2,262 research outputs found
Effect of Light Fermions on the Confinement Transition in QCD-like Theories
Dependence of the confinement transition parameters on the fermion content
provides information on the mechanism of confinement. Recent progress in
lattice gauge theories has allowed to study it for light flavor number and found this transition to shift toward significantly stronger
coupling. We propose an explanation for that: light fermions can occupy the
chromo-magnetic monopoles, via zero modes, making them "distinguishable" and
unsuitable for Bose-Einstein Condensation. Such dilution of unoccuplied
monopoles is compensated by stronger coupling that makes them lighter and more
numerous. We also suggest that flavor-carrying quark-monopole objects account
for the density beyond quark Fermi sphere seen in cold dense phase of
lattice QCD.Comment: 4 pages, 1 figure; few references added; close to the final published
versio
Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells
The α-mannosidase I inhibitor kifunensine inhibited N-glycan processing in long-term cultures of Chinese hamster ovary cells, allowing deglycosylation and crystallization of the homodimeric extracellular region of the inhibitory glycoprotein receptor CTLA-4 (CD152)
Residues and World-Sheet Instantons
We reconsider the question of which Calabi-Yau compactifications of the
heterotic string are stable under world-sheet instanton corrections to the
effective space-time superpotential. For instance, compactifications described
by (0,2) linear sigma models are believed to be stable, suggesting a remarkable
cancellation among the instanton effects in these theories. Here, we show that
this cancellation follows directly from a residue theorem, whose proof relies
only upon the right-moving world-sheet supersymmetries and suitable compactness
properties of the (0,2) linear sigma model. Our residue theorem also extends to
a new class of "half-linear" sigma models. Using these half-linear models, we
show that heterotic compactifications on the quintic hypersurface in CP^4 for
which the gauge bundle pulls back from a bundle on CP^4 are stable. Finally, we
apply similar ideas to compute the superpotential contributions from families
of membrane instantons in M-theory compactifications on manifolds of G_2
holonomy.Comment: 47 page
Recommendations for dealing with waste contaminated with Ebola virus: a Hazard Analysis of Critical Control Points approach
Objective To assess, within communities experiencing Ebola virus outbreaks, the risks associated with the disposal of human waste and to generate recommendations for mitigating such risks. Methods A team with expertise in the Hazard Analysis of Critical Control Points framework identified waste products from the care of individuals with Ebola virus disease and constructed, tested and confirmed flow diagrams showing the creation of such products. After listing potential hazards associated with each step in each flow diagram, the team conducted a hazard analysis, determined critical control points and made recommendations to mitigate the transmission risks at each control point. Findings The collection, transportation, cleaning and shared use of blood-soiled fomites and the shared use of latrines contaminated with blood or bloodied faeces appeared to be associated with particularly high levels of risk of Ebola virus transmission. More moderate levels of risk were associated with the collection and transportation of material contaminated with bodily fluids other than blood, shared use of latrines soiled with such fluids, the cleaning and shared use of fomites soiled with such fluids, and the contamination of the environment during the collection and transportation of blood-contaminated waste. Conclusion The risk of the waste-related transmission of Ebola virus could be reduced by the use of full personal protective equipment, appropriate hand hygiene and an appropriate disinfectant after careful cleaning. Use of the Hazard Analysis of Critical Control Points framework could facilitate rapid responses to outbreaks of emerging infectious disease
Training of Instrumentalists and Development of New Technologies on SOFIA
This white paper is submitted to the Astronomy and Astrophysics 2010 Decadal
Survey (Astro2010)1 Committee on the State of the Profession to emphasize the
potential of the Stratospheric Observatory for Infrared Astronomy (SOFIA) to
contribute to the training of instrumentalists and observers, and to related
technology developments. This potential goes beyond the primary mission of
SOFIA, which is to carry out unique, high priority astronomical research.
