The quest for a donor: probability based methods offer help

When a patient in need of a stem cell transplant has no compatible donor within his or her closest family, and no matched unrelated donor can be found, a remaining option is to search within the patient’s extended family. This situation often arises when the patient is of an ethnic minority, originating from a country that lacks a well-developed stem cell donor program, and has HLA haplotypes that are rare in his or her country of residence. Searching within the extended family may be time-consuming and expensive, and tools to calculate the probability of a match within groups of untested relatives would facilitate the search. We present a general approach to calculating the probability of a match in a given relative, or group of relatives, based on the pedigree, and on knowledge of the genotypes of some of the individuals. The method extends previous approaches by allowing the pedigrees to be consanguineous and arbitrarily complex, with deviations from Hardy-Weinberg equilibrium. We show how this extension has a considerable effect on results, in particular for rare haplotypes. The methods are exemplified using freeware programs to solve a case of practical importance

The role of (de-)essentialisation within siting conflicts: an interdisciplinary approach

Large-scale renewable energy and associated technologies (RET), such as high voltage power lines (HVPL), often meet opposition from the local communities living nearby. Research has suggested that one of the main aspects that might contribute to this is the fact that RET are represented as industrial and urban, and thus, as having a different essence from rural landscapes, where they are usually deployed and which are represented as natural and unspoilt. However, this 'hypothesis' of landscape essentialisation shaping people's responses to RET has not been explicitly examined. By drawing upon research from Social Psychology and Human Geography on essentialisation, we will examine if and how landscape (de-)essentialisation plays a role in people's responses to RET. Namely, by examining it as a rhetorical construction that can be strategically used to negotiate and legitimize given relations with place and associated responses to RET.Focus groups were conducted in the UK and Norway with members of local communities to be affected by the construction of HVPLs that will connect to new low carbon energy technologies. Analyses show that participants present British and Norwegian rural landscapes in general and HVPL as having two different essences, which justifies opposition to those infrastructures. However, analyses also show that essentialisation of the countryside is strategically used. Namely, participants also present the countryside in the place where they live as having more of the essence of the British or Norwegian countryside than other areas of the UK and Norway. In turn, this allows them to legitimize claims that whereas HVPL are 'out of place' in the countryside in general, they are more so in the place where they live.The implications of these results for the definition of acceptable locations for RET and for research on people-place relations and responses to place change, are discussed.info:eu-repo/semantics/acceptedVersio

On global properties of passivity-based control of an inverted pendulum,”

SUMMARY The paper adresses the problem of stabilization of a speci"c target position of underactuated Lagrangian or Hamiltonian systems. We propose to solve the problem in two steps: "rst to stabilize a set with the target position being a limit point for all trajectories originating in this set and then to switch to a locally stabilizing controller. We illustrate this approach by the well-known example of inverted pendulum on a cart. Particularly, we design a controller which makes the upright position of the pendulum and zero displacement of the cart a limit point for almost all trajectories. We derive a family of static feedbacks such that any solution of the closed loop system except for those originating on some two-dimensional manifold approaches an arbitrarily small neighbourhood of the target position. The proposed technique is based on the passivity properties of the inverted pendulum. A possible extension to a more general class of underactuated mechanical systems is discussed

Magnetic variability in the young solar analog KIC 10644253: Observations from the Kepler satellite and the HERMES spectrograph

The continuous photometric observations collected by the Kepler satellite over 4 years provide a whelm of data with an unequalled quantity and quality for the study of stellar evolution of more than 200000 stars. Moreover, the length of the dataset provide a unique source of information to detect magnetic activity and associated temporal variability in the acoustic oscillations. In this regards, the Kepler mission was awaited with great expectation. The search for the signature of magnetic activity variability in solar-like pulsations still remained unfruitful more than 2 years after the end of the nominal mission. Here, however, we report the discovery of temporal variability in the low-degree acoustic frequencies of the young (1 Gyr-old) solar analog KIC 10644253 with a modulation of about 1.5 years with significant temporal variations along the duration of the Kepler observations. The variations are in agreement with the derived photometric activity. The frequency shifts extracted for KIC 10644253 are shown to result from the same physical mechanisms involved in the inner sub-surface layers as in the Sun. In parallel, a detailed spectroscopic analysis of KIC 10644253 is performed based on complementary ground-based, high-resolution observations collected by the HERMES instrument mounted on the MERCATOR telescope. Its lithium abundance and chromospheric activity S-index confirm that KIC 10644253 is a young and more active star than the Sun.Comment: Accepted for publication in A&A, 12 pages, 8 figure

