Geometry Analysis of an Inverse-Geometry Volumetric CT System With Multiple Detector Arrays

An inverse-geometry volumetric CT (IGCT) system for imaging in a single fast rotation without cone-beam artifacts is being developed. It employs a large scanned source array and a smaller detector array. For a single-source/single-detector implementation, the FOV is limited to a fraction of the source size. Here we explore options to increase the FOV without increasing the source size by using multiple detectors spaced apart laterally to increase the range of radial distances sampled. We also look at multiple source array systems for faster scans. To properly reconstruct the FOV, Radon space must be sufficiently covered and sampled in a uniform manner. Optimal placement of the detectors relative to the source was determined analytically given system constraints (5cm detector width, 25cm source width, 45cm source-to-isocenter distance). For a 1x3 system (three detectors per source) detector spacing (DS) was 18deg and source-to-detector distances (SDD) were 113, 100 and 113cm to provide optimum Radon sampling and a FOV of 44cm. For multiple-source systems, maximum angular spacing between sources cannot exceed 125deg since detectors corresponding to one source cannot be occluded by a second source. Therefore, for 2x3 and 3x3 systems using the above DS and SDD, optimum spacing between sources is 115deg and 61deg respectively, requiring minimum scan rotations of 115deg and 107deg. Also, a 3x3 system can be much faster for full 360deg dataset scans than a 2x3 system (120deg vs. 245deg). We found that a significantly increased FOV can be achieved while maintaining uniform radial sampling as well as a substantial reduction in scan time using several different geometries. Further multi-parameter optimization is underway

Rate of false conviction of criminal defendants who are sentenced to death

The rate of erroneous conviction of innocent criminal defendants is often described as not merely unknown but unknowable. There is no systematic method to determine the accuracy of a criminal conviction; if there were, these errors would not occur in the first place. As a result, very few false convictions are ever discovered, and those that are discovered are not representative of the group as a whole. In the United States, however, a high proportion of false convictions that do come to light and produce exonerations are concentrated among the tiny minority of cases in which defendants are sentenced to death. This makes it possible to use data on death row exonerations to estimate the overall rate of false conviction among death sentences. The high rate of exoneration among death-sentenced defendants appears to be driven by the threat of execution, but most death-sentenced defendants are removed from death row and resentenced to life imprisonment, after which the likelihood of exoneration drops sharply. We use survival analysis to model this effect. and estimate that if all death-sentenced defendants remained under sentence of death indefinitely, at least 4.1 % would be exonerated. We conclude that this is a conservative estimate of the proportion of false conviction among death sentences in the United States

Superconducting Films for Absorber-Coupled MKID Detectors for Sub-Millimeter and Far-Infrared Astronomy

We describe measurements of the properties, at dc, gigahertz, and terahertz frequencies, of thin (10 nm) aluminum films with 10 ohm/{rm square}$ normal state sheet resistance. Such films can be applied to construct microwave kinetic inductance detector arrays for submillimeter and far-infrared astronomical applications in which incident power excites quasiparticles directly in a superconducting resonator that is configured to present a matched-impedance to the high frequency radiation being detected. For films 10 nm thick, we report normal state sheet resistance, resistance-temperature curves for the superconducting transition, quality factor and kinetic inductance fraction for microwave resonators made from patterned films, and terahertz measurements of sheet impedance measured with a Fourier Transform Spectrometer. We compare properties with similar resonators made from niobium 600 nm thick

Precision control of thermal transport in cryogenic single-crystal silicon devices