SOFIA is a Boeing 747SP aircraft with a 2.5 meter telescope. It will enable
astronomical observations anywhere, any time, and at most wavelengths between
0.3 microns and 1.6 mm not accessible from ground-based observatories. These
attributes, accruing from the mobility and flight altitude of SOFIA, guarantee
a wealth of scientific return. Its instrument teams (nine in the first
generation) and guest investigators will do suborbital astronomy in a
shirt-sleeve environment. The project will invest $10M per year in science
instrument development over a lifetime of 20 years. This, frequent flight
opportunities, and operation that enables rapid changes of science instruments
and hands-on in-flight access to the instruments, assure a unique and extensive
potential - both for training young instrumentalists and for encouraging and
deploying nascent technologies. Novel instruments covering optical, infrared,
and submillimeter bands can be developed for and tested on SOFIA by their
developers (including apprentices) for their own observations and for those of
guest observers, to validate technologies and maximize observational
effectiveness.Comment: 10 pages, no figures, White Paper for Astro 2010 Survey Committee on
State of the Professio
Assessing the implementation and effectiveness of the Electronic Patient Reported Outcome Tool for Seniors with Complex Care Needs:Mixed Methods Study
BACKGROUND: Goal-oriented care is being adopted to deliver person-centered primary care to older adults with multimorbidity and complex care needs. Although this model holds promise, its implementation remains a challenge. Digital health solutions may enable processes to improve adoption; however, they require evaluation to determine feasibility and impact. OBJECTIVE: This study aims to evaluate the implementation and effectiveness of the electronic Patient-Reported Outcome (ePRO) mobile app and portal system, designed to enable goal-oriented care delivery in interprofessional primary care practices. The research questions driving this study are as follows: Does ePRO improve quality of life and self-management in older adults with complex needs? What mechanisms are likely driving observed outcomes? METHODS: A multimethod, pragmatic randomized controlled trial using a stepped-wedge design and ethnographic case studies was conducted over a 15-month period in 6 comprehensive primary care practices across Ontario with a target enrollment of 176 patients. The 6 practices were randomized into either early (3-month control period; 12-month intervention) or late (6-month control period; 9-month intervention) groups. The primary outcome measure of interest was the Assessment of Quality of Life-4D (AQoL-4D). Data were collected at baseline and at 3 monthly intervals for the duration of the trial. Ethnographic data included observations and interviews with patients and providers at the midpoint and end of the intervention. Outcome data were analyzed using linear models conducted at the individual level, accounting for cluster effects at the practice level, and ethnographic data were analyzed using qualitative description and framework analysis methods. RESULTS: Recruitment challenges resulted in fewer sites and participants than expected; of the 176 target, only 142 (80.6%) patients were identified as eligible to participate because of lower-than-expected provider participation and fewer-than-expected patients willing to participate or perceived as ready to engage in goal-setting. Of the 142 patients approached, 45 (32%) participated. Patients set a variety of goals related to self-management, mental health, social health, and overall well-being. Owing to underpowering, the impact of ePRO on quality of life could not be definitively assessed; however, the intervention group, ePRO plus usual care (mean 15.28, SD 18.60) demonstrated a nonsignificant decrease in quality of life (t(24)=−1.20; P=.24) when compared with usual care only (mean 21.76, SD 2.17). The ethnographic data reveal a complex implementation process in which the meaningfulness (or coherence) of the technology to individuals’ lives and work acted as a key driver of adoption and tool appraisal. CONCLUSIONS: This trial experienced many unexpected and significant implementation challenges related to recruitment and engagement. Future studies could be improved through better alignment of the research methods and intervention to the complex and diverse clinical settings, dynamic goal-oriented care process, and readiness of provider and patient participants. TRIAL REGISTRATION: ClinicalTrials.gov NCT02917954; https://clinicaltrials.gov/ct2/show/NCT0291795
The metabolic regimes of 356 rivers in the United States
A national-scale quantification of metabolic energy flow in streams and rivers can improve understanding of the temporal dynamics of in-stream activity, links between energy cycling and ecosystem services, and the effects of human activities on aquatic metabolism. The two dominant terms in aquatic metabolism, gross primary production (GPP) and aerobic respiration (ER), have recently become practical to estimate for many sites due to improved modeling approaches and the availability of requisite model inputs in public datasets. We assembled inputs from the U.S. Geological Survey and National Aeronautics and Space Administration for October 2007 to January 2017. We then ran models to estimate daily GPP, ER, and the gas exchange rate coefficient for 356 streams and rivers across the continental United States. We also gathered potential explanatory variables and spatial information for cross-referencing this dataset with other datasets of watershed characteristics. This dataset offers a first national assessment of many-day time series of metabolic rates for up to 9 years per site, with a total of 490,907 site-days of estimates.We thank Jill Baron and the USGS Powell Center for financial support for this collaborative effort (Powell Center Working Group title: "Continental-scale overview of stream primary productivity, its links to water quality, and consequences for aquatic carbon biogeochemistry"). Additional financial support came from the USGS NAWQA program and Office of Water Information. NSF grants DEB-1146283 and EF1442501 partially supported ROH. A post-doctoral grant from the Basque Government partially supported MA. NAG was supported by the U.S. Department of Energy's Office of Science, Biological and Environmental Research. Oak Ridge National Laboratory is managed by UT-Battelle, LLC, for the U.S. Department of Energy under contract DE-AC05-00OR22725. Leah Colasuonno provided expert logistical support of our working group meetings. The developers of USGS ScienceBase were very helpful both in hosting this dataset and in responding to our requests. Randy Hunt and Mike Fienen of the USGS Wisconsin Modeling Center graciously provided access to their HTCondor cluster. Mike Vlah provided detailed and insightful reviews of the data and metadata
Deconvolution of Images from BLAST 2005: Insight into the K3-50 and IC 5146 Star-Forming Regions
We present an implementation of the iterative flux-conserving Lucy-Richardson
(L-R) deconvolution method of image restoration for maps produced by the
Balloon-borne Large Aperture Submillimeter Telescope (BLAST). We have analyzed
its performance and convergence extensively through simulations and
cross-correlations of the deconvolved images with available highresolution
maps. We present new science results from two BLAST surveys, in the Galactic
regions K3-50 and IC 5146, further demonstrating the benefits of performing
this deconvolution.
