Les mondes sociaux : un concept migrateur entre deux paradigmes,

International audienc

Les mondes sociaux : un concept migrateur entre deux paradigmes,

International audienc

Enhanced scanning electron microscopy images using muscovite mica, an example with Rhizaria

International audienceMuscovite mica sheets were used as a support to capture scanning electron microscopy pictures of marine biological samples. The physical properties of the cleaved muscovite mica provide a clean background, which greatly reduces the postprocessing of images, thereby enhancing them and resulting in impressive images. We chose siliceous Rhizaria for this investigation due to their morphological diversity and elaborate skeletons

Electrochemistry of cytochrome c immobilized on cardiolipin-modified electrodes: a probe for protein – lipid interactions

Electrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL) / phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry. At low ionic strength, we observed two redox-active subpopulations characterized by distinct values of potential (E1/2) and electron transfer rate constant (kET). At high ionic strength, only one subpopulation was detected, consistent with the existence of very stable cyt c – CL adducts, most probably formed by hydrophobic interactions between the protein and the fatty acid (FA) chains carried by CL. This subpopulation exhibits a comparatively high kET value (> 300 s−1) apparently changing with the structure of the FA chains of CL, i.e. 18:2(n-6) or 14:0. Our study suggests that electrochemistry can be a useful technique for probing protein − lipid interactions, and more particularly the role played by the specific structure of the FA chains of CL on cyt c binding

Electrochemistry of cytochrome c immobilized on cardiolipin-modified electrodes: a probe for protein – lipid interactions

International audienceElectrochemistry of cytochrome c (cyt c) immobilized on a cardiolipin (CL) / phosphatidylcholine (PC) film supported on a glassy carbon electrode was investigated using variable-frequency AC voltammetry. At low ionic strength, we observed two redox-active subpopulations characterized by distinct values of potential (E1/2) and electron transfer rate constant (kET). At high ionic strength, only one subpopulation was detected, consistent with the existence of very stable cyt c – CL adducts, most probably formed by hydrophobic interactions between the protein and the fatty acid (FA) chains carried by CL. This subpopulation exhibits a comparatively high kET value (> 300 s−1) apparently changing with the structure of the FA chains of CL, i.e. 18:2(n-6) or 14:0. Our study suggests that electrochemistry can be a useful technique for probing protein − lipid interactions, and more particularly the role played by the specific structure of the FA chains of CL on cyt c binding

Intra‐epidermal nerve endings progress within keratinocyte cytoplasmic tunnels in normal human skin

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Defining requirements for an Augmented Reality system to overcome the challenges of creating and using design representations in co-design sessions

Within co-design sessions involving designers and non-designers, the type and characteristics of the design representations employed is known to impact the performance of such sessions in terms of idea generation, idea evaluation and communication. This study captures the challenges practitioners face in creating and using design representations for co-design sessions and goes on to investigate the potential of Spatial Augmented Reality (SAR) to overcome those challenges. The advantages of SAR in this application are that, multiple concepts can be represented using one physical model, concepts can be modified live during the session, and additional equipment (such as head mounted displays or handheld devices) is not required, thus eliminating any possible interference with the natural interactions between participants. Interviews with design practitioners and trials with a prototype SAR system are used to identify the key challenges faced by practitioners in their current use of design representations, and to capture the technology requirements for a SAR sys- tem for use in co-design sessions. These fi ndings can inform the work of technology developers and researchers working on systems to support co-design sessions

Flecainide-induced pneumonitis: a case report.

BACKGROUND: We report a case of acute respiratory distress associated with a histological pattern of acute fibrinous and organizing pneumonia, and discuss the possible responsibility of flecainide therapy. CASE PRESENTATION: A 61-year-old African woman developed a rapidly progressive dyspnea and required admission in the intensive care unit for orotracheal intubation and mechanical ventilation. Chest X-ray examination revealed bilateral infiltrates predominating in the basal part of both lungs. Lung computed tomography disclosed bilateral ground-glass opacities and septal thickening. After exclusion of the most common causes of infectious or immune pneumonia, a toxic origin was investigated and flecainide toxicity was considered. Lung biopsy was consistent with the unusual pattern of acute fibrinous and organizing pneumonia. Clinical and radiological improvement was noted after corticosteroid therapy, but the patient died from septic complications. CONCLUSION: Flecainide-induced lung injury has rarely been reported in the literature and remains a diagnosis of exclusion. The histological pattern of acute fibrinous and organizing pneumonia has been previously observed with amiodarone. There are no firm guidelines for the treatment of acute fibrinous and organizing pneumonia, but some patients may positively respond to corticosteroids

Author Correction: Proteinaceous secretion of bioadhesive produced during crawling and settlement of Crassostrea gigas larvae

International audienceAn amendment to this paper has been published and can be accessed via a link at the top of the paper