Anti-melanocortin-4 receptor autoantibodies in obesity

Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients. Methods: The autoAbs were detected after screening of 216 patients' sera by using direct and inhibition ELISA with an N-terminal sequence of the MC4R. Binding to the native MC4R was evaluated by flow cytometry and pharmacological effects by measuring adenylyl cyclase activity. Results: Positive results in all tests were obtained in patients with overweight or obesity (prevalence: 3.6%) but not in normal weight patients. The selective binding properties of anti-MC4R autoAbs were confirmed by surface plasmon resonance and by immunoprecipitation with the native MC4R. Finally it was demonstrated that these autoAbs increased food intake in rats after passive transfer via intracerebroventricular injection. Conclusion: These observations suggest that inhibitory anti-MC4R autoAbs might contribute to the development of obesity in a small subpopulation of patients

The Effect of Fertilizer Treatments at Three Compactness Levels on Qualitative Traits of Sport Lawn in Winter Season

Lawn quality, which introduces by good color, density, uniformity and texture varies depending on the species, maintenance operation, and time of the year. In the current study, the effect of organic fertilizers containing Leaf Mold (LM), Rice Husk (RH), manure, Spent Mushroom Compost (SMC), a mixture of LM, RH and SMC (mixture 1), a mixture of LM, RH and manure (mixture 2), with the ratio of 1:1:1 and control (no fertilizer) at three levels of soil compactness including roller weights of 36, 56, 76 kilograms on qualitative traits of sport lawn were investigated in winter season. Treatments were applied in a strip plot design with three replications, in research farm of Gorgan University of Agricultural Sciences and Natural Resources during fall 2008-2009. According to achieved results, manure and RH treatments in first and second compaction and manure treatment in third compaction level showed the highest amount of chlorophyll content. In visual assessment, the highest and lowest of lawn quality was observed in the manure and the control treatment respectively. In first and second compaction, the maximum height was observed in manure treatment. Control and LM treatments showed the minimum height. In third compaction, maximum and minimum heights were associated with manure and control treatment respectively

Spitzer Space Telescope Infrared Observations of the Binary Neutron Star Merger GW170817

We present Spitzer Space Telescope 3.6 and 4.5 micron observations of the binary neutron star merger GW170817 at 43, 74, and 264 days post-merger. Using the final observation as a template, we uncover a source at the position of GW170817 at 4.5 micron with a brightness of 22.9+/-0.3 AB mag at 43 days and 23.8+/-0.3 AB mag at 74 days (the uncertainty is dominated by systematics from the image subtraction); no obvious source is detected at 3.6 micron to a 3-sigma limit of >23.3 AB mag in both epochs. The measured brightness is dimmer by a factor of about 2-3 times compared to our previously published kilonova model, which is based on UV, optical, and near-IR data at <30 days. However, the observed fading rate and color (m_{3.6}-m_{4.5}> 0 AB mag) are consistent with our model. We suggest that the discrepancy is likely due to a transition to the nebular phase, or a reduced thermalization efficiency at such late time. Using the Spitzer data as a guide, we briefly discuss the prospects of observing future binary neutron star mergers with Spitzer (in LIGO/Virgo Observing Run 3) and the James Webb Space Telescope (in LIGO/Virgo Observing Run 4 and beyond).Comment: 6 pages, 2 figures, submitted to ApJ

A review of potential suggested drugs for coronavirus disease (COVID-19) treatment

The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high prevalence and easy transmission, which is expanding globally with no conventional treatment or vaccine. The new virus revealed 79 and 50 genomic similarities with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively. Accordingly, since the disease resists testing and adopting new therapeutics, repositioning pre-existing drugs may present a fast and attractive strategy with known safety, characteristics, and dosage used. However, they are not specific and targeted. Therefore, several drugs have been investigated for their efficacy and safety in the treatment of COVID-19; most of them are undergoing clinical trials. This article summarizes clinical investigations of potential therapeutic drugs used as COVID-19 therapy. Subsequently, it prepares a pattern of results and therapeutic targets to help further experiment designs. We have investigated drugs as classified in the following three groups; 1) The drugs which computationally showed effectiveness (in silico) but needed further lab confirmations; 2) Emetine, Teicoplanin, and Nelfinavir have shown effectiveness in vitro; 3) The drugs currently under clinical trial. © 2021 Elsevier B.V

Improved constraints on H0 from a combined analysis of gravitational-wave and electromagnetic emission from GW170817

