The Electromagnetic Form Factor of the Kaon in the Light-Front Approach

The kaon electromagnetic form factor is calculated within a light-front constituent quark model (LFCQM). The electromagnetic components of the current are extracted from the Feynman triangle diagram within the light-front approach. We also obtain the electroweak decay constant and the charge radius for the kaon in the light-front approach. In this work, the kaon observables are calculated and a fairly good agreement is obtained with a very higher accuracy when compared with the experimental data.Comment: Paper with 4 pages, 1 figure, reference: XII HADRON PHYSICS Conference - to appear in AIP Conference Proceeding

Electromagnetic Structure of the Pion

In this work, we analyze the electromagnetic structure of the pion. We calculate its electromagnetic radius and electromagnetic form factor in low and intermediate momentum range. Such observables are determined by means of a theoretical model that takes into account the constituent quark and antiquark of the pion within the formalism of light-front field theory. In particular, we consider a nonsymmetrical vertex in this model, with which we calculate the electromagnetic form factor of the pion in an optimized way, so that we obtain a value closer to the experimental charge radius of the pion. The theoretical calculations are also compared with the most recent experimental data involving the pion electromagnetic form factor and the results show very good agreement.Comment: Paper with 4 pages, 1 figure, presented in XII HADRON PHYSICS Conference - to appear in AIP Conference Proceeding

Pion and kaon elastic form factors in a refined light-front model

Within the framework of light-front field theory, we reassess the electromagnetic form factors of the pion and kaon. Comparison with experiment is made for the full range of momentum transfer, q^2<0, including recent data. The light-front model's single regulator mass, m_R, of the \bar qq bound-state vertex function is initially adjusted to reproduce the weak decay constants, f_\pi\ and f_K, and both meson's charge radii, r_\pi\ and r_K. We study the behavior of these observables under variation of the quark masses and find an optimized parameter set, m_u=m_d, m_s and m_R, for which they are in sensibly better agreement with experiment than in a previous analysis; a feature also observed for the elastic form factors, in particular at small q^2. This model refinement is important in view of an extension to vector and heavy-light mesons.Comment: 5 pages, 8 figures; minor corrections, version published in PRC C86, 038202 (2012

Tolerance to water deficit of cowpea genotypes

Objetivou-se, neste trabalho, avaliar o efeito do déficit hídrico sobre as características fisiológicas e produtivas do feijão-caupi e selecionar genótipos tolerantes à seca. Avaliaram-se a condutância estomática, o potencial hídrico foliar, a temperatura das folhas e a produtividade de grãos de 20 genótipos de feijão-caupi nas condições de solo e clima de Teresina, Piauí, no ano de 2008 e se conduziram dois experimentos em delineamento de blocos ao acaso com 20 tratamentos e quatro repetições, um sob déficit hídrico durante a fase reprodutiva e outro sob irrigação plena, para fins de comparação. O déficit hídrico, que foi obtido aplicando-se aproximadamente metade da lâmina requerida pelo feijão-caupi, reduziu em 72% a condutância estomática, 62% o potencial de água nas folhas, 60% a produção de grãos e aumentou em 11,7% a temperatura foliar. Nas condições de déficit hídrico treze genótipos produziram acima da média (466 kg ha-1), com destaque para o BRS-Paraguaçu, Pingo-de-ouro-1-2 e Pingo-de-ouro-2, que produziram 712 kg ha-1, 667 kg ha-1 e 642 kg ha-1, respectivamente. Em média, a produtividade de grãos dos genótipos sob irrigação plena foi 150% superior.The objective of this study was to evaluate physiological and productive characteristics of cowpea under water deficit and total irrigation, under soil and climate conditions of Teresina, Piauí State, in 2008. The stomatal conductance, leaf water potential, leaf temperature and grain yield of twenty cowpea cultivars were evaluated. Two experiments were carried out in a randomized block design with 20 treatments and four replications, one under water deficit during the reproductive phase and another one under total irrigation. The water deficit was obtained applying half of the water depth required by cowpea. The water deficit reduced 72% of the stomatal conductance, 40% the leaf transpiration, 62% of the leaf water potential, 60% of the grain yield and increased 11.7% the leaf temperature. Under water deficit, 13 genotypes produced above average (466 kg ha-1), and BRS-Paraguaçu, Pingo-de-ouro-1-2 and Pingo-de-ouro-2 presented the best grain yield with712 kg ha-1, 667 kg ha-1 and 642 kg ha-1, respectively. The average grain yield of the experiment under total irrigation was 150% higher

Biopolymeric materials used as nonviral vectors: a review

Bacterial transformation and gene transfection can be understood as being the results of introducing specific genetic material into cells, resulting in gene expression, and adding a new genetic trait to the host cell. Many studies have been carried out to investigate different types of lipids and cationic polymers as promising nonviral vectors for DNA transfer. The present study aimed to carry out a systematic review on the use of biopolymeric materials as nonviral vectors. The methodology was carried out based on searches of scientific articles and applications for patents published or deposited from 2006 to 2020 in different databases for patents (EPO, USPTO, and INPI) and articles (Scopus, Web of Science, and Scielo). The results showed that there are some deposits of patents regarding the use of chitosan as a gene carrier. The 16 analyzed articles allowed us to infer that the use of biopolymers as nonviral vectors is limited due to the low diversity of biopolymers used for these purposes. It was also observed that the use of different materials as nonviral vectors is based on chemical structure modifications of the material, mainly by the addition of cationic groups. Thus, the use of biopolymers as nonviral vectors is still limited to only a few polysaccharide types, emphasizing the need for further studies involving the use of different biopolymers in processes of gene transfer.info:eu-repo/semantics/publishedVersio

pH-responsive phthalate cashew gum nanoparticles for improving drugs delivery and anti-Trypanosoma cruzi efficacy

