292 research outputs found
Degree of adaptive male mate choice is positively correlated with female quality variance
When the cost of reproduction for males and variance in female quality are high, males are predicted to show adaptive mate choice. Using Drosophila melanogaster, we test this prediction and show that sperm limited males preferentially mated with young and/or well fed females. The preferred females had higher reproductive output – direct evidence of adaptive precopulatory male mate choice. Our most striking finding is the strong positive correlation between the degree of mating bias showed by the males and the variance in the fitness of the females. We discuss the possible mechanism for such adaptive male mate choice and propose that such choice has important consequences with respect to the existing understanding of the mating system and the evolution of aging
Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial
Objective: To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses.
Design: Twelve non-diabetic adults with overweight and obesity received 20 g/day of inulin-propionate ester (IPE), designed to selectively deliver propionate to the colon, a high-fermentable fibre control (inulin) and a low-fermentable fibre control (cellulose) in a randomised, double-blind, placebo-controlled, cross-over design. Outcome measurements of metabolic responses, inflammatory markers and gut bacterial composition were analysed at the end of each 42-day supplementation period.
Results: Both IPE and inulin supplementation improved insulin resistance compared with cellulose supplementation, measured by homeostatic model assessment 2 (mean±SEM 1.23±0.17 IPE vs 1.59±0.17 cellulose, p=0.001; 1.17±0.15 inulin vs 1.59±0.17 cellulose, p=0.009), with no differences between IPE and inulin (p=0.272). Fasting insulin was only associated positively with plasma tyrosine and negatively with plasma glycine following inulin supplementation. IPE supplementation decreased proinflammatory interleukin-8 levels compared with cellulose, while inulin had no impact on the systemic inflammatory markers studied. Inulin promoted changes in gut bacterial populations at the class level (increased Actinobacteria and decreased Clostridia) and order level (decreased Clostridiales) compared with cellulose, with small differences at the species level observed between IPE and cellulose.
Conclusion: These data demonstrate a distinctive physiological impact of raising colonic propionate delivery in humans, as improvements in insulin sensitivity promoted by IPE and inulin were accompanied with different effects on the plasma metabolome, gut bacterial populations and markers of systemic inflammation
Contribution of Recipient-Derived Cells in Allograft Neointima Formation and the Response to Stent Implantation
Allograft coronary disease is the dominant cause of increased risk of death after cardiac transplantation. While the percutaneous insertion of stents is the most efficacious revascularization strategy for allograft coronary disease there is a high incidence of stent renarrowing. We developed a novel rabbit model of sex-mismatched allograft vascular disease as well as the response to stent implantation. In situ hybridization for the Y-chromosome was employed to detect male cells in the neointima of stented allograft, and the population of recipient derived neointimal cells was measured by quantitative polymerase chain reaction and characterized by immunohistochemistry. To demonstrate the participation of circulatory derived cells in stent neointima formation we infused ex vivo labeled peripheral blood mononuclear cells into native rabbit carotid arteries immediately after stenting. Fourteen days after stenting the neointima area was 58% greater in the stented vs. non-stented allograft segments (p = 0.02). Male cells were detected in the neointima of stented female-to-male allografts. Recipient-derived cells constituted 72.1±5.7% and 81.5±4.2% of neointimal cell population in the non-stented and stented segments, respectively and the corresponding proliferation rates were only 2.7±0.5% and 2.3±0.2%. Some of the recipient-derived neointimal cells were of endothelial lineage. The ex vivo tagged cells constituted 9.0±0.4% of the cells per high power field in the stent neointima 14 days after stenting. These experiments provide important quantitative data regarding the degree to which host-derived blood-borne cells contribute to neointima formation in allograft vasculopathy and the early response to stent implantation
Stress ocupacional e alteração do Estatuto da Carreira Docente português
Este estudo foi realizado com 1162 professores, tendo como objetivo analisar a experiência de stress e a síndrome de “burnout”, antes a após a alteração do Estatuto da Carreira Docente em Portugal. Assim, foram efetuadas duas avaliações em momentos temporais distintos, assumindo-se um plano transversal de recolha de dados (2004/2005, n=689 e 2008/2009, n=473). O protocolo de avaliação incluiu medidas de fontes de stress (Questionário de Stress nos Professores, Gomes, Silva, Mourisco, Mota, & Montenegro, 2006) e de “burnout” (Inventário de “Burnout” de Maslach – Versão para Professores, Maslach, Jackson, & Leiter, 1996; Maslach, Jackson, & Schwab, 1996, Adaptação de Gomes et al., 2006). Os resultados indicaram que a experiência de stress e de “burnout” aumentou entre as duas avaliações, verificando-se em 2008/2009 aumentos em áreas relacionadas com as pressões de tempo/excesso de trabalho e com o trabalho burocrático/administrativo e, inversamente, diminuições em áreas relacionadas com as diferentes capacidades e motivações dos alunos. Quanto à predição da síndrome de “burnout”, não se verificaram alterações substanciais nas variáveis preditoras nos dois momentos. Em síntese, os resultados indicaram aumentos nas exigências profissionais dos professores, mas não se pode afirmar que tal se deva às alterações do Estatuto da Carreira Docente uma vez que não observámos alterações no stress associado à carreira docente.(undefined
Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974
