595 research outputs found
Incorporating cross-cultural issues in psychotherapy: a relational framework
The purpose of this context statement is to trace my professional journey into the field of cross-cultural psychotherapy over a 20 year period. The personal factors that led me to this particular journey and the way they influenced my professional interests and choices are outlined. Although the context statement is based largely on the two text publications (1994 and 2010), it is important to mention that the latter text contains an updated version of most of my publications with the aim of providing a comprehensive cross-cultural text ‘under one roof’. I summarise the existential/phenomenological theoretical underpinnings discussed in the first text. The second text also has a philosophical underpinning but is largely based on a psychoanalytically informed theoretical base. In later sections, I indicate aspects which I have drawn upon from my publications and training, and how my thinking has evolved towards a relational framework. Furthermore, I identify the most significant professionals from around the world, which have facilitated my professional development, have inspired my career path and those I have collaborated with (teaching, publications and clinical work). During the two decades my learning comes from different and complementary sources: clinical work with children and adults, as well as both support and therapeutic groups. This substantial clinical experience took place through private practice, via different Hospitals, Voluntary and Charity organisations, and years of teaching and supervising child and adult counsellors, psychotherapists and psychologists and through an international network. Additionally, I describe the varied roles I have held on professional committees, including editorial reviewer, internal and external university examiner nationally and internationally, as well as psychological report writing for legal/insurance purposes. All have made a significant contribution to my learning
Validation of the Vitiligo Noticeability Scale: a patient-reported outcome measure of Vitiligo treatment success
Background:
Patient-reported outcome measures are rarely used in vitiligo trials. The Vitiligo Noticeability Scale (VNS) is a new patient-reported outcome measure assessing how ‘noticeable’ the vitiligo patches are after treatment. The noticeability of vitiligo after treatment is an important indicator of treatment success from the patient’s perspective.
Objectives:
This study aimed to evaluate the construct validity, acceptability and interpretability of the VNS. Our main hypothesis was that the VNS would be a better and more consistent indicator of treatment success than percentage repigmentation.
Methods:
Clinicians (n=33) and patients with vitiligo (n=101) examined 39 image pairs, each depicting a vitiligo lesion pre- and post-treatment. Using an online questionnaire, respondents gave a global assessment of treatment success and a VNS score for treatment response. Clinicians also estimated percentage repigmentation of lesions (75). Treatment success was defined as ‘Yes’ on global assessment, a VNS score of 4 or 5, and more than 75% repigmentation. Agreement between respondents and the different scales was assessed using kappa statistics.
Results:
VNS scores were associated with both patient- and clinician-reported global treatment success (κ = 0.54 and κ = 0.47, respectively). Percentage repigmentation showed a weaker association with patient- and clinician-reported global treatment success (κ = 0.39 and κ = 0.29, respectively). VNS scores of 4 or 5 can be interpreted as representing treatment success. Images depicting post-treatment hyperpigmentation were less likely to be rated as successful.
Conclusions:
The VNS is a valid patient-reported measure of vitiligo treatment success. Further validation of the VNS is required, using larger sets of clinical pre- and post-treatment images, affecting a wider range of anatomical sites
The Role of Leadership in Communities of Learning
This article is a systematic literature review aimed at providing a comprehensive overview of the implementation of the Kāhui Ako | Communities of Learning policy in Aotearoa New Zealand. This policy seeks to improve student outcomes through collaborative networks of schools emphasising the importance of network leadership in initiating and co-ordinating systemic change. This review examines the available evidence on the ways in which these school networks operate and how network leadership responds to local needs and environments. Review data included a total of 16 studies from the empirical literature resulting in four main organisational processes and patterns of interaction: (1) relationships building focusing on trust; (2) press for system-wide coherence; (3) knowledge exchange; and (4) collaborative work. Our findings suggest that achieving high levels of alignment and coherence within the Kāhui Ako policy is a key factor for meaningful implementation, challenging to achieve, and requires ongoing attention
The Impact of the Early Career Framework (ECF) Programme on the Work Engagement, Wellbeing and Retention of Teachers: A Longitudinal Study, 2021–2026. Interim Research Report #2: Early Career Teachers' and Mentors' Reported Experiences with the ECF Programme
Research is an integral part of the UCL’s Early Career Framework (ECF) programme. This is the second report in a series of research publications from the UCL Centre for Educational Leadership-led project, The Impact of the ECF Programme on the Work Engagement, Wellbeing and Retention of Teachers: A Longitudinal Study, 2021–2026.