We have resolved three clumps within a radius of 4.'5 inside the star-forming
molecular cloud containing K3-50. Combining the well-resolved dust emission map
with available multi-wavelength data, we have constrained the Spectral Energy
Distributions (SEDs) of five clumps to obtain masses (M), bolometric
luminosities (L), and dust temperatures (T). The L-M diagram has been used as a
diagnostic tool to estimate the evolutionary stages of the clumps. There are
close relationships between dust continuum emission and both 21-cm radio
continuum and 12CO molecular line emission.
The restored extended large scale structures in the Northern Streamer of IC
5146 have a strong spatial correlation with both SCUBA and high resolution
extinction images. A dust temperature of 12 K has been obtained for the central
filament. We report physical properties of ten compact sources, including six
associated protostars, by fitting SEDs to multi-wavelength data. All of these
compact sources are still quite cold (typical temperature below ~ 16 K) and are
above the critical Bonner-Ebert mass. They have associated low-power Young
Stellar Objects (YSOs). Further evidence for starless clumps has also been
found in the IC 5146 region.Comment: 13 pages, 12 Figures, 3 Table
Kepler Mission Stellar and Instrument Noise Properties
Kepler Mission results are rapidly contributing to fundamentally new
discoveries in both the exoplanet and asteroseismology fields. The data
returned from Kepler are unique in terms of the number of stars observed,
precision of photometry for time series observations, and the temporal extent
of high duty cycle observations. As the first mission to provide extensive time
series measurements on thousands of stars over months to years at a level
hitherto possible only for the Sun, the results from Kepler will vastly
increase our knowledge of stellar variability for quiet solar-type stars. Here
we report on the stellar noise inferred on the timescale of a few hours of most
interest for detection of exoplanets via transits. By design the data from
moderately bright Kepler stars are expected to have roughly comparable levels
of noise intrinsic to the stars and arising from a combination of fundamental
limitations such as Poisson statistics and any instrument noise. The noise
levels attained by Kepler on-orbit exceed by some 50% the target levels for
solar-type, quiet stars. We provide a decomposition of observed noise for an
ensemble of 12th magnitude stars arising from fundamental terms (Poisson and
readout noise), added noise due to the instrument and that intrinsic to the
stars. The largest factor in the modestly higher than anticipated noise follows
from intrinsic stellar noise. We show that using stellar parameters from
galactic stellar synthesis models, and projections to stellar rotation,
activity and hence noise levels reproduces the primary intrinsic stellar noise
features.Comment: Accepted by ApJ; 26 pages, 20 figure
The Ursinus Weekly, October 10, 1969
Seven join, six leave Ursinus faculty • UC and 500 colleges schedule Vietnam moratorium Wednesday; Classes not officially cancelled • William D. Reimert dies, Ursinus Board President • Dr. E. Lewis\u27 math textbook aids Ursinus blind students • Pre-Med convention • Dean Harris weds Bryn Mawr man • Editorial: A very good year • Focus: Mike Stoner in exile • Compulsory convocation: Its validity and purpose • New view of Ursinus • Dr. Rice endorses Vietnam moratorium • Kitchen cynic: Suppose U.C. had mandatory convocations • Perspectives • To eat or not to eat • Board names new members • Spotlight: Mr. Jones, cook • Centennial plans • Opinion: Suggestions for revision of the school calendar • Weaver raps • Faculty portrait: Mrs. Lucas • Woodstock vs. Ursinus • Essay on the new age • Building plans • Freshman class • Harriers extend streak to 26 • Shuman, Mangan potential greats • Flying Dutchmen edge Bears on late T.D. • Ursinus drops grid opener to Diplomats • Registration system analyzed • Lack of needed funds signals impending collapse of agency • Astronaut Scott Carpenter opens Fall Forum series • Ursinus accounting students rank first twice, and secondhttps://digitalcommons.ursinus.edu/weekly/1149/thumbnail.jp
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