A Comparison of Materials in Knee Sleeves for Osteoarthritis: Affects and Function

Limited research has been done on specific materials in knee sleeves and the impact on the knee sleeve effectiveness. PURPOSE: The purpose of this study is to investigate the different types of materials in knee sleeves used for managing knee osteoarthritis symptoms. Neoprene, nylon-spandex, and copper infused knee sleeves used to determine which material is the most effective in managing osteoarthritis symptoms. METHODS: Four males and four females (age= 37.6±11.6 yrs, ht=167.9±10.9 cm, wt=69.1±33.4 kg, %BF= 33.7±12.1kg) participated in four randomly assigned trials: Trial 1 was completed without wearing any knee sleeves and trials 2-4 were completed wearing a knee sleeve. Repeated measures ANOVAs were used to examine the effect of knee swelling, pain, range of motion (ROM), balance, walk time, step counts, and average torque power. Alpha was set at .05 for all tests. RESULTS: No significant differences were found in knee swelling, pain, range of motion (ROM), balance, walk time, step counts, and average torque power between the four conditions (no sleeve, neoprene, spandex, and copper compression © sleeves), p\u3e.05. CONCLUSIONS: These findings suggest that knee sleeves do not influence knee swelling, pain, range of motion (ROM), balance, walk time, step counts, and average torque power in knee osteoarthritis. This research was funded by the A&M-SA College of Education and Human Development’s Student Research Grant

Proteogenomic Analysis of Bacteria and Archaea: A 46 Organism Case Study

Experimental evidence is increasingly being used to reassess the quality and accuracy of genome annotation. Proteomics data used for this purpose, called proteogenomics, can alleviate many of the problematic areas of genome annotation, e.g. short protein validation and start site assignment. We performed a proteogenomic analysis of 46 genomes spanning eight bacterial and archaeal phyla across the tree of life. These diverse datasets facilitated the development of a robust approach for proteogenomics that is functional across genomes varying in %GC, gene content, proteomic sampling depth, phylogeny, and genome size. In addition to finding evidence for 682 novel proteins, 1336 new start sites, and numerous dubious genes, we discovered sites of post-translational maturation in the form of proteolytic cleavage of 1175 signal peptides. The number of novel proteins per genome is highly variable (median 7, mean 15, stdev 20). Moreover, comparison of novel genes with the current genes did not reveal any consistent abnormalities. Thus, we conclude that proteogenomics fulfills a yet to be understood deficiency in gene prediction. With the adoption of new sequencing technologies which have higher error rates than Sanger-based methods and the advances in proteomics, proteogenomics may become even more important in the future

X-ray Halos and Large Grains in the Diffuse Interstellar Medium

Recent observations with dust detectors on board the interplanetary spacecraft Ulysses and Galileo have recorded a substantial flux of large interstellar grains with radii between 0.25 and 2.0 mu entering the solar system from the local interstellar cloud. The most commonly used interstellar grain size distribution is characterized by a a^-3.5 power law in grain radii a, and extends to a maximum grain radius of 0.25 mu. The extension of the interstellar grain size distribution to such large radii will have a major effect on the median grain size, and on the amount of mass needed to be tied up in dust for a given visual optical depth. It is therefore important to investigate whether this population of larger dust particles prevails in the general interstellar medium, or if it is merely a local phenomenon. The presence of large interstellar grains can be mainly inferred from their effect on the intensity and radial profiles of scattering halos around X-ray sources. In this paper we examine the grain size distribution that gives rise to the X-ray halo around Nova Cygni 1992. The results of our study confirm the need to extend the interstellar grain size distribution in the direction of this source to and possibly beyond 2.0 mu. The model that gives the best fit to the halo data is characterized by: (1) a grain size distribution that follows an a^-3.5 power law up to 0.50 mu, followed by an a^-4.0 extension from 0.50 mu to 2.0 mu; and (2) silicate and graphite (carbon) dust-to-gas mass ratios of 0.0044 and 0.0022, respectively, consistent with solar abundances constraints. Additional observations of X-ray halos probing other spatial directions are badly needed to test the general validity of this result.Comment: 17 pages, incl. 1 figure, accepted for publ. by ApJ Letter

Molecular systematics of the Middle American genus Hypopachus (Anura: Microhylidae)