We report on the diffusive-ballistic thermal conductance of multi-moded single-crystal silicon beams measured below 1 K. It is shown that the phonon mean-free-path $\ell$ is a strong function of the surface roughness characteristics of the beams. This effect is enhanced in diffuse beams with lengths much larger than $\ell$, even when the surface is fairly smooth, 5-10 nm rms, and the peak thermal wavelength is 0.6 $\mu$m. Resonant phonon scattering has been observed in beams with a pitted surface morphology and characteristic pit depth of 30 nm. Hence, if the surface roughness is not adequately controlled, the thermal conductance can vary significantly for diffuse beams fabricated across a wafer. In contrast, when the beam length is of order $\ell$, the conductance is dominated by ballistic transport and is effectively set by the beam area. We have demonstrated a uniformity of $\pm$8% in fractional deviation for ballistic beams, and this deviation is largely set by the thermal conductance of diffuse beams that support the micro-electro-mechanical device and electrical leads. In addition, we have found no evidence for excess specific heat in single-crystal silicon membranes. This allows for the precise control of the device heat capacity with normal metal films. We discuss the results in the context of the design and fabrication of large-format arrays of far-infrared and millimeter wavelength cryogenic detectors

Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL) in a patient taking fingolimod

A 55-year-old man with relapsing-remitting multiple sclerosis on fingolimod presented to the dermatology clinic with skin lesions on the left temple and cheek. Histopathology showed a diffuse infiltrate of enlarged, atypical lymphocytes throughout the dermis with an overlying grenz zone and a subpopulation of scattered smaller lymphocytes and plasma cells. Epstein-Barr virus-encoded RNA in situ hybridization stain was positive. Based on the morphologic and immunophenotypic findings, a diagnosis of EBV-positive diffuse large B-cell lymphoma was made. This case aims to raise awareness for the dermatologist that patients on fingolimod may be at increased risk of lymphoproliferative disorders

Pennsylvania’s True Commonwealth: The State of Manufacturing – Challenges and Opportunities (Full Report)

The Industrial Resource Center Network of Pennsylvania is the state’s affiliate of the National Institute of Standards and Technology’s Hollings Manufacturing Extension Partnership program. Both the IRC program and the MEP have longstanding traditions of self-assessment and evolution as ways of being accountable to the public and of promoting continuous improvement. The IRC program and the MEP are charged with helping manufacturing in general, and small to midsized manufacturers in particular, improve their competitive position. The IRC program uses the outcomes from these assessments to think about the challenges their constituents face due to rapid evolution in the globally competitive environment. Additionally, the IRC Program has joined with the MEP to discover best management and production practices, standardize them in terms of educational and training practices, and then disseminate these practices widely. Again, this is with an emphasis on small and midsized establishments and businesses. This report builds on the 2004 report, Manufacturing Pennsylvania’s Future, written by Deloitte Consulting and the Maxine Goodman Levin College of Urban Affairs at Cleveland State University. In August 2010, as the negative impact of the Great Recession was beginning to ebb and after a decade of global competitive challenges, the IRC Program embarked on a new round of self-evaluation and assessment. The economic development and nonprofit management research groups at Cleveland State University’s Levin College were engaged to examine the state of manufacturing in the Commonwealth, discover the management practices of the “best of the best” manufacturers in the state, and suggest practice innovations that would enhance the competitive position of Pennsylvania’s manufacturers. This work was undertaken with the MPI Group. The project was supported by funding from the Industrial Resource Center program, the Hollings Manufacturing Extension Partnership of the National Institute of Standards and Technology, the John D.and Catherine T. MacArthur Foundation’s Network on Building Resilient Regions, and the Pennsylvania Department of Community and Economic Development, with funding provided by the National Telecommunications and Information Administration. The work benefited from the advice and review of an external advisory board that was facilitated by Ken Voytek, NIST/MEP’s chief economist, and Joe Houldin, CEO of the Delaware Valley Industrial Resource Center. They worked with: Emily DeRocco, President, the Manufacturing Institute of the National Association of Manufacturers; Samuel Leiken, Vice President of the Council on Competitiveness; Howard Wial, Ph.D., Fellow of the Metropolitan Policy Program of the Brookings Institution; and Mike Trebing, Senior Economic Analyst, Federal Reserve Bank of Philadelphia. The work was also reviewed and discussed by the IRC’s Strategic Advisory Board and the directors of the network\u27s seven centers. The report also benefited from data provided by the Central Pennsylvania Workforce Development Corporation (CPWDC). The research team acknowledges the many contributions of our advisers and funders. Their participation and support do not mean that each agrees with all we have written. The team alone is responsible for the findings and interpretation of the data

