289 research outputs found
Mechanisms of pulsus paradoxus during resistive respiratory loading and asthma
To determine the mechanisms of pulsus paradoxus during asthma, six subjects known to have cold air bronchial hyperreactivity were studied while in a quiescent phase of their disease. All were free of significant airway obstruction at the time of study. After placement of an esophageal balloon to estimate intrathoracic pressure, the subjects were assessed during quiet breathing, resistive airway loading and then during a stable period of airway obstruction induced by cold air. Steady state left ventricular volume and performance were measured using radionuclide ventriculography; right ventricular volume was calculated from the stroke volume ratio and right ventricular ejection fraction. Cardiac cycles were segregated according to their occurrence in inspiration or expiration using a flow signal from a pneumotachograph.Combined inspiratory and expiratory resistance produced pulsus paradoxus and changes in esophageal pressure that were similar to those during asthma and significantly greater than those during quiet breathing. These changes were accompanied by decreases in left ventricular diastolic volume and stroke volume during inspiration, and increases in these variables during expiration; right ventricular volume and stroke volume demonstrated changes reciprocal to those seen in the left ventricle. These data indicate that during periods of increase in airway resistance, abnormal pulsus paradoxus results from an exaggeration in the normal inspiratory-expiratory difference in stroke volume mediated primarily by the effects of intrathoracic pressure on ventricular preload
Examining within-person relationships between state assessments of affect and eudaimonic well-being using multi-level structural equation modeling
Prior research has highlighted the possibility that current affect may be interchangeable with state assessments of other dimensions of subjective well-being. In the present study, we conducted a systematic replication and extension by examining the relationship between state assessments of affect and eudaimonic well-being (meaning, core self-evaluation, authenticity, and gratitude) in a 14-day diary assessment (N = 207 with 2,147 assessments). We utilized multi-level structural equation modeling (ML-SEM) with affect as a time-varying covariate and found that the impact of affect for these outcomes was less consequential than for assessments of state satisfaction, and that the impact of positive affect on these dimensions was stronger than that of negative affect
A new photon recoil experiment: towards a determination of the fine structure constant
We report on progress towards a measurement of the fine structure constant to
an accuracy of or better by measuring the ratio of the
Planck constant to the mass of the cesium atom. Compared to similar
experiments, ours is improved in three significant ways: (i) simultaneous
conjugate interferometers, (ii) multi-photon Bragg diffraction between same
internal states, and (iii) an about 1000 fold reduction of laser phase noise to
-138 dBc/Hz. Combining that with a new method to simultaneously stabilize the
phases of four frequencies, we achieve 0.2 mrad effective phase noise at the
location of the atoms. In addition, we use active stabilization to suppress
systematic effects due to beam misalignment.Comment: 12 pages, 9 figure
Low availability of choline in utero disrupts development and function of the retina
Adequate supply of choline, an essential nutrient, is necessary to support proper brain development. Whether prenatal choline availability plays a role in development of the visual system is currently unknown. In this study, we addressed the role of in utero choline supply for the development and later function of the retina in a mouse model. We lowered choline availability in the maternal diet during pregnancy and assessed proliferative and differentiation properties of retinal progenitor cells (RPCs) in the developing prenatal retina, as well as visual function in adult offspring. We report that low choline availability during retinogenesis leads to persistent retinal cytoarchitectural defects, ranging from focal lesions with displacement of retinal neurons into subretinal space to severe hypocellularity and ultrastructural defects in photoreceptor organization. We further show that low choline availability impairs timely differentiation of retinal neuronal cells, such that the densities of early-born retinal ganglion cells, amacrine and horizontal cells, as well as cone photoreceptor precursors, are reduced in low choline embryonic d 17.5 retinas. Maintenance of higher proportions of RPCs that fail to exit the cell cycle underlies aberrant neuronal differentiation in low choline embryos. Increased RPC cell cycle length, and associated reduction in neurofibromin 2/Merlin protein, an upstream regulator of the Hippo signaling pathway, at least in part, explain aberrant neurogenesis in low choline retinas. Furthermore, we find that animals exposed to low choline diet in utero exhibit a significant degree of intraindividual variation in vision, characterized by marked functional discrepancy between the 2 eyes in individual animals. Together, our findings demonstrate, for the first time, that choline availability plays an essential role in the regulation of temporal progression of retinogenesis and provide evidence for the importance of adequate supply of choline for proper development of the visual system
Small-scale magnetic buoyancy and magnetic pumping effects in a turbulent convection
We determine the nonlinear drift velocities of the mean magnetic field and
nonlinear turbulent magnetic diffusion in a turbulent convection. We show that
the nonlinear drift velocities are caused by the three kinds of the
inhomogeneities, i.e., inhomogeneous turbulence; the nonuniform fluid density
and the nonuniform turbulent heat flux. The inhomogeneous turbulence results in
the well-known turbulent diamagnetic and paramagnetic velocities. The nonlinear
drift velocities of the mean magnetic field cause the small-scale magnetic
buoyancy and magnetic pumping effects in the turbulent convection. These
phenomena are different from the large-scale magnetic buoyancy and magnetic
pumping effects which are due to the effect of the mean magnetic field on the
large-scale density stratified fluid flow. The small-scale magnetic buoyancy
and magnetic pumping can be stronger than these large-scale effects when the
mean magnetic field is smaller than the equipartition field. We discuss the
small-scale magnetic buoyancy and magnetic pumping effects in the context of
the solar and stellar turbulent convection. We demonstrate also that the
nonlinear turbulent magnetic diffusion in the turbulent convection is
anisotropic even for a weak mean magnetic field. In particular, it is enhanced
in the radial direction. The magnetic fluctuations due to the small-scale
dynamo increase the turbulent magnetic diffusion of the toroidal component of
the mean magnetic field, while they do not affect the turbulent magnetic
diffusion of the poloidal field.Comment: 13 pages, 4 figure, REVTEX4, Geophysical and Astrophysical Fluid
Dynamics, in pres
A model-based approach for multiple QoS in scheduling: from models to implementation
Meeting multiple Quality of Service (QoS) requirements is an important factor in the success of complex software systems. This paper presents an automated, model-based scheduler synthesis approach for scheduling application software tasks to meet multiple QoS requirements. As a first step, it shows how designers can meet deadlock-freedom and timeliness requirements, in a manner that (i) does not over-provision resources, (ii) does not require architectural changes to the system, and that (iii) leaves enough degrees of freedom to pursue further properties. A major benefit of our synthesis methodology is that it increases traceability, by linking each scheduling constraint with a specific pair of QoS property and underlying platform execution model, so as to facilitate the validation of the scheduling constraints and the understanding of the overall system behaviour, required to meet further QoS properties.
