530 research outputs found
Holographic two-point functions for 4d log-gravity
We compute holographic one- and two-point functions of critical
higher-curvature gravity in four dimensions. The two most important operators
are the stress tensor and its logarithmic partner, sourced by ordinary massless
and by logarithmic non-normalisable gravitons, respectively. In addition, the
logarithmic gravitons source two ordinary operators, one with spin-one and one
with spin-zero. The one-point function of the stress tensor vanishes for all
Einstein solutions, but has a non-zero contribution from logarithmic gravitons.
The two-point functions of all operators match the expectations from a
three-dimensional logarithmic conformal field theory.Comment: 35 pages; v2: typos corrected, added reference; v3: shorter
introduction, minor changes in the text in section 3, added reference;
published versio
Cardiogenic shock following administration of propofol and fentanyl in a healthy woman: a case report
<p>Abstract</p> <p>Introduction</p> <p>Cardiogenic shock is very uncommon in healthy people. The differential diagnosis for patients with acute heart failure in previously healthy hearts includes acute myocardial infarction and myocarditis. However, many drugs can also depress myocardial function. Propofol and fentanyl are frequently used during different medical procedures. The cardiovascular depressive effect of both drugs has been well established, but the development of cardiogenic shock is very rare when these agents are used.</p> <p>Case presentation</p> <p>After a minor surgical intervention, a 32-year-old Caucasian woman with no significant medical history went into sudden hemodynamic deterioration due to acute heart failure. An urgent echocardiogram showed severe biventricular dysfunction and an estimated left ventricular ejection fraction of 20%. Extracorporeal life support and mechanical ventilation were required. Five days later her ventricular function had fully recovered, which allowed the progressive withdrawal of medical treatment. Prior to her hospital discharge, cardiac MRI showed neither edema nor pathological deposits on the delayed contrast enhancement sequences. At her six-month follow-up examination, the patient was asymptomatic and did not require treatment.</p> <p>Conclusion</p> <p>Although there are many causes of cardiogenic shock, the presence of abrupt hemodynamic deterioration and the absence of a clear cause could be related to the use of propofol and fentanyl.</p
Taming the zoo of supersymmetric quantum mechanical models
We show that in many cases nontrivial and complicated supersymmetric quantum
mechanical (SQM) models can be obtained from the simple model describing free
dynamics in flat complex space by two operations: (i) Hamiltonian reduction and
(ii) similarity transformation of the complex supercharges. We conjecture that
it is true for any SQM model.Comment: final version published in JHE
Challenges of Profile Likelihood Evaluation in Multi-Dimensional SUSY Scans
Statistical inference of the fundamental parameters of supersymmetric
theories is a challenging and active endeavor. Several sophisticated algorithms
have been employed to this end. While Markov-Chain Monte Carlo (MCMC) and
nested sampling techniques are geared towards Bayesian inference, they have
also been used to estimate frequentist confidence intervals based on the
profile likelihood ratio. We investigate the performance and appropriate
configuration of MultiNest, a nested sampling based algorithm, when used for
profile likelihood-based analyses both on toy models and on the parameter space
of the Constrained MSSM. We find that while the standard configuration is
appropriate for an accurate reconstruction of the Bayesian posterior, the
profile likelihood is poorly approximated. We identify a more appropriate
MultiNest configuration for profile likelihood analyses, which gives an
excellent exploration of the profile likelihood (albeit at a larger
computational cost), including the identification of the global maximum
likelihood value. We conclude that with the appropriate configuration MultiNest
is a suitable tool for profile likelihood studies, indicating previous claims
to the contrary are not well founded.Comment: 21 pages, 9 figures, 1 table; minor changes following referee report.
Matches version accepted by JHE
Extended supersymmetric sigma models in AdS_4 from projective superspace
There exist two superspace approaches to describe N=2 supersymmetric
nonlinear sigma models in four-dimensional anti-de Sitter (AdS_4) space: (i) in
terms of N=1 AdS chiral superfields, as developed in arXiv:1105.3111 and
arXiv:1108.5290; and (ii) in terms of N=2 polar supermultiplets using the AdS
projective-superspace techniques developed in arXiv:0807.3368. The virtue of
the approach (i) is that it makes manifest the geometric properties of the N=2
supersymmetric sigma-models in AdS_4. The target space must be a non-compact
hyperkahler manifold endowed with a Killing vector field which generates an
SO(2) group of rotations on the two-sphere of complex structures. The power of
the approach (ii) is that it allows us, in principle, to generate hyperkahler
metrics as well as to address the problem of deformations of such metrics.
