546 research outputs found
Verification of Magnitude and Phase Responses in Fixed-Point Digital Filters
In the digital signal processing (DSP) area, one of the most important tasks
is digital filter design. Currently, this procedure is performed with the aid
of computational tools, which generally assume filter coefficients represented
with floating-point arithmetic. Nonetheless, during the implementation phase,
which is often done in digital signal processors or field programmable gate
arrays, the representation of the obtained coefficients can be carried out
through integer or fixed-point arithmetic, which often results in unexpected
behavior or even unstable filters. The present work addresses this issue and
proposes a verification methodology based on the digital-system verifier
(DSVerifier), with the goal of checking fixed-point digital filters w.r.t.
implementation aspects. In particular, DSVerifier checks whether the number of
bits used in coefficient representation will result in a filter with the same
features specified during the design phase. Experimental results show that
errors regarding frequency response and overflow are likely to be identified
with the proposed methodology, which thus improves overall system's
reliability
Micromanipulation of InP lasers with optoelectronic tweezers for integration on a photonic platform
The integration of light sources on a photonic platform is a key aspect of the fabrication of self-contained photonic circuits with a small footprint that does not have a definitive solution yet. Several approaches are being actively researched for this purpose. In this work we propose optoelectronic tweezers for the manipulation and integration of light sources on a photonic platform and report the positional and angular accuracy of the micromanipulation of standard Fabry-PĆ©rot InP semiconductor laser die. These lasers are over three orders of magnitude bigger in volume than any previously assembled with optofluidic techniques and the fact that they are industry standard lasers makes them significantly more useful than previously assembled microdisk lasers. We measure the accuracy to be 2.5 Ā± 1.4 Āµm and 1.4 Ā± 0.4Ā° and conclude that optoelectronic tweezers are a promising technique for the micromanipulation and integration of optoelectronic components in general and semiconductor lasers in particular
Retrospective Study of Midazolam Protocol for Prehospital Behavioral Emergencies
Introduction: Agitated patients in the prehospital setting pose challenges for both patient care and emergency medical services (EMS) provider safety. Midazolam is frequently used to control agitation in the emergency department setting; however, limited data exist in the prehospital setting. We describe our experience treating patients with midazolam for behavioral emergencies in a large urban EMS system. We hypothesized that using midazolam for acute agitation leads to improved clinical conditions without causing significant clinical deterioration.Methods: We performed a retrospective review of EMS patient care reports following implementation of a behavioral emergencies protocol in a large urban EMS system from February 2014āJune 2016. For acute agitation, paramedics administered midazolam 1 milligram (mg) intravenous (IV), 5 mg intramuscular (IM), or 5 mg intranasal (IN). Results were analyzed using descriptive statistics, Leveneās test for assessing variance among study groups, and t-test to evaluate effectiveness based on route.Results: In total, midazolam was administered 294 times to 257 patients. Median age was 30 (interquartile range 24ā42) years, and 66.5% were male. Doses administered were 1 mg (7.1%) and 5 mg (92.9%). Routes were IM (52.0%), IN (40.8%), and IV (7.1%). A second dose was administered to 37 patients. In the majority of administrations, midazolam improved the patientās condition (73.5%) with infrequent adverse events (3.4%). There was no significant difference between the effectiveness of IM and IN midazolam (71.0% vs 75.4%; p = 0.24).Conclusion: A midazolam protocol for prehospital agitation was associated with reduced agitation and a low rate of adverse events
Prokineticin ligands and receptors are expressed in the human fetal ovary and regulate germ cell expression of COX2
CONTEXT: Fetal ovarian development and primordial follicle formation underpin future female fertility. Prokineticin (PROK) ligands regulate cell survival, proliferation and angiogenesis in adult reproductive tissues including the ovary. However, their expression and function during fetal ovarian development remains unclear.OBJECTIVE: To investigate expression and localization of the PROK ligands, receptors and their downstream transcriptional targets in the human fetal ovary.SETTING: This study was conducted at the University of Edinburgh.PARTICIPANTS: Ovaries were collected from 37 morphologically normal human fetuses.DESIGN AND MAIN OUTCOME MEASURES: mRNA and protein expression of PROK ligands and receptors was determined in human fetal ovaries using