The Relationships of Leptin, Adiponectin Levels and Paraoxonase Activity with Metabolic and Cardiovascular Risk Factors in Females Treated with Psychiatric Drugs

OBJECTIVES: The aim of this study was to investigate serum leptin, adiponectin and paraoxonase1 levels in adult females receiving pharmacotherapy for various psychiatric disorders. METHODS: The study group consisted of 32 obese females (mean age 40.53 ± 11.00 years, mean body mass index 35.44 ± 5.33 kg/m²) who were receiving treatment for psychiatric disorders, and the control group included 22 obese females (mean age 35.95 ± 9.16 years, mean body mass index 30.78 ± 3.33 kg/m²) who were free of psychiatric disorders. Analyses were performed using a bioelectrical impedance device. Fasting blood samples were obtained for complete blood count and various biochemical tests, including determination of leptin, adiponectin and paraoxonase1 activity. RESULTS: Body mass index, waist and hip circumference, body fat percentage, fasting blood glucose, insulin, glycosylated hemoglobin, homeostasis model assesment of insulin resistance, alanine transaminase, aspartate tarnsaminase, and leptin levels were significantly higher in the study group than in controls. Although body weight was positively correlated with leptin levels in both groups, body weight was negatively correlated with adiponectin levels in the control group and positively correlated with adiponectin levels in the study group. In the study group, body mass index and hip circumference correlated positively with leptin levels, hip circumference correlated positively with adiponectin levels, and waist to hip ratio correlated positively with paraoxonase levels. In the control group, body mass index as well as waist and hip circumferences were positively correlated with leptin levels. Weight, body mass index, and hip circumference were also negatively correlated with the adiponectin/leptin ratio in the control group. CONCLUSION: This study indicates a higher risk for obesity-related disorders, particularly metabolic syndrome, diabetes and cardiovascular disease, in patients treated with psychiatric drugs

Hepatitis B Vaccination Results Which dose is Sufficient for Immunosuppressive Patients? Single or Double?

Aim: Despite effective HBV vaccine and vaccination programs, Hepatitis B still causes nearly one million deaths annually, according to the World Health Organization. The immunization rates are high by hepatitis B vaccination especially in young healthy population. However, advanced age, comorbidities and immune deficiency affect the rates of vaccine response negatively. We aimed to evaluate the factors affecting the vaccine response in the patients who received hepatitis B vaccine in our hospital retrospectively.Materials and Methods: Patients who received hepatitis B vaccine and followed-up for immunization status were evaluated retrospectively in our vaccination unit. The patients were examined in terms of age, comorbidities, vaccine scheme, vaccine dose, utilization of immunosuppressive-biological agents, immunization success, and common characteristics of patients who did not develop immunity.Results: Anti-HBs titers were significantly lower in patients over 50 years old. In addition, lower Anti-Hbs titers were detected in patients with comorbidity and who received immunosuppressive therapy. Statistically higher Anti-HBs titers were obtained with double dose vaccination than single dose vaccination in patients receiving immunosuppressive treatment. Moreover, it was documented that a single dose vaccination protocol was applied to all seven patients who failed vaccination. Six of these patients were over 50 years old, two were diabetic, five were diagnosed with rheumatic disease and all of them were using biological agents.Conclusion: Vaccination before treatment in patients who will receive immunosuppressive therapy, administration of high dose vaccines in patients under immunosuppressive therapy or delaying immunosuppressive therapy during vaccination may be considered as appropriate alternatives. Considering the safety and cost-effectiveness of high-dose hepatitis B vaccine, it should be preferred in the immunosuppressive patient group

Germline Pathogenic Variants Identified by Targeted Next-Generation Sequencing of Susceptibility Genes in Pheochromocytoma and Paraganglioma

The aim of this study was to evaluate germline variant frequencies of pheochromocytoma and paraganglioma targeted susceptibility genes with next-generation sequencing method. Germline DNA from 75 cases were evaluated with targeted next-generation sequencing on an Illumina NextSeq550 instrument. KIF1B, RET, SDHB, SDHD, TMEM127, and VHL genes were included in the study, and Sanger sequencing was used for verifying the variants. The pathogenic/likely pathogenic variants were in the VHL, RET, SDHB, and SDHD genes, and the diagnosis rate was 24% in this study. Three different novel pathogenic variants were determined in five cases. This is the first study from Turkey, evaluating germline susceptibility genes of pheochromocytoma and paraganglioma with a detection rate of 24% and three novel variants. All patients with pheochromocytoma and paraganglioma need clinical genetic testing with expanded targeted gene panels for higher diagnosis rates