The paper shows how the methodology is applied in practice and also presents a prototype implementation infrastructure for executing an application on top of common operating systems, without requiring modifications of the latter
Optimal designs for rational function regression
We consider optimal non-sequential designs for a large class of (linear and
nonlinear) regression models involving polynomials and rational functions with
heteroscedastic noise also given by a polynomial or rational weight function.
The proposed method treats D-, E-, A-, and -optimal designs in a
unified manner, and generates a polynomial whose zeros are the support points
of the optimal approximate design, generalizing a number of previously known
results of the same flavor. The method is based on a mathematical optimization
model that can incorporate various criteria of optimality and can be solved
efficiently by well established numerical optimization methods. In contrast to
previous optimization-based methods proposed for similar design problems, it
also has theoretical guarantee of its algorithmic efficiency; in fact, the
running times of all numerical examples considered in the paper are negligible.
The stability of the method is demonstrated in an example involving high degree
polynomials. After discussing linear models, applications for finding locally
optimal designs for nonlinear regression models involving rational functions
are presented, then extensions to robust regression designs, and trigonometric
regression are shown. As a corollary, an upper bound on the size of the support
set of the minimally-supported optimal designs is also found. The method is of
considerable practical importance, with the potential for instance to impact
design software development. Further study of the optimality conditions of the
main optimization model might also yield new theoretical insights.Comment: 25 pages. Previous version updated with more details in the theory
and additional example
Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays
Average charged multiplicities have been measured separately in , and
light quark () events from decays measured in the SLD experiment.
Impact parameters of charged tracks were used to select enriched samples of
and light quark events, and reconstructed charmed mesons were used to select
quark events. We measured the charged multiplicities:
,
, from
which we derived the differences between the total average charged
multiplicities of or quark events and light quark events: and . We compared
these measurements with those at lower center-of-mass energies and with
perturbative QCD predictions. These combined results are in agreement with the
QCD expectations and disfavor the hypothesis of flavor-independent
fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants
that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants
would predict COPD and associated phenotypes.
Methods We constructed a polygenic risk score using a genome-wide association study of lung function (FEV1 and
FEV1/forced vital capacity [FVC]) from the UK Biobank and SpiroMeta. We tested this polygenic risk score in nine
cohorts of multiple ethnicities for an association with moderate-to-severe COPD (defined as FEV1/FVC <0·7 and FEV1
<80% of predicted). Associations were tested using logistic regression models, adjusting for age, sex, height, smoking
pack-years, and principal components of genetic ancestry. We assessed predictive performance of models by area
under the curve. In a subset of studies, we also studied quantitative and qualitative CT imaging phenotypes that
reflect parenchymal and airway pathology, and patterns of reduced lung growth.
Findings The polygenic risk score was associated with COPD in European (odds ratio [OR] per SD 1·81
[95% CI 1·74–1·88] and non-European (1·42 [1·34–1·51]) populations. Compared with the first decile, the tenth decile
of the polygenic risk score was associated with COPD, with an OR of 7·99 (6·56–9·72) in European ancestry and
4·83 (3·45–6·77) in non-European ancestry cohorts. The polygenic risk score was superior to previously described
genetic risk scores and, when combined with clinical risk factors (ie, age, sex, and smoking pack-years), showed
improved prediction for COPD compared with a model comprising clinical risk factors alone (AUC 0·80 [0·79–0·81]
vs 0·76 [0·75–0·76]). The polygenic risk score was associated with CT imaging phenotypes, including wall area
percent, quantitative and qualitative measures of emphysema, local histogram emphysema patterns, and destructive
emphysema subtypes. The polygenic risk score was associated with a reduced lung growth pattern.
Interpretation A risk score comprised of genetic variants can identify a small subset of individuals at markedly
increased risk for moderate-to-severe COPD, emphysema subtyp
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