39 research outputs found

    Cerebrospinal fluid and serum antiphospholipid antibodies in multiple sclerosis, Guillain-Barré syndrome and systemic lupus arythematosus

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    Immuneglobulins isotypes (IgG and IgM) for myelin basic protein (MBP), cerebrosides (CER), gangliosides (GANG) and cardiolipin (CARD) were detected in the cerebrospinal fluid (CSF) from 33 patients with multiple sclerosis (MS), 18 with Guillain-Barré syndrome (GBS) and 30 with systemic lupus erythematosus (SLE). In MS patients occurred positive and significant levels of IgG-MBP in 51,5% (p<0.05) and IgM-MBP in only 18.2%, IgG-CARD in 46.2%, as long as CER and GANG were detected in almost 20%. From serum samples of MS patients 20.6% presented IgG-MBP, while 53% showed positive levels foi IgM-MBP. The CSF analysis of patients with GBS showed that 56.3% revealed IgG-MBP (p<0.05), 53% for IgM-MBP. 3&.5% for IgG-CER and 23% for IgM-CER, while 50% of patients had IgG-CARD, as long -as 31% also had IgG-GANG. The serum evaluation from 14 patients showed that 18.8% had positive concentrations of IgG-MBP and 56.3% presented IgM-MBP (p<0.05) Except for 50% of patients with SLE who presented positive CSF levels of IgG-CARD. only 24.1% had positive levels of IgG-MBP. We believe that the presence of antiphosphohoid antibodies in CSF of the above mentioned diseases occurred as immune epiphenomena, but their appearance would permit the maintenance of and perpetuate the immune event

    The role of external experts in crisis situations: A research synthesis of 114 post-crisis evaluation reports in the Netherlands

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    This explorative study examines the role of external experts in crisis situations and the conditions under which their involvement contributes to adequate crisis management. Existing crisis management research tends to focus on stakeholder analysis, and the valuable input of experts during crisis preparation. Consequently, the role of external experts during the crisis response phase has been largely overlooked. This is somewhat surprising given the crucial role that is often attributed to external experts. To fill this gap, we have investigated the role of external experts by conducting a research synthesis of 114 post-crisis evaluation reports relating to 60 crises in the Netherlands between 2000 and 2013. The analysis shows that external experts are frequently involved and often play prominent roles in the crisis response. These external experts are often not actively recruited by the (strategic) crisis management response structure. In addition, the contributions and activities of external experts tend to be scarcely coordinated by the (strategic) crisis management response structure. Based on an in-depth analysis of the evaluation reports, we identify six opportunities and threats related to expert involvement in crisis situations, and ten conditions under which expert involvement contributes to adequate crisis management
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