Functional Evolution of a cis-Regulatory Module

Lack of knowledge about how regulatory regions evolve in relation to their structure–function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences. To address this we applied reverse genetics to carry out a functional genetic complementation analysis of a eukaryotic cis-regulatory module—the even-skipped stripe 2 enhancer—from four Drosophila species. The evolution of this enhancer is non-clock-like, with important functional differences between closely related species and functional convergence between distantly related species. Functional divergence is attributable to differences in activation levels rather than spatiotemporal control of gene expression. Our findings have implications for understanding enhancer structure–function, mechanisms of speciation and computational identification of regulatory modules

О НЕОБХОДИМОСТИ СОЗДАНИЯ КОНЦЕПЦИИ ФОРМИРОВАНИЯ МАТЕМАТИЧЕСКОЙ КОМПЕТЕНТНОСТИ БУДУЩИХ УЧИТЕЛЕЙ НАЧАЛЬНЫХ КЛАССОВ

Today’s situation in society is characterized by change of requirements to the graduate of the higher school that attracts transformation of the purposes and tasks of the higher school. The professional standard of the teacher competences – focused according to which, the graduate of pedagogical higher education institution has to have the complete, created certain professional competences which will allow him to be successful in the pedagogical detail.Purpose. Article is devoted, a subject, relevant in the conditions of a modern educational paradigm, justification of need of creation of the complete system concept of formation of mathematical competence of future teacher initial classes.Method or methodology of carrying out work. In a basis of a research of system of formation of mathematical competence of future elementary school teachers fundamental provisions of domestic system of higher education, S.I. Arkhangelsky, P.L. Galperin, O.S. Grebenyuk, V.V. Davydov, A.N. Leontyev, V.A. Slastenin, M.Yu. Rozhkov’s works other are put. Theories of system approach in education (V.G. Budanov, V.V. Guzeev, E.N. Gusinsky, F.F. Korolev, G.P. Schedrovitsky, etc. Theory of activity (A.L. Alekseev, A.G. Asmolov, L.S. Vygotsky, A.N. Leontyev, A.V. Petrovsky, S.L. Rubenstein, D.B. Elkonin I.S. Yakimanskaya, etc.) Based on the theory of competence-based approach in vocational training (I.A. Zimnyaya, N.V Kuzmina, G.M. Kodzhaspirova, I.A. Kolesnikova, J. Raven, N. Chomsky, V. Hutmakher, A.V. Hutorskoy, etc.), we have developed a reasonable multi-stage way of educational activity of students in development of knowledge by them ability and skills of mathematical competence,Results. Results of work are that the author proves need of creation of the concept of formation of mathematical competence of students of pedagogical higher education institutions, future elementary school teachers.Scope of results. Results of a research can be applied in educational process of pedagogical higher education institutions.Сегодняшняя ситуация в обществе характеризуется изменением требований к выпускнику высшей школы, что влечет трансформацию целей и задач самой высшей школы. Профессиональный стандарт педагога компетентностно - ориентированный, согласно которому, выпускник педагогического вуза должен обладать целостными, сформированными определенными профессиональными компетенциями, которые позволят ему быть успешным в своей педагогической детальности.Цель. Статья посвящена, актуальной в условиях современной образовательной парадигмы теме, обоснования необходимости создания целостной системной концепцииформирования математической компетентности будущего учителя начальный классов.Метод или методология проведения работы. В основу исследования системы формирования математической компетентности будущих учителей начальных классов заложены фундаментальные положения отечественной системы высшего профессионального образования, труды С.И. Архангельского, П.Л. Гальперина, О.С. Гребенюка, В.В. Давыдова, А.Н. Леонтьева, В.А. Сластенина, М.Ю. Рожкова др. Теории системного подхода в образовании (В.Г. Буданов, В.В. Гузеев, Э.Н. Гусинский, Ф.Ф. Королев, Г.П. Щедровицкий и др. Теория деятельности (А.Л. Алексеев, А.Г. Асмолов, Л.С. Выготский, А.Н. Леонтьев, А.В. Петровский, С.Л. Рубинштейн, Д.Б. Эльконин И.С. Якиманская и др.) Основываясь на теории компетентностного подхода в профессиональной подготовке (И.А.Зимняя, Н.В Кузьмина, Г.М. Коджаспирова, И.А. Колесникова, Дж. Равен, Н. Хомский, В. Хутмахер, А.В. Хуторской и др.), нами разработан обоснованный многоэтапный путь образовательной деятельности студентов в освоении ими знаний умении и навыков математической компетентности,Результаты. Результаты работы заключаются в том, что автор обосновывает необходимость создания концепции формирования математической компетентности студентов педагогических вузов, будущих учителей начальных классов.Область применения результатов. Результаты исследования могут быть применены в образовательном процессе педагогических вузов

