61 research outputs found
ΠΠ»Π΅ΠΌΠ΅Π½ΡΠ°ΡΠ½ΡΠ΅ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ°ΡΡΠ½ΡΠΌΠΈ Π³ΠΈΠΏΠ΅ΡΠ³Π΅ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΡΠ΄Π°ΠΌΠΈ
Structurally parametric identification of object descrete models with delay for tuning smith controllers
Construction of Smith digital controller on the basis of equivalence principle of dynamic object models with delay has been suggeste
ΠΠ΄Π°ΠΏΡΠΈΠ²Π½Π°Ρ ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΡ Π½Π΅ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ½ΡΡ Π³ΠΈΠ΄ΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ "ΠΠ»Π°ΡΡ-ΡΠΊΠ²Π°ΠΆΠΈΠ½Π°" ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠ½ΡΠ΅Π³ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ
Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΠΈ Π½Π΅ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ½ΡΡ
Π³ΠΈΠ΄ΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ "ΠΏΠ»Π°ΡΡ-ΡΠΊΠ²Π°ΠΆΠΈΠ½Π°", ΠΈ ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅ΡΡΡ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΠΊ ΠΈΡ
ΡΠ΅ΡΠ΅Π½ΠΈΡ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠΉ Π½Π° ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΈΠ½ΡΠ΅Π³ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Π° Π°Π΄Π°ΠΏΡΠΈΠ²Π½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΠΈ. ΠΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ ΠΏΡΠΈΠΌΠ΅ΡΡ, ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΠΈΠ΅ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅ΠΌΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π°
ΠΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅Π·Π΅ΡΠ²ΠΎΠ² Π±Π°Π»Π°Π½ΡΠΈΡΡΡΡΠΈΡ ΠΌΠΎΡΠ½ΠΎΡΡΠ΅ΠΉ ΡΠ½Π΅ΡΠ³ΠΎΡΠΈΡΡΠ΅ΠΌΡ Π£ΠΊΡΠ°ΠΈΠ½Ρ Π·Π° ΡΡΠ΅Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΡ Π°ΠΊΠΊΡΠΌΡΠ»ΡΡΠΎΡΠΎΠ²
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΠΈΠ½Π΄ΡΠΊΡΠΈΠ²Π½ΠΎΡΡΠ΅ΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΡΠΊΠΎΡΡ ΠΈ ΡΠ°ΡΡΠ΅ΡΠ½ΠΈΡ Π½Π° ΡΠ°Π±ΠΎΡΡ ΡΠΈΠ½Ρ ΡΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΌΠ°ΡΠΈΠ½Ρ ΠΏΡΠΈ ΠΏΠ΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠ°ΡΡΠΎΡΠ΅ ΠΏΠΈΡΠ°Π½ΠΈΡ
ΠΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΠΈΡΡΠ²ΡΠ½ΡΠΊΠΎΠ³ΠΎ Π°Π½ΡΡΠ°ΡΠΈΡΠ° ΠΊΠ°ΠΊ ΡΡΡΡΡ Π΄Π»Ρ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΡΠ»Π΅ΠΊΡΡΠΎΠ΄Π½ΡΡ ΠΈΠ·Π΄Π΅Π»ΠΈΠΉ
Β«ΠΠΠ€ΠΠΠΠΠΠΠΠΠΠΠΠ§ΠΠΒ» ΠΠΠΠ¦ΠΠΠ¦ΠΠ― ΠΠ ΠΠΠ’ΠΠΠ Π―Π Π’ΠΠ ΠΠΠ― Π ΠΠΠΠΠ’ΠΠ£Π€ΠΠΠΠΠΠΠΠΠΠΠΠ Π’Π ΠΠΠ‘ΠΠΠΠΠΠΠ Π₯ΠΠ₯- Π₯Π₯Π‘Π’ΠΠΠΠ’Π’Π―
Π ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ Π°Π²ΡΠΎΡ Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΠ΅Ρ ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΡΡ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΡΡ Π€.
