60 research outputs found
Corneal confocal microscopy detects a reduction in corneal endothelial cells and nerve fibres in patients with acute ischemic stroke
YesEndothelial dysfunction and damage underlie cerebrovascular disease and ischemic stroke. We
undertook corneal confocal microscopy (CCM) to quantify corneal endothelial cell and nerve
morphology in 146 patients with an acute ischemic stroke and 18 age-matched healthy control
participants. Corneal endothelial cell density was lower (P<0.001) and endothelial cell area (P<0.001)
and perimeter (P<0.001) were higher, whilst corneal nerve fbre density (P<0.001), corneal nerve
branch density (P<0.001) and corneal nerve fbre length (P=0.001) were lower in patients with acute
ischemic stroke compared to controls. Corneal endothelial cell density, cell area and cell perimeter
correlated with corneal nerve fber density (P=0.033, P=0.014, P=0.011) and length (P=0.017,
P=0.013, P=0.008), respectively. Multiple linear regression analysis showed a signifcant independent
association between corneal endothelial cell density, area and perimeter with acute ischemic stroke
and triglycerides. CCM is a rapid non-invasive ophthalmic imaging technique, which could be used to
identify patients at risk of acute ischemic stroke.Qatar National Research Fund Grant BMRP2003865
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Preserved organic matter in a fossil Ocean Continent Transition in the Alps: the example of Totalp, SE Switzerland
Letter to the Editor: A possible case of myiasis in a wild moustached tamarin, Saguinus mystax (Callitrichinae, Cebidae)
Early changes of intracranial pressure, perfusion pressure, and blood flow after acute head injury
Fluid resuscitation from severe hemorrhagic shock using diaspirin cross-linked hemoglobin fails to improve pancreatic and renal perfusion
Impact of brief prewarming on anesthesia-related core-temperature drop, hemodynamics, microperfusion and postoperative ventilation in cytoreductive surgery of ovarian cancer: a randomized trial
A green racer snake (Philodryas nattereri, Colubridae) killed but not eaten by a blonde capuchin monkey (Sapajus flavius, Cebidae)
Exploring scenarios of chikungunya mitigation with a data-driven agent-based model of the 2014–2016 outbreak in Colombia
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