Age-related modifications in CYP-dependent drug metabolism: role of stress

Accumulating clinical evidence indicates extensive inter-individual variations in the effectiveness and adverse effects of standard treatment protocols, which are largely attributed to the multifactorial regulation of the hepatic CYP-dependent drug metabolism that is connected with either transcriptional or post-translational modifications. Age and stress belong to the most important factors in CYP gene regulation. Alterations in neuroendocrine responses to stress, which are associated with modified hypothalamo-pituitary-adrenal axis function, usually accompany ageing. In this light, ageing followed by a decline of the functional integrity of organs, including liver, a failure in preserving homeostasis under stress, increased morbidity and susceptibility to stress, among others, holds a determinant role in the CYP-catalyzed drug metabolism and thus, in the outcome and toxicity of pharmacotherapy. Modifications in the drug metabolizing capacity of the liver with age have been reported and in particular, a decline in the activity of the main CYP isoforms in male senescent rats, indicating decreased metabolism and higher levels of the drug-substrates in their blood. These factors along with the restricted experience in the use of the most medicines in childhood and elderly, could explain at an extent the inter-individual variability in drug efficacy and toxicity outcomes, and underscore the necessity of designing the treatment protocols, accordingly

The Iowa Homemaker vol.5, no.7

Table of Contents The True Spirit of Christmas by Dr. O. H. Cessna, page 1 Something Different for Christmas Greetings by Elizabeth Johnson, page 2 The Purchase Price of Beauty by Dr, Elizabeth Hoyt, page 3 Can You Visualize Your Hat Problem by Florence Faust, page 4 Decorating the Christmas Tree by Margaret Ericson, page 5 Christmas – For Him by Dorothy Harp and Louise Corsaut, page 5 With Iowa State Home Economics Association, page 6 Preparing the Girl for Motherhood by Dr. Florence Brown Sherborn, page 7 Girls’ 4-H Clubs, page 10 Fuel Economy in the Kitchen by Miriam Rapp, page 11 When We Are Very Young by Anna Johnson, page 12 Editorial, page 13 Who’s There and Where, page 14 Eternal Question, page 16 If You Would Have Health by Margaret Whistler, page 1

Kardiopulmonalno oživljavanje: povijesni pregled od početka do kraja XIX. stoljeća

Social laws and religious beliefs throughout history underscore the leaps and bounds that the science of resuscitation has achieved from ancient times until today. The effort to resuscitate victims goes back to ancient history, where death was considered a special form of sleep or an act of God. Biblical accounts of resuscitation attempts are numerous. Resuscitation in the Middle Ages was forbidden, but later during Renaissance, any prohibition against performing cardiopulmonary resuscitation (CPR) was challenged, which finally led to the Enlightenment, where scholars attempted to scientifically solve the problem of sudden death. It was then that the various components of CPR (ventilation, circulation, electricity, and organization of emergency medical services) began to take shape. The 19th century gave way to hallmarks both in the ventilatory support (intubation innovations and the artificial respirator) and the open- and closed chest circulatory support. Meanwhile, novel defibrillation techniques had been employed and ventricular fibrillation described. The groundbreaking discoveries of the 20th century finally led to the scientific framework of CPR. In 1960, mouth-to-mouth resuscitation was eventually combined with chest compression and defibrillation to become CPR as we now know it. This review presents the scientific milestones behind one of medicine’s most widely used fields.Društveni zakoni i religijska vjerovanja tijekom povijesti ogledalo su skokovitog razvoja znanosti oživljavanja od starine do danas. Pokušaji oživljavanja idu daleko u povijest, kada se smrt smatrala posebnim oblikom sna, odnosno Božjom voljom. Brojni su biblijski primjeri pokušaja oživljavanja. U srednjem je vijeku, međutim, oživljavanje bilo zabranjeno da bi posloje u renesansi takve zabrane kardiopulmonalnog oživljavanja bile stavljene pod pitanje te da bi konačno u doba prosvjetiteljstva znanstvenici pokušali riješiti problem nagle smrti. Upravo su se u to doba prvi put osvijestili različiti dijelovi kardiopulmonalnog oživljavanja poput ventilacije, cirkulacije, struje i organizacije hitnih službi. U XIX. se stoljeću naglo razvila ventilacijska potpora (inovacijama u intubaciji i umjetnim plućima) te potpora za otvorenu i zatvorenu cirkulaciju u prsnom košu. U međuvremenu su se razvile nove tehnike defibrilacije te je opisana ventrikulska fibrilacija. Dvadeseto stoljeće pak donosi važna otkrića koja su napokon dala znanstveni okvir kardiopulmonalnom oživljavanju. Godine 1960. sjedinjeni su disanje usta na usta s kompresijom prsnog koša i defibrilacijom, tj. onim što danas smatramo kardiopulmonalnim oživljavanjem. Ovaj se pregled osvrće na najvažnija mjesta u povijesti razvoja jednoga od najviše korišteni polja medicine

Toward a Mixed-Methods Research Approach to Content Analysis in The Digital Age: The Combined Content-Analysis Model and its Applications to Health Care Twitter Feeds