BACKGROUND: Anxiety is a serious personal health condition and represents a substantial burden to overall quality of life. Additionally anxiety disorders represent a significant cost to the health care system as well as employers through benefits coverage and days missed due to incapacity. This study sought to explore the effectiveness of naturopathic care on anxiety symptoms using a randomized trial. METHODS: Employees with moderate to severe anxiety of longer than 6 weeks duration were randomized based on age and gender to receive naturopathic care (NC) (n = 41) or standardized psychotherapy intervention (PT) (n = 40) over a period of 12 weeks. Blinding of investigators and participants during randomization and allocation was maintained. Participants in the NC group received dietary counseling, deep breathing relaxation techniques, a standard multi-vitamin, and the herbal medicine, ashwagandha (Withania somnifera) (300 mg b.i.d. standardized to 1.5% with anolides, prepared from root). The PT intervention received psychotherapy, and matched deep breathing relaxation techniques, and placebo. The primary outcome measure was the Beck Anxiety Inventory (BAI) and secondary outcome measures included the Short Form 36 (SF-36), Fatigue Symptom Inventory (FSI), and Measure Yourself Medical Outcomes Profile (MY-MOP) to measure anxiety, mental health, and quality of life respectively. Participants were blinded to the placebo-controlled intervention. RESULTS: Seventy-five participants (93%) were followed for 8 or more weeks on the trial. Final BAI scores decreased by 56.5% (p<0.0001) in the NC group and 30.5% (p<0.0001) in the PT group. BAI group scores were significantly decreased in the NC group compared to PT group (p = 0.003). Significant differences between groups were also observed in mental health, concentration, fatigue, social functioning, vitality, and overall quality of life with the NC group exhibiting greater clinical benefit. No serious adverse reactions were observed in either group. RELEVANCE: Many patients seek alternatives and/or complementary care to conventional anxiety treatments. To date, no study has evaluated the potential of a naturopathic treatment protocol to effectively treat anxiety. Knowledge of the efficacy, safety or risk of natural health products, and naturopathic treatments is important for physicians and the public in order to make informed decisions. INTERPRETATION: Both NC and PT led to significant improvements in patients' anxiety. Group comparison demonstrated a significant decrease in anxiety levels in the NC group over the PT group. Significant improvements in secondary quality of life measures were also observed in the NC group as compared to PT. The whole system of naturopathic care for anxiety needs to be investigated further including a closer examination of the individual components within the context of their additive effect. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN78958974
Direct Optimal Mapping Image Power Spectrum and its Window Functions
The key to detecting neutral hydrogen during the epoch of reionization (EoR)
is to separate the cosmological signal from the dominating foreground
radiation. We developed direct optimal mapping (Xu et al. 2022) to map
interferometric visibilities; it contains only linear operations, with full
knowledge of point spread functions from visibilities to images. Here we
present an FFT-based image power spectrum and its window functions based on
direct optimal mapping. We use noiseless simulation, based on the Hydrogen
Epoch of Reionization Array (HERA) Phase I configuration, to study the image
power spectrum properties. The window functions show power leakage
from the foreground-dominated region into the EoR window; the 2D and 1D power
spectra also verify the separation between the foregrounds and the EoR.
Furthermore, we simulated visibilities from a -complete array and
calculated its image power spectrum. The result shows that the foreground--EoR
leakage is further suppressed below , dominated by the tapering
function sidelobes; the 2D power spectrum does not show signs of the horizon
wedge. The -complete result provides a reference case for future 21cm
cosmology array designs.Comment: Submitted to Ap
Direct Optimal Mapping for 21cm Cosmology: A Demonstration with the Hydrogen Epoch of Reionization Array
Motivated by the desire for wide-field images with well-defined statistical
properties for 21cm cosmology, we implement an optimal mapping pipeline that
computes a maximum likelihood estimator for the sky using the interferometric
measurement equation. We demonstrate this direct optimal mapping with data from
the Hydrogen Epoch of Reionization (HERA) Phase I observations. After
validating the pipeline with simulated data, we develop a maximum likelihood
figure-of-merit for comparing four sky models at 166MHz with a bandwidth of
100kHz. The HERA data agree with the GLEAM catalogs to <10%. After subtracting
the GLEAM point sources, the HERA data discriminate between the different
continuum sky models, providing most support for the model of Byrne et al.
2021. We report the computation cost for mapping the HERA Phase I data and
project the computation for the HERA 320-antenna data; both are feasible with a
modern server. The algorithm is broadly applicable to other interferometers and
is valid for wide-field and non-coplanar arrays.Comment: 16 pages, 10 figures, 2 tables, published on Ap
The neutron and its role in cosmology and particle physics
Experiments with cold and ultracold neutrons have reached a level of
precision such that problems far beyond the scale of the present Standard Model
of particle physics become accessible to experimental investigation. Due to the
close links between particle physics and cosmology, these studies also permit a
deep look into the very first instances of our universe. First addressed in
this article, both in theory and experiment, is the problem of baryogenesis ...
The question how baryogenesis could have happened is open to experimental
tests, and it turns out that this problem can be curbed by the very stringent
limits on an electric dipole moment of the neutron, a quantity that also has
deep implications for particle physics. Then we discuss the recent spectacular
observation of neutron quantization in the earth's gravitational field and of
resonance transitions between such gravitational energy states. These
measurements, together with new evaluations of neutron scattering data, set new
constraints on deviations from Newton's gravitational law at the picometer
scale. Such deviations are predicted in modern theories with extra-dimensions
that propose unification of the Planck scale with the scale of the Standard
Model ... Another main topic is the weak-interaction parameters in various
fields of physics and astrophysics that must all be derived from measured
neutron decay data. Up to now, about 10 different neutron decay observables
have been measured, much more than needed in the electroweak Standard Model.
This allows various precise tests for new physics beyond the Standard Model,
competing with or surpassing similar tests at high-energy. The review ends with
a discussion of neutron and nuclear data required in the synthesis of the
elements during the "first three minutes" and later on in stellar
nucleosynthesis.Comment: 91 pages, 30 figures, accepted by Reviews of Modern Physic
Naturalizing Institutions: Evolutionary Principles and Application on the Case of Money
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