Funding Information: The authors acknowledge Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco ( FACEPE ) for a scholarship. This study was supported by funding from the Spanish Group CTS-946 and project P18-RT-3786 . Publisher Copyright: © 2023 Elsevier B.V.Nanotechnology is a crucial technology in recent years has resulted in new and creative applications of nanomedicine. Polymeric nanoparticles have increasing demands in pharmaceutical applications and require high reproducibility, homogeneity, and control over their properties. Work explores the use of cashew phthalate gum (PCG) as a particle-forming polymer. PCG exhibited a pH-sensitive behavior due to the of acid groups on its chains, and control drug release. We report the development of nanoparticles carrying benznidazole. Formulations were characterized by DLS, encapsulation efficiency, drug loading, FTIR, pH-responsive behavior, release, and in vitro kinetics. Interaction between polymer and drug was an evaluated by molecular dynamics. Morphology was observed by SEM, and in vitro cytotoxicity by MTT assay. Trypanocidal effect for epimastigote and trypomastigote forms was also evaluated. NPs responded to the slightly basic pH, triggering the release of BNZ. In acidic medium, they presented small size, spherical shape, and good stability. It was indicated NP with enhanced biological activity, reduced cytotoxicity, high anti T. cruzi performance, and pH-sensitive release. This work investigated properties related to the development and enhancement of nanoparticles. PCG has specific physicochemical properties that make it a promising alternative to drug delivery, however, there are still challenges to be overcome.publishersversionpublishe

Larvicidal effects of endophytic and basidiomycete fungus extracts on Aedes and Anopheles larvae (Diptera, Culicidae)

Introduction: In vitro bioassays were performed to access the larvicidal activity of crude extracts from the endophytic fungus Pestalotiopsis virgulata (Melanconiales, Amphisphaeriaceae) and the saprophytic fungus Pycnoporus sanguineus (Basidiomycetes, Polyporaceae) against the mosquitoes Aedes aegypti and Anopheles nuneztovari. Methods: The extracts were tested at concentrations of 100, 200, 300, 400 and 500ppm. Ethyl acetate mycelia (EAM) extracts and liquid culture media (LCM) from Pe. virgulata and Py. sanguineus were tested against third instar larvae of Ae. aegypti and An. nuneztovari. Results: The larvicidal activity of the EAM extracts from Pe. virgulata against Ae. aegypti had an LC50=101.8ppm, and the extract from the basidiomycete fungus Py. sanguineus had an LC50=156.8ppm against the Ae. aegypti larvae. The Pe. virgulata extract had an LC50=16.3ppm against the An. nuneztovari larvae, and the Py. sanguineus extract had an LC50=87.2ppm against these larvae. Conclusions: These results highlight the larvicidal effect of EAM extracts from the endophyte Pe. virgulata against the two larval mosquitoes tested. Thus, Pe. virgulata and Py. sanguineus have the potential for the production of bioactive substances against larvae of these two tropical disease vectors, with An. nuneztovari being more susceptible to these extracts

Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae)

Our taxonomic interest in the Neoraputia stimulated an investigation of N. paraensis searching for alkaloids. Fractions were monitored by ¹H NMR and ESI-MS/MS and only those which showed features of anthranilate alkaloids and flavonoids absent in the previous investigations were examined. Stems afforded the alkaloids flindersine, skimmianine, 8-methoxyflindersine and dictamnine; leaves yielded 3',4',7,8-tetramethoxy-5,6-(2,2-dimethylpyrano)-flavone, 3',4',5,7,8-pentamethoxyflavone, 5-hydroxy-3',4',6,7-tetramethoxyflavone, 3',4'-methylenedioxy-5,6,7-trimethoxyflavone and 5-hydroxy-3',4'-methylenedioxy-6,7-dimethoxyflavone. The alkaloids have remained undiscovered for 10 years. A number of flavonoids isolated from N. paraensis, N. magnifica, Murraya paniculata, Citrus sinensis graft (Rutaceae), Lonchocarpus montanus (Leguminosae) were evaluated for their ability to inhibit the enzymatic activity of the protein glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi. Highly oxygenated flavones and isoflavone were the most actives.Nosso interesse quimiotaxonômico sobre Neoraputia nos estimulou a examinar N. paraensis, visando a busca de alcalóides. As frações foram monitoradas via RMN ¹H e ESI-EM/EM e foram analisadas somente aquelas cujos espectros apresentavam características de alcalóides do ácido antranílico e flavonóides não isolados anteriormente. Foram isolados do caule os alcalóides flindersina, skimmianina, 8-metoxiflindersina e dictamnina; das folhas os flavonóides 3',4',7,8-tetrametoxi-5,6-(2,2-dimetilpirano)-flavona, 3',4',5,7,8-pentametoxiflavona, 5-hidroxi-3',4',6,7-tetrametoxiflavona, 3',4'-metilenodioxi-5,6,7-trimetoxiflavona e 5-hidroxi-3',4'-metilenodioxi-6,7-dimetoxiflavona,. Os alcalóides do ácido antranílico não foram encontrados em dez anos. Vários flavonóides isolados de N. paraensis, N. magnifica, Murraya paniculata, enxerto de Citrus sinensis (Rutaceae) e Lonchocarpus montanus (Leguminosae) foram testados frente a gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi, visando verificar seus potenciais em inibir a atividade da enzima. Os flavonóides polimetoxilados e um isoflavonóide foram os mais ativos.380387Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES