1,528 research outputs found

    Political and Media Discourses about Integrating Refugees in the UK

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    The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.This article addresses political and media discourses about integrating refugees in the UK in the context of the “refugee crisis”. A discursive psychological approach is presented as the best way to understand what talk about the concept is used to accomplish in these debates. A large corpus of political discussions (13 hours of debate featuring 146 politicians) and 960 newspaper articles from the UK were discourse analysed. The analysis identified five dilemmas about integration: Integration is positive and necessary, but challenging; Host communities are presented as welcoming, but there are limits to their capacity; Refugees are responsible for integration, but host communities need to provide support; Good refugees integrate, bad ones don't; Refugees are vulnerable and are skilled. All are used to warrant the inclusion or exclusion of refugees. The responsibility of western nations to support refugees is therefore contingent on the refugees behaving in specific ways

    Human-Machine Communication Scholarship Trends: An Examination of Research From 2011 to 2021 in Communication Journals

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    Despite a relatively short history, the modern-day study of communication has grown into multiple subfields. To better understand the relationship between Human-Machine Communication (HMC) research and traditional communication science, this study examines the published scholarship in 28 communication-specific journals from 2011–2021 focused on human-machine communication (HMC). Findings suggest limited prior emphasis of HMC research within the 28 reviewed journals; however, more recent trends show a promising future for HMC scholarship. Additionally, HMC appears to be diverse in the specific context areas of research in the communication context. Finally, we offer future directions of research and suggestions for the development of HMC

    Enhanced He-alpha emission from "smoked" Ti targets irradiated with 400nm, 45 fs laser pulses

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    We present a study of He-like 1s(2)-1s2p line emission from solid and low-density Ti targets under similar or equal to 45 fs laser pulse irradiation with a frequency doubled Ti: Sapphire laser. By varying the beam spot, the intensity on target was varied from 10(15) W/cm(2) to 10(19) W/cm(2). At best focus, low density "smoked" Ti targets yield similar to 20 times more He-alpha than the foil targets when irradiated at an angle of 45 degrees with s-polarized pulses. The duration of He-alpha emission from smoked targets, measured with a fast streak camera, was similar to that from Ti foils

    Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon

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    To profile the messenger RNA (mRNA) expression for the 23 known genes of matrix metalloproteinases (MMPs), 19 genes of ADAMTS, 4 genes of tissue inhibitors of metalloproteinases (TIMPs), and ADAM genes 8, 10, 12, and 17 in normal, painful, and ruptured Achilles tendons. Tendon samples were obtained from cadavers or from patients undergoing surgical procedures to treat chronic painful tendinopathy or ruptured tendon. Total RNA was extracted and mRNA expression was analyzed by quantitative real-time reverse transcription–polymerase chain reaction, normalized to 18S ribosomal RNA. In comparing expression of all genes, the normal, painful, and ruptured Achilles tendon groups each had a distinct mRNA expression signature. Three mRNA were not detected and 14 showed no significant difference in expression levels between the groups. Statistically significant (P < 0.05) differences in mRNA expression, when adjusted for age, included lower levels of MMPs 3 and 10 and TIMP-3 and higher levels of ADAM-12 and MMP-23 in painful compared with normal tendons, and lower levels of MMPs 3 and 7 and TIMPs 2, 3, and 4 and higher levels of ADAMs 8 and 12, MMPs 1, 9, 19, and 25, and TIMP-1 in ruptured compared with normal tendons. The distinct mRNA profile of each tendon group suggests differences in extracellular proteolytic activity, which would affect the production and remodeling of the tendon extracellular matrix. Some proteolytic activities are implicated in the maintenance of normal tendon, while chronically painful tendons and ruptured tendons are shown to be distinct groups. These data will provide a foundation for further study of the role and activity of many of these enzymes that underlie the pathologic processes in the tendon

    Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability

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    <p>Abstract</p> <p>Background</p> <p>NEK1, the first mammalian ortholog of the fungal protein kinase never-in-mitosis A (NIMA), is involved early in the DNA damage sensing/repair pathway. A defect in DNA repair in NEK1-deficient cells is suggested by persistence of DNA double strand breaks after low dose ionizing radiation (IR). NEK1-deficient cells also fail to activate the checkpoint kinases CHK1 and CHK2, and fail to arrest properly at G1/S or G2/M-phase checkpoints after DNA damage.</p> <p>Results</p> <p>We show here that NEK1-deficient cells suffer major errors in mitotic chromosome segregation and cytokinesis, and become aneuploid. These NEK1-deficient cells transform, acquire the ability to grow in anchorage-independent conditions, and form tumors when injected into syngeneic mice. Genomic instability is also manifest in <it>NEK1 </it>+/- mice, which late in life develop lymphomas with a much higher incidence than wild type littermates.</p> <p>Conclusion</p> <p>NEK1 is required for the maintenance of genome stability by acting at multiple junctures, including control of chromosome stability.</p

    Individual freedom versus collective responsibility: too many rights make a wrong?

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    Individuals might reasonably expect the freedom to make their own decisions regarding their health. However, what happens when an individual's wishes conflict with what is in that individual's best interests? How far should an individual's rights be restricted for his or her own benefit? Similarly, what limitations should be placed on an individual's behaviour when that person's wishes go against what is good for the population in general? Here we discuss the issues that can arise when the rights of individuals conflict with individual and population benefits in relation to infectious diseases

    Legacy iron and steel wastes in the UK: Extent, resource potential, and management futures

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    This is the author accepted manuscript. The final version is available on open access from Elsevier via the DOI in this recordThe iron and steel industry has a long tradition of bulk reuse of slags for a range of construction applications. Growing interest in recent years has seen slag resource recovery options extend to critical raw material recovery and atmospheric carbon capture. Full scale deployment of such technologies is currently limited in part by absent or partial inventories of slag deposit locations, data on composition, and volume estimates in many jurisdictions. This paper integrates a range of spatial information to compile a database of iron and steel slag deposits in mainland United Kingdom (UK) for the first time and evaluate the associated resource potential. Over 190 million tonnes of legacy iron and steel slag are present across current and former iron and steel working regions of the UK, with particular concentrations in the north west and north east of England, and central Scotland. While significant potential stockpiles of blast furnace and basic oxygen furnace slag could provide up to 0.9 million tonnes of vanadium and a cumulative carbon dioxide capture potential of 57–138 million tonnes, major management challenges for resource recovery are apparent. Over one third are located in close proximity to designated conservation areas which may limit resource recovery. Furthermore, land use analyses show that many of the sites have already been redeveloped for housing (nearly 30% urban cover). Deposits from recent decades in current or recently closed steel-working areas may have the greatest potential for resource recovery where such ambitions could be coupled with site restoration and regeneration efforts.Natural Environment Research Council (NERC)Engineering and Physical Sciences Research Council (EPSRC)Economic and Social Research Council (ESRC)UK Department for Business Energy and Industrial Strategy (BEIS

    Studies of the decays D^0 \rightarrow K_S^0K^-\pi^+ and D^0 \rightarrow K_S^0K^+\pi^-

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    The first measurements of the coherence factor R_{K_S^0K\pi} and the average strong--phase difference \delta^{K_S^0K\pi} in D^0 \to K_S^0 K^\mp\pi^\pm decays are reported. These parameters can be used to improve the determination of the unitary triangle angle \gamma\ in B^- \rightarrow D~K\widetilde{D}K^- decays, where D~\widetilde{D} is either a D^0 or a D^0-bar meson decaying to the same final state, and also in studies of charm mixing. The measurements of the coherence factor and strong-phase difference are made using quantum-correlated, fully-reconstructed D^0D^0-bar pairs produced in e^+e^- collisions at the \psi(3770) resonance. The measured values are R_{K_S^0K\pi} = 0.70 \pm 0.08 and \delta^{K_S^0K\pi} = (0.1 \pm 15.7)^\circ for an unrestricted kinematic region and R_{K*K} = 0.94 \pm 0.12 and \delta^{K*K} = (-16.6 \pm 18.4)^\circ for a region where the combined K_S^0 \pi^\pm invariant mass is within 100 MeV/c^2 of the K^{*}(892)^\pm mass. These results indicate a significant level of coherence in the decay. In addition, isobar models are presented for the two decays, which show the dominance of the K^*(892)^\pm resonance. The branching ratio {B}(D^0 \rightarrow K_S^0K^+\pi^-)/{B}(D^0 \rightarrow K_S^0K^-\pi^+) is determined to be 0.592 \pm 0.044 (stat.) \pm 0.018 (syst.), which is more precise than previous measurements.Comment: 38 pages. Version 3 updated to include the erratum information. Errors corrected in Eqs (25), (26), 28). Fit results updated accordingly, and external inputs updated to latest best known values. Typo corrected in Eq(3)- no other consequence
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