A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression

Verbal and visuospatial working memory (WM) impairment is a well-documented finding in psychiatric patients suffering from major psychoses such as schizophrenia or bipolar affective disorder. However, in major depression (MDD) the literature on the presence and the extent of WM deficits is inconsistent. The use of a multitude of different WM tasks most of which lack process-specificity may have contributed to these inconsistencies. Eighteen MDD patients and 18 healthy controls matched with regard to age, gender and education were tested using process- and circuit-specific WM tasks for which clear brain-behaviour relationships had been established in prior functional neuroimaging studies. Patients suffering from acute MDD showed a selective impairment in articulatory rehearsal of verbal information in working memory. By contrast, visuospatial WM was unimpaired in this sample. There were no significant correlations between symptom severity and WM performance. These data indicate a dysfunction of a specific verbal WM system in acutely ill patients with MDD. As the observed functional deficit did not correlate with different symptom scores, further, longitudinal studies are required to clarify whether and how this deficit is related to illness acuity and clinical state of MDD patients

Bacterial Deposition of Gold on Hair: Archeological, Forensic and Toxicological Implications

Trace metal analyses in hair are used in archeological, forensic and toxicological investigations as proxies for metabolic processes. We show metallophilic bacteria mediating the deposition of gold (Au), used as tracer for microbial activity in hair post mortem after burial, affecting results of such analyses. Methodology/Principal Findings Human hair was incubated for up to six months in auriferous soils, in natural soil columns (Experiment 1), soils amended with mobile Au(III)-complexes (Experiment 2) and the Au-precipitating bacterium Cupriavidus metallidurans (Experiment 3), in peptone-meat-extract (PME) medium in a culture of C. metallidurans amended with Au(III)-complexes (Experiment 4), and in non-auriferous soil (Experiment 5). Hair samples were analyzed using scanning electron microscopy, confocal microscopy and inductively coupled plasma-mass spectrometry. In Experiments 1–4 the Au content increased with time (P = 0.038). The largest increase was observed in Experiment 4 vs. Experiment 1 (mean = 1188 vs. 161 µg Kg−1, Fisher's least significance 0.001). The sulfur content, a proxy for hair metabolism, remained unchanged. Notably, the ratios of Au-to-S increased with time (linear trend P = 0.02) and with added Au and bacteria (linear trend, P = 0.005), demonstrating that larger populations of Au-precipitating bacteria and increased availability of Au increased the deposition of Au on the hair. Conclusion/Significance Interactions of soil biota with hair post mortem may distort results of hair analyses, implying that metal content, microbial activities and the duration of burial must be considered in the interpretation of results of archeological, forensic and toxicological hair analyses, which have hitherto been proxies for pre-mortem metabolic processesGenevieve Phillips, Frank Reith, Clifford Qualls, Abdul-Mehdi Ali, Mike Spilde and Otto Appenzelle

Can We Really Prevent Suicide?

Every year, suicide is among the top 20 leading causes of death globally for all ages. Unfortunately, suicide is difficult to prevent, in large part because the prevalence of risk factors is high among the general population. In this review, clinical and psychological risk factors are examined and methods for suicide prevention are discussed. Prevention strategies found to be effective in suicide prevention include means restriction, responsible media coverage, and general public education, as well identification methods such as screening, gatekeeper training, and primary care physician education. Although the treatment for preventing suicide is difficult, follow-up that includes pharmacotherapy, psychotherapy, or both may be useful. However, prevention methods cannot be restricted to the individual. Community, social, and policy interventions will also be essentia

Patterns of risk and protective factors in the intergenerational cycle of maltreatment

his study investigates the continuation and discontinuation of the intergenerational transmission of child maltreatment within the first 13 months of the child’s life. Differences in risk factors and parenting styles between families who initiate (Initiators), maintain (Maintainers) or break (Cycle Breakers) the intergenerational cycle of child maltreatment are explored in comparison to control families (Controls). One hundred and three Health Visitors were trained to assess risk factors and parenting styles of 4,351 families, at both 4–6 weeks and 3–5 months after birth. Maintainers, Initiators and Cycle Breakers had a significantly higher prevalence for the majority of risk factors and poor parenting styles than Controls. Protective factors of financial solvency and social support distinguished Cycle Breakers from Maintainers and Initiators. Therefore, it is the presence of protective factors that distinguish Cycle Breakers from families who were referred to Child Protection professionals in the first year after birth. A conceptual, hierarchical model that considers history of abuse, risk and protective factors, in turn, is proposed to assess families for the potential of child maltreatment