POSSIBILITIES OF DIGITAL EDUCATIONAL TECHNOLOGIES AS A WAY OF ORGANIZING A DIGITAL EDUCATIONAL ENVIRONMENT

The article reveals the concepts of digital technologies and digital educational technologies as a way of organizing a digital educational environment and a means of forming students’ universal skills that will be applicable in their future professional and personal growth. The purpose of the article is to identify the possibilities of digital educational technologies, as well as the classification of digital resources and tools that contribute to improving the effectiveness of schoolchildren’s learning. Methodology. The basis of the research is formed by the methods of studying and analyzing scientific publications that study aspects of the problem under study, summarizing one’s own experience in the use of digital educational technologies in the educational process, as well as systematizing the studied information. Results. The possibilities of digital educational technologies in the educational process are described as a way of organizing a digital educational environment. It was revealed that digital educational technologies in close connection with digital educational resources in the educational process give the educational process dynamism, activating mental, cognitive, communicative and educational functions in the classroom. Practical implications. The results obtained can be applied in the didactics of higher and secondary schools

Sustainability of the regional financial system: a case study of the Northwestern Federal District

[EN] This article provides an assessment of the sustainability of Russian regions' financial systems. The study is based on the methods of generalization and synthesis, correlation-regression analysis, and multivariate classification. Since the structure of the regional financial system is complex, several works are devoted to studying its sustainability issues. The relevance of the study topic is confirmed by the lack of a systematic approach to assessing the integral index of sustainability and the possibility of using various tools in determining the complex indicator. Methods: This methodology with application of mathematical statistics methods makes it possible to assess the financial system sustainability in four sectors, to include the leading indicators in the assessment, and to identify regions with extreme values of debt burden indicators. The method was tested for the regions of the Northwestern Federal District (NWFD) for the period 2010 - 2019 to classify the regions according to three levels of debt sustainability. Data collection from the 1 st January to 30 th April 2022 included statistical data from government open internet sources, sectors studied relate to government, and municipal budgets in the NWFD. Authors analyzed regional debt sustainability indicators and identified themes in the field of sustainability studies for the NWFD. Results: An increased level of financial system sustainability was observed among the NWFD regions in the corporative and personal finance sectors, indicating a significant contribution of businesses and households to maintaining the balance and sustainability of the financial system in Russia as a whole. The results of the study also identified that the NWFD regions belong to three clusters: cluster 1 - high debt sustainability; cluster 2 - medium debt sustainability; and cluster 3 - low debt sustainability.: The research of E.G.K., S.E.B, and N.S.A. is partially funded by the Ministry of Science and Higher Education of the Russian Federation under the strategic academic leadership program 'Priority 2030' (Agreement 075-15-2021-1333, dated 30.09.2021).Barykin, S.; Mikheev, A.; Kiseleva, E.; Putikhin, Y.; De La Poza, E.; Alekseeva, N. (2023). Sustainability of the regional financial system: a case study of the Northwestern Federal District. F1000Research. 11(908):1-21. https://doi.org/10.12688/f1000research.123197.21211190

Strategic reporting methodology and its reliability audit

The paper reveals the significance of business entities’ forecasting and strategic reporting. The reporting appears to be an essential source of information for highly efficient strategic management and profits receivable for internal users. Financial activity of Rostov and Kras-nodar region’s business entities of different incorporations and industries was taken as an object of current research. Authors developed specific classification of forecasting reporting forms and key performance indicators’ framework depending on aims and objectives Authors proved strong need in de-velopment of strategic reporting methodology. Reporting drawn up according to the method-ology allows generating informational support of analysis and control of business entities core strategies’ implementing, including internal and external factors & risks’ to increase the capital and firm value. The paper highlights strategy audit features as well, considered as related services according to the Federal Law on Auditing. Authors provide the term and stages of strategy audit. The research resulted in development of special strategic reporting software “Strategic, cap-ital-value oriented reporting framework”, special auditing software “Strategic business entities activity audit” coupled with detailed algorithm description.peer-reviewe

Virtual Construction using Map-based Approach

The paper presents a general map-based approach to prototyping of products in virtual reality environments. Virtual prototyping of products is considered as a consistent simulation and visualization process mapping the source product model into its target visual representations. The approach enables to interrelate formally the product and visual information models with each other by defining mapping rules, to specify a prototyping scenario as a composition of map instances, and then to explore particular product models in virtual reality environments by interpreting the composed scenario. Having been realized, the proposed approach provides for the strongly formalized method and the common software framework to build virtual prototyping applications. As a result, the applications gain in expressiveness, reusability and reliability, as well as take on additional runtime flexibility..