The luminosity distance measurement of GW170817 derived from GW analysis in Abbott et al. 2017 (here, A17:H0) is highly correlated with the measured inclination of the NS-NS system. To improve the precision of the distance measurement, we attempt to constrain the inclination by modeling the broad-band X-ray-to-radio emission from GW170817, which is dominated by the interaction of the jet with the environment. We update our previous analysis and we consider the radio and X-ray data obtained at $t<40$ days since merger. We find that the afterglow emission from GW170817 is consistent with an off-axis relativistic jet with energy $10^{48}\,\rm{erg}<E_{k}\le 3\times 10^{50} \,\rm{erg}$ propagating into an environment with density $n\sim10^{-2}-10^{-4} \,\rm{cm^{-3}}$, with preference for wider jets (opening angle $\theta_j=15$ deg). For these jets, our modeling indicates an off-axis angle $\theta_{\rm obs}\sim25-50$ deg. We combine our constraints on $\theta_{\rm obs}$ with the joint distance-inclination constraint from LIGO. Using the same $\sim 170$ km/sec peculiar velocity uncertainty assumed in A17:H0 but with an inclination constraint from the afterglow data, we get a value of $H_0=$$74.0 \pm \frac{11.5}{7.5}$ \mbox{km/s/Mpc}, which is higher than the value of $H_0=$$70.0 \pm \frac{12.0}{8.0}$ \mbox{km/s/Mpc} found in A17:H0. Further, using a more realistic peculiar velocity uncertainty of 250 km/sec derived from previous work, we find $H_0=$$75.5 \pm \frac{11.6}{9.6}$ km/s/Mpc for H0 from this system. We note that this is in modestly better agreement with the local distance ladder than the Planck CMB, though a significant such discrimination will require $\sim 50$ such events. Future measurements at $t>100$ days of the X-ray and radio emission will lead to tighter constraints.Comment: Submitted to ApJL. Comments Welcome. Revised uncertainties in v

A review of potential suggested drugs for coronavirus disease (COVID-19) treatment

The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high prevalence and easy transmission, which is expanding globally with no conventional treatment or vaccine. The new virus revealed 79 and 50 genomic similarities with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively. Accordingly, since the disease resists testing and adopting new therapeutics, repositioning pre-existing drugs may present a fast and attractive strategy with known safety, characteristics, and dosage used. However, they are not specific and targeted. Therefore, several drugs have been investigated for their efficacy and safety in the treatment of COVID-19; most of them are undergoing clinical trials. This article summarizes clinical investigations of potential therapeutic drugs used as COVID-19 therapy. Subsequently, it prepares a pattern of results and therapeutic targets to help further experiment designs. We have investigated drugs as classified in the following three groups; 1) The drugs which computationally showed effectiveness (in silico) but needed further lab confirmations; 2) Emetine, Teicoplanin, and Nelfinavir have shown effectiveness in vitro; 3) The drugs currently under clinical trial. © 2021 Elsevier B.V

The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/VIRGO GW170817. VI. Radio Constraints on a Relativistic Jet and Predictions for Late-Time Emission from the Kilonova Ejecta

We present Very Large Array (VLA) and Atacama Large Millimeter/sub-millimeter Array ALMA radio observations of GW\,170817, the first Laser Interferometer Gravitational-wave Observatory (LIGO)/Virgo gravitational wave (GW) event from a binary neutron star merger and the first GW event with an electromagnetic (EM) counterpart. Our data include the first observations following the discovery of the optical transient at both the centimeter ($13.7$ hours post merger) and millimeter ($2.41$ days post merger) bands. We detect faint emission at 6 GHz at 19.47 and 39.23 days after the merger, but not in an earlier observation at 2.46 d. We do not detect cm/mm emission at the position of the optical counterpart at frequencies of 10-97.5 GHz at times ranging from 0.6 to 30 days post merger, ruling out an on-axis short gamma-ray burst (SGRB) for energies $\gtrsim 10^{48}$ erg. For fiducial SGRB parameters, our limits require an observer viewer angle of $\gtrsim 20^{\circ}$. The radio and X-ray data can be jointly explained as the afterglow emission from an SGRB with a jet energy of $\sim 10^{49}-10^{50}$ erg that exploded in a uniform density environment with $n\sim 10^{-4}-10^{-2}$ cm$^{-3}$, viewed at an angle of $\sim 20^{\circ}-40^{\circ}$ from the jet axis. Using the results of our light curve and spectral modeling, in conjunction with the inference of the circumbinary density, we predict the emergence of late-time radio emission from the deceleration of the kilonova (KN) ejecta on a timescale of $\sim 5-10$ years that will remain detectable for decades with next-generation radio facilities, making GW\,170817 a compelling target for long-term radio monitoring.Comment: 8 pages, 4 figures, 1 table. ApJL, in press. Keywords: GW170817, LV

Relation for the nonequilibrium population of the interface states: effects on the bias dependence of the ideality factors

By an analysis of the exchange of carriers through a semiconductor junction, a general relationship for the nonequilibrium population of the interface states in Schottky barrier diodes has been derived. Based on this relationship, an analytical expression for the ideality factor valid in the whole range of applied bias has been given. This quantity exhibits two different behaviours depending on the value of the applied bias with respect to a critical voltage. This voltage, which depends on the properties of the interfacial layer, constitutes a new parameter to complete the characterization of these junctions. A simple interpretation of the different behaviours of the ideality factor has been given in terms of the nonequilibrium charging properties of interface states, which in turn explains why apparently different approaches have given rise to similar results. Finally, the relevance of our results has been considered on the determination of the density of interface states from nonideal current-voltage characteristics and in the evaluation of the effects of the interfacial layer thickness in metal-insulator-semiconductor tunnelling diodes