We present the first phylogenetic study on the widespread Middle American microhylid frog genus Hypopachus. Partial sequences of mitochondrial (12S and 16S ribosomal RNA) and nuclear (rhodopsin) genes (1275 bp total) were analyzed from 43 samples of Hypopachus, three currently recognized species of Gastrophryne, and seven arthroleptid, brevicipitid and microhylid outgroup taxa. Maximum parsimony (PAUP), maximum likelihood (RAxML) and Bayesian inference (MrBayes) optimality criteria were used for phylogenetic analyses, and BEAST was used to estimate divergence dates of major clades. Population-level analyses were conducted with the programs NETWORK and Arlequin. Results confirm the placement of Hypopachus and Gastrophryne as sister taxa, but the latter genus was strongly supported as paraphyletic. The African phrynomerine genus Phrynomantis was recovered as the sister taxon to a monophyletic Chiasmocleis, rendering our well-supported clade of gastrophrynines paraphyletic. Hypopachus barberi was supported as a disjunctly distributed highland species, and we recovered a basal split in lowland populations of Hypopachus variolosus from the Pacific versant of Mexico and elsewhere in the Mesoamerican lowlands. Dating analyses from BEAST estimate speciation within the genus Hypopachusoccurred in the late Miocene/early Pliocene for most clades. Previous studies have not found bioacoustic or morphological differences among these lowland clades, and our molecular data support the continued recognition of two species in the genus Hypopachus

Dual NHC/photoredox catalytic synthesis of 1,4-diketones using an MR-TADF photocatalyst (DiKTa)

The authors thank AstraZeneca and the University of St Andrews for funding (Case studentship to C.P.).The use of the recently reported organic multi-resonant thermally activated delayed fluorescence (MR-TADF) photocatalyst DiKTa allows for the modular synthesis of 1,4-diketones under mild and metal-free conditions. The reaction proceeds via a three-component relay process in the presence of an N-heterocyclic carbene (NHC) organocatalyst.Publisher PDFPeer reviewe

Constraints on the Progenitor of SN 2010jl and Pre-Existing Hot Dust in its Surrounding Medium

A search for the progenitor of SN~2010jl, an unusually luminous core-collapse supernova of Type~IIn, using pre-explosion {\it Hubble}/WFPC2 and {\it Spitzer}/IRAC images of the region, yielded upper limits on the UV and near-infrared (IR) fluxes from any candidate star. These upper limits constrain the luminosity and effective temperature of the progenitor, the mass of any preexisting dust in its surrounding circumstellar medium (CSM), and dust proximity to the star. A {\it lower} limit on the CSM dust mass is required to hide a luminous progenitor from detection by {\it Hubble}. {\it Upper} limits on the CSM dust mass and constraints on its proximity to the star are set by requiring that the absorbed and reradiated IR emission not exceed the IRAC upper limits. Using the combined extinction-IR emission constraints we present viable $M_d-R_1$ combinations, where $M_d$ and $R_1$ are the CSM dust mass and its inner radius. These depend on the CSM outer radius, dust composition and grain size, and the properties of the progenitor. The results constrain the pre-supernova evolution of the progenitor, and the nature and origin of the observed post-explosion IR emission from SN~2010jl. In particular, an $\eta$~Car-type progenitor will require at least 4~mag of visual extinction to avoid detection by the {\it Hubble}. This can be achieved with dust masses $\gtrsim 10^{-3}$~\msun\ (less than the estimated 0.2-0.5~\msun\ around $\eta$~Car) which must be located at distances of $\gtrsim 10^{16}$~cm from the star to avoid detection by {\it Spitzer}.Comment: Accepted for publication in the ApJ. 14 pages 10 figures. The complete figure set for Figure 10 (24 images) is available in the online journa

Soft X-ray Scattering and Halos from Dust

Small angle scatterings of X-rays by interstellar dust particles create halos around x-ray sources. By observing these halos with sufficient angular resolution it is possible to derive information about both the spatial distribution of the dust along the line of sight to the source and some of the physical properties of the scattering dust particles. Previous analyses of halos have been used to infer that the scattering dust particles must be fluffy. These fluffy dust particles have also been suggested as a possible solution to the interstellar carbon "crisis." This crisis results from the discrepancy between the available ISM carbon abundance and the amount required to be in dust to account for the average ISM extinction. Dwek (1997), however, pointed out that fluffy dust particles may not solve the carbon crisis. In light of this, we re-examine the evidence for fluffy dust in the ISM from x-ray scattering data. We find that previous studies overestimated the intensity of the halos by using the RG approximation, which fails for energies below 1 keV. Using the exact Mie solution we find that below 1 keV the scattering becomes much less efficient. Applying the Mie calculations to the x-ray halo observed around Nova Cygni 1992, we conclude that the data can be explained by scattering from regular dust, and does not require interstellar dust particles to be fluffy.Comment: latex, uses aaspp4.sty, 21 pages + 10 figures. Submitted to the Astrophysical Journa

emergent behavior in a coupled economic and coastline model for beach nourishment