Effect of arbuscular mycorrhizal fungi and poultry manure on growth and nutrients contents of maize in different soil type

Public concerned about food safety and quality have raised interest in manipulating soil nutrients management strategies that could reduce potential threat on environment and sustain food production. Recently, the application of arbuscular mycorrhizal fungi (AMF)as bio-fertilizer has gained recognition especially, in low-input agriculture. The fungi are known to improve plant nutrition and growth. However, this effect may differ according to soil properties and nutrients concentration. A greenhouse experiment was conducted to investigate the effect of AMF and poultry manure (PM) on growth and nutrients contents in maize compared to chemical fertilizer; and to determine the effect of soil properties on colonization potential of AMF. The experiment consists of 13 treatments combinations in 2 soil types (loam and peat), viz; 6 application rates of composted PM in tones (t) ha-1 (0, 4, 6, 8, 10 and 12) and 2 levels of AMF; inoculated (+AMF) and un-inoculated (- AMF) plus recommended dose of NPK (RD NPK). Un-inoculated plants showed no symptoms of root colonization and recorded no AMF spore under both soils. Addition of PM stimulated AMF colonization and sporulation, the highest root colonization (RC %) and spore counts were recorded at 8 t PM+AMF under loam and 12 t PM+AMF in peat soils. Shoot dry biomass at 8 and 12 t PM+AMF under loam and peat were comparable to RD NPK. Applying 8 and 12 t PM+AMF in loam and peat recorded the highest N& K comparable to RD NPK. However, P content in shoot were statistically higher at 8,10 & 12 t PM+AMF in loam and at 12 t PM+AMF in peat compared to RD NPK. Application of 10 & 12 t PM+AMF in loam significantly decreased plant growth, lowered AMF RC%, and nutrient content (N & K). There was a strong positive correlation between shoot dry biomass and RC % in loam (R 2 = 0.740 P<0.01) and peat (R 2 =0.884 P<0.01). From the results of this study, it could be concluded that AMF have increased the efficiency use of PM and their integration have the potential to improve plant growth due to enhanced nutrients uptake and stimulated RC% in both soils. Results also indicated significantly higher shoot dry biomass, nutrients content (N, P, & K), spore counts and RC % in loam soil compared to peat, indicating that soil properties has a significant influence on effectiveness AMF

Pennsylvania’s True Commonwealth: The State of Manufacturing – Challenges and Opportunities (Full Report)