ΠΡΠ΅Π½ΡΠ°Π½ΠΎ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΠΏΡΠΎΡΠ΅ΡΡ ΠΊΠΎΠ½ΡΡΠΈΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡΠ½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ
Π΄Π°Π½Π½ΠΎΡΡΠ΅ΠΉβ Π²Π½ΡΡΡΠ΅Π½Π½Π΅Π΅
ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠ΅Π΄ΠΌΠ΅ΡΠ°. Π’Π°ΠΊΠΎΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΡΡΠ°Π» Π½ΠΎΠ²ΡΠΌ Π°ΠΊΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Β«ΡΠΌΠΏΠΈΡΠΈΡΠ½ΠΎΡΡΠΈΒ» ΠΈ
ΠΏΠΎΠΏΡΡΠΊΠΎΠΉ Π²ΠΎΠ·ΠΎΠ±Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΈΠ»ΠΎΡΠΎΡΠΈΠ΅ΠΉ ΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΏΠΎΠ½ΡΡΠΈΡ
Β«ΠΈΠ½ΡΠ΅Π½ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΡΡΡΒ», ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅ΠΎΡΠ΅ΡΠΈΠΊΠΎ-ΠΏΠΎΠ·Π½Π°Π²Π°ΡΠ΅Π»ΡΠ½ΡΠΌ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΎΠΌ.In this investigation author analyses empirical psychology of F.Brentano βthe procces of constitute
spontaneous facts as inside existence the object.
This idea have an influence development of the transcendental phenomenology, hermeneutical
phenomenology and have be essential for development of the contemporary philosophy of the value
The role of CaΒ²βΊ and other ion channels in AVP-stimulated ACTH release from ovine anterior pituitary cells
The role and regulation of CaΒ²βΊ and other ion channels in the in vitro adrenocorticotropin (ACTH) response to arginine vasopressin (AVP), were investigated in static cultures of ovine anterior pituitary cells. Previous evidence suggests that the action of AVP in ACTH secreting (corticotroph) cells involves the activation of the polyphosphoinositide-derived (PI) second-messenger system, and has also been shown to be dependent on CaΒ²βΊ influx. In this report, a variety of chemically distinct blockers of CaΒ²βΊ influx, including the organic agents (methoxyverapamil (D600), nifedipine and diltiazem) and the inorganic ions (CdΒ²βΊ and CoΒ²βΊ) were all found to cause large reductions in the AVP-stimulated ACTH response, providing further evidence that the AVP-induced response is dependent on CaΒ²βΊ influx to a large degree. However, the entire AVP-induced response was not inhibited by the blockers, suggesting that other factors, such as release of intracellularly stored CaΒ²βΊ also participates in this response. The blocking agents used in this study are all classified as blockers of L-type (L-) voltage-sensitive CaΒ²βΊ channels (VSCC), and thus the results suggest that L-VSCC are responsible for the bulk of the CaΒ²βΊ influx that underlies the AVP-induced response. The inorganic blocking ions also inhibit T-type (T-) VSCC, and thus it is possible that these channels also contribute to the response.
In cells that possess voltage-activated CaΒ²βΊ channels, raising the extracellular KβΊ concentration ([KβΊ]e) typically evokes hormone secretion, due to depolarisation-induced CaΒ²βΊ influx via the voltage-sensitive channels. Raising [KβΊ]e caused ACTH secretion from ovine corticotrophs, and this response was also sensitive to VSCC blockers. These results provide further support for the presence of VSCC in ovine corticotrophs.
Simultaneous stimulation with AVP and raised [KβΊ]e caused a level of ACTH secretion that was less than the sum of the individual responses, when the concentrations of the secretagogues were moderate to high. This result is consistent with the hypothesis that both secretagogues activate, to some extent, the same population of CaΒ²βΊ channels during their respective responses. At low concentrations of the secretagogues, a synergistic response was observed. Further experimentation and analysis suggested that this response may be generated at the level of CaΒ²βΊ influx, and thus raised the possibility that the VSCC may be subject to dual voltage and voltage-independent regulation.