BACKGROUND: Twitter’s 140-character microblog posts are increasingly used to access information and facilitate discussions among health care professionals and between patients with chronic conditions and their caregivers. Recently, efforts have emerged to investigate the content of health care-related posts on Twitter. This marks a new area for researchers to investigate and apply content analysis (CA). In current infodemiology, infoveillance and digital disease detection research initiatives, quantitative and qualitative Twitter data are often combined, and there are no clear guidelines for researchers to follow when collecting and evaluating Twitter-driven content. OBJECTIVE: The aim of this study was to identify studies on health care and social media that used Twitter feeds as a primary data source and CA as an analysis technique. We evaluated the resulting 18 studies based on a narrative review of previous methodological studies and textbooks to determine the criteria and main features of quantitative and qualitative CA. We then used the key features of CA and mixed-methods research designs to propose the combined content-analysis (CCA) model as a solid research framework for designing, conducting, and evaluating investigations of Twitter-driven content. METHODS: We conducted a PubMed search to collect studies published between 2010 and 2014 that used CA to analyze health care-related tweets. The PubMed search and reference list checks of selected papers identified 21 papers. We excluded 3 papers and further analyzed 18. RESULTS: Results suggest that the methods used in these studies were not purely quantitative or qualitative, and the mixed-methods design was not explicitly chosen for data collection and analysis. A solid research framework is needed for researchers who intend to analyze Twitter data through the use of CA. CONCLUSIONS: We propose the CCA model as a useful framework that provides a straightforward approach to guide Twitter-driven studies and that adds rigor to health care social media investigations. We provide suggestions for the use of the CCA model in elder care-related contexts

How Do Cytokines Trigger Genomic Instability?

Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer

Serum Iron and Nitric Oxide Production in Trypanosoma brucei Infected Rats Treated with Tetracycline

The effects of tetracycline on serum iron, nitric oxide production, and haematological parameters in Trypanosoma brucei infected rats were investigated. T. brucei infected and uninfected rats were treated with tetracycline intraperitoneally at 10mg/kg body weight. Four rats each from various groups were treated daily from the first day parasites were sighted in the blood and continued until the animals died. Infected rats, treated and untreated, were sacrificed daily for the serum iron levels and nitric oxide synthase activities. For haematological parameters, infected and uninfected but treated rats were sacrificed on days 7 and 12 along with untreated rats. Results showed that tetracycline brought about a significant reduction in the serum iron status and a modulation of nitric oxide synthase activity of T. brucei infected rats. Red blood cell counts, haemoglobin concentrations, packed cell volumes, white blood cell and platelet counts were also significantly higher in infected as a result of treatment with tetracycline. The results from this study suggest that, tetracycline which has previously been reported as a possible cheap drug in the management of African trypanosomiasis, probably exerts its trypanocidal action through reduction in serum iron status, which in turn modulates nitric oxide synthase activity, thereby reducing the severity of anaemia in infected rat

Developments in Radiation-Hardened Electronics Applicable to the Vision for Space Exploration

The Radiation Hardened Electronics for Space Exploration (RHESE) project develops the advanced technologies required to produce radiation hardened electronics, processors, and devices in support of the anticipated requirements of NASA's Constellation program. Methods of protecting and hardening electronics against the encountered space environment are discussed. Critical stages of a spaceflight mission that are vulnerable to radiation-induced interruptions or failures are identified. Solutions to mitigating the risk of radiation events are proposed through the infusion of RHESE technology products and deliverables into the Constellation program's spacecraft designs

Adrenal Aging and Its Implications on Stress Responsiveness in Humans

Normal aging results in subtle changes both in ACTH and cortisol secretion. Most notable is the general increase in mean daily serum cortisol levels in the elderly, without a noteworthy alteration in the normal circadian rhythm pattern. Glucocorticoid excess seen in the elderly population can have serious consequences in both the structural and functional integrity of various key areas in the brain, including the hippocampus, amygdala, prefrontal cortex, with consequent impairment in normal memory, cognitive function, and sleep cycles. The chronically elevated glucocorticoid levels also impinge on the normal stress response in the elderly, leading to an impaired ability to recover from stressful stimuli. In addition to the effects on the brain, glucocorticoid excess is associated with other age-related changes, including loss of muscle mass, hypertension, osteopenia, visceral obesity, and diabetes, among others. In contrast to the increase in glucocorticoid levels, other adrenocortical hormones, particularly serum aldosterone and DHEA (the precursor to androgens and estrogens) show significant decreases in the elderly. The underlying mechanisms for their decrease remain unclear. While the adrenomedullary hormone, norephinephrine, shows an increase in plasma levels, associated with a decrease in clearance, no notable changes observed in plasma epinephrine levels in the elderly. The multiplicity and complexity of the adrenal hormone changes observed throughout the normal aging process, suggests that age-related alterations in cellular growth, differentiation, and senescence specific to the adrenal gland must also be considered

Differences in the Determinants of Retirement Preparation between Farm and Nonfarm Households

As principal farm operators age, retirement and succession planning has become increasingly important to the U.S. agriculture industry. This study examined differences in the determinants of retirement preparation between farm and nonfarm households using the Survey of Consumer Finances. Factors such as risk preferences, financial capability, human capital, and other demographic characteristics of farmers that may play a role in their decision to plan for retirement were examined. Retirement planning was investigated by running three separate sets of logistic regressions on the overall sample, farm households, and nonfarm households. Likelihood of consulting a financial planner, expecting to leave a bequest, and household net worth were used as dependent variables. Results indicate some significant differences between farm and nonfarm households and highlight limitations in currently available data sets for studies such as this one. Implications for practitioners, researchers, and policymakers regarding farm family retirement and succession planning are discussed