Melting of peridotites through to granites: A simple thermodynamic model in the system KNCFMASHTOCr

A new set of thermodynamic models is presented for calculating phase relations in bulk compositions extending from peridotite to granite, from 0.001 to 70 kbar and from 650 °C to peridotite liquidus temperatures, in the system K 2 O–Na 2 O–CaO–FeO–MgO–Al 2 O 3 –SiO 2 –H 2 O–TiO 2 –Fe 2 O 3 –Cr 2 O 3 (KNCFMASHTOCr). The models may be used to calculate phase equilibria in partial melting of a large range of mantle and crustal compositions. They provide a good fit to experimental phase relation topologies and melt compositions across the compositional range of the model. Compared with the preliminary model of Jennings & Holland (2015) for peridotite–basalt melting relations, the inclusion of K 2 O and TiO 2 allows for better modelling of small melt fractions in peridotite melting, and in reproducing rutile-bearing eclogite melting at high pressures. An improved order–disorder model for spinel is now incorporated. Above 10 kbar pressure, wet partial melting relations may be significantly affected by the dissolution of silicates in aqueous fluid, so the set of models includes an aqueous low-density silicate-bearing fluid in addition to a high-density H 2 O-bearing silicate melt. Oxygen fugacity may be readily calculated for the whole range of bulk compositions investigated, and the effect of water content on melt fO 2 is assessed.Natural Environment Research Council grant (NE/ J021539/1

A unification of probabilistic choice within a design-based model of reversible computation

We see reversible computing as a generalisation of sequential computation obtained by revoking the law of the excluded miracle. Our execution language includes naked guarded commands and non-deterministic choice. Choices which lead to miraculous continuations invoke reverse computation, and non-deterministic choice plays the rôle of provisional choice within a backtracking context. We require probabilistic choice for symmetry breaking and sampling large search spaces, but must formulate it differently from previous approaches to obtain the required interactions between probabilistic choice and non-deterministic choice and between probabilistic choice and feasibility. Our formulation allows us to derive the post-distributions which characterise a program, and we use these to construct a relational model. We consider refinement as containment of convex closures within distribution space, qualified with additional conditions to avoid over-refinement. We link the non-probabilistic and probabilistic versions of the model with a Galois connection and show that classical designs are a retract of our probabilistic designs. We consider the interaction between probabilistic and non-deterministic choice and find the same initially counter-intuitive results that have been noted by other investigators. We provide an alternative formulation, within the same model, of oblivious non-determinism, which allows all non-deterministic choices to be moved to the start of a computation. We consider the interaction between probabilistic choice and feasibility that is required to match an operational interpretation in which infeasible commands provoke reverse execution, and we present a small case study to show how the interaction between probabilistic choice and feasibility can be exploited in a practical program. All programming structures described here are supported by our implementation platform, the Reversible Virtual Machine, whose development has accompanied our theoretical investigations

Evaluating the importance of metamorphism in the foundering of continental crust

The metamorphic conditions and mechanisms required to induce foundering in deep arc crust are assessed using an example of representative lower crust in SW New Zealand. Composite plutons of Cretaceous monzodiorite and gabbro were emplaced at ~1.2 and 1.8 GPa are parts of the Western Fiordland Orthogneiss (WFO); examples of the plutons are tectonically juxtaposed along a structure that excised ~25 km of crust. The 1.8 GPa Breaksea Orthogneiss includes suitably dense minor components (e.g. eclogite) capable of foundering at peak conditions. As the eclogite facies boundary has a positive dP/dT, cooling from supra-solidus conditions (T > 950 ºC) at high-P should be accompanied by omphacite and garnet growth. However, a high monzodioritic proportion and inefficient metamorphism in the Breaksea Orthogneiss resulted in its positive buoyancy and preservation. Metamorphic inefficiency and compositional relationships in the 1.2 GPa Malaspina Pluton meant it was never likely to have developed densities sufficiently high to founder. These relationships suggest that the deep arc crust must have primarily involved significant igneous accumulation of garnet–clinopyroxene (in proportions >75%). Crustal dismemberment with or without the development of extensional shear zones is proposed to have induced foundering of excised cumulate material at P > 1.2 GPa

