SOLVENT EFFECTS ON THE ELECTRONIC ABSORPTION SPECTRA OF SOME ANALYTICAL INDICATORS

Electronic absorption spectra of selected ligands (Alloxan, Carmine, Naphthol Yellow S, Hematoxylin and Cyanine) were recorded in presence of different solvents (H2O, Ethyl acetate, Ethanol, DMF, Isopropyl alcohol, Amyl alcohol and Butanol) of variable physical properties. The electronic transitions were assigned. The data are analyzed based on the multiple linear regression technique explained from the views of different solvent parameters. Statistical analyses of the effect of solvents on the electronic spectra of the present ligands have been investigated

Suppressing bladder artifacts in bone SPECT of the pelvis

Objective: Bladder-filling reconstruction artifacts have a detrimental effect on the image quality of pelvic bone single photon emission computed tomography (SPECT). Using a simple protocol consisting of forced diuresis coupled with intravenous (IV) hydration, this study was undertaken to obtain an artifact-free pelvic SPECT after discarding the residual urinary activity. Methods: Thirty patients were enrolled. In group I, pelvic SPECT was performed directly after normal void, whereas in group II, SPECT was preceded by IV injection of 0.5 mg/kg furosemide (maximum 40 mg) coupled with IV infusion of 500 cc of physiologic saline. Bladder-filling reconstruction artifacts were analyzed in group I patients, who had their images reconstructed using both filtered backprojection and iterative algorithms, both qualitatively and quantitatively by means of regions of interest (ROIs) drawn around the artifact-bearing bone areas as well as the corresponding contralateral sites. For group II patients, besides visual analysis, ROIs were placed over the sites corresponding to those of the group I patients. In every patient, total counts of each ROI were normalized to a reference ROI placed over the sacrum, and a ratio was created. Results: Using filtered backprojection, two forms of artifacts were identified in group I patients: first, a streak pattern that extended to the sacro-iliac joint in nine (60%) patients, the hip joint in five (33%), the superior pubic rami in four (27%), the sacrum in three (20%), and the ischium in one (6%); second, a count loss subtype which extended to the hip joints in nine (60%) patients. Corresponding values after iterative reconstruction were two (13%) for the sacro-iliac joint, three (20%) for the hip joint, one (6%) for the superior pubic ramus, and one (6%) for the sacrum. In five (33%) patients, residual count loss artifacts were still identifiable after iterative reconstruction. However in group II, no such effects were observed because the bladder activity reached near background level in 14 (93%) of 15 patients after three successive voids with a 3.5-fold decrease in the mean value of total bladder count in comparison with group I patients. A statistically significant difference was found between artifact- and non-artifact-harboring ROIs in group I whichever the method used for reconstruction, whereas the values of right and left hemi-pelvis ROIs/sacrum in group II were almost identical. Conclusions: Forced diuresis coupled with parenteral hydration facilitates the acquisition of an artifact-free pelvic SPECT. Especially for clinical questions that focus on femoral heads and pubic bones, applying the aforementioned protocol may improve the diagnostic accuracy of pelvic bone SPEC

Osteoprotegerin, soluble receptor activator nuclear factor-κB ligand, nuclear factor kappa B and intestinal trefoil factor 3 are promising biomarkers in diagnosis and follow- up inflammatory bowel disease patients

Background: Inflammatory bowel disease (IBD) is a condition in which the gastrointestinal system becomes inflamed for no apparent reason. Its incidence increased during the last few decades. As a result, it's critical to understand how to validate a clinical diagnosis and monitor any progress using a simple procedure. Osteoprotegerin (OPG), which interacts with RANKL, regulates RANK/RANKL signaling. OPG is a decoy receptor for soluble receptor activator of nuclear factor-B ligand (sRANKL), which stimulates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and the healing trefoil factor 3 (TFF3), which could be employed as in the diagnosis and follow-up of IBD patients, biomarkers are used. Objectives: The aim of the current work was to evaluate the role of RANKL (sRANKL), OPG, NF-κB , and TFF3 in in the diagnosis of active IBD. Subjects and methods: Thirty-five newly diagnosed untreated IBD patients and thirty-five healthy controls were included in this study. Patients were then given particular treatment either in the form of cortisone, mesalamin, immunotherapy or infliximab and immunotherapy for 3 months and attend for second visit. OPG, sRANKL, NF-κB and TFF3 levels were estimated by ELISA method using commercial kits in patients before and after treatment and healthy control. Results: Patients with IBD had significantly increased levels of OPG, sRANKL, NF-B, and TFF3 than healthy controls (P =0.0001). After 3 months of treatment, patients' levels of NF-B and TFF3 were significantly lower (p = 0.0001 and 0.03, respectively). Conclusion: The biomarkers OPG, sRANKL, NF-κB , and TFF3 show promise in the diagnosis of active IBD. The decrease in NF-κB and TFF3 following treatment suggests that be used as biomarkers to track disease activity and treatment effectiveness

