38 research outputs found
Bladder cancer, a unique model to understand cancer immunity and develop immunotherapy approaches
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
International audienceWith the mechanistic understanding of immune checkpoints and success in checkpoint blockade using antibodies for the treatment of certain cancers, immunotherapy has become one of the hottest areas in cancer research, with promise of long-lasting therapeutic effect. Currently, however, only a proportion of cancers have a good response to checkpoint inhibition immunotherapy. Better understanding of the cancer response and resistance mechanisms is essential to fully explore the potential of immunotherapy to cure the majority of cancers. Bladder cancer, one of the most common and aggressive malignant diseases, has been successfully treated both at early and advanced stages by different immunotherapeutic approaches, bacillus Calmette-Guérin (BCG) intravesical instillation and anti-PD-1/PD-L1 immune checkpoint blockade, respectively. Therefore, it provides a good model to investigate cancer immune response mechanisms and to improve the efficiency of immunotherapy. Here, we review bladder cancer immunotherapy with equal weight on BCG and anti-PD-1/PD-L1 therapies and demonstrate why and how bladder cancer can be used as a model to study the predictors and mechanisms of cancer immune response and shine light on further development of immunotherapy approaches and response predictive biomarkers to improve immunotherapy of bladder cancer and other malignancies. We review the success of BCG and anti-PD-1/PD-L1 treatment of bladder cancer, the underlying mechanisms and the therapeutic response predictors, including the limits to our knowledge. We then highlight briefly the adaptation of immunotherapy approaches and predictors developed in other cancers for bladder cancer therapy. Finally, we explore the potential of using bladder cancer as a model to investigate cancer immune response mechanisms and new therapeutic approaches, which may be translated into immunotherapy of other human cancers
Challenges for Allergy Diagnosis in Regions with Complex Pollen Exposures
- Author
- A Mari
- A Mari
- A Orovitg
- AL Weck de
- Araceli Díaz-Perales
- B Calabozo
- B Erbas
- BE Garcia
- C Harwanegg
- C Moreno
- C Radauer
- C Radauer
- CH Meyer
- D Barber
- D Barber
- D Barber
- D Barber
- D Caillaud
- D Charpin
- D Charpin
- D Pomponi
- Domingo Barber
- EM King
- G Gadermaier
- G Salcedo
- G Salcedo
- GD Hao
- H Breiteneder
- H Nelson
- I Lauer
- J Bousquet
- J Cuesta-Herranz
- J Sastre
- J Sastre
- JA Asturias
- JA Asturias
- K Fötisch
- K Honda
- K Paschinger
- L Tordesillas
- LA Darrow
- M Jutel
- M San Miguel-Moncin
- M Smith
- M Villalba
- Mayte Villalba
- MD Chapman
- MI Alvarado
- MW Boehme
- N Johansen
- N Wopfner
- O Cromwell
- O Duffort
- O Palomares
- PC Turkeltaub
- R Asero
- R Asero
- R Asero
- R Barderas
- R Barderas
- R Hiller
- R Sanchez-Monge
- R Valenta
- R Valenta
- R Valenta
- S Aasmul-Olsen
- S Dreborg
- S Dreborg
- S Mas
- S Vieths
- S Vrtala
- S Vrtala
- SR Durham
- SS Mohapatra
- Tomas Chivato
- U Berger
- WM Becker
- WM Becker
- WR Thomas
- Y Okamoto
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as diagnostic tools including allergen micro arrays that facilitate the simultaneous testing of more than 100 allergen components. Specific diagnosis is the basis of allergy practice and is always aiming to select the best therapeutic or avoidance intervention. As a consequence, redundant or irrelevant information might be adding unnecessary cost and complexity to daily clinical practice. A rational use of the different diagnostic alternatives would allow a significant improvement in the diagnosis and treatment of allergic patients, especially for those residing in complex pollen exposure areas
Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020
- Author
- Abdolreza Advani
- Abror Abdurakhimov
- Adam Meijer
- Adam Novotný
- Adriano Tagliabracci
- Aleksander Mahnic
- Alessandro Marcello
- Alexander Graf
- Alexander Lercher
- Alexander Nagy
- Alexander Nikolayevich Shvalov
- Alexander T Dilthey
- Alexandr Shevtsov
- Alexandra Popa
- Alexandra Trkola
- Alexey Shchetinin
- Aleš Briksí
- Ali Raza Awan
- Alisher Abdullaev
- Alm Erik
- Alvin X Han
- Amandine Perrin
- Aminu S Jahun
- Ana da Silva Filipe
- Anders Fomsgaard
- Andrea Thürmer
- Andreas Bergthaler
- Andreas Nitsche
- Andreas Walker
- Andres Anton
- Angela Marchbank
- Anita Lucaci
- Anke K Wienecke-Baldacchino
- Anna Ivanova
- Anna Papa
- Anna Yakovleva
- Anthony Underwood
- Antonino Di Caro
- Artem Fadeev
- Artemis Gavriil
- Aykut Ozdarendeli
- Barbara Bartolini
- Ben Taylor
- Benedikt Agerer
- Bert Vanmechelen
- Björn-Erik Ole Jensen
- Bojana Tesovic
- Boris Klempa
- Broberg Eeva K
- Can Holyavkin
- Catherine Moore
- Catherine Ragimbeau
- Celine Petersen
- Ceren Cevik
- Cesare Em Gruber
- Chantal Reusken
- Charlotte Abigail Nelson
- Chiara Turchi
- Chloe Fisher
- Christian Beisel
- Christina Christodoulou
- Christina Tryfonos
- Christoph Bock
- Colin A Russell
- Colin Anthony
- Concetta Castilletti
- Connor Thomas
- Corin Yeats
- Cristina Andres
- Damir Garcia-Cehic
- Dana Koptides
- Daniel Strelow
- Danilo Licastro
- David Baker
- Dejan Vidanovic
- Denis Victorovich Antonets
- Detlef Kindgen-Milles
- Diana Rusňáková
- Dilbar Dalimova
- Dimitrios Chatzidimitriou
- Edita Staroňová
- Elena Tichá
- Elena Vasil’Evna Gavrilova
- Emil Aa Sørensen
- Etienne Simon-Loriere
- Fabiana Gambaro
- Fabrizio Stefani
- Federica Alessandrini
- Fenella D Halstead
- Filip Rokić
- Filomena Melchionda
- Flora Donati
- Florian Laubscher
- Francesca Romeri
- Franco Salerno
- Galo A Goig
- George Krashias
- Georgia Gioula
- Giuseppe D’Auria
- Gizem Dinler-Doganay
- Grant Hall
- Griselda de Marco
- Guillaume Fournier
- Gunsu Aydin
- Harry Vennema
- Hazel Yetiskin
- Helena Jirincova
- Helmut Blum
- Hodcroft Emma B
- Ian Goodfellow
- Igor Jurak
- Iliana Georgana
- Ilker Karacan
- Inmaculada Casas
- Inmaculada Galan-Vendrell
- Inês Costa
- Irving Cancino-Muñoz
- Isabel Cuesta De La Plaza
- Ivan Topolsky
- Iñaki Comas
- Jablonski
- Jacques Izopet
- Jakob Brandt
- Jakob-Wendelin Genger
- Jan Geryk
- Jan Laine
- Jan Richter
- Janine Michel
- Janis Klovins
- Jannik Fonager
- Jaromira Vecerova
- Jeremy Volkening
- Joan Martí-Carreras
- Joana Isidro
- Joel Alexander Southgate
- Jonathan
- Josep Quer
- Joshua Maksimovic
- João Paulo Gomes
- Joël Mossong
- Juan Ledesma
- Jörg Timm
- Karla Spellman
- Karoline Bragstad
- Katarzyna Pancer
- Katerina Polackova
- Kateřina Kvapilová
- Kathrine Stene-Johansen
- Kathryn Mccluggage
- Kevin Ariën
- Khalil Abudahab
- Kim Philipp
- Klaus Pfeffer
- Komissarov Andrey B
- Kristian Schønning
- Krystyna Bienkowska-Szewczyk
- Krzysztof Pyrc
- Lance Turtle
- Laura Di Sante
- Lenka Kramna
- Levent Doganay
- Lidia Ruiz-Roldán
- Lisanna Hülse
- Llúcia Martínez-Priego
- LoretoFerrús-Abad
- Lovro TrgovecGreif
- Lucille Rainbow
- Ludmila Novakova
- Lukas Endler
- Lukasz Rabalski
- Luke R Green
- Luke W Meredith
- Luís Vieira
- M Estee Torok
- Maja Rupnik
- Malte Kohns Vasconcelos
- Manuela Torres-Puente
- Marcel Andree
- Margaret A Hughes
- Maria Exindari
- Maria Lind Karlberg
- Maria Piñana
- Mariana G López
- Marianne Nielsine Skov
- Marianne Wedde
- Mariia Sergeeva
- Marine Murtskhvaladze
- Mario Poljak
