39 research outputs found
A contemporaneous infrared flash from a long gamma-ray burst: an echo from the central engine
The explosion that results in a cosmic gamma-ray burst (GRB) is thought to
produce emission from two physical processes -- the activity of the central
engine gives rise to the high-energy emission of the burst through internal
shocking and the subsequent interaction of the flow with the external
environment produces long-wavelength afterglow. While afterglow observations
continue to refine our understanding of GRB progenitors and relativistic
shocks, gamma-ray observations alone have not yielded a clear picture of the
origin of the prompt emission nor details of the central engine. Only one
concurrent visible-light transient has been found and was associated with
emission from an external shock. Here we report the discovery of infrared (IR)
emission contemporaneous with a GRB, beginning 7.2 minutes after the onset of
GRB 041219a. Our robotic telescope acquired 21 images during the active phase
of the burst, yielding the earliest multi-colour observations of any
long-wavelength emission associated with a GRB. Analysis of an initial IR pulse
suggests an origin consistent with internal shocks. This opens a new
possibility to study the central engine of GRBs with ground-based observations
at long wavelengths.Comment: Accepted to Nature on March 1, 2005. 9 pages, 4 figures, nature12.cls
and nature1.cls files included. This paper is under press embargo until print
publicatio
A comparison of cervical delta-shaped anastomosis and circular stapled anastomosis after esophagectomy
Protein Signature of Lung Cancer Tissues
Lung cancer remains the most common cause of cancer-related mortality. We applied a highly multiplexed proteomic technology (SOMAscan) to compare protein expression signatures of non small-cell lung cancer (NSCLC) tissues with healthy adjacent and distant tissues from surgical resections. In this first report of SOMAscan applied to tissues, we highlight 36 proteins that exhibit the largest expression differences between matched tumor and non-tumor tissues. The concentrations of twenty proteins increased and sixteen decreased in tumor tissue, thirteen of which are novel for NSCLC. NSCLC tissue biomarkers identified here overlap with a core set identified in a large serum-based NSCLC study with SOMAscan. We show that large-scale comparative analysis of protein expression can be used to develop novel histochemical probes. As expected, relative differences in protein expression are greater in tissues than in serum. The combined results from tissue and serum present the most extensive view to date of the complex changes in NSCLC protein expression and provide important implications for diagnosis and treatment
Cell–cell and cell–matrix dynamics in intraperitoneal cancer metastasis
The peritoneal metastatic route of cancer dissemination is shared by cancers of the ovary and gastrointestinal tract. Once initiated, peritoneal metastasis typically proceeds rapidly in a feed-forward manner. Several factors contribute to this efficient progression. In peritoneal metastasis, cancer cells exfoliate into the peritoneal fluid and spread locally, transported by peritoneal fluid. Inflammatory cytokines released by tumor and immune cells compromise the protective, anti-adhesive mesothelial cell layer that lines the peritoneal cavity, exposing the underlying extracellular matrix to which cancer cells readily attach. The peritoneum is further rendered receptive to metastatic implantation and growth by myofibroblastic cell behaviors also stimulated by inflammatory cytokines. Individual cancer cells suspended in peritoneal fluid can aggregate to form multicellular spheroids. This cellular arrangement imparts resistance to anoikis, apoptosis, and chemotherapeutics. Emerging evidence indicates that compact spheroid formation is preferentially accomplished by cancer cells with high invasive capacity and contractile behaviors. This review focuses on the pathological alterations to the peritoneum and the properties of cancer cells that in combination drive peritoneal metastasis