RHIC and LHC phenomena with an unified parton transport

We discuss recent applications of the partonic pQCD based cascade model BAMPS with focus on heavy-ion phenomeneology in hard and soft momentum range. The nuclear modification factor as well as elliptic flow are calculated in BAMPS for RHIC end LHC energies. These observables are also discussed within the same framework for charm and bottom quarks. Contributing to the recent jet-quenching investigations we present first preliminary results on application of jet reconstruction algorithms in BAMPS. Finally, collective effects induced by jets are investigated: we demonstrate the development of Mach cones in ideal matter as well in the highly viscous regime

Hunting for Dark Matter Coannihilation by Mixing Dijet Resonances and Missing Transverse Energy

Simplified models of the dark matter (co)annihilation mechanism predict striking new collider signatures untested by current searches. These models, which were codified in the coannihilation codex, provide the basis for a dark matter (DM) discovery program at the Large Hadron Collider (LHC) driven by the measured DM relic density. In this work, we study an exemplary model featuring $s$-channel DM coannihilation through a scalar diquark mediator as a representative case study of scenarios with strongly interacting coannihilation partners. We discuss the full phenomenology of the model, ranging from low energy flavor constraints, vacuum stability requirements, and precision Higgs effects to direct detection and indirect detection prospects. Moreover, motivated by the relic density calculation, we find significant portions of parameter space are compatible with current collider constraints and can be probed by future searches, including a proposed analysis for the novel signature of a dijet resonance accompanied by missing transverse energy (MET). Our results show that the $13$ TeV LHC with $100~\mathrm{fb}^{-1}$ luminosity should be sensitive to mediators as heavy as 1 TeV and dark matter in the 400--500 GeV range. The combination of searches for single and paired dijet peaks, non-resonant jets + MET excesses, and our novel resonant dijet + MET signature have strong coverage of the motivated relic density region, reflecting the tight connections between particles determining the dark matter abundance and their experimental signatures at the LHC.Comment: 35 pages, 9 figure

Relativistic shock waves and Mach cones in viscous gluon matter

To investigate the formation and the propagation of relativistic shock waves in viscous gluon matter we solve the relativistic Riemann problem using a microscopic parton cascade. We demonstrate the transition from ideal to viscous shock waves by varying the shear viscosity to entropy density ratio n/s. Furthermore we compare our results with those obtained by solving the relativistic causal dissipative fluid equations of Israel and Stewart (IS), in order to show the validity of the IS hydrodynamics. Employing the parton cascade we also investigate the formation of Mach shocks induced by a high-energy gluon traversing viscous gluon matter. For n/s = 0.08 a Mach cone structure is observed, whereas the signal smears out for n/s >=0.32

Role of ethylene on various ripening pathways and on the development of sensory quality of Charentais cantaloupe melons

Charentais melons (Cucumis melo L., var cantalupensis Naud.) in which ethylene biosynthesis has been suppressed by an antisense ACC oxidase gene have been used to better understand the role of ethylene in the regulation of the ripening process of climacteric fruit and on the development of sensory qualities. We have shown that a number of biochemical and molecular processes associated with the ripening of climacteric fruit are ethylene-independent. In some cases, such as softening of the flesh, the same pathway comprises both ethylene-dependent and -independent components. The various ethylene-dependent events exhibit differential sensitivity to ethylene. The threshold level for degreening of the rind is 1 ppm, while 2.5 ppm are required to trigger the ethylene-dependent component of the softening process. The saturating level of ethylene for all these events is less than 5 ppm, which is by far lower than the internal ethylene concentrations found in the fruit at the climacteric peak (around 100 ppm). Detachment of the fruit influences the development of respiratory climacteric. Fruit remaining attached to the vine, although producing higher levels of ethylene, exhibit a reduced climacteric rise in respiration as compared to detached fruit. The response of antisense ACO fruit to exogenous ethylene in terms of respiration is higher in detached than in attached fruit. Ethylene-suppressed melons show a severe reduction of aroma volatiles production, particularly in ester production. In the biosynthetic pathway of aliphatic esters, the dehydrogenation of fatty acids and aldehydes appears to be ethylene-dependent. In contrast, alcohol acetylation comprises ethylene-dependent and ethylene-independent components, probably corresponding to differentially regulated alcohol acetyl transferases. In terms of sensory quality, these data show that the extension of shelf-life through the inhibition of ethylene production has some beneficial effects on texture and sugar accumulation but is detrimental for the generation of aroma

Efficient implementation of code-based identification/signatures schemes

International audienceIn this paper we present efficient implementations of several code-based identification schemes, namely the Stern scheme, the Véron scheme and the Cayrel-Véron-El Yousfi scheme. For a security of 80 bits, we obtain a signature in respectively 1.048 ms, 0.987 ms and 0.594 ms

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy.