- Mark Smyth
- Mark Whitehead
- Mark Zorec
- Markus Antwerpen
- Martin D Curran
- Martin Kašný
- Martin Schou Pedersen
- Martin Senekowitsch
- Martina Ličková
- Maryam Zaheri
- María Alma Bracho
- María Iglesias Caballero
- Mathias C Walter
- Matthew R Gemmell
- Matthew Wyles
- Mattias Haukland
- Maurer-Stroh Sebastian
- Max Von Kleist
- Maximilian Muenchhoff
- Melidou Angeliki
- Mercedes Jiménez
- Michael Huber
- Michael Schuster
- Michal Holub
- Milan Macek Jr
- Mireia Coscollá
- Miroslav Zajac
- Miša Korva
- Monika Sláviková
- Monta Ustinova
- Morten Rasmussen
- Muhammet Ali Uygut
- Nato Kotaria
- Neher Richard A
- Neris García-González
- Neta S Zuckerman
- Neven Sučić
- Nicasio Mancini
- Nicola Clementi
- Oksana Savicka
- Olav Hungnes
- Oleg Victorovich Pyankov
- Oliver Drechsel
- Oliver T Keppler
- Oliver Vugrek
- Olli Vapalahti
- Ondrej Cinek
- Ortwin Adams
- Oskar Karlsson Lindsjö
- O’Toole Áine
- Paola Cristina Resende
- Paola Stefanelli
- Patrizia Bagnarelli
- Paula Ruíz-Hueso
- Pavel Dřevínek
- Pedro Falé Ferreira
- Pedro Pechirra
- Pereyaslov Dmitriy
- Petr Brož
- Petr Hubáček
- Petr Klempt
- Petr Kvapil
- Philippe Selhorst
- Pierlanfranco D’Agaro
- Piet Maes
- Pilar Jiménez
- Rachel Tucker
- Ralf Dürrwald
- Raphael Tc Lee
- Raquel Guiomar
- Rasmus H Kirkegaard
- Rene Kmiecinski
- Richard Eccles
- Richard Gregory
- Rinat Amirovich Maksyutov
- Robert Beer
- Ruslan Kalendar
- Safiah Afifi
- Sam Haldenby
- Samo Zakotnik
- Samuel Cordey
- Sandra Broddesson
- Sandra Carbó-Ramirez
- Sandra Hauka
- Sanne Løkkegaard Larsen
- Sara Caucci
- Sara Giordana Rimoldi
- Sara Monzón Fernández
- Sarai Varona Fernández
- Sergey Alexandrovich Bodnev
- Shahlo Turdikulova
- Shaikh Terkis Islam Pavel
- Shazaad S Y Ahmad
- Shilpa Yadahalli
- Simon Knutson
- Stavros Bashiardes
- Stefan Krebs
- Stefan Schmutz
- Stefano Menzo
- Stefano Polesello
- Stella Pappa
- Stephan Fuchs
- Stephan W Aberle
- Stephanie Goya
- Steve Paterson
- Susana Posada-Céspedes
- Sylvie Behillil
- Sylvie van der Werf
- Symeon Metallidis
- Sílvia Duarte
- Søren M Karst
- Tanja Stadler
- Tarja Sironen
- Tatjana AvšičŽupanc
- Tatyana Vladimirovna Tregubchak
- Teemu Smura
- The WHO European Region sequencing laboratories and GISAID EpiCoV group (Niko Beerenwinkel
- Theresa Enkirch
- Theresa Feltwell
- Thomas Penz
- Thomas Y Michaelsen
- Thorsten Wolff
- Tina Senff
- Tobias Schär
- Tobias Wienemann
- Tomas Pumarola
- Tomaž
- Tomislav Rukavina
- Tomáš Szemes
- Tony Wawina-Bokalanga
- Torsten Feldt
- Torsten Houwaart
- Trine Sørensen
- Tugba Kizilboga-Akgun
- Valerio Onofri
- Vang Le-Quy
- Verena Keitel
- Verena Kufner
- Vincent Enouf
- Vita Rovite
- Vladimir Gushchin
- Vítor Borges
- William L Hamilton
- Yerlan Ramanculov
- Álvaro Chiner-Oms
- Ángel Zaballos
- Publication venue
- Publication date
- 01/01/2020
- Field of study
We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- Antón Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- Araújo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
- Bae SH
- Baehrecke EH
- Baek A
- Baek S-H
- Baek SH
- Bagetta G
- Bagniewska-Zadworna A
- Bai H
- Bai J
- Bai X
- Bai Y
- Bairagi N
- Baksi S
- Balazadeh S
- Balbi T
- Baldari CT
- Balduini W
- Ballabio A
- Ballester M
- Balzan R
- Bandopadhyay R
- Banerjee S
- Banerjee S
- Bao Y
- Baptista MS
- Baracca A
- Barbati C
- Bargiela A
- Barilà D
- Barlow PG
- Barmada SJ
- Barreiro E
- Barreto GE
- Bartek J
- Bartel B
- Bartolome A
- Barve GR
- Basagoudanavar SH
- Bassham DC
- Bast RC
- Basu A
- Batoko H
- Batten I
- Baulieu EE
- Baumgarner BL
- Bayry J
- Beale R
- Beau I
- Beaumatin F
- Bechara LRG
- Beck GR
- Beers MF
- Begun J
- Behl C
- Behrends C
- Behrens GMN
- Bei R
- Bejarano E
