the field of biological pest control. At the present time there are numerous DBMS products available on the market. The most popular are Oracle©, dBase©, DB2©, MS SQL Server© and Access©. Access is a part of the Microsoft Office product and can be considered as a prototype of DBMS with limited functionality. These products vary in price and capacity, and therefore the budgetary constraints and the requirements of a particular database application determine their utility. The evolution of database products has been rapid, reflecting advances in the theory of databases during the last 35-40 years. Beginning with simple data files with direct access, these database products now include very sophisticated file systems with complex interrelationships. More recently, there has been a series of new database applications named Relational Database Management Systems (RDBMS). Their development was a product of the advancement in IT, which forced DBMS to adapt. One of these advancements was the creation of distributed computer systems using local or wide-area networks (LAN/WAN) at the end of the 1980s and early 1990s (Date, 2003). These networks stimulated development of new methods for remote database connection, and the improvements of client/server technologies when databases are organized on a computer server separated from those remotely accessed and used to enter data. The uses of DBMS can be very diverse, but this chapter focuses on the application of DBMS in the field of biology, more specifically in entomology and integrated pest management (IPM)

The Role of Databases in Areawide Pest Management

The simplest definition of the term \u27database\u27 is given in Webster\u27s dictionary as \u27a comprehensive collection of related data organized for convenient access, generally in a computer\u27 (Random House, 1996). This term appeared in the late 1960s because of the evolution of computer software and the need to distinguish the specialized computer systems for the storage and manipulation of data, called database management systems (DBMS) (Neufeld and Cornog, 1986). Today, the acronym \u27DBMS\u27 is universally understood within Information Technology (IT), just like the acronym \u27Bt\u27 for \u27Bacillus thuringiensis\u27 is in the field of biological pest control. At the present time there are numerous DBMS products available on the market. The most popular are Oracle©, dBase©, DB2©, MS SQL Server© and Access©. Access is a part of the Microsoft Office product and can be considered as a prototype of DBMS with limited functionality. These products vary in price and capacity, and therefore the budgetary constraints and the requirements of a particular database application determine their utility. The evolution of database products has been rapid, reflecting advances in the theory of databases during the last 35-40 years. Beginning with simple data files with direct access, these database products now include very sophisticated file systems with complex interrelationships. More recently, there has been a series of new database applications named Relational Database Management Systems (RDBMS). Their development was a product of the advancement in IT, which forced DBMS to adapt. One of these advancements was the creation of distributed computer systems using local or wide-area networks (LAN/WAN) at the end of the 1980s and early 1990s (Date, 2003). These networks stimulated development of new methods for remote database connection, and the improvements of client/server technologies when databases are organized on a computer server separated from those remotely accessed and used to enter data. The uses of DBMS can be very diverse, but this chapter focuses on the application of DBMS in the field of biology, more specifically in entomology and integrated pest management (IPM)

Rat Stem-Cell Factor Induces Splenocytes Capable Of Regenerating The Thymus

Cytokine regulation of prethymic T-lymphoid progenitor-cell proliferation and/or differentiation has not been well-defined, although much is known of cytokine regulation of hemopoietic stem- and progenitor-cell development. Here we use a recently identified hemopoietic growth factor, stem-cell factor (SCF) (a form of the c-kit ligand), and a transplant model of thymocyte regeneration to assess the effect of SCF on the in vivo generation of prethymic, thymocyte progenitor-cell activity. We show that recombinant rat SCF (rrSCF164 administered to weanling rats selectively induces an increase in thymocyte progenitor activity in the spleens of treated rats as compared to rats treated with vehicle, polyethylene glycol (PEG)-conjugated rat albumin, or recombinant human granulocyte colony-stimulating factor (rhG-CSF). These data demonstrate that administration of SCF in vivo affects extrathymic-origin thymocyte regenerating cells and may influence, directly or indirectly, early prethymic stages of T-cell lymphopoiesis in addition to its known effect on early stages of myelopoiesis and erythropoiesis

TEF, Vol. 1 No. 1

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