Here we show how to relate the formulation (ii) to (i) by integrating out an
infinite number of N=1 AdS auxiliary superfields and performing a superfield
duality transformation. We also develop a novel description of the most general
N=2 supersymmetric nonlinear sigma-model in AdS_4 in terms of chiral
superfields on three-dimensional N=2 flat superspace without central charge.
This superspace naturally originates from a conformally flat realization for
the four-dimensional N=2 AdS superspace that makes use of Poincare coordinates
for AdS_4. This novel formulation allows us to uncover several interesting
geometric results.Comment: 88 pages; v3: typos corrected, version published in JHE
Aspects of Non-minimal Gauge Mediation
A large class of non-minimal gauge mediation models, such as (semi-)direct
gauge mediation, predict a hierarchy between the masses of the supersymmetric
standard model gauginos and those of scalar particles. We perform a
comprehensive study of these non-minimal gauge mediation models, including mass
calculations in semi-direct gauge mediation, to illustrate these features, and
discuss the phenomenology of the models. We point out that the cosmological
gravitino problem places stringent constraints on mass splittings, when the
Bino is the NLSP. However, the GUT relation of the gaugino masses is broken
unlike the case of minimal gauge mediation, and an NLSP other than the Bino
(especially the gluino NLSP) becomes possible, relaxing the cosmological
constraints. We also discuss the collider signals of the models.Comment: 56 pages, 8 figures; v2:minor corrections, references added; v3:minor
correction
Off-shell superconformal nonlinear sigma-models in three dimensions
We develop superspace techniques to construct general off-shell N=1,2,3,4
superconformal sigma-models in three space-time dimensions. The most general
N=3 and N=4 superconformal sigma-models are constructed in terms of N=2 chiral
superfields. Several superspace proofs of the folklore statement that N=3
supersymmetry implies N=4 are presented both in the on-shell and off-shell
settings. We also elaborate on (super)twistor realisations for (super)manifolds
on which the three-dimensional N-extended superconformal groups act
transitively and which include Minkowski space as a subspace.Comment: 67 pages; V2: typos corrected, one reference added, version to appear
on JHE
A Profile Likelihood Analysis of the Constrained MSSM with Genetic Algorithms
The Constrained Minimal Supersymmetric Standard Model (CMSSM) is one of the
simplest and most widely-studied supersymmetric extensions to the standard
model of particle physics. Nevertheless, current data do not sufficiently
constrain the model parameters in a way completely independent of priors,
statistical measures and scanning techniques. We present a new technique for
scanning supersymmetric parameter spaces, optimised for frequentist profile
likelihood analyses and based on Genetic Algorithms. We apply this technique to
the CMSSM, taking into account existing collider and cosmological data in our
global fit. We compare our method to the MultiNest algorithm, an efficient
Bayesian technique, paying particular attention to the best-fit points and
implications for particle masses at the LHC and dark matter searches. Our
global best-fit point lies in the focus point region. We find many
high-likelihood points in both the stau co-annihilation and focus point
regions, including a previously neglected section of the co-annihilation region
at large m_0. We show that there are many high-likelihood points in the CMSSM
parameter space commonly missed by existing scanning techniques, especially at
high masses. This has a significant influence on the derived confidence regions
for parameters and observables, and can dramatically change the entire
statistical inference of such scans.Comment: 47 pages, 8 figures; Fig. 8, Table 7 and more discussions added to
Sec. 3.4.2 in response to referee's comments; accepted for publication in
JHE
CD271-selected mesenchymal stem cells from adipose tissue enhance cartilage repair and are less angiogenic than plastic adherent mesenchymal stem cells
CD271 is a marker of bone marrow MSCs with enhanced differentiation capacity for bone or cartilage repair. However, the nature of CD271+ MSCs from adipose tissue (AT) is less well understood. Here, we investigated the differentiation, wound healing and angiogenic capacity of plastic adherent MSCs (PA MSCs) versus CD271+ MSCs from AT. There was no difference in the extent to which PA MSCs and CD271+ MSCs formed osteoblasts, adipocytes or chondrocytes in vitro. In contrast, CD271+ MSCs transplanted into athymic rats significantly enhanced osteochondral wound healing with reduced vascularisation in the repair tissue compared to PA MSCs and control animals; there was little histological evidence of mature articular cartilage formation in all animals. Conditioned medium from CD271+ MSC cultures was less angiogenic than PA MSC conditioned medium, and had little effect on endothelial cell migration or endothelial tubule formation in vitro. The low angiogenic activity of CD271+ MSCs and improved early stage tissue repair of osteochondral lesions when transplanted, along with a comparable differentiation capacity along mesenchymal lineages when induced, suggests that these selected cells are a better candidate than PA MSCs for the repair of cartilaginous tissue
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