- Bel S
- Belaid A
- Belgareh-Touzé N
- Bellarosa C
- Belleudi F
- Bello-Morales R
- Belló Pérez M
- Beltran JSDO
- Beltran S
- Benbrook DM
- Bendorius M
- Benitez BA
- Benito-Cuesta I
- Bensalem J
- Berchtold MW
- Berezowska S
- Bergamaschi D
- Bergami M
- Bergmann A
- Berliocchi L
- Berlioz-Torrent C
- Bernard A
- Berthoux L
- Besirli CG
- Besteiro S
- Betin VM
- Beyaert R
- Bezbradica JS
- Bhaskar K
- Bhatia-Kissova I
- Bhattacharya R
- Bhattacharya S
- Bhattacharyya S
- Bhuiyan MS
- Bhutia SK
- Bi L
- Bi X
- Biden TJ
- Bijian K
- Billes VA
- Binart N
- Bincoletto C
- Birgisdottir AB
- Bjorkoy G
- Blanco G
- Blas-Garcia A
- Blasiak J
- Blomgran R
- Blomgren K
- Blum JS
- Boada-Romero E
- Boban M
- Boesze-Battaglia K
- Boeuf P
- Boland B
- Bomont P
- Bonaldo P
- Bonam SR
- Bonfili L
- Bonifacino JS
- Boone BA
- Bootman MD
- Bordi M
- Borner C
- Bornhauser BC
- Borthakur G
- Bosch J
- Bose S
- Botana LM
- Botas J
- Boulanger CM
- Boulton ME
- Bourdenx M
- Bourgeois B
- Bourke NM
- Bousquet G
- Boya P
- Bozhkov PV
- Bozi LHM
- Bozkurt TO
- Brackney DE
- Brand-Saberi B
- Brandts CH
- Braun RJ
- Braus GH
- Bravo-Sagua R
- Bravo-San Pedro JM
- Brest P
- Bringer M-A
- Briones-Herrera A
- Broaddus VC
- Brodersen P
- Brodsky JL
- Brody SL
- Bronson PG
- Bronstein JM
- Brown CN
- Brown RE
- Brum PC
- Brumell JH
- Brunetti-Pierri N
- Bruno D
- Bryson-Richardson RJ
- Bucci C
- Buch S
- Buchan JR
- Buchrieser C
- Buckingham EM
- Budak H
- Budini M
- Bueno M
- Buitrago-Molina LE
- Bultynck G
- Burada F
- Buraschi S
- Burgoyne JR
- Burón MI
- Bustos V
- Butturini E
- Byrd A
- Bánréti Á
- Büttner S
- Cabas I
- Cabrera-Benitez S
- Cadwell K
- Cai J
- Cai L
- Cai Q
- Cairó M
- Calbet JA
- Caldwell GA
- Caldwell KA
- Call JA
- Calvani R
- Calvo AC
- Calvo-Rubio Barrera M
- Camara NO
- Camonis JH
- Camougrand N
- Campanella M
- Campbell EM
- Campbell-Valois F-X
- Campello S
- Campesi I
- Campos JC
- Camuzard O
- Cancino J
- Candido de Almeida D
- Canesi L
- Caniggia I
- Canonico B
- Cantí C
- Cao B
- Caraglia M
- Caramés B
- Carchman EH
- Cardenal-Muñoz E
- Cardenas C
- Cardenas L
- Cardoso SM
- Carew JS
- Carle GF
- Carleton G
- Carloni S
- Carmona-Gutierrez D
- Carneiro LA
- Carnevali O
- Carosi JM
- Carra S
- Carrier A
- Carrier L
- Carroll B
- Carter AB
- Carvalho AN
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- Casas C
- Casas J
- Cassioli C
- Castillo EF
- Castillo K
- Castillo-Lluva S
- Castoldi F
- Castori M
- Castro AF
- Castro-Caldas M
- Castro-Hernandez J
- Castro-Obregon S
- Catz SD
- Cavadas C
- Cavaliere F
- Cavallini G
- Cavinato M
- Cayuela ML
- Cebollada Rica P
- Cecarini V
- Cecconi F
- Cechowska-Pasko M
- Cenci S
- Ceperuelo-Mallafré V
- Cerqueira JJ
- Cerutti JM
- Cervia D
- Cetintas VB
- Cetrullo S
- Chae H-J
- Chagin AS
- Chai C-Y
- Chakrabarti G
- Chakrabarti O
- Chakraborty T
- Chakraborty T
- Chami M
- Chamilos G
- Chan DW
- Chan ED
- Chan EYW
- Chan H
- Chan HH
- Chan HYE
- Chan MTV
- Chan YS
- Chandra PK
- Chang C
- Chang C-P
- Chang H-C
- Chang K
- Chao J
- Chapman T
- Charlet-Berguerand N
- Chatterjee S
- Chaube SK
- Chaudhary A
- Chauhan S
- Chaum E
- Checler F
- Cheetham ME
- Chen C-S
- Chen G-C
- Chen J-F
- Chen L
- Chen L
- Chen LL
- Chen M
- Chen M-K
- Chen N
- Chen Q
- Chen R-H
- Chen S
- Chen W
- Chen W
- Chen X
- Chen X-M
- Chen X-W
- Chen Y
- Chen Y
- Chen Y
- Chen Y-G
- Chen Y-J
- Chen Y-Q
- Chen Z
- Chen Z
- Chen Z
- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
- Cheng X
- Cheng X-T
- Cheng Y
- Cheng Z
- Cheong H
- Cheong JK
- Chernyak BV
- Cherry S
- Cheung CFR
- Cheung CHA
- Cheung K-H
- Chevet E
- Chi RJ
- Chiang AKS
- Chiaradonna F
- Chiarelli R
- Chiariello M
- Chica N
- Chiocca S