The Industrial Resource Center Network of Pennsylvania is the state’s affiliate of the National Institute of Standards and Technology’s Hollings Manufacturing Extension Partnership program. Both the IRC program and the MEP have longstanding traditions of self-assessment and evolution as ways of being accountable to the public and of promoting continuous improvement. The IRC program and the MEP are charged with helping manufacturing in general, and small to midsized manufacturers in particular, improve their competitive position. The IRC program uses the outcomes from these assessments to think about the challenges their constituents face due to rapid evolution in the globally competitive environment. Additionally, the IRC Program has joined with the MEP to discover best management and production practices, standardize them in terms of educational and training practices, and then disseminate these practices widely. Again, this is with an emphasis on small and midsized establishments and businesses. This report builds on the 2004 report, Manufacturing Pennsylvania’s Future, written by Deloitte Consulting and the Maxine Goodman Levin College of Urban Affairs at Cleveland State University. In August 2010, as the negative impact of the Great Recession was beginning to ebb and after a decade of global competitive challenges, the IRC Program embarked on a new round of self-evaluation and assessment. The economic development and nonprofit management research groups at Cleveland State University’s Levin College were engaged to examine the state of manufacturing in the Commonwealth, discover the management practices of the “best of the best” manufacturers in the state, and suggest practice innovations that would enhance the competitive position of Pennsylvania’s manufacturers. This work was undertaken with the MPI Group. The project was supported by funding from the Industrial Resource Center program, the Hollings Manufacturing Extension Partnership of the National Institute of Standards and Technology, the John D.and Catherine T. MacArthur Foundation’s Network on Building Resilient Regions, and the Pennsylvania Department of Community and Economic Development, with funding provided by the National Telecommunications and Information Administration. The work benefited from the advice and review of an external advisory board that was facilitated by Ken Voytek, NIST/MEP’s chief economist, and Joe Houldin, CEO of the Delaware Valley Industrial Resource Center. They worked with: Emily DeRocco, President, the Manufacturing Institute of the National Association of Manufacturers; Samuel Leiken, Vice President of the Council on Competitiveness; Howard Wial, Ph.D., Fellow of the Metropolitan Policy Program of the Brookings Institution; and Mike Trebing, Senior Economic Analyst, Federal Reserve Bank of Philadelphia. The work was also reviewed and discussed by the IRC’s Strategic Advisory Board and the directors of the network\u27s seven centers. The report also benefited from data provided by the Central Pennsylvania Workforce Development Corporation (CPWDC). The research team acknowledges the many contributions of our advisers and funders. Their participation and support do not mean that each agrees with all we have written. The team alone is responsible for the findings and interpretation of the data

Cross-Neutralisation of Novel Bombali Virus by Ebola Virus Antibodies and Convalescent Plasma Using an Optimised Pseudotype-Based Neutralisation Assay.

Ebolaviruses continue to pose a significant outbreak threat, and while Ebola virus (EBOV)-specific vaccines and antivirals have been licensed, efforts to develop candidates offering broad species cross-protection are continuing. The use of pseudotyped virus in place of live virus is recognised as an alternative, safer, high-throughput platform to evaluate anti-ebolavirus antibodies towards their development, yet it requires optimisation. Here, we have shown that the target cell line impacts neutralisation assay results and cannot be selected purely based on permissiveness. In expanding the platform to incorporate each of the ebolavirus species envelope glycoprotein, allowing a comprehensive assessment of cross-neutralisation, we found that the recently discovered Bombali virus has a point mutation in the receptor-binding domain which prevents entry into a hamster cell line and, importantly, shows that this virus can be cross-neutralised by EBOV antibodies and convalescent plasma

The effect of workplace mobility on air pollution exposure inequality - a case study in the Central Belt of Scotland

A large number of epidemiological studies have identified air pollution as a major risk to human health. Exposures to the pollutants PM2.5, NO2 and O3 cause cardiovascular and respiratory diseases, cancer and premature mortality. Whilst previous studies have reported demographic inequalities in exposure, with the most deprived and susceptible often being disproportionately exposed to the highest pollutant concentrations, the vast majority of these studies have quantified exposure based only on individuals' place of residence. Here we use anonymised personal data from UK Census 2011, and hourly modelled air pollution concentrations at 0.8 km × 1.4 km spatial resolution in the Central Belt of Scotland, to investigate how inclusion of time spent at place of work or study affects demographic inequalities in exposure. We split the population by sex, ethnic group, age and socio-economic status. Exposure gradients are observed across all demographic characteristics. Air pollution exposures of males are more affected by workplace exposures than females. The White ethnic group has the lowest exposures to NO2 and PM2.5, and highest to O3. Exposures to NO2 and PM2.5 tend to peak between the ages of 21 and 30, but those aged 31–50 tend to be most impacted by the inclusion of time spent at workplace in the exposure assessment. People in the two least deprived deciles consistently have the lowest residential-only and combined residential-workplace exposure to NO2 and PM2.5, but experience the highest increase in exposure when including workplace. Overall, including workplace exposure results in relatively small change in median exposure but attenuates some of the exposure inequalities associated with ethnicity and socioeconomic status observed in exposure assessments based only on place of residence