Developed coastal areas often exhibit a strong systemic coupling between shoreline dynamics and economic dynamics. Beach nourishment , a common erosion-control practice, involves mechanically depositing sediment from outside the local littoral system onto an actively eroding shoreline to alter shoreline morphology. Natural sediment-transport processes quickly rework the newly engineered beach, causing further changes to the shoreline that in turn affect subsequent beach-nourishment decisions. To the limited extent that this landscape/economic coupling has been considered, evidence suggests that towns tend to employ spatially myopic economic strategies under which individual towns make isolated decisions that do not account for their neighbors. What happens when an optimization strategy that explicitly ignores spatial interactions is incorporated into a physical model that is spatially dynamic? The long-term attractor that develops for the coupled system (the state and behavior to which the system evolves over time) is unclear. We link an economic model, in which town-manager agents choose economically optimal beach-nourishment intervals according to past observations of their immediate shoreline, to a simplified coastal-dynamics model that includes alongshore sediment transport and background erosion (e.g. from sea-level rise). Simulations suggest that feedbacks between these human and natural coastal processes can generate emergent behaviors. When alongshore sediment transport and spatially myopic nourishment decisions are coupled, increases in the rate of sea-level rise can destabilize economically optimal nourishment practices into a regime characterized by the emergence of chaotic shoreline evolution

An Untriggered Search for Optical Bursts

We present an untriggered search for optical bursts with the ROTSE-I telephoto array. Observations were taken which monitor an effective 256 square degree field continuously over 125 hours to m_{ROTSE}=15.7. The uniquely large field, moderate limiting magnitude and fast cadence of $\sim$10 minutes permits transient searches in a new region of sensitivity. Our search reveals no candidate events. To quantify this result, we simulate potential optical bursts with peak magnitude, m_{p}, at t=10 s, which fade as f=(\frac{t}{t_{0}}) ^{\alpha_{t}}, where \alpha_t < 0. Simple estimates based on observational evidence indicate that a search of this sensitivity begins to probe the possible region occupied by GRB orphan afterglows. Our observing protocol and image sensitivity result in a broad region of high detection efficiency for light curves to the bright and slowly varying side of a boundary running from [\alpha_{t},m_{p}]=[-2.0,6.0] to [-0.3,13.2]. Within this region, the integrated rate of brief optical bursts is less than 1.1\times 10^{-8} {\rm s}^{-1} {\rm deg}^{-2}. At $\sim$22 times the observed GRB rate from BATSE, this suggests a limit on \frac{\theta_{opt}}{\theta_{\gamma}}\lesssim 5 where \theta_{opt} and \theta_{\gamma} are the optical and gamma-ray collimation angles, respectively. Several effects might explain the absence of optical bursts, and a search of the kind described here but more sensitive by about 4 magnitudes should offer a more definitive probe.Comment: 8 pages, 6 figures, 1 tabl

Orange is the new green: exploring the restorative capacity of seasonal foliage in schoolyard trees

Urban schoolyard environments are increasingly characterized by a proliferation of hard surfaces with little if any greenery. Schoolyard “greening” initiatives are becoming increasingly popular; however, schoolyard designs often fail to realize their restorative potential. In this quasi-experimental study, a proposed schoolyard greening project was used to visualize alternative planting designs and seasonal tree foliage; these design alternatives were subsequently used as visual stimuli in a survey administered to children who will use the schoolyard to assess the perceived restorative capacity of different design features. The findings indicate that seasonal changes in tree foliage enhance the perceived restorative quality of schoolyard environments. Specifically, fall foliage colour, when compared to green foliage, is rated as being perceived to be equally restorative for children. Additionally, seasonal planting, including evergreen conifers, may enhance the restorative quality of the schoolyard especially when deciduous trees are leafless. Landscape design professionals, community-based organizations, and other decision-makers in schoolyard greening efforts should strategically consider their tree choices to maximize year-round support for healthy attention functioning in children through restoration