Reddit Users' Questions and Concerns about Anesthesia

Background. Patients utilize social media in search of support networks. Reddit is one of the most popular social media sites and allows users to anonymously connect. Anesthesia patients are actively using Reddit to discuss their treatment options and experiences within the medical system. Methods. Posts published on an active Reddit forum on Anesthesia (i.e., /r/Anesthesia) were used. Big Query was used to collect posts from /r/Anesthesia. We collected 3,288 posts published between December 2015 and August 2019. We collected a control group of 3,288 posts from a Reddit forum not related to Anesthesia. Using latent Dirichlet allocation (LDA) we extracted 20 topics from our data set. The LDA topic themes most associated with posts in /r/Anesthesia compared to the control group were determined. Results. LDA analysis of posts in /r/Anesthesia relative to a control group produced 6 distinct categories of posts (Table 1). The posts most associated with /r/Anesthesia when compared to a control group were posts belonging to the “Physician-Patient Experience” category (Cohen’s d= 0.389) while the posts least associated with /r/Anesthesia were from the “Uncertainties” category of posts (Cohen’s d= 0.147). Example experiences from members of the /r/Anesthesia forum highlight subjective experiences of patients undergoing anesthesiology. Conclusions. The language used on social media can provide insights into an individual's experience with anesthesia and inform physicians about patient concerns. Anesthesiologists are poised to address these concerns and prevent anonymous misinformation by providing verified physician insights on the forum /r/Anesthesia

Pricing and hedging of derivatives based on non-tradable underlyings

This paper is concerned with the study of insurance related derivatives on financial markets that are based on non-tradable underlyings, but are correlated with tradable assets. We calculate exponential utility-based indifference prices, and corresponding derivative hedges. We use the fact that they can be represented in terms of solutions of forward-backward stochastic differential equations (FBSDE) with quadratic growth generators. We derive the Markov property of such FBSDE and generalize results on the differentiability relative to the initial value of their forward components. In this case the optimal hedge can be represented by the price gradient multiplied with the correlation coefficient. This way we obtain a generalization of the classical 'delta hedge' in complete markets

Random Hermite differential equations: Mean square power series solutions and statistical properties

This paper deals with the construction of random power series solution of second order linear differential equations of Hermite containing uncertainty through its coefficients and initial conditions. Under appropriate hypotheses on the data, we establish that the constructed random power series solution is mean square convergent. We provide conditions in order to obtain random polynomial solutions and, as a consequence, random Hermite polynomial are introduced. Also, the main statistical functions of the approximate stochastic process solution generated by truncation of the exact power series solution are given. Finally, we apply the proposed technique to several illustrative examples comparing the numerical results with respect to those provided by other available approaches including Monte Carlo simulation. © 2011 Elsevier Inc. All rights reserved.This work has been partially supported by the Spanish M.C.Y.T. and FEDER grants MTM2009-08587, DPI2010-20891-C02-01 as well as the Universitat Politecnica de Valencia grant PAID-06-09 (Ref. 2588).Calbo Sanjuán, G.; Cortés López, JC.; Jódar Sánchez, LA. (2011). Random Hermite differential equations: Mean square power series solutions and statistical properties. Applied Mathematics and Computation. 218(7):3654-3666. https://doi.org/10.1016/j.amc.2011.09.008S36543666218

Study of CdI2{\rm CdI_2} nanocrystals dispersed in amorphous Sb2S3{\rm Sb_2S_3} matrix

Crystalline nanoparticles of cadmium iodide where suspended in the amorphous matrix of antimony trisulphide. Both materials are layered structured and have large band-gaps however cadmium iodide exhibits polytypism, i.e. it exists in various different crystalline states. Different crystalline states are marked by wholely different dielectric constants which give rise to sharp surface plasmon resonance (SPR) peaks in the UV-visible. The manuscript details the variation in SPR's with heat-treatment of the films.Comment: 10 pages 8 figures submitted to PR

Evaluation of alternative solvents in common amide coupling reactions : replacement of dichloromethane and N,N-dimethylformamide

A range of alternative solvents have been evaluated within amidation reactions employing common coupling reagents with a view to identifying suitable replacements for dichloromethane and N,N-dimethylformamid

Could magnetic properties be used to image a grouted rock volume?

