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Architecture for nuclear energy in the 21st century
Global and regional scenarios for future energy demand have been assessed from the perspectives of nuclear materials management. From these the authors propose creation of a nuclear fuel cycle architecture which maximizes inherent protection of plutonium and other nuclear materials. The concept also provides technical and institutional flexibility for transition into other fuel cycle systems, particularly those involving breeder reactors. The system, its implementation timeline, and overall impact are described in the paper
Reduced Intensity Allogeneic Hematopoietic Cell Transplantation in Older Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes: Comparable Outcomes With Unrelated Umbilical Cord Blood and HLA-Identical Sibling Donors
Scale invariance in coarsening of binary and ternary fluids
Phase separation in binary and ternary fluids is studied using a two
dimensional Lattice Gas Automata. The lengths, given by the the first zero
crossing point of the correlation function and the total interface length is
shown to exhibit power law dependence on time. In binary mixtures, our data
clearly indicate the existence of a regime having more than one length scale
where the coarsening process proceeds through the rupture and reassociation of
domains. In ternary fluids; in the case of symmetric mixtures there exists a
regime with a single length scale having dynamic exponent 1/2, while in
asymmetric mixtures our data establish the break down of scale invariance.Comment: 20 pages, 13 figure
Prognostic significance of precordial ST segment depression during inferior myocardial infarction in the thrombolytic era: Results in 16,521 patients
Objectives. We examined the prognostic significance of precordial ST segment depression among patients with an acute inferior myocardial infarction. Background. Although precordial ST segment depression has been associated with a poor prognosis, this correlation has not been adequately quantified, partly because of small sample sizes and methodologic limitations in previous studies. Methods. We examined the clinical and angiographic outcomes of 16,521 patients with an acute inferior myocardial infarction who underwent thrombolysis in the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO-I) study. Patients were classified into those without precordial ST segment depression (n = 6,422 [38.9%]), those with ST segment depression in leads V1 to V3 only (n = 5,850 [35.4%]), those with ST segment depression in leads V4 to V6 only (n = 876 [5.3%]) and those with ST segment depression in both leads V1 to V3 and leads V4 to V6 (n = 3,373 [20.4%]) on initial electrocardiography. Outcome measures included postinfarction complications (second- or third-degree heart block, congestive heart failure or shock) and 30-day and 1-year mortality. Results. Patients with precordial ST segment depression had larger infarctions, more postinfarction complications and a higher mortality rate than those without precordial ST segment depression (4.7% vs. 3.2% at 30 days; 5.0% vs. 3.4% at 1 year; both p < 0.001), regardless of whether ST segment depression was noted in leads V1 to V6 or in leads V4 to V6. The magnitude of precordial ST segment depression (sum of leads V1 to V6) added significant independent prognostic information after adjustment for clinical risk factors; the risk of 30-day mortality increased by 36% for every 0.5 mV of precordial ST segment depression. Conclusions. Assessment of the magnitude of precordial ST segment depression is useful for acute risk stratification in patients with an inferior myocardial infarction
Constraints on the pMSSM from LAT Observations of Dwarf Spheroidal Galaxies
We examine the ability for the Large Area Telescope (LAT) to constrain
Minimal Supersymmetric Standard Model (MSSM) dark matter through a combined
analysis of Milky Way dwarf spheroidal galaxies. We examine the Lightest
Supersymmetric Particles (LSPs) for a set of ~71k experimentally valid
supersymmetric models derived from the phenomenological-MSSM (pMSSM). We find
that none of these models can be excluded at 95% confidence by the current
analysis; nevertheless, many lie within the predicted reach of future LAT
analyses. With two years of data, we find that the LAT is currently most
sensitive to light LSPs (m_LSP < 50 GeV) annihilating into tau-pairs and
heavier LSPs annihilating into b-bbar. Additionally, we find that future LAT
analyses will be able to probe some LSPs that form a sub-dominant component of
dark matter. We directly compare the LAT results to direct detection
experiments and show the complementarity of these search methods.Comment: 24 pages, 9 figures, submitted to JCA
Relativistic analysis of the 208Pb(e,e'p)207Tl reaction at high momentum
The recent 208Pb(e,e'p)207Tl data from NIKHEF-K at high missing momentum
(p_m>300 MeV/c) are compared to theoretical results obtained with a fully
relativistic formalism previously applied to analyze data on the low missing
momentum (p_m < 300 MeV/c) region. The same relativistic optical potential and
mean field wave functions are used in the two p_m-regions. The spectroscopic
factors of the various shells are extracted from the analysis of the low-p_m
data and then used in the high-p_m region. In contrast to previous analyses
using a nonrelativistic mean field formalism, we do not find a substantial
deviation from the mean field predictions other than that of the spectroscopic
