304 research outputs found
U.S. Variations in Child Health System Performance: A State Scorecard
Ranks state child health systems on thirteen measurements of five dimensions: access, quality, costs, equity, and potential to lead healthy lives. Highlights variations, regional patterns, and correlations between indicators and with demographic factors
Child relationships in the middle grades
Thesis (Ed.M.)--Boston Universit
Cast Glance Near Infrared Imaging Observations of the Space Shuttle During Hypersonic Re-Entry
High resolution calibrated infrared imagery of the Space Shuttle was obtained during hypervelocity atmospheric entries of the STS-119, STS-125 and STS128 missions and has provided information on the distribution of surface temperature and the state of the airflow over the windward surface of the Orbiter during descent. This data collect was initiated by NASA s Hypersonic Thermodynamic Infrared Measurements (HYTHIRM) team and incorporated the use of air- and land-based optical assets to image the Shuttle during atmospheric re-entry. The HYTHIRM objective is to develop and implement a set of mission planning tools designed to establish confidence in the ability of an existing optical asset to reliably acquire, track and return global quantitative surface temperatures of the Shuttle during entry. On Space Shuttle Discovery s STS-119 mission, NASA flew a specially modified thermal protection system tile and instrumentation package to monitor heating effects from boundary layer transition during re-entry. On STS-119, the windward airflow on the port wing was deliberately disrupted by a four-inch wide and quarter-inch tall protuberance built into the modified tile. In coordination with this flight experiment, a US Navy NP-3D Orion aircraft was flown 28 nautical miles below Discovery and remotely monitored surface temperature of the Orbiter at Mach 8.4 using a long-range infrared optical package referred to as Cast Glance. Approximately two months later, the same Navy Cast Glance aircraft successfully monitored the surface temperatures of the Orbiter Atlantis traveling at approximately Mach 14.3 during its return from the successful Hubble repair mission. In contrast to Discovery, Atlantis was not part of the Boundary Layer Transition (BLT) flight experiment, thus the vehicle was not configured with a protuberance on the port wing. In September 2009, Cast Glance was again successful in capturing infrared imagery and monitoring the surface temperatures on Discovery s next flight, STS-128. Again, NASA flew a specially modified thermal protection system tile and instrumentation package to monitor heating effects from boundary layer transition during re-entry. During this mission, Cast Glance was able to image laminar and turbulent flow phenomenology optimizing data collection for Mach 14.7. The purpose of this paper is to describe key elements associated with STS-119/125/128 mission planning and execution from the perspective of the Cast Glance flight crew that obtained the imagery. The paper will emphasize a human element of experience, expertise and adaptability seamlessly coupled with Cast Glance system and sensor technology required to manually collect the required imagery. Specific topics will include a near infrared (NIR) camera upgrade that was implemented just prior to the missions, how pre-flight radiance modeling was utilized to optimize the IR sensor configuration, communications, the development of aircraft test support positions based upon Shuttle trajectory information, support to contingencies such as Shuttle one orbit wave-offs/west coast diversions and then the Cast Glance perspective during an actual Shuttle imaging mission
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Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia
Human motor activity has a robust, intrinsic fractal structure with similar patterns from minutes to hours. The fractal activity patterns appear to be physiologically important because the patterns persist under different environmental conditions but are significantly altered/reduced with aging and Alzheimer's disease (AD). Here, we report that dementia patients, known to have disrupted circadian rhythmicity, also have disrupted fractal activity patterns and that the disruption is more pronounced in patients with more amyloid plaques (a marker of AD severity). Moreover, the degree of fractal activity disruption is strongly associated with vasopressinergic and neurotensinergic neurons (two major circadian neurotransmitters) in postmortem suprachiasmatic nucleus (SCN), and can better predict changes of the two neurotransmitters than traditional circadian measures. These findings suggest that the SCN impacts human activity regulation at multiple time scales and that disrupted fractal activity may serve as a non-invasive biomarker of SCN neurodegeneration in dementia
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Metabolite Responsive Nanoparticle-Protein Complex
Stimuli responsive polymers are an efficient means of targeted therapy. Compared to conventional agents, they increase bioavailability and efficacy. In particular, polymer hydrogel nanoparticles (NPs) can be designed to respond when exposed to a specific environmental stimulus such as pH or temperature. However, targeting a specific metabolite as the trigger for stimuli response could further elevate selectivity and create a new class of bioresponsive materials. In this work we describe an N-isopropylacrylamide (NIPAm) NP that responds to a specific metabolite characteristic of a hypoxic environment found in cancerous tumors. NIPAm NPs were synthesized by copolymerization with an oxamate derivative, a known inhibitor of lactate dehydrogenase (LDH). The oxamate functionalized NPs (OxNP) efficiently sequestered LDH to produce an OxNP-protein complex. When exposed to elevated concentrations of lactic acid, a substrate of LDH and a metabolite characteristic of hypoxic tumor microenvironments, OxNP-LDH complexes swelled (65%). The OxNP-LDH complexes were not responsive to structurally related small molecules. This work demonstrates a proof of concept for tuning NP responsiveness by conjugation with a key protein to target a specific metabolite of disease
Partisipasi Mahasiswa KKN melalui kegiatan Penanaman Mangrove dan Pembersihan Pantai MamokengDesa Tulehu Kabupaten Maluku Tengah
Areal pesisir Pantai Mamokeng Desa Tulehu memiliki keanekaragaman hayati yang tinggi, namun mengalami tekanan akibat aktivitas manusia yang tinggi di sekitar perairan. Salah satu program Kuliah Kerja Nyata mahasiswa Universitas Pattimura Ambon tahun 2021 di Desa Tulehu yakni penanaman Mangrove dan pembersihan pantai. Kegiatan menggunakan metode observasi dan edukasi. Kegiatan penanaman Mangrove dilaksanakan dalam dua tahapan, yaitu persiapan dan pelaksanaan. Tahap persiapan meliputi survey lapangan, pengambilan bibit Mangrove, dan pemotongan kayu Nani untuk dijadikan ajir. Kegiatan dilaksanakan pada akhir Oktober 2021 dengan melibatkan mahasiswa KKN Desa Tulehu, dosen pembimbing lapangan, kelompok pemuda Dusun Rupaitu, Komunitas Anak Pesisir, dan Babinsa Dusun Rupaitu. Bibit Mangrove ditanam sebanyak 310 bibit yang diperoleh melalui dukungan Balai Pengelolaan daerah Aliran Sungai dan Hutan Lindung Waehapu. Tujuan dari kegiatan yang dilaksanakan yakni untuk meningkatkan kesadaran masyarakat terhadap kebersihan lingkungan khususnya pesisir pantai. Hasil yang diperoleh dari kegiatan ini yakni terbentuknya komunitas Mangrove yang baru di areal pantai serta pantai menjadi lebih bersih dan tertata dengan baik
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