- Chiong M
- Chiou S-H
- Chiramel AI
- Chiurchiù V
- Cho D-H
- Choe S-K
- Choi AMK
- Choi ME
- Choudhury KR
- Chow NS
- Chu CT
- Chua JJE
- Chua JP
- Chung H
- Chung KP
- Chung S
- Chung S-H
- Chung Y-L
- Cianfanelli V
- Ciechomska IA
- Cifuentes M
- Cinque L
- Cirak S
- Cirone M
- Clague MJ
- Clarke R
- Clementi E
- Coccia EM
- Codogno P
- Cohen E
- Cohen MM
- Colasanti T
- Colasuonno F
- Colbert RA
- Colell A
- Coll NS
- Collins MO
- Colombo MI
- Colón-Ramos DA
- Combaret L
- Comincini S
- Cominetti MR
- Consiglio A
- Conte A
- Conti F
- Contu VR
- Cookson MR
- Coombs KM
- Coppens I
- Corasaniti MT
- Cordes N
- Corkery DP
- Cortese K
- Costa MDC
- Costantino S
- Costelli P
- Coto-Montes A
- Crack PJ
- Crespo JL
- Criollo A
- Crippa V
- Cristofani R
- Csizmadia T
- Cuadrado A
- Cui B
- Cui J
- Cui Y
- Cui Y
- Culetto E
- Cumino AC
- Cybulsky AV
- Czaja MJ
- Czuczwar SJ
- D'Adamo S
- D'Amelio M
- D'Arcangelo D
- D'Lugos AC
- D'Orazi G
- da Silva JA
- Dafsari HS
- Dagda RK
- Dagdas Y
- Daglia M
- Dai X
- Dai Y
- Dai Y
- Dal Col J
- Dalhaimer P
- Dalla Valle L
- Dallenga T
- Dalmasso G
- Damme M
- Dando I
- Dantuma NP
- Darling AL
- Das H
- Dasarathy S
- Dasari SK
- Dash S
- Daumke O
- Dauphinee AN
- Davies JS
- Davis RJ
- Davis T
- Dayalan Naidu S
- De Amicis F
- De Bosscher K
- De Felice F
- De Franceschi L
- De Leonibus C
- de Mattos Barbosa MG
- De Meyer GRY
- De Milito A
- De Nunzio C
- De Palma C
- De Santi M
- De Virgilio C
- De Zio D
- Debnath J
- DeBosch BJ
- Decuypere J-P
- Deehan MA
- Deflorian G
- DeGregori J
- Dehay B
- Del Rio G
- Delaney JR
- Delbridge LMD
- Delorme-Axford E
- Delpino MV
- Demarchi F
- Dembitz V
- Demers ND
- Deng H
- Deng Z
- Dengjel J
- Dent P
- Denton D
- DePamphilis ML
- Der CJ
- Deretic V
- Descoteaux A
- Devis L
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- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC
- Author
- Abi B
- Abud A Abed
- Acciarri R
- Acero MA
- Adames MR
- Adamov G
- Adamowski M
- Adams D
- Adinolfi M
- Aduszkiewicz A
- Aguilar J
- Ahmad Z
- Ahmed J
- Aimard B
- Ali-Mohammadzadeh B
- Alion T
- Allison K
- Alonso MJ Rodriguez
- AlRashed M
- Alt C
- Alton A
- Alvarez R
- Alzas P Barham
- Amedo P
- Anderson J
- Andreopoulos C
- Andreotti M
- Andrews M
- Andrianala F
- Andringa S
- Anfimov N
- Ankowski A
- Antoniassi M
- Antonova M
- Antoshkin A
- Antusch S
- Aranda-Fernandez A
- Arellano L
- Arnold LO
- Arroyave MA
- Asaadi J
- Asquith L
- Aurisano A
- Aushev V
- Autiero D
- Ayala Lara V
- Ayala-Torres M
- Azfar F
- Back A
- Back H
- Back JJ
- Backhouse C
- Bagaturia I
- Bagby L
- Balashov N
- Balasubramanian S
- Baldi P
- Baller B
- Bambah B
- Barao F
- Barenboim G
- Barker G
- Barkhouse W
- Barnes C
- Barr G
- Barranco Monarca J
- Barros A
- Barros N
- Barrow JL
- Basharina-Freshville A
- Bashyal A
- Basque V
- Batchelor C
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- Wallbank M
- Wallis C
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- Wisniewski W
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- Wu W
- Xiao Y
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- Yankelevich A
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- Yoon YS
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- Zamorano B
- Zani A
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- Zeller GP
- Zennamo J
- Zeug K
- Zhang C
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- Zhivun E
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- Zimmerman ED
- Zucchelli S
- Zuklin J
- Zutshi V
- Zwaska R
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 16/07/2022
- Field of study
DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6 × 6 × 6 m 3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019-2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light. The scintillation light signal in these detectors can provide the trigger for non-beam events. In addition, it adds precise timing capabilities and improves the calorimetry measurements. In ProtoDUNE-DP, scintillation and electroluminescence light produced by cosmic muons in the LArTPC is collected by photomultiplier tubes placed up to 7 m away from the ionizing track. In this paper, the ProtoDUNE-DP photon detection system performance is evaluated with a particular focus on the different wavelength shifters, such as PEN and TPB, and the use of Xe-doped LAr, considering its future use in giant LArTPCs. The scintillation light production and propagation processes are analyzed and a comparison of simulation to data is performed, improving understanding of the liquid argon properties
Innate immune properties of selected human neuropeptides against Moraxella catarrhalis and nontypeable Haemophilus influenzae
- Author
- A Braun
- A Dakhama
- A Giacometti
- AA Ahmed
- Adam Jankowski
- Agnieszka Skowyra
- C Hauser-Kronenberg
- CE Schelburne
- CJ Hansen
- D Ganea
- D Mukundan
- Daria Augustyniak
- DM Hoover
- DM Underhill
- DS Billal
- E Garcia-Garcia
- E Gasteiger
- EM Sternberg
- G Deleage
- G Zhao
- H Schwarz
- H Wang
- H-P Kuo
- H-Y Lee
- HW Chu
- I Lamprou
- IA El Karim
- IJ Elenkov
- J Janiszewski
- J Kyte
- J Richter
- J-PS Powers
- Jan Gutowicz
- JM Figueroa
- K Kowalska
- KA Brogden
- KA Brogden
- M Dathe
- M Delgado
- M Gallicchio
- M Ichinose
- M Levite
- M Levite
- MC Cuesta
- MD Harzenetter
- MG Belvisi
- N Heiniger
- NC Kaneider
- NM Iovine
- P Chanez
- P Rice
- Paweł Mackiewicz
- R Grantham
- RC Allen
- RI Lehrer
- RJ Lehrer
- S Basak
- S Bedoui
- S Bedoui
- S Dunzendorfer
- S Hellström
- S Joly
- S Medina
- S Sánchez-Gómez
- SA Killough
- SJ Moghaddam
- SM Zughaier
- SP De Vries
- T Schmitter
- T Tecle
- TD Starner
- TF Murphy
- TF Murphy
- V Nizet
- W Ding
- W-Z Ho
- Zuzanna Drulis-Kawa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Liquid biopsies come of age: towards implementation of circulating tumour DNA
- Author
- A Marchetti
- A Marziali
- A Narayan
- A Romanel
- A Santiago-Walker
- AA Kamat
- AD Nygaard
- AG Sacher
- AL Norris
- AM Newman
- AM Newman
- AR Thierry
- AR Thierry
- AR Thierry
- B Han
- B Vogelstein
- BK Thakur
- BS Sorensen
- C Alix-Panabières
- C Bettegowda
- C Caldas
- C Kahlert
- C Oshiro
- C Song
- CA Parkinson
- Carlos Caldas
- CH Rhodes
- Charles Massie
- CLC Ip
- CP Paweletz
- CR Newton
- CS Ross-Innes
- D Abdueva
- D Dressman
- D Nadano
- D Sidransky
- D Sidransky
- DC García-Olmo
- DJ Mcbride
- DW Bianchi
- DY Wu
- E Gormally
- E Gormally
- E Heitzer
- E Heitzer
- E Kidess
- E Kirkizlar
- E Long-Mira
- E Olsson
- E Zonta
- EC de Bruin
- EJ Lipson
- EM Rodrigues Filho
- EM Swisher
- ES Gray
- EWH To
- F Amant
- F Diehl
- F Diehl
- F Janku
- F Mouliere
- F Mouliere
- F Mouliere
- F Scherer
- Florent Mouliere
- G Genovese
- G Gremel
- G Schiavon
- G Siravegna
- G Sozzi
- GD Sorenson
- GR Oxnard
- GR Oxnard
- H Kimura
- H Saito
- H Schwarzenbach
- H Shao
- HH Popper
- HR Underhill
- I Botezatu
- I De Vlaminck
- I De Vlaminck
- I Garcia-Murillas
- I Kinde
- I Kinde
- I Kinde
- I Martincorena
- I Medina Diaz
- J Belic
- J Li
- J Quick
- J Tie
- J Tie
- J Zhang
- J-S Frenel
- J-Y Douillard
- J-Y Douillard
- JA Beaver
- JA Hyett
- JA Olsen
- James D. Brenton
- Javier Garcia-Corbacho
- JD Thompson
- JJ Chabon
- JL Sherwood
- Jonathan C. M. Wan
- K Birkenkamp-Demtröder
- K Sun
- KB Sriram
- KCA Chan
- KCA Chan
- KCA Chan
- KCA Chan
- KL Reckamp
- KLG Spindler
- KS Thress
- KS Thress
- L De Mattos-Arruda