The Association of Growth and Maturation with Injury in Academy Soccer Players: A Narrative Review

Background The point of fastest growth during somatic maturation is termed ‘peak height velocity’ (PHV), and the chronological age at which this occurs varies considerably. Academy football (soccer) players are typically categorised by chronological age, yet many children of the same age will naturally mature and grow at different ages and rates, respectively, which could affect injury risk. However, despite nearly two decades of studies investigating the association of growth and maturation with injury in academy footballers, confusion remains. Objective To critically appraise the literature concerning the association of maturity timing, maturity status and growth rate with injury in academy football. Methods Scopus, PubMed, SPORTDiscus and CINAHL databases were screened from inception until April 2025. Study design, setting, sample size, methods for estimating maturity timing/maturity status/growth rate, and injury reporting were evaluated in this narrative review to determine individual study quality. Results A total of 472 articles were screened with data extracted from 26 eligible studies published between 2007 and 2025. Conclusions We found that (i) early maturing players suffer more soft-tissue injuries than on-time or late maturing players; (ii) more growth-related injuries occur circa-PHV than pre- or post-PHV, but post-PHV players generally have greater injury risk than circa- or pre-PHV; and (iii) fast growth (stature increase ≥ 7.2 cm per year) increases injury risk in academy footballers. However, all eligible studies demonstrated inherent limitations and none investigated the impact of maturity timing, maturity status or growth rate on injury in female academy players, indicating future research should address these issues

Genes and Athletic Performance: The 2023 Update

Phenotypes of athletic performance and exercise capacity are complex traits influenced by both genetic and environmental factors. This update on the panel of genetic markers (DNA polymorphisms) associated with athlete status summarises recent advances in sports genomics research, including findings from candidate gene and genome-wide association (GWAS) studies, meta-analyses, and findings involving larger-scale initiatives such as the UK Biobank. As of the end of May 2023, a total of 251 DNA polymorphisms have been associated with athlete status, of which 128 genetic markers were positively associated with athlete status in at least two studies (41 endurance-related, 45 power-related, and 42 strength-related). The most promising genetic markers include the AMPD1 rs17602729 C, CDKN1A rs236448 A, HFE rs1799945 G, MYBPC3 rs1052373 G, NFIA-AS2 rs1572312 C, PPARA rs4253778 G, and PPARGC1A rs8192678 G alleles for endurance; ACTN3 rs1815739 C, AMPD1 rs17602729 C, CDKN1A rs236448 C, CPNE5 rs3213537 G, GALNTL6 rs558129 T, IGF2 rs680 G, IGSF3 rs699785 A, NOS3 rs2070744 T, and TRHR rs7832552 T alleles for power; and ACTN3 rs1815739 C, AR ≥21 CAG repeats, LRPPRC rs10186876 A, MMS22L rs9320823 T, PHACTR1 rs6905419 C, and PPARG rs1801282 G alleles for strength. It should be appreciated, however, that elite performance still cannot be predicted well using only genetic testing

The gut microbiome variability of a butterflyfish increases on severely degraded Caribbean reefs.

Environmental degradation has the potential to alter key mutualisms that underlie the structure and function of ecological communities. How microbial communities associated with fishes vary across populations and in relation to habitat characteristics remains largely unknown despite their fundamental roles in host nutrition and immunity. We find significant differences in the gut microbiome composition of a facultative coral-feeding butterflyfish (Chaetodon capistratus) across Caribbean reefs that differ markedly in live coral cover (∼0-30%). Fish gut microbiomes were significantly more variable at degraded reefs, a pattern driven by changes in the relative abundance of the most common taxa potentially associated with stress. We also demonstrate that fish gut microbiomes on severely degraded reefs have a lower abundance of Endozoicomonas and a higher diversity of anaerobic fermentative bacteria, which may suggest a less coral dominated diet. The observed shifts in fish gut bacterial communities across the habitat gradient extend to a small set of potentially beneficial host associated bacteria (i.e., the core microbiome) suggesting essential fish-microbiome interactions may be vulnerable to severe coral degradation