The success of immunotherapy has led to a myriad of clinical trials accompanied by efforts to gain mechanistic insight and identify predictive signatures for personalization. However, many immune monitoring technologies face investigator bias, missing unanticipated cellular responses in limited clinical material. We present here a mass cytometry (CyTOF) workflow for standardized, systems-level biomarker discovery in immunotherapy trials. To broadly enumerate immune cell identity and activity, we established and extensively assessed a reference panel of 33 antibodies to cover major cell subsets, simultaneously quantifying activation and immune checkpoint molecules in a single assay. This assay enumerates ≥98% of peripheral immune cells with ≥4 positively identifying antigens. Robustness and reproducibility are demonstrated on multiple samples types, across two research centers and by orthogonal measurements. Using automated analysis, we identify stratifying immune signatures in bone marrow transplantation-associated graft-versus-host disease. Together, this validated workflow ensures comprehensive immunophenotypic analysis and data comparability and will accelerate biomarker discovery

A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model

Background: In order to better understand the multifactorial nature of osteoporosis, animal models are utilized and compared to healthy controls. Female sheep are well established as a model for osteoporosis induced by ovariectomy, calcium and vitamin D low diet, application of steroids, or a combination of these treatments. Transcriptional studies can be performed by applying quantitative real time PCR (RT-qPCR). RT-qPCR estimates mRNA-levels of target genes in relation to reference genes. A chosen set of reference genes should not show variation under experimental conditions. Currently, no standard reference genes are accepted for all tissue types and experimental conditions. Studies examining reference genes for sheep are rare and only one study described stable reference in mandibular bone. However, this type of bone differs from trabecular bone where most osteoporotic fractures occur. The present study aimed at identifying a set of reference genes for relative quantification of transcriptional activity of ovine spine bone and ovine in vitro differentiated mesenchymal stromal cells (MSC) for reliable comparability. Methods: Twelve candidate reference genes belonging to different functional classes were selected and their expression was measured from cultured ovMSCs (n = 18) and ovine bone samples (n = 16), respectively. RefFinder was used to rank the candidate genes. Results: We identified B2M, GAPDH, RPL19 and YWHAZ as the best combination of reference genes for normalization of RT-qPCR results for transcriptional analyses of these ovine samples. Conclusion: This study demonstrates the importance of applying a set of reference genes for RT-qPCR analysis in sheep. Based on our data we recommend using four identified reference genes for relative quantification of gene expression studies in ovine bone or for in vitro experiments with osteogenically differentiated ovine MSCs

May I Suggest? Comparing Three PLE Recommender Strategies

Personal learning environment (PLE) solutions aim at empowering learners to design (ICT and web-based) environments for their learning activities, mashingup content and people and apps for different learning contexts. Widely used in other application areas, recommender systems can be very useful for supporting learners in their PLE-based activities, to help discover relevant content, peers sharing similar learning interests or experts on a specific topic. In this paper we examine the utilization of recommender technology for PLEs. However, being confronted by a variety of educational contexts we present three strategies for providing PLE recommendations to learners. Consequently, we compare these recommender strategies by discussing their strengths and weaknesses in general

D3.1 Validation of technical specifications of ECO modules

The objective of this document is to list the most important technical specifications of each MOOC platform that will be integrated in the overall ECO architecture. The objective of this particular task is to carry out analysis of all the technical specifications of each of the modules/platforms that are to be integrated in the global ECO platform. Once integration will be done, an Open Data exposure solution will be implemented by means of integrating an Open Data Catalog platform such as CKAN.ICT Policy Support Programme as part of the Competitiveness and Innovation framework Programme (CIP) - grant number 62112