24 research outputs found
Human Bocavirus, a Respiratory and Enteric Virus
In Spain, human bocavirus (HBoV) was detected in 48 (9.1%) of 527 children with gastroenteritis at similar frequency as for children with respiratory illness (40/520, 7.7%). Fecal excretion adds new concern about the transmission of HBoV. To our knowledge, this report is the first to document HBoV in human feces
Social, economic, and health impact of the respiratory syncytial virus: a systematic search
BACKGROUND:
Bronchiolitis caused by the respiratory syncytial virus (RSV) and its related complications are common in infants born prematurely, with severe congenital heart disease, or bronchopulmonary dysplasia, as well as in immunosuppressed infants. There is a rich literature on the different aspects of RSV infection with a focus, for the most part, on specific risk populations. However, there is a need for a systematic global analysis of the impact of RSV infection in terms of use of resources and health impact on both children and adults. With this aim, we performed a systematic search of scientific evidence on the social, economic, and health impact of RSV infection.
METHODS:
A systematic search of the following databases was performed: MEDLINE, EMBASE, Spanish Medical Index, MEDES-MEDicina in Spanish, Cochrane Plus Library, and Google without time limits. We selected 421 abstracts based on the 6,598 articles identified. From these abstracts, 4 RSV experts selected the most relevant articles. They selected 65 articles. After reading the full articles, 23 of their references were also selected. Finally, one more article found through a literature information alert system was included.
RESULTS:
The information collected was summarized and organized into the following topics: 1. Impact on health (infections and respiratory complications, mid- to long-term lung function decline, recurrent wheezing, asthma, other complications such as otitis and rhino-conjunctivitis, and mortality; 2. Impact on resources (visits to primary care and specialists offices, emergency room visits, hospital admissions, ICU admissions, diagnostic tests, and treatments); 3. Impact on costs (direct and indirect costs); 4. Impact on quality of life; and 5. Strategies to reduce the impact (interventions on social and hygienic factors and prophylactic treatments).
CONCLUSIONS:
We concluded that 1. The health impact of RSV infection is relevant and goes beyond the acute episode phase; 2. The health impact of RSV infection on children is much better documented than the impact on adults; 3. Further research is needed on mid- and long-term impact of RSV infection on the adult population, especially those at high-risk; 4. There is a need for interventions aimed at reducing the impact of RSV infection by targeting health education, information, and prophylaxis in high-risk populations.The project was funded by an unrestricted grant from AbbVie.S
Percentage evolution of serotypes (number of a specific serotype/total isolates in each period) included in the 7-valent pneumococcal conjugate vaccine.
<p>Percentage evolution of serotypes (number of a specific serotype/total isolates in each period) included in the 7-valent pneumococcal conjugate vaccine.</p
Patients with reinfections caused by the same serotype as the initial infection.
a<p>PCV7â¶7-valent pneumococcal conjugate vaccination (PCV7 included serotypes: 4, 6B, 9V, 14, 18C, 19F and 23F).</p>b<p>Pulse-field gel electrophoresis pattern, arbitrary named MLSTâ=âmultilocus sequence typing.</p
General characteristics of patients and pneumococcal acute otitis media (AOM) episodes.
1<p>Relapses were not included as distinct episodes.</p
Concordancia en niños entre las resistencias de la vĂa aĂ©rea medidas mediante pletismografĂa con y sin cierre del oclusor
Long-Term Burden and Respiratory Effects of Respiratory Syncytial Virus Hospitalization in Preterm InfantsâThe SPRING Study
<div><p>The health status of premature infants born 32<sup>1</sup>-35<sup>0</sup> weeksâ gestational age (wGA) hospitalized for RSV infection in the first year of life (cases; n = 125) was compared to that of premature infants not hospitalized for RSV (controls; n = 362) through 6 years. The primary endpoints were the percentage of children with wheezing between 2-6 years and lung function at 6 years of age. Secondary endpoints included quality of life, healthcare resource use, and allergic sensitization. A significantly higher proportion of cases than controls experienced recurrent wheezing through 6 years of age (46.7% vs. 27.4%; p = 0.001). The vast majority of lung function tests appeared normal at 6 years of age in both cohorts. In children with pulmonary function in the lower limit of normality (FEV<sub>1</sub> Z-score [-2; -1]), wheezing was increased, particularly for cases vs. controls (72.7% vs. 18.9%, p = 0.002). Multivariate analysis revealed the most important factor for wheezing was RSV hospitalization. Quality of life on the respiratory subscale of the TAPQOL was significantly lower (p = 0.001) and healthcare resource utilization was significantly higher (p<0.001) in cases than controls. This study confirms RSV disease is associated with wheezing in 32-35 wGA infants through 6 years of age.</p></div
Wheezing through 6 years of age<sup>a</sup>.
<p>Wheezing through 6 years of age<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125422#t002fn002" target="_blank"><sup>a</sup></a>.</p