Integration of a mean-torque diesel engine model into a hardware-in-the-loop shipboard network simulation using lambda tuning

This study describes the creation of a hardware-in-the-loop (HIL) environment for use in evaluating network architecture, control concepts and equipment for use within marine electrical systems. The environment allows a scaled hardware network to be connected to a simulation of a multi-megawatt marine diesel prime mover, coupled via a synchronous generator. This allows All-Electric marine scenarios to be investigated without large-scale hardware trials. The method of closing the loop between simulation and hardware is described, with particular reference to the control of the laboratory synchronous machine, which represents the simulated generator(s). The fidelity of the HIL simulation is progressively improved in this study. First, a faster and more powerful field drive is implemented to improve voltage tracking. Second, the phase tracking is improved by using two nested proportional–integral–derivative–acceleration controllers for torque control, tuned using lambda tuning. The HIL environment is tested using a scenario involving a large constant-power load step. This provides a very severe test of the HIL environment, and also reveals the potentially adverse effects of constant-power loads within marine power systems

A method for the evaluation and optimisation of power losses and reliability of supply in a distribution network

This paper presents two methods for evaluating and optimizing the configuration of a distribution network. A new loss-optimization method is described which partitions, optimizes and then recombines the network topology to identify the lowest loss configurations available. A reliability evaluation method is presented which evaluates, on a load-by-load basis, the most effective restoration path and the associated time. In contrast to previously-reported methods, the operation of different types of switch is integrated into this approach, reducing dependency on pre-determined restoration times for each load each fault location. This provides a more accurate estimate of the outage durations through identification of the specific restoration method for each load under each fault condition. The optimization method applied is shown to be effective in identifying optimally-reliable network topologies. Significant benefits are shown to be available

Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials

Background - It has been suggested that statins substantially reduce the risk of venous thromboembolic events. We sought to test this hypothesis by performing a meta-analysis of both published and unpublished results from randomised trials of statins. Methods and Findings - We searched MEDLINE, EMBASE, and Cochrane CENTRAL up to March 2012 for randomised controlled trials comparing statin with no statin, or comparing high dose versus standard dose statin, with 100 or more randomised participants and at least 6 months' follow-up. Investigators were contacted for unpublished information about venous thromboembolic events during follow-up. Twenty-two trials of statin versus control (105,759 participants) and seven trials of an intensive versus a standard dose statin regimen (40,594 participants) were included. In trials of statin versus control, allocation to statin therapy did not significantly reduce the risk of venous thromboembolic events (465 [0.9%] statin versus 521 [1.0%] control, odds ratio [OR] = 0.89, 95% CI 0.78–1.01, p = 0.08) with no evidence of heterogeneity between effects on deep vein thrombosis (266 versus 311, OR 0.85, 95% CI 0.72–1.01) and effects on pulmonary embolism (205 versus 222, OR 0.92, 95% CI 0.76–1.12). Exclusion of the trial result that provided the motivation for our meta-analysis (JUPITER) had little impact on the findings for venous thromboembolic events (431 [0.9%] versus 461 [1.0%], OR = 0.93 [95% CI 0.82–1.07], p = 0.32 among the other 21 trials). There was no evidence that higher dose statin therapy reduced the risk of venous thromboembolic events compared with standard dose statin therapy (198 [1.0%] versus 202 [1.0%], OR = 0.98, 95% CI 0.80–1.20, p = 0.87). Risk of bias overall was small but a certain degree of effect underestimation due to random error cannot be ruled out. Please see later in the article for the Editors' Summary. Conclusions - The findings from this meta-analysis do not support the previous suggestion of a large protective effect of statins (or higher dose statins) on venous thromboembolic events. However, a more moderate reduction in risk up to about one-fifth cannot be ruled out

Assessment of highly distributed power systems using an integrated simulation approach

In a highly distributed power system (HDPS), micro renewable and low carbon technologies would make a significant contribution to the electricity supply. Further, controllable devices such as micro combined heat and power (CHP) could be used to assist in maintaining stability in addition to simply providing heat and power to dwellings. To analyse the behaviour of such a system requires the modelling of both the electrical distribution system and the coupled microgeneration devices in a realistic context. In this paper a pragmatic approach to HDPS modelling is presented: microgeneration devices are simulated using a building simulation tool to generate time-varying power output profiles, which are then replicated and processed statistically so that they can be used as boundary conditions for a load flow simulation; this is used to explore security issues such as under and over voltage, branch thermal overloading, and reverse power flow. Simulations of a section of real network are presented, featuring different penetrations of micro-renewables and micro-CHP within the ranges that are believed to be realistically possible by 2050. This analysis indicates that well-designed suburban networks are likely to be able to accommodate such levels of domestic-scale generation without problems emerging such as overloads or degradation to the quality of supply

Congestion management with aggregated delivery of flexibility using distributed energy resources

