109 research outputs found
Regulation of haemopoietic stemâcell proliferation in mice carrying the Slj allele
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/1984
- Field of study
We investigated a haemