Effects of TMD evolution and partonic flavor on e+e−e^+e^- annihilation into hadrons

We calculate the transverse momentum dependence in the production of two back-to-back hadrons in electron-positron annihilations at the medium/large energy scales of BES-III and BELLE experiments. We use the parameters of the transverse-momentum-dependent (TMD) fragmentation functions that were recently extracted from the semi-inclusive deep-inelastic-scattering multiplicities at low energy from HERMES. TMD evolution is applied according to different approaches and using different parameters for the nonperturbative part of the evolution kernel, thus exploring the sensitivity of our results to these different choices and to the flavor dependence of parton fragmentation functions. We discuss how experimental measurements could discriminate among the various scenarios.Comment: 33 pages, 10 composite figures, JHEP style fil

El enfoque colectivista de Makarenko como contribución en la formación del educando

The present investigation entitled "Makarenko's collectivist approach as a contribution to the formation of the student" had as its starting point the construction of Makarenko's pedagogical thought, precisely, we approached it in the context of the Russian revolution. Immediately we reaffirm that Makarenko embraced a scientific conception of the world, I mean dialectical materialism, a philosophical method that allowed him to know his objective reality and transform it, all this points to the relationship between theory and practice or saying and doing; Consequently, it implies turning bad into good, that is the work for results that modern society demands. The pedagogue masterfully created and applied the collectivist method, a transformative method, which gives education the mass character. At the same time, Makarenko has the merit of having masterfully transmitted pedagogical knowledge, teaching the learner to think and reason. But this was not achieved at once, but through several periods of doubts and torturing errors, making it clear that after several attempts victory is achieved. In this sense, he discovered that in order to work successfully in the school, it was not only necessary to teach, but also to know how to educate, taking into account the individual characteristics and potential of each student. It should be noted that Makarenko's educational work was carried out in the midst of enormous difficulties, such as children and young delinquents (offenders of the law), economic crisis and period of wars. Makareko's teaching, for those of us who are heading to teaching work, lies in the following, to educate everyone at the same time, and not each one separately, one must have the necessary perspective, equally understandable to all. At the same time, do not think that you educate the child only when you talk to him, reprimand him or command him. You educate him at every moment of his life, even when he is not at home with you. How they talk to other people and about other people, how they are happy or sad, their way of treating friends and enemies, how they laugh, how they read the press are details that are all very important for the child. So the training that the teacher and the parents exercise regarding the student is permanent and crucial in the lives of the children.La presente investigación intitulada “El enfoque colectivista de Makarenko como contribución en la formación del educando” tuvo como punto de partida la construcción del pensamiento pedagógico de Makarenko, precisamente, lo abordamos en el contexto de la revolución rusa. En seguida reafirmamos, que Makarenko abrazó una concepción científica del mundo, me refiero al materialismo dialéctico, método filosófico que le permitió conocer su realidad objetiva y transformarlo, todo ello apunta a la relación entre la teoría y la práctica o el decir y el hacer; en consecuencia, implica convertir lo malo en bueno, he ahí el trabajo por resultados que demanda la sociedad moderna. El pedagogo creó y aplicó magistralmente el método colectivista, un método transformador, que le otorga a la educación, el carácter de masa. Al mismo tiempo, Makarenko, tiene el mérito de haber transmitido el conocimiento pedagógico con maestría, enseñando a pensar y razonar al educando. Pero esto no lo logró de golpe, sino a través de varios periodos de dudas y errores torturantes, dejando claro que después de varios intentos se alcanza la victoria. En tal sentido, descubrió que para trabajar exitosamente en la escuela no sólo hacía falta enseñar, sino también saber educar, tener en cuenta sus particularidades individuales y sus potencialidades de cada educando. Cabe precisar que el trabajo educativo de Makarenko se realizó en medio de enormes dificultades, como son niños y jóvenes delincuentes (infractores de la ley), crisis económica y periodo de guerras. La enseñanza de Makareko, para quienes nos enrumbamos a la labor docente radica en lo siguiente, para educar a todos a la vez, y no cada uno por separado, hay que tener la perspectiva necesaria, igualmente comprensible a todos. A su vez, no vayan a creer que ustedes educan al niño sólo cuando hablan con él, le reprenden o le mandan. Ustedes lo educan en todos los momentos de su vida, hasta cuando no está en casa con Ustedes. Como hablan con otras personas y de otras gentes, cómo se alegran o entristecen, su forma de tratar a amigos y enemigos, cómo se ríen, cómo lee la prensa son detalles que todos tienen para el niño suma importancia. Entonces la formación que ejerce el maestro y los padres de familia respecto al educando es permanente y crucial en la vida de los niños

A First Evaluation of the Usefulness of Kudzu Starch in Cultural Heritage Restoration