ECF reform lies at the heart of the Department for Education’s teacher recruitment and retention strategy. The purpose of this mixed methods research is to assess the extent to which (and the ways in which) early career teachers’ (ECTs’) and their mentors’ learning experiences with the ECF programme influence their decisions to stay in teaching, move schools, or leave the profession.
All ECTs and mentors in the UCL-led ECF programme were invited to complete a survey about their learning experiences with the ECF programme between June and October 2022. Of the approximately 12,000 invited ECTs and mentors, over 1,700 responded (response rate of 14%). The acquired sample of respondents is representative of national ECT and mentor populations in terms of gender, ethnicity, school phase and contract type, giving us confidence about the relevance and representativeness of our ECTs’ and mentors’ reported learning and career experiences to those of their peers nationally
The impact of the ECF programme on the work engagement, wellbeing and retention of teachers: a longitudinal study 2021-2026: Interim Research Report
The role of JAZ proteins in plant defence and hormone crosstalk.
Phytohormones
have
a
crucial
role
in
plant
defence
responses.
The
role
of
each
specific
phytohormone
is
contingent
on
whether
the
pathogen
is
a
bio-‐
or
a
necrotroph.
In
the
case
of
the
hemibiotrophic
Pseudomonas
syringae
pv
tomato
(DC3000)
and
the
model
plant
Arabidopsis
thaliana,
the
interaction
of
the
three
key
plant
hormones,
salicylic
acid
(SA),
jasmonic
acid
(JA)
and
abscisic
acid
(ABA),
ultimately
dictates
the
outcome
of
the
infection.
Post-‐invasion
defence
responses,
chiefly
regulated
by
the
SA
dependent
pathway
are
compromised
by
the
antagonistic
action
of
JA
and
ABA.
It
is
this
he
complex
crosstalk
between
the
hormone
pathways
that
propels
susceptibility
or
resistance.
The
Jasmonate
ZIM
domain
(JAZ)
transcription
repressors
are
crucial
part
of
the
JA
signaling
cascade.
JAZs
form
a
co-‐receptor
with
F-‐BOX
Coronatine
Insensitive
(COI)
1
that
binds
the
bioactive
form
of
JA,
Jasmonic
Isoleucine
(JA-‐Ile).
Subsequent
to
this
JA
perception
is
the
specific
degradation
of
JAZ
proteins
that
allows
transcription
of
early
JA-‐related
genes.
Interestingly
the
bacterial
phytotoxin
coronatine,
which
is
a
JA-‐Ile
mimic,
increases
bacterial
virulence
by
exploiting
the
JA
signaling
pathway.
In
this
project
we
establish
the
DC3000
induced
susceptibility
of
jaz10
and
jaz5/10
loss
of
function
mutants
that
substantiates
JAZ
specificity
and
confirms
coronatine-‐induced
virulence.
In
addition,
we
demonstrate
the
different
manifestation
of
symptom
development
caused
by
absence
of
key
positive
regulators
of
plant
defence,
SA
and
JAZ5/JAZ10
and
uncover
the
severely
compromised
phenotype
of
jaz5/jaz10/aao3/sid2-1.
Finally
we
produce
the
tools
that
will
allow
further
research
of
JAZ
protein
interactions
Leadership Learning Programme: Leading into the Future. Launch event presentation
Reconnect London and the UCL Centre for Educational Leadership are delighted to launch their free leadership programme “Leading into the Future”. This research-informed leadership programme will target senior leaders in London-based schools within a broad range of contexts.
In this launch event, we look forward to introducing the programme to you and thinking about and exploring together:
Why does school leadership matters?
How will this project support the work of senior leaders in London schools?
Why do we need to re-consider how we evaluate leadership impact
A combined experimental and computational framework to evaluate the behavior of therapeutic cells for peripheral nerve regeneration
Recent studies have explored the potential of tissue-mimetic scaffolds in encouraging nerve regeneration. One of the major determinants of the regenerative success of cellular nerve repair constructs is the local microenvironment, particularly native low oxygen conditions which can affect implanted cell survival and functional performance. In vivo, cells reside in a range of environmental conditions due to the spatial gradients of nutrient concentrations that are established. Here we evaluate in vitro the differences in cellular behaviour that such conditions induce, including key biological features such as oxygen metabolism, glucose consumption, cell death, and VEGF secretion. Experimental measurements are used to devise and parameterise a mathematical model that describes the behaviour of the cells. The proposed model effectively describes the interactions between cells and their microenvironment and could in the future be extended, allowing researchers to compare the behaviour of different therapeutic cells. Such a combinatorial approach could be used to accelerate the clinical translation of nerve repair constructs by identifying which critical design features should be optimised when fabricating engineered nerve repair conduits. This article is protected by copyright. All rights reserved
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