qRT-PCR, immunoblotting and immunohistochemistry. Functional studies were performed using a human germ tumour cell line (TCam-2) stably transfected with PROKR1.RESULTS: Expression of PROK1 and PROKR1 was significantly higher in mid-gestation ovaries (17-20 weeks) than at earlier gestations (8-11 and 14-16 weeks). PROK2 significantly increased across the gestations examined. PROKR2 expression remained unchanged. PROK ligand and receptor proteins were predominantly localised to germ cells (including oocytes within primordial follicles) and endothelial cells, indicating these cell types to be the targets of PROK signalling in the human fetal ovary. PROK1 treatment of a germ cell line stably-expressing PROKR1 resulted in ERK phosphorylation, and elevated COX2 expression.CONCLUSIONS: Developmental changes in expression and regulation of COX2 and pERK by PROK1 suggest that PROK ligands may be novel regulators of germ cell development in the human fetal ovary, interacting within a network of growth and survival factors prior to primordial follicle formation.</p
Accurate Phase Calibration for Digital Beam-Forming in Multi-Transceiver HF Radar System
The TIGER-3 radar is being developed as an āall digitalā radar with 20 integrated digital transceivers, each connected to a separate antenna. Using phased array antenna techniques, radiated power is steered towards a desired direction based on the relative phases within the array elements. This paper proposes an accurate phase measurement method to calibrate the phases of the radio output signals using Field Programmable Gate Array (FPGA) technology. The method sequentially measures the phase offset between the RF signal generated by each transceiver and a reference signal operated at the same frequency. Accordingly, the transceiver adjusts its phase in order to align to the reference phase. This results in accurately aligned phases of the RF output signals and with the further addition of appropriate phase offsets, digital beamforming (DBF) can be performed steering the beam in a desired direction. The proposed method is implemented on a Virtex-5 VFX70T device. Experimental results show that the calibration accuracy is of 0.153 degrees with 14 MHz operating frequency
A Low Cost Technique for Adding Microlasers to a Silicon Photonic Platform
In this paper we report the physical micromanipulation of standard InP telecommunications laser die in a liquid
medium by means of optoelectronic tweezers. Optoelectronic tweezers have been shown to use much less optical
power than optical tweezers, they do not require a coherent light source to function and the creation of multiple
traps is straightforward. These properties make the technique a very good candidate for the massive parallel
micromanipulation of optoelectronic components for assembly on a photonic platform. We discuss the positional
and orientation accuracy of the optoelectronic tweezers in relation to the alignment requirements for low-loss
coupling between the light sources and the other components in a photonic platform. Our experiments indicate
that the accuracy is better than 2 Āµm and 2ā¦ for translations and rotations, respectively
Clustering and Sharing Incentives in BitTorrent Systems
Peer-to-peer protocols play an increasingly instrumental role in Internet
content distribution. Consequently, it is important to gain a full
understanding of how these protocols behave in practice and how their
parameters impact overall performance. We present the first experimental
investigation of the peer selection strategy of the popular BitTorrent protocol
in an instrumented private torrent. By observing the decisions of more than 40
nodes, we validate three BitTorrent properties that, though widely believed to
hold, have not been demonstrated experimentally. These include the clustering
of similar-bandwidth peers, the effectiveness of BitTorrent's sharing
incentives, and the peers' high average upload utilization. In addition, our
results show that BitTorrent's new choking algorithm in seed state provides
uniform service to all peers, and that an underprovisioned initial seed leads
to the absence of peer clustering and less effective sharing incentives. Based
on our observations, we provide guidelines for seed provisioning by content
providers, and discuss a tracker protocol extension that addresses an
identified limitation of the protocol
Death receptor 3 (TNFRSF25) increases mineral apposition by osteoblasts and region specific new bone formation in the axial skeleton of male DBA/1 mice
Fraser L. Collins and this work were funded by an Arthritis Research UK PhD studentship (Grant Code: 18598) awarded to Anwen S. Williams, Eddie C. Y. Wang, and Michael D. Stone. Eddie C. Y. Wang was additionally funded by MRC Project Grant G0901119. Funding for open access was kindly provided by Cardiff University.Peer reviewedPublisher PD
Visible-Light-Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters:Rapid Access to Ī³-Amino Boronic Esters
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