Testing in Football: A Narrative Review

Football clubs regularly test and monitor players, with different approaches reflecting player age and competitive level. This narrative review aims to summarise justifications for testing and commonly used testing protocols. We also aim to discuss the validity and reliability of specific tests used to assess football players and provide a holistic overview of protocols currently used in football or those demonstrating potential utility. The PubMed, SportDiscus, and Google Scholar databases were screened for relevant articles from inception to September 2024. Articles that met our inclusion criteria documented tests for several purposes, including talent identification or the assessment of growth/maturation, physiological capacity, sport-specific skill, health status, monitoring fatigue/recovery, training adaptation, and injury risk factors. We provide information on specific tests of anthropometry, physical capacity, biochemical markers, psychological indices, injury risk screening, sport-specific skills, and genetic profile and highlight where certain tests may require further evidence to support their use. The available evidence suggests that test selection and implementation are influenced by financial resources, coach perceptions, and playing schedules. The ability to conduct field-based testing at low cost and to test multiple players simultaneously appear to be key drivers of test development and implementation among practitioners working in elite football environments

A 5-Year Analysis of Weight Cycling Practices in a Male World Champion Professional Boxer: Potential Implications for Obesity and Cardiometabolic Disease

Weight cycling is thought to increase the risk of obesity and cardiometabolic disease in nonathletic and athletic populations. However, the magnitude and frequency of weight cycling is not well characterized in elite athletes. To this end, we quantified the weight cycling practices of a male World Champion professional boxer competing at super middleweight (76.2 kg). Over a 5-year period comprising 11 contests, we assessed changes in body mass (n = 8 contests) and body composition (n = 6 contests) during the training camp preceding each contest. Time taken to make weight was 11 ± 4 weeks (range: 4–16). Absolute and relative weight loss for each contest was 12.4 ± 2.1 kg (range: 9.8–17.0) and 13.9% ± 2.0% (range: 11.3–18.2), respectively. Notably, the athlete commenced each training camp with progressive increases in fat mass (i.e., 12.5 and 16.1 kg for Contests 1 and 11) and reductions in fat-free mass (i.e., 69.8 and 67.5 kg for Contests 1 and 11, respectively). Data suggest that weight cycling may lead to “fat overshooting” and further weight gain in later life. Larger scale studies are now required to characterize the weight cycling practices of elite athletes and robustly assess future cardiometabolic disease risk. From an ethical perspective, practitioners should be aware of the potential health consequences associated with weight cycling

Genetic Polymorphisms Related to VO2max Adaptation Are Associated With Elite Rugby Union Status and Competitive Marathon Performance

PURPOSE: Genetic polymorphisms have been associated with the adaptation to training in maximal oxygen uptake (V˙O2max). However, the genotype distribution of selected polymorphisms in athletic cohorts is unknown, with their influence on performance characteristics also undetermined. This study investigated whether the genotype distributions of 3 polymorphisms previously associated with V˙O2max training adaptation are associated with elite athlete status and performance characteristics in runners and rugby athletes, competitors for whom aerobic metabolism is important. METHODS: Genomic DNA was collected from 732 men including 165 long-distance runners, 212 elite rugby union athletes, and 355 nonathletes. Genotype and allele frequencies of PRDM1 rs10499043 C/T, GRIN3A rs1535628 G/A, and KCNH8 rs4973706 T/C were compared between athletes and nonathletes. Personal-best marathon times in runners, as well as in-game performance variables and playing position, of rugby athletes were analyzed according to genotype. RESULTS: Runners with PRDM1 T alleles recorded marathon times ∼3 minutes faster than CC homozygotes (02:27:55 [00:07:32] h vs 02:31:03 [00:08:24] h, P = .023). Rugby athletes had 1.57 times greater odds of possessing the KCNH8 TT genotype than nonathletes (65.5% vs 54.7%, χ2 = 6.494, P = .013). No other associations were identified. CONCLUSIONS: This study is the first to demonstrate that polymorphisms previously associated with V˙O2max training adaptations in nonathletes are also associated with marathon performance (PRDM1) and elite rugby union status (KCNH8). The genotypes and alleles previously associated with superior endurance-training adaptation appear to be advantageous in long-distance running and achieving elite status in rugby union