Supersymmetric mode converters

Originally developed in the context of quantum field theory, the concept of supersymmetry (SUSY) can be used to systematically design a new class of optical structures. In this work, we demonstrate how key features arising from optical supersymmetry can be exploited to control the flow of light for mode division multiplexing applications. Superpartner configurations are experimentally realized in coupled optical networks, and the corresponding light dynamics in such systems are directly observed. We show that SUSY can be judiciously utilized to remove the fundamental mode of a multimode optical structure, while establishing global phase matching conditions for the remaining set of modes. Along these lines, supersymmetry may serve as a promising platform for a new generation of versatile optical components with novel properties and functionalities.Comment: 14 pages, 4 figure

Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling.

Pendrin is a Cl-/HCO3- exchanger expressed in the apical regions of renal intercalated cells. Following pendrin gene ablation, blood pressure falls, in part, from reduced renal NaCl absorption. We asked if pendrin is expressed in vascular tissue and if the lower blood pressure observed in pendrin null mice is accompanied by reduced vascular reactivity. Thus, the contractile responses to KCl and phenylephrine (PE) were examined in isometrically mounted thoracic aortas from wild-type and pendrin null mice. Although pendrin expression was not detected in the aorta, pendrin gene ablation changed contractile protein abundance and increased the maximal contractile response to PE when normalized to cross sectional area (CSA). However, the contractile sensitivity to this agent was unchanged. The increase in contractile force/cross sectional area observed in pendrin null mice was due to reduced cross sectional area of the aorta and not from increased contractile force per vessel. The pendrin-dependent increase in maximal contractile response was endothelium- and nitric oxide-independent and did not occur from changes in Ca2+ sensitivity or chronic changes in catecholamine production. However, application of 100 nM angiotensin II increased force/CSA more in aortas from pendrin null than from wild type mice. Moreover, angiotensin type 1 receptor inhibitor (candesartan) treatment in vivo eliminated the pendrin-dependent changes contractile protein abundance and changes in the contractile force/cross sectional area in response to PE. In conclusion, pendrin gene ablation increases aorta contractile force per cross sectional area in response to angiotensin II and PE due to stimulation of angiotensin type 1 receptor-dependent signaling. The angiotensin type 1 receptor-dependent increase in vascular reactivity may mitigate the fall in blood pressure observed with pendrin gene ablation

Near‐Intrinsic Photo‐ and Electroluminescence from Single‐Walled Carbon Nanotube Thin Films on BCB‐Passivated Surfaces

Their outstanding electrical and optical properties make semiconducting single-walled carbon nanotubes (SWCNTs) highly suitable for charge transport and emissive layers in near-infrared optoelectronic devices. However, the luminescence spectra of SWCNT thin films on commonly used glass and Si/SiO2 substrates are often compromised by broadening of the main excitonic emission and unwanted low-energy sidebands. Surface passivation with a commercially available, low dielectric constant, cross-linked bis-benzocyclobutene-based polymer (BCB) enhances the emission properties of SWCNTs to the same level as hexagonal boron nitride (h-BN) flakes do. The presence of BCB suppresses sideband emission, especially from the Y1 band, which is attributed to defects introduced by the interaction of the nanotube lattice with oxygen-containing terminal groups of the substrate surface. The facile and reproducible deposition of homogeneous BCB films over large areas combined with their resistance against common solvents and chemicals employed during photolithography make them compatible with standard semiconductor device fabrication. Utilizing this approach, light-emitting (6,5) SWCNT network field-effect transistors are fabricated on BCB-treated glass substrates with excellent electrical characteristics and near-intrinsic electroluminescence. Hence, passivation with BCB is proposed as a standard treatment for substrates used for spectroscopic investigations of and optoelectronic devices with SWCNTs and other low-dimensional emitters

The Semileptonic Decays B→πlνB\to\pi l\nu and D→πlνD\to\pi l\nu from Lattice QCD

We present a lattice QCD calculation of the form factors and differential decay rates for semileptonic decays of the heavy-light mesons $B$ and $D$ to the final state $\pi l\nu$. The results are obtained with three methodological improvements over previous lattice calculations: a matching procedure that reduces heavy-quark lattice artifacts, the first study of lattice-spacing dependence, and the introduction of kinematic cuts to reduce model dependence. We show that the main systematics are controllable (within the quenched approximation) and outline how the calculations could be improved to aid current experiments in the determination of~$|V_{ub}|$ and~$|V_{cd}|$.Comment: 35 pp, 12 fig

TGF-Beta Modulates the Integrity of the Blood Brain Barrier In Vitro, and Is Associated with Metabolic Alterations in Pericytes

The blood–brain barrier (BBB) is a selectively permeable boundary that separates the circulating blood from the extracellular fluid of the brain and is an essential component for brain homeostasis. In glioblastoma (GBM), the BBB of peritumoral vessels is often disrupted. Pericytes, being important to maintaining BBB integrity, can be functionally modified by GBM cells which induce proliferation and cell motility via the TGF-β-mediated induction of central epithelial to mesenchymal transition (EMT) factors. We demonstrate that pericytes strengthen the integrity of the BBB in primary endothelial cell/pericyte co-cultures as an in vitro BBB model, using TEER measurement of the barrier integrity. In contrast, this effect was abrogated by TGF-β or conditioned medium from TGF-β secreting GBM cells, leading to the disruption of a so far intact and tight BBB. TGF-β notably changed the metabolic behavior of pericytes, by shutting down the TCA cycle, driving energy generation from oxidative phosphorylation towards glycolysis, and by modulating pathways that are necessary for the biosynthesis of molecules used for proliferation and cell division. Combined metabolomic and transcriptomic analyses further underscored that the observed functional and metabolic changes of TGF-β-treated pericytes are closely connected with their role as important supporting cells during angiogenic processes

(1S,2R,4S)-1-[(Benzyl­amino)­meth­yl]-4-(prop-1-en-2-yl)cyclo­hexane-1,2-diol

The title compound, C17H25NO2, was synthesized by epoxidation of the double bond of (S)-perillyl alcohol [(S)-4-isopropenyl-1-cyclo­hexenyl­methanol], followed by the oxirane ring-opening by benzyl­amine using [Ca(CF3CO2)2] as catalyst under solvent-free condition at 313 K. The mol­ecular conformation is stabilized by an intra­molecular O—H⋯N hydrogen bond. In the crystal, mol­ecules are linked by inter­molecular N—H⋯O hydrogen bonds, forming chains parallel to the a axis, which are further connected by O—H⋯O hydrogen bonds into sheets parallel to (010). The absolute configuration of the mol­ecule is known from the synthetic procedure

Direct CP Violation in B -> X_s gamma Decays as a Signature of New Physics

We argue that the observation of a sizable direct CP asymmetry A_{CP} in the inclusive decays B -> X_s gamma would be a clean signal of New Physics. In the Standard Model, A_{CP} can be calculated reliably and is found to be below 1% in magnitude. In extensions of the Standard Model with new CP-violating couplings, large CP asymmetries are possible without conflicting with the experimental value of the branching ratio for the decays B -> X_s gamma. In particular, large asymmetries arise naturally in models with enhanced chromo-magnetic dipole operators. Some generic examples of such models are explored and their implications for the semileptonic branching ratio and charm yield in B decays discussed.Comment: several references added and some numerical results updated to include QED corrections (version to appear in Physical Review D