In this study, the feasibility to develop a detectable permeation grouting system is tested, based on the addition of magnetic materials to the grout, specifically, magnetite. A magnetic-based detection system is selected for development because unlike other previously trialled detection methods, magnetic fields are detectable over large distances within the subsurface, and importantly, attenuation of the magnetic field is not strongly dependent on the material properties of the surrounding rock. To test the conceptual feasibility of such a system, a finite element based numerical model is developed to simulate the magnetic field anomaly that can be achieved by the addition of magnetic materials to a cement grout. The model is verified against an analytical solution and then used to predict the magnetic field generated by a grouted cylinder of rock, assuming a fixed percentage of uniformly distributed magnetic minerals, and a central injection borehole. Two field trials are conducted to verify the detectable grouting concept, the first using a walkover survey that allowed mapping of the magnetic signal in 2D. The second is designed to mimic magnetic field measurements from a borehole monitoring array, with a single central magnetic grout block (representing the grout close to the injection point). Results of the two field trials show that the magnetic cement is detectable, even when the background magnetic noise within the surrounding soils/rocks is significant. A good agreement is obtained between the measured and the modelled magnetic anomaly. This research opens the door to the development of a ‘detectable’ magnetic grouting system, that can increase confidence in the integrity of grouted rock volumes and reduce the inefficiencies currently present in the grouting industry, enabling in-situ real-time optimisation of grouting campaigns

Parametric hazard rate models for long-term sickness absence

PURPOSE: In research on the time to onset of sickness absence and the duration of sickness absence episodes, Cox proportional hazard models are in common use. However, parametric models are to be preferred when time in itself is considered as independent variable. This study compares parametric hazard rate models for the onset of long-term sickness absence and return to work. METHOD: Prospective cohort study on sickness absence with four follow-up years of 53,830 employees working in the private sector in the Netherlands. The time to onset of long-term (>6 weeks) sickness absence and return to work were modelled by parametric hazard rate models. RESULTS: The exponential parametric model with a constant hazard rate most accurately described the time to onset of long-term sickness absence. Gompertz-Makeham models with monotonically declining hazard rates best described return to work. CONCLUSIONS: Parametric models offer more possibilities than commonly used models for time-dependent processes as sickness absence and return to work. However, the advantages of parametric models above Cox models apply mainly for return to work and less for onset of long-term sickness absence

Business and Information Technology Alignment Measurement -- a recent Literature Review

Since technology has been involved in the business context, Business and Information Technology Alignment (BITA) has been one of the main concerns of IT and Business executives and directors due to its importance to overall company performance, especially today in the age of digital transformation. Several models and frameworks have been developed for BITA implementation and for measuring their level of success, each one with a different approach to this desired state. The BITA measurement is one of the main decision-making tools in the strategic domain of companies. In general, the classical-internal alignment is the most measured domain and the external environment evolution alignment is the least measured. This literature review aims to characterize and analyze current research on BITA measurement with a comprehensive view of the works published over the last 15 years to identify potential gaps and future areas of research in the field.Comment: 12 pages, Preprint version, BIS 2018 International Workshops, Berlin, Germany, July 18 to 20, 2018, Revised Paper

Ipl1/aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis

Cells coordinate spindle formation with DNA repair and morphological modifications to chromosomes prior to their segregation to prevent cell division with damaged chromosomes. Here we uncover a novel and unexpected role for Aurora kinase in preventing the formation of spindles by Clb5-CDK (S-CDK) during meiotic prophase I and when the DDR is active in budding yeast. This is critical since S-CDK is essential for replication during premeiotic S-phase as well as double-strand break induction that facilitates meiotic recombination and, ultimately, chromosome segregation. Furthermore, we find that depletion of Cdc5 polo kinase activity delays spindle formation in DDR-arrested cells and that ectopic expression of Cdc5 in prophase I enhances spindle formation, when Ipl1 is depleted. Our findings establish a new paradigm for Aurora kinase function in both negative and positive regulation of spindle dynamics