Towards Sustainable Environment in G7 Nations: The Role of Renewable Energy Consumption, Eco-innovation and Trade Openness

Some of the globe’s most economically advanced nations make up the G7 (Canada, Japan, France, Germany, Italy, United States and United Kingdom). Nevertheless, in tandem with such strong economic growth, the environmental conditions in these nations have deteriorated, raising serious issues among stakeholders. Therefore, we examine the effect of eco-innovation and trade openness on CO2 emissions in G7 nations. We also take into account the role of renewable energy, economic growth and nonrenewable energy use using a dataset covering the period from 1990–2019. We employed recent econometric techniques such as slope heterogeneity (SH) and cross-sectional dependence (CSD), Westerlund cointegration, fully modified ordinary least square (FMOLS), dynamic ordinary least square (DOLS), panel quantile regression and panel causality tests to assess these associations. The outcomes of the CSD and SH tests disclosed that using a first-generation unit root test will produce biase outcomes. Furthermore, the outcomes of the Westerlund cointegration disclosed support long-run association between CO2 and its drivers. In addition, the results of the long-run estimators (FMOLS and DOLS) unveiled that nonrenewable energy and trade openness contribute to the damage to the environment while economic expansion, renewable energy and eco-innovation enhance the quality of the environment. Furthermore, the outcomes of GDP, REC and ECO curb CO2 while NREC energy and TO surge CO2. Finally, the outcomes of the panel causality test unveiled that CO2 emissions can be predicted by all the exogenous variables. Copyright © 2022 Olanrewaju, Irfan, Altuntaş, Agyekum, Kamel and El-Naggar

Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficileof novel 3-biaryl-N-benzylpropan-1-amine derivatives

The synthesis of a series of benzimidazole-N-benzylpropan-1-amines and adenine-N-benzylpropan-1-amines is described. Subsequent evaluation against two strains of the anaerobic bacterium Clostridium difficile was performed with three amine derivatives displaying MIC values of 16 μg/mL. Molecular docking studies of the described amines determined that the amines interact within two active site pockets of C. difficile methionyl tRNA synthetase with methoxy substituents in the benzyl ring and an adenine biaryl moiety resulting in optimal binding interaction

Proučavanje relativističke tvorbe hadrona prema naprijed i unatrag u sudarima 3he i 4he s jezgrama u emulziji na energiji ubrzivača u dubni

The experimental results on 3He- and 4He-emulsion interactions accompanied by relativistic (shower) hadrons flying into the backward (θlab ≤ 90◦ ) hemisphere at 4.5 AGeV/c are presented and analyzed. The dependence of the probabilities of these interactions on the different target sizes, impact parameter and projectile spectator charges is studied. An investigation of average values and multiplicity distributions of these hadrons for the interactions with light and heavy emulsion nuclei has been carried out. In addition, the correlations between the multiplicities of different types of the emitted particles are studied. The data show that backward shower particles are a sensitive target parameter. The values of impact parameters can be used as good indicators for selecting events which occured with light or heavy emulsion nuclei. A comparison with the modified cascade model shows a good performance in describing the data produced in the region having less cascading (i.e. interactions with light nuclei). As for the interactions with heavy nuclei, the model overestimates the experimental data.Predstavljamo eksperimentalne rezultate i analize mjerenja međudjelovanja 3He i 4He u emulziji na 4.5 AGeV/c, u kojima se opažaju relativistički pljuskovi hadrona koji lete unatrag (θlab ≤ 90◦ ). Proučavamo ovisnost vjerojatnosti tih međudjelovanja o veličini jezgre mete, sudarnom parametru i naboju projektila-promatrača. Istražili smo prosječne vrijednosti i raspodjele višestrukosti hadrona za lake i teške jezgre u emulziji. Nadalje, proučavali smo korelacije višestrukosti različitih izlaznih čestica. Podaci pokazuju da su pljuskovi čestica unatrag osjetljiv parametar jezgri mete. Vrijednosti parametara mogu poslužiti kao dobar pokazatelj sudara s lakim odnosno teškim jezgrama. Usporedba s promijenjenim kaskadnim modelom pokazuje dobro slaganje s podacima u kojima je manje kaskada (tj. Manje sudara s lakim jezgrama). Rezultati tog modela za teške jezgre veći su od eksperimentalnih podataka