- L De Mattos-Arruda
- L De Mattos-Arruda
- L Fernandez-Cuesta
- L Mao
- L Melchior
- L Xi
- LAJ Diaz
- LR Yates
- M Allyse
- M Beránek
- M Dvor˘áková
- M Gerlinger
- M Guha
- M Hill
- M Ilié
- M Jamal-Hanjani
- M Jung
- M Loose
- M Murtaza
- M Murtaza
- M Reck
- M Russo
- M Russo
- M Schreuer
- M Schwaederle
- M Stroun
- M Stroun
- M Willems
- M-T Gansauge
- MB Giacona
- MC Schwaederle
- MG Best
- MJ Duffy
- MJ Mosko
- MJ Overman
- MP Morelli
- MW Schmitt
- MW Snyder
- N Karachaliou
- N Nair
- N Rosenfeld
- N Umetani
- N-W Tsai
- NBY Tsui
- Nitzan Rosenfeld
- O Gautschi
- P Burnham
- P Jiang
- P Jiang
- P Mandel
- P Ulz
- P Ulz
- PA Cohen
- PA VanderLaan
- PM Ellis
- PV Toro
- Q Kang
- R Fazel
- R Guerrero-Preston
- R Lebofsky
- R Lehmann-Werman
- RB Lanman
- Richard Baird
- RJ Leary
- RJ Leary
- RJ Sullivan
- S Breitbach
- S Breitbach
- S Dietz
- S El Messaoudi
- S El Messaoudi
- S Jahr
- S Misale
- S Mohan
- S Nishimoto
- S Takeda
- S Tug
- S Turajlic
- S Wang
- S Webb
- S Wei
- S-J Dawson
- SA Leon
- SE Norton
- SH Cheng
- SH Naik
- Simon Pacey
- SK Mithani
- SM Gartler
- SN Tamkovich
- SV Kostyuk
- T Forshew
- T Lecomte
- T Reinert
- TKF Yung
- TM Chused
- TM Gorges
- TM Gorges
- V Taly
- W Pan
- X Qian
- Y Kuang
- Y Wang
- Y Wang
- Y-B Kuo
- Y-H Su
- YM Lo
- YMD Lo
- YMD Lo
- YMD Lo
- YS Ju
- YWL Zheng
- YYN Lui
- Z Piotrowska
- Publication venue
- Nature Reviews Cancer
- Publication date
- 30/01/2017
- Field of study
Improvements in genomic and molecular methods are expanding the range of potential applications for circulating tumour DNA (ctDNA), both in a research setting and as a ‘liquid biopsy’ for cancer management. Proof-of-principle studies have demonstrated the translational potential of ctDNA for prognostication, molecular profiling and monitoring. The field is now in an exciting transitional period in which ctDNA analysis is beginning to be applied clinically, although there is still much to learn about the biology of cell-free DNA. This is an opportune time to appraise potential approaches to ctDNA analysis, and to consider their applications in personalized oncology and in cancer research.We would like to acknowledge the support of The University of Cambridge, Cancer Research UK (grant numbers A11906, A20240, A15601) (to N.R., J.D.B.), the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement n. 337905 (to N.R.), the Cambridge Experimental Cancer Medicine Centre, and Hutchison Whampoa Limited (to N.R.), AstraZeneca (to R.B., S.P.), the Cambridge Experimental Cancer Medicine Centre (ECMC) (to R.B., S.P.), and NIHR Biomedical Research Centre (BRC) (to R.B., S.P.). J.G.C. acknowledges clinical fellowship support from SEOM
Recommended from our members
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
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- Aarestrup J
- Abarca-Gomez L
- Abbasi-Kangevari M
- Abdeen ZA
- Abdrakhmanova S
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Agren A
- Aguenaou H
- Aguilar-Salinas CA
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Asfoor D
- Al Hourani HM
- Al Nsour M
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Hinai H
- Al-Lahou B
- Al-Lawati JA
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
- Alieva AV
- Alkandari A
- Alkerwi A
- Alkhatib BM
- Allin K
- Alomary SA
- Alomirah HF
- Alshangiti AM
- Alvarez-Pedrerol M
- Aly E
- Amarapurkar DN
- Amoah J
- Amougou N
- Amouyel P
- Andersen LB
- Anderssen SA
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- Angquist L
- Anicet AK
- Anjana RM
- Ansari-Moghaddam A
- Anufrieva E
- Aounallah-Skhiri H
- Araujo J
- Ariansen I
- Aris T
- Arku RE
- Arlappa N
- Aryal KK
- Aspelund T
