An aqueous one-pot route to gold/quantum rod heterostructured nanoparticles functionalized with DNA

International audienc

Prise en charge des parasitoses de l'enfant à l'officine (poux, tiques, gale, vers)

Les ectoparasitoses sont des dermatoses parasitaires ubiquitaires et contagieuses représentées essentiellement par la pédiculose du cuir chevelu et la gale. Elles constituent un véritable enjeu de santé publique au vu de leur importance prévalence dans les collectivités et des problèmes thérapeutiques. Le développement de nouveaux agents antiparasitaires et l'émergence de résistances aux insecticides imposent la réévaluation des stratégies de prise en charge de ces ectoparasitoses. La méningo-encéphalite à tiques est une maladie virale transmise à l'homme par morsure de tiques. Elle fait partie des arboviroses (arthropod-borne viruses). Il n'existe pas de traitement spécifique. La vaccination représente la mesure préventive essentielle. Du fait de leur méconnaissance de l'hygiène alimentaire, les enfants sont souvent infestés par les parasites intestinaux. Les traitements actuels sont efficaces, bien tolérés, et d'administration facileThe ectoparasites are ubiquitous and contagious parasitic skin diseases, mainly represented by head lice and scabies. Regarding to their high prevalence in the community and therapeutic problems, they from a real public health issue. Considering the development of new antiparasitic agents and the emergence of resistance to insecticides, an ectoparasites support strategies reassessment is needed. Meningoencephalitis is a viral disease transmitted to human race through the bite of ticks. It is part of arboviruses (arthropod-borne viruses). There is no specific treatment. Vaccination is the major preventive measure. Because of their lack of food hygiene, children are often infected with intestinal parasites. Current treatments are effective, well tolerated and easily administered.RENNES1-BU Santé (352382103) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Metabolite damage and its repair or pre-emption

It is increasingly evident that metabolites suffer various kinds of damage, that such damage happens in all organisms, and that cells have dedicated systems for damage repair and containment. Firstly, chemical biology is demonstrating that diverse metabolites are damaged by side-reactions of ‘promiscuous’ enzymes or by spontaneous chemical reactions, that the products are useless or toxic, and that the unchecked buildup of these products can be devastating. Secondly, genetic and genomic evidence from pro- and eukaryotes is implicating a network of novel, conserved enzymes that repair damaged metabolites or somehow pre-empt damage. Metabolite (i.e. small molecule) repair is analogous to macromolecule (DNA and protein) repair and appears from comparative genomic evidence to be equally widespread. Comparative genomics also implies that metabolite repair could be the function of many conserved protein families lacking known activities. How – and how well – cells deal with metabolite damage impacts fields ranging from medical genetics to metabolic engineering