In recent times, the use of natural and harmless products for the environment and restorer is taking place in the field of Cultural Heritage restoration. In this sense, wheat, rice and corn starches as adhesives, have suitable characteristics without toxicity risks. A new starch in this field, is the Kudzu, an almost pure compound (99.5% starch) that is processed by a natural way from a plant called Pueraria lobata. This is a preliminary study of the potential use of Kudzu starch for the restoration of Cultural Heritage, focusing, firstly, in its capacity as adhesive through a comparative evaluation with common starches. The accelerated aging process carried out proved that Kudzu ensures optimal chromatic behaviour. On the other hand, the main problem in starch paste is the biological colonization. The daidzein, a natural antimicrobial compound implicit in Kudzu starch, confirmed the resistance to microorganism in this preliminary approach. The evaluation of the adhesive capacity, and the reversibility of the starches, suggest that Kudzu starch is a valid adhesive in the field of paper restoration. Thus, the potential of this starch in the conservation of Cultural Heritage is evidenced and its use as cleaner, resistance to biological colonization and consolidant is promising.This work has been supported by the MADyLIN project (Grant No. BIA2017-87063-P) funded by the Spanish Agency for Research AEI (MINEICO/FEDER-UE). The author wishes to acknowledge professional support of the Interdisciplinary Thematic Platform from CSIC Open Heritage: Research and Society (PTI-PAIS). Technical and human support provided Macroconduct, Mesostructure and Nanotechnology by SGIker (UPV/EHU, MICINN, GV/EJ, ERDF and ESF) are also gratefully acknowledge

The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional networks rather than connectivity throughout the entire brain. Here, we investigated differences in resting-state functional connectivity between OCD patients and healthy controls (HC) using mega-analysis of data from 1024 OCD patients and 1028 HC from 28 independent samples of the ENIGMA-OCD consortium. We assessed group differences in whole-brain functional connectivity at both the regional and network level, and investigated whether functional connectivity could serve as biomarker to identify patient status at the individual level using machine learning analysis. The mega-analyses revealed widespread abnormalities in functional connectivity in OCD, with global hypo-connectivity (Cohen’s d: -0.27 to -0.13) and few hyper-connections, mainly with the thalamus (Cohen’s d: 0.19 to 0.22). Most hypo-connections were located within the sensorimotor network and no fronto-striatal abnormalities were found. Overall, classification performances were poor, with area-under-the-receiver-operating-characteristic curve (AUC) scores ranging between 0.567 and 0.673, with better classification for medicated (AUC = 0.702) than unmedicated (AUC = 0.608) patients versus healthy controls. These findings provide partial support for existing pathophysiological models of OCD and highlight the important role of the sensorimotor network in OCD. However, resting-state connectivity does not so far provide an accurate biomarker for identifying patients at the individual level

Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK:a multicentre, longitudinal cohort study - PHOSP-COVID

BACKGROUND: The long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown.METHODS: Adult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5 months and 1 year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (i.e., asthma, COPD or bronchiectasis) were compared to the non-airways group.RESULTS: A total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1 year, the airways group participants were less likely to feel fully recovered (20.4% versus 33.2%, p&lt;0.001), had higher burden of anxiety (29.1% versus 22.0%, p=0.002), depression (31.2% versus 24.7%, p=0.006), higher percentage of impaired mobility using short physical performance battery ≤10 (57.4% versus 45.2%, p&lt;0.001) and 27% had a new disability (assessed by the Washington Group Short Set on Functioning) versus 16.6%, p=0.014. HRQoL assessed using EQ-5D-5L Utility Index was lower in the airways group (mean±SD 0.64±0.27 versus 0.73±0.25, p&lt;0.001). Burden of breathlessness, fatigue and cough measured using a study-specific tool was higher in the airways group.CONCLUSION: Individuals with pre-existing airway diseases hospitalised due to COVID-19 were less likely to feel fully recovered, had lower physiological performance measurements, more burden of symptoms and reduced HRQoL up to 1 year post-hospital discharge.</p

The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R):protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium

Introduction Many adults hospitalised with COVID-19 have persistent symptoms such as fatigue, breathlessness and brain fog that limit day-to-day activities. These symptoms can last over 2 years. Whilst there is limited controlled studies on interventions that can support those with ongoing symptoms, there has been some promise in rehabilitation interventions in improving function and symptoms either using face-to-face or digital methods, but evidence remains limited and these studies often lack a control group. Methods and analysis This is a nested single-blind, parallel group, randomised control trial with embedded qualitative evaluation comparing rehabilitation (face-to-face or digital) to usual care and conducted within the PHOSP-COVID study. The aim of this study is to determine the effectiveness of rehabilitation interventions on exercise capacity, quality of life and symptoms such as breathlessness and fatigue. The primary outcome is the Incremental Shuttle Walking Test following the eight week intervention phase. Secondary outcomes include measures of function, strength and subjective assessment of symptoms. Blood inflammatory markers and muscle biopsies are an exploratory outcome. The interventions last eight weeks and combine symptom-titrated exercise therapy, symptom management and education delivered either in a face-to-face setting or through a digital platform (www.yourcovidrecovery.nhs.uk). The proposed sample size is 159 participants, and data will be intention-to-treat analyses comparing rehabilitation (face-to-face or digital) to usual care. Ethics and dissemination Ethical approval was gained as part of the PHOSP-COVID study by Yorkshire and the Humber Leeds West Research NHS Ethics Committee, and the study was prospectively registered on the ISRCTN trial registry (ISRCTN13293865). Results will be disseminated to stakeholders, including patients and members of the public, and published in appropriate journals. Article summary Strengths and limitations of this study • This protocol utilises two interventions to support those with ongoing symptoms of COVID-19 • This is a two-centre parallel-group randomised controlled trial • The protocol has been supported by patient and public involvement groups who identified treatments of symptoms and activity limitation as a top priorit