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- Assembekov B
- Assuncao MCF
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- Woldeyohannes M
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- Wong EB
- Wong JE
- Wong NI
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- Wong-McClure RA
- Woo J
- Woodward M
- Wu FC
- Wu H-Y
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- Wu LJ
- Wu S
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- Xu H
- Xu L
- Yaacob NA
- Yamborisut U
- Yan L
- Yan W
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- Yang Y
- Yardim N
- Yasuharu T
- Yiallouros PK
- Yngve A
- Yoosefi M
- Yoshihara A
- Yotov Y
- You QS
- You S-L
- Younger-Coleman NO
- Yu Y
- Yu Y-L
- Yusof SM
- Yusoff AF
- Yusoff MFM
- Zaccagni L
- Zafiropulos V
- Zainuddin AA
- Zakavi SR
- Zamani F
- Zambon S
- Zampelas A
- Zamrazilova H
- Zapata ME
- Zargar AH
- Zaw KK
- Zayed AA
- Zdrojewski T
- Zeglen M
- Zejglicova K
- Zeng Y
- Zentai A
- Zhang B
- Zhang L
- Zhang Z-Y
- Zhao D
- Zhao M-H
- Zhao W
- Zhecheva YV
- Zhen S
- Zheng W
- Zheng Y
- Zholdin B
- Zhou B
- Zhou M
- Zhu D
- Zimmet P
- Zins M
- Zitt E
- Zocalo Y
- Zoghlami N
- Zuziak M
- Publication venue
- Elsevier
- Publication date
- 14/03/2024
- Field of study
Background
Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods
We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median).
Findings
From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness.
Interpretation
The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity.
Funding
UK Medical Research Council, UK Research and Innovation (Research England), UK Research and Innovation (Innovate UK), and European Union
Diminishing benefits of urban living for children and adolescents’ growth and development
- Author
- Abarca-Gómez L
- Abdeen ZA
- Abdrakhmanova S
- Abdul Rahim HF
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Aguenaou H
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Hourani HM
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Lahou B
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
- Alkandari A
- Alkerwi A
- Alkhatib BM
- Allin K
- Alvarez-Pedrerol M
- Aly E
- Amarapurkar DN
- Amoah J
- Amougou N
- Amouyel P
- Andersen LB
- Anderssen SA
- Androutsos O
- Anjana RM
- Ansari-Moghaddam A
- Anufrieva E
- Aounallah-Skhiri H
- Araújo J
- Ariansen I
- Aris T
- Arku RE
- Arlappa N
- Aryal KK
- Aseffa N
- Aspelund T
- Assah FK
- Assembekov B
- Assunção MCF
- Aung MS
- Auvinen J
- Avdičová M
- Avi S
- Azevedo A
- Azimi-Nezhad M
- Azizi F
- Azmin M
- Babu BV
- Baharudin A
- Bahijri S
- Bakacs M
- Baker JL
- Balakrishna N
- Balanova Y
- Bamoshmoosh M
- Banach M
- Banegas JR
- Bao TQ
- Baran J
- Baran R
- Barbagallo CM
- Barceló A
- Baretić M
- Barkat A
- Barnoya J
- Barrera L
- Barreto M
- Barros AJD
- Barros MVG
- Bartosiewicz A
- Basit A
- Bastos JLD
- Bata I
- Batieha AM
- Batista AP
- Batista RL
- Battakova Z
- Baur LA
- Bayauli PM
- Beaglehole R
- Bebakar WMW
- Bel-Serrat S
- Belavendra A
- Ben Romdhane H
- Benchekor SM
- Benedics J
- Benet M
- Bennett JE
- Bentham J
- Bere E
- Bergh IH
- Berhane Y
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
AbstractOptimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.</jats:p
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
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- Abarca-Gómez L
- Abbasi-Kangevari M
- Abdeen ZA
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- Publication venue
- Elsevier
- Publication date
- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining https://researchonline.ljmu.ac.uk/images/research_banner_face_lab_290.jpgunderweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity