Comments on Microcausality, Chaos, and Gravitational Observables

Observables in gravitational systems must be non-local so as to be invariant under diffeomorphism gauge transformations. But at the classical level some such observables can nevertheless satisfy an exact form of microcausality. This property is conjectured to remain true at all orders in the semiclassical expansion, though with limitations at finite $\hbar$ or $\ell_{Planck}$. We also discuss related issues concerning observables in black hole spacetimes and comment on the senses in which they do and do not experience the form of chaos identified by Shenker and Stanford. In particular, in contrast to the situation in a reflecting cavity, this chaos does not afflict observables naturally associated with Hawking radiation for evaporating black holes.Comment: 16 pages, 1 figure; references adde

No static bubbling spacetimes in higher dimensional Einstein-Maxwell theory

We prove that any asymptotically flat static spacetime in higher dimensional Einstein-Maxwell theory must have no magnetic field. This implies that there are no static soliton spacetimes and completes the classification of static non-extremal black holes in this theory. In particular, these results establish that there are no asymptotically flat static spacetimes with non-trivial topology, with or without a black hole, in Einstein-Maxwell theory.Comment: 9 pages. v2: minor edits, references adde

First order parent formulation for generic gauge field theories

We show how a generic gauge field theory described by a BRST differential can systematically be reformulated as a first order parent system whose spacetime part is determined by the de Rham differential. In the spirit of Vasiliev's unfolded approach, this is done by extending the original space of fields so as to include their derivatives as new independent fields together with associated form fields. Through the inclusion of the antifield dependent part of the BRST differential, the parent formulation can be used both for on and off-shell formulations. For diffeomorphism invariant models, the parent formulation can be reformulated as an AKSZ-type sigma model. Several examples, such as the relativistic particle, parametrized theories, Yang-Mills theory, general relativity and the two dimensional sigma model are worked out in details.Comment: 36 pages, additional sections and minor correction

Onset and decay of the 1 + 1 Hawking–Unruh effect: what the derivative-coupling detector saw

We study an Unruh–DeWitt particle detector that is coupled to the proper time derivative of a real scalar field in 1 + 1 spacetime dimensions. Working within first-order perturbation theory, we cast the transition probability into a regulator- free form, and we show that the transition rate remains well defined in the limit of sharp switching. The detector is insensitive to the infrared ambiguity when the field becomes massless, and we verify explicitly the regularity of the massless limit for a static detector in Minkowski half-space. We then consider a massless field for two scenarios of interest for the Hawking–Unruh effect: an inertial detector in Minkowski spacetime with an exponentially receding mirror, and an inertial detector in (1 + 1)-dimensional Schwarzschild spacetime, in the Hartle–Hawking–Israel and Unruh vacua. In the mirror spacetime the transition rate traces the onset of an energy flux from the mirror, with the expected Planckian late time asymptotics. In the Schwarzschild spacetime the transition rate of a detector that falls in from infinity gradually loses thermality, diverging near the singularity proportionally to r−3 2

Mesenchymal Stem Cells Exhibit Firm Adhesion, Crawling, Spreading and Transmigration across Aortic Endothelial Cells: Effects of Chemokines and Shear

Mesenchymal stem cells (MSCs) have anti-inflammatory and immunosuppressive properties and may be useful in the therapy of diseases such as arteriosclerosis. MSCs have some ability to traffic into inflamed tissues, however to exploit this therapeutically their migratory mechanisms need to be elucidated. This study examines the interaction of murine MSCs (mMSCs) with, and their migration across, murine aortic endothelial cells (MAECs), and the effects of chemokines and shear stress. The interaction of mMSCs with MAECs was examined under physiological flow conditions. mMSCs showed lack of interaction with MAECs under continuous flow. However, when the flow was stopped (for 10min) and then started, mMSCs adhered and crawled on the endothelial surface, extending fine microvillous processes (filopodia). They then spread extending pseudopodia in multiple directions. CXCL9 significantly enhanced the percentage of mMSCs adhering, crawling and spreading and shear forces markedly stimulated crawling and spreading. CXCL9, CXCL16, CCL20 and CCL25 significantly enhanced transendothelial migration across MAECs. The transmigrated mMSCs had down-regulated receptors CXCR3, CXCR6, CCR6 and CCR9. This study furthers the knowledge of MSC transendothelial migration and the effects of chemokines and shear stress which is of relevance to inflammatory diseases such as arteriosclerosis