factors, which appear to be consistent with both low- and high-p_m data. We
find that the difference between results of relativistic and nonrelativistic
formalisms is enhanced in the p_m<0 region that will be interesting to explore
experimentally.Comment: 12 pages, LaTeX+Revtex, included 3 postscript figures. To appear in
the Physical Review C (Rapid Communications
Phase separating binary fluids under oscillatory shear
We apply lattice Boltzmann methods to study the segregation of binary fluid
mixtures under oscillatory shear flow in two dimensions. The algorithm allows
to simulate systems whose dynamics is described by the Navier-Stokes and the
convection-diffusion equations. The interplay between several time scales
produces a rich and complex phenomenology. We investigate the effects of
different oscillation frequencies and viscosities on the morphology of the
phase separating domains. We find that at high frequencies the evolution is
almost isotropic with growth exponents 2/3 and 1/3 in the inertial (low
viscosity) and diffusive (high viscosity) regimes, respectively. When the
period of the applied shear flow becomes of the same order of the relaxation
time of the shear velocity profile, anisotropic effects are clearly
observable. In correspondence with non-linear patterns for the velocity
profiles, we find configurations where lamellar order close to the walls
coexists with isotropic domains in the middle of the system. For particular
values of frequency and viscosity it can also happen that the convective
effects induced by the oscillations cause an interruption or a slowing of the
segregation process, as found in some experiments. Finally, at very low
frequencies, the morphology of domains is characterized by lamellar order
everywhere in the system resembling what happens in the case with steady shear.Comment: 1 table and 12 figures in .gif forma
Relativistic versus Nonrelativistic Optical Potentials in A(e,e'p)B Reactions
We investigate the role of relativistic and nonrelativistic optical
potentials used in the analysis of () data. We find that the
relativistic calculations produce smaller () cross sections even in the
case in which both relativistic and nonrelativistic optical potentials fit
equally well the elastic proton--nucleus scattering data. Compared to the
nonrelativistic impulse approximation, this effect is due to a depletion in the
nuclear interior of the relativistic nucleon current, which should be taken
into account in the nonrelativistic treatment by a proper redefinition of the
effective current operator.Comment: Added one new figure, the formalism section has been enlarged and the
list of references updated. Added one appendix. This version will appear in
Phys. Rev. C. Revtex 3.0, 6 figures (not included). Full postscript version
of the file and figures available at
http://www.nikhefk.nikhef.nl/projects/Theory/preprints
Linking Structural Racism and Discrimination and Breast Cancer Outcomes: A Social Genomics Approach
We live in a society where individuals and communities are marginalized because of their race or ethnicity. This structural inequity extracts enormous health and societal costs, decreasing access to cancer care and increasing health disparities, especially among the most vulnerable. In an effort to identify causes of disparities, we have incorporated individual sociodemographic characteristics (eg, income and education) and other social determinants of health (eg, access to care, insurance, and transportation needs), as well as biologic markers (eg, genetic predisposition to disease) that can serve as therapeutic targets into our research
Constraints on Dark Matter Annihilation in Clusters of Galaxies with the Fermi Large Area Telescope
Nearby clusters and groups of galaxies are potentially bright sources of
high-energy gamma-ray emission resulting from the pair-annihilation of dark
matter particles. However, no significant gamma-ray emission has been detected
so far from clusters in the first 11 months of observations with the Fermi
Large Area Telescope. We interpret this non-detection in terms of constraints
on dark matter particle properties. In particular for leptonic annihilation
final states and particle masses greater than ~200 GeV, gamma-ray emission from
inverse Compton scattering of CMB photons is expected to dominate the dark
matter annihilation signal from clusters, and our gamma-ray limits exclude
large regions of the parameter space that would give a good fit to the recent
anomalous Pamela and Fermi-LAT electron-positron measurements. We also present
constraints on the annihilation of more standard dark matter candidates, such
as the lightest neutralino of supersymmetric models. The constraints are
particularly strong when including the fact that clusters are known to contain
substructure at least on galaxy scales, increasing the expected gamma-ray flux
by a factor of ~5 over a smooth-halo assumption. We also explore the effect of
uncertainties in cluster dark matter density profiles, finding a systematic
uncertainty in the constraints of roughly a factor of two, but similar overall
conclusions. In this work, we focus on deriving limits on dark matter models; a
more general consideration of the Fermi-LAT data on clusters and clusters as
gamma-ray sources is forthcoming.Comment: accepted to JCAP, Corresponding authors: T.E. Jeltema and S. Profumo,
minor revisions to be consistent with accepted versio
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