Conversion in Turkish : an overview

This paper presents an overview of possible cases of conversion in Turkish. I argue that apparent cases of conversion between nouns and adjectives are cases of syntactic transposition, and apparent cases of conversion between nouns/adjectives and verbs are end products of phonological changes in the history of the language, which resulted in pairs of lexemes that are formally identical synchronically, but not historically. This does not mean that no cases of morphological conversion can be traced in the language. I will present two cases of secondary word-class conversion from derived, inflected and uninflected words to toponyms which might be taken as instances of morphological conversion or derivation by zero-affixation

Kurum Kültürünün İletişim Memnuniyetine Etkisi

Kurumların yoğun rekabet ortamında var olma mücadelesi verdiği günümüz ekonomik ve toplumsal düzende farklılığı yaratmak en büyük avantaj olarak karşımıza çıkmaktadır. Kurumların farklılık yaratabilecekleri ve rakiplerinden ayrışabilecekleri en önemli unsur ise kurum kültürüdür. Çünkü kültürün var olduğu yerde oluşum, gelişim, değişim ve yenilenme gibi birçok yapılanma karşımıza çıkmaktadır. Kurum kültürü ‘durağan’ değil ‘hareketli’ bir kavramdır ve bu durum da kurumlara önemli bir avantaj yaratmaktır. Kurum kültürünün temelinde insan vardır. Kuruma giren her yeni birey, kurumun kültürünü öğrendiği gibi, bu kültürün taşıyıcısı ve aktarıcısıdır. Kurumların en önemli paydaşlarından olan çalışanlar kültürün aktarımını gerçekleştirirken, çalışanların motivasyonu, tatmini ve kurum içindeki iletişimin güçlü bir şekilde sağlanması kültürün güçlenmesine de imkan sağlamaktadır. Bu çalışmanın amacı, Denison’ın kurum kültürü modeli çerçevesinde, çalışanların iletişim memnuniyetini belirlemektir. Bu doğrultuda, örnek kurum olarak seçilen Garanti Bankası çalışanlarıyla anket çalışması yapılmıştır. Kurumun kültür yapısı bu model çerçevesinde ortaya konulmuş ve bu yapının iletişim memnuniyetine olan etkisi tespit edilmeye çalışılmıştır. Yapılan çalışma sonucunda, Denison’ın kurum kültürü modelinde bulunan misyon, uyum, katılım ve tutarlılığın, iletişim memnuniyetine olan etkisi belirlenmiştir. Denison’ın kurum kültürü modeli faktörleri ile iletişim memnuniyeti arasında uyum öğesi haricinde anlamlı bir ilişki bulunmuştur. Bu tespit, kurumun yöneticileri ve çalışanlarının algıladıkları ‘kurum kültürü’ ile ‘iletişim memnuniyeti’ arasındaki ilişkiyi değerlendirmemiz açısından önem taşımaktadır

Corporate Social Responsibility In Turkey: An Analysis Through Web Sites

In today’s business environment, there is no chance for a corporation to be succeeded simply by doing profit oriented business. Corporations are the living entities along with their stakeholders therefore corporations are expected to be responsive on the cultural, environmental and economic issues of society. Socially responsible programs that corporations execute would contribute the corporate image and reputation. Furthermore, these programs benefit both corporations and society. The aim of this study is to examine the presence and organization of information on corporate responsibility present on the corporate web sites of companies which are in the Capital top 500 list. We will choose the top 100 companies on the top 500 list. By using content analysis, identified corporate responsibility issues will be analyzed. In this study, the information given in the web sites of these top 100 companies will be analyzed. We will be examining how the information is organized, presented, and related to the corporate responsibilities

The role of pharmacotherapy in female sexual dysfunctions

Pek çok çalışlma cinsel işlev bozukluğunun kadınlarda erkeklerden daha yaygın olduğunu düşündürtmekle birlikte, kadın cinsel işlev bozuklukları (KCİB) tedavisinde kullanılabilecek onaylanmış bir ilâç henüz mevcut değildir. Bununla birlikte, KCİB tedavisiyle ilişkili birkaç ana farmakolojik yolak mevcuttur. Bunlar dopaminerjik agonistler, melanokortin stimüle edici hormon, adrenerjik agonistler, nitrik oksit sistemi, prostaglandinler ve androjenleri içerir. Bu yazı KCB tedavisinde yararlı olmas› beklenen ilâç gruplarınıgözden geçirmektedi