New Developments in the Casimir Effect

We provide a review of both new experimental and theoretical developments in the Casimir effect. The Casimir effect results from the alteration by the boundaries of the zero-point electromagnetic energy. Unique to the Casimir force is its strong dependence on shape, switching from attractive to repulsive as function of the size, geometry and topology of the boundary. Thus the Casimir force is a direct manifestation of the boundary dependence of quantum vacuum. We discuss in depth the general structure of the infinities in the field theory which are removed by a combination of zeta-functional regularization and heat kernel expansion. Different representations for the regularized vacuum energy are given. The Casimir energies and forces in a number of configurations of interest to applications are calculated. We stress the development of the Casimir force for real media including effects of nonzero temperature, finite conductivity of the boundary metal and surface roughness. Also the combined effect of these important factors is investigated in detail on the basis of condensed matter physics and quantum field theory at nonzero temperature. The experiments on measuring the Casimir force are also reviewed, starting first with the older measurements and finishing with a detailed presentation of modern precision experiments. The latter are accurately compared with the theoretical results for real media. At the end of the review we provide the most recent constraints on the corrections to Newtonian gravitational law and other hypothetical long-range interactions at submillimeter range obtained from the Casimir force measurements.Comment: 275 pages,29 figures, to appear in Physics Report

Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation

Background: The neuroinflammatory response following traumatic brain injury (TBI) is known to be a key secondary injury factor that can drive ongoing neuronal injury. Despite this, treatments that have targeted aspects of the inflammatory pathway have not shown significant efficacy in clinical trials. Main body: We suggest that this may be because classical inflammation only represents part of the story, with activation of neurogenic inflammation potentially one of the key initiating inflammatory events following TBI. Indeed, evidence suggests that the transient receptor potential cation channels (TRP channels), TRPV1 and TRPA1, are polymodal receptors that are activated by a variety of stimuli associated with TBI, including mechanical shear stress, leading to the release of neuropeptides such as substance P (SP). SP augments many aspects of the classical inflammatory response via activation of microglia and astrocytes, degranulation of mast cells, and promoting leukocyte migration. Furthermore, SP may initiate the earliest changes seen in blood-brain barrier (BBB) permeability, namely the increased transcellular transport of plasma proteins via activation of caveolae. This is in line with reports that alterations in transcellular transport are seen first following TBI, prior to decreases in expression of tight-junction proteins such as claudin-5 and occludin. Indeed, the receptor for SP, the tachykinin NK1 receptor, is found in caveolae and its activation following TBI may allow influx of albumin and other plasma proteins which directly augment the inflammatory response by activating astrocytes and microglia. Conclusions: As such, the neurogenic inflammatory response can exacerbate classical inflammation via a positive feedback loop, with classical inflammatory mediators such as bradykinin and prostaglandins then further stimulating TRP receptors. Accordingly, complete inhibition of neuroinflammation following TBI may require the inhibition of both classical and neurogenic inflammatory pathways.Frances Corrigan, Kimberley A. Mander, Anna V. Leonard and Robert Vin

The Advancement of Biomaterials in Regulating Stem Cell Fate.

Stem cells are well-known to have prominent roles in tissue engineering applications. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can differentiate into every cell type in the body while adult stem cells such as mesenchymal stem cells (MSCs) can be isolated from various sources. Nevertheless, an utmost limitation in harnessing stem cells for tissue engineering is the supply of cells. The advances in biomaterial technology allows the establishment of ex vivo expansion systems to overcome this bottleneck. The progress of various scaffold fabrication could direct stem cell fate decisions including cell proliferation and differentiation into specific lineages in vitro. Stem cell biology and biomaterial technology promote synergistic effect on stem cell-based regenerative therapies. Therefore, understanding the interaction of stem cell and biomaterials would allow the designation of new biomaterials for future clinical therapeutic applications for tissue regeneration. This review focuses mainly on the advances of natural and synthetic biomaterials in regulating stem cell fate decisions. We have also briefly discussed how biological and biophysical properties of biomaterials including wettability, chemical functionality, biodegradability and stiffness play their roles