81 research outputs found
Liquid crystals as amplifiers of molecular chirality
Bepaalde organisch chemische moleculen komen voor in twee vormen die volledig identiek zijn op één eigenschap na. De twee vormen zijn namelijk spiegelbeelden. Dat onderscheid wordt in de chemie chiraliteitgenoemd. Rienk Eelkema onderzocht hoe je chiraliteit kunt gebruiken voor het ontwikkelen van nieuwe materialen. Daarbij keek hij met name naar het gedrag van zogenaamde moleculaire motoren en schakelaars in vloeibaar kristallijnen films. De resultaten van dit onderzoek werden eerder dit jaar in Nature gepubliceerd (zie persbericht nr. 26 op de RUG website)
Dynamics of hydroxide-ion-driven reversible autocatalytic networks
An autocatalytic reaction network is designed utilising the interplay of hydroxide concentration dependent reactions and acid–base equilibria of imine hydrolysis
Gelation Landscape Engineering Using a Multi-Reaction Supramolecular Hydrogelator System
Simultaneous control of the kinetics and
thermodynamics of two different types of covalent
chemistry allows pathway selectivity in the formation of
hydrogelating molecules from a complex reaction network.
This can lead to a range of hydrogel materials with vastly
different properties, starting from a set of simple starting
compounds and reaction conditions. Chemical reaction
between a trialdehyde and the tuberculosis drug isoniazid
can form one, two, or three hydrazone connectivity
products, meaning kinetic gelation pathways can be
addressed. Simultaneously, thermodynamics control the
formation of either a keto or an enol tautomer of the
products, again resulting in vastly different materials.
Overall, this shows that careful navigation of a reaction
landscape using both kinetic and thermodynamic
selectivity can be used to control material selection from
a complex reaction network
The emerging landscape of single-molecule protein sequencing technologies
Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biological discovery and open new avenues for ultrasensitive disease diagnostics.This Perspective describes new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell proteomics.</p
- …