Increasing penetrations of small scale electricity generation and storage technologies are making an important contribution to the decentralisation and decarbonisation of power system control and operation. Although not currently realised, coordination of local distributed energy resources (DERs) and a greater degree of demand flexibility through digital aggregation, offer the potential to lower the cost of energy at source and to enable remuneration for consumer participation, addressing the rising costs of energy supply, which impacts strongly on all consumers. Methods are required to manage potential distribution network constraints caused by flexible DERs, as well as for determining the risk to delivery of flexibility from these DERs for aggregators. A heuristic network flexibility dispatch methodology is proposed, which can be used to calculate the probability of constraints, and any required adjustments of flexible agent positions to resolve them, at half hourly resolution. The aggregator can use this methodology to manage their portfolio risk, while a distribution system operator can estimate required flexibility to manage constraints down to low voltage level

Direct Dynamic Protein-Affinity Selection Mass-Spectrometry

A new methodology is described enabling the affinity screening of potential ligands towards the human estrogen receptor alpha ligand binding domain (ERα-LBD). In-solution incubation is performed of the analyte and the His-tagged ERα-LBD. The bound complex is immobilized on a nickel-loaded protein-affinity selection column, where after the unbound fraction is removed. The immobilized protein–ligand complex is exposed to a decreased pH value and an increased organic modifier concentration releasing the ligand for MS detection, and precipitating the proteins on a filter positioned between the affinity column and the mass spectrometer. The trapping column can be regenerated for reuse at least 70 times. The advantages of the methodology over existing methodologies are the absence of a pre-concentration as well as a chromatographic separation step, resulting in a significantly shorter analysis time compared to previously described procedures, and in addition, allowing the determination of solutes with unfavorable chromatographic properties. The overall analysis time now can be reduced about 250% to approximately 6 min. Replacing the filters after every measurement results in an intra-day standard deviation of 14.8% and an inter-day standard deviation of 21.3%

Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)

Funding The project was funded by the National Institute for Health Research Health Technology Assessment Programme (Project Number 07/60/18). The Health Services Research Unit and the Health Economics Research Unit are funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. Acknowledgements The authors wish to thank the women who participated in the PROSPECT study. We also thank Margaret MacNeil for her secretarial support and data management; Dawn McRae and Lynda Constable for their trial management support; the programming team in CHaRT, led by Gladys McPherson; members of the Project Management Group for their ongoing advice and support of the study; and the staff at the recruitment sites who facilitated the recruitment, treatment and follow up of study participants.Peer reviewedPublisher PD

Design of a DSO-TSO balancing market coordination scheme for decentralised energy

The proliferation of distributed generation and the electrification of heat and transport pose significant challenges to distribution system operators (DSOs) and transmission system operators (TSOs). These challenges include the choice between network upgrades or operating increasingly constrained networks, with a reliance on the flexibility of distributed energy resources (DERs). This study presents a novel market-based coordination scheme, which allows both the DSO and TSO to access DER flexibility, while respecting distribution system limits. The DSO's objective in this work is to minimise the cost incurred by DSO adjustments to DERs, required to ensure stable distribution network operation. The methodology presented has the advantages of being compatible with existing TSO balancing market operation, and scalable enough to include multiple DSO markets coordinating with the TSO. The approach is demonstrated on a section of Great Britain distribution network, using high DER growth scenario data for the year 2030. The case studies demonstrate the proposed DSO market mechanism to maintain thermal and voltage limits during periods of peak demand and DER output. The DSO is given priority in using DERs to solve distribution network constraints, however, significant flexibility remains for the TSO even during periods of peak demand and maximum export

A 'civilized' drink and a 'civilizing' industry: wine growing and cultural imagining in colonial New South Wales

My starting point for this thesis was the absence of a foundation history of Australian wine growing conducted by an historian rather than researchers in other disciplines or the media. I have used existing work on wine history in New South Wales from 1788 to 1901 alongside a significant body of new research to create an historical argument suitable for incorporation into more broadly-themed narratives of Australian history and to inform studies of wine growing in other academic fields. My main argument is that although wine growing proved of little economic value in colonial primary production compared with nation-building commodities - such as pastoralism, wheat growing and gold - advocates of the cultivation of wine grapes believed wine growing embodied beneficial, even transformative, cultural value so they persisted in attempting to create a ‘civilizing’ industry producing a ‘civilized’ drink despite lacklustre consumption of their product and very modest profits. Several times, from 1788 to 1901, these advocates spoke out or wrote about wine and wine growing as capable of creating order in a wild or ‘savage’ landscape and within a settler society shaped culturally by shifting adaptations to both imported and ‘native’ influences in agriculture as well as alcohol production, consumption and distribution. While the methodological framework employed here falls mainly within cultural and economic history, sociological theories have contributed to findings on causation. The result is a comprehensive narrative of colonial wine growing in New South Wales enriched by links to key developments in Australian colonial history and with reference to wine growing in other British colonies or former territories

A systematic review of the use of an expertise-based randomised controlled trial design

Acknowledgements JAC held a Medical Research Council UK methodology (G1002292) fellowship, which supported this research. The Health Services Research Unit, Institute of Applied Health Sciences (University of Aberdeen), is core-funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. Views express are those of the authors and do not necessarily reflect the views of the funders.Peer reviewedPublisher PD