The possibility that voltage-independent regulation of VSCC activity by protein kinase C (PKC), part of the PI second-messenger system, occurred during the response to AVP was explored by down-regulating PKC activity. This was achieved by chronic exposure of pituitary cells to the PKC-activating phorbol ester, 12-0-tetradecanoylphorbol 13 -acetate (TPA). This treatment totally inactivated PKC, reduced the responses to AVP, but not KβΊe and abolished the synergistic interaction between AVP and KβΊe. Thus these results are consistent with a role for PKC in the AVP-induced ACTH response, and with the hypothesis that the synergistic response occurs due to voltage-independent (chemical) regulation of VSCC. This hypothesis was further supported by the finding that simultaneous stimulation with TPA plus raised [KβΊ]e caused synergistic ACTH responses.
The possibility that PKC activates VSCC was investigated by examining the effects of VSCC blockers on TPA-stimulated ACTH release. The organic blocker, D600, and the inorganic ion, CoΒ²βΊ, both reduced the TPA-induced response. However, the patterns of inhibition were not entirely consistent with those previously observed for inhibition of AVP-induced secretion. Thus an additional protocol, reducing or removing CaΒ²βΊ from the extracellular medium, was employed to investigate the involvement of CaΒ²βΊ influx during the response to TPA. This protocol reduced both AVP- and TPA-stimulated ACTH release, and thus provided additional evidence that the AVP-induced response is dependent on CaΒ²βΊ influx, and further suggested that PKC can activate CaΒ²βΊ influx in ovine corticotrophs. Thus the possibility that AVP-activated PKC can affect VSCC activity in corticotroph cells is a viable hypothesis.
Voltage regulation of VSCC by AVP, and the effects on ACTH secretion, were also investigated. The possibility that AVP may create a depolarisation stimulus via PKC-mediated inhibition of a KβΊ current that is active at rest, was examined. Exposure of cells to the KβΊ channel blocker tetraethylammonium (TEA), stimulated a small increase in ACTH release that was sensitive to CaΒ²βΊ channel blockers. These findings are consistent with the hypothesis under investigation.
Exposure of cells to TEA in the presence of AVP or TPA enhanced the responses to these secretagogues, suggesting that a (possibly CaΒ²βΊ-activated) KβΊ current (distinct from the one discussed in the previous paragraph) is present in ovine corticotrophs, and may act to regulate the cellular response to these agents. Removal of external NaβΊ caused a small reduction in AVP-stimulated ACTH release, suggesting that Na+ channels may play a minor role in the response to AVP. These investigations extend the current knowledge regarding the regulation of the AVP-induced ACTH response, particularly with respect to ovine cells
End-to-End Data Analytics Framework for 5G Architecture
Data analytics can be seen as a powerful tool for the fifth-generation (5G) communication system to enable the transformation of the envisioned challenging 5G features into a reality. In the current 5G architecture, some first features toward this direction have been adopted by introducing new functions in core and management domains that can either run analytics on collected communication-related data or can enhance the already supported network functions with statistics collection and prediction capabilities. However, possible further enhancements on 5G architecture may be required, which strongly depend on the requirements as set by vertical customers and the network capabilities as offered by the operator. In addition, the architecture needs to be flexible in order to deal with network changes and service adaptations as requested by verticals. This paper explicitly describes the requirements for deploying data analytics in a 5G system and subsequently presents the current status of standardization activities. The main contribution of this paper is the investigation and design of an integrated data analytics framework as a key enabling technology for the service-based architectures (SBAs). This framework introduces new functional entities for application-level, data network, and access-related analytics to be integrated into the already existing analytics functionalities and examines their interactions in a service-oriented manner. Finally, to demonstrate predictive radio resource management, we showcase a particular implementation for application and radio access network analytics, based on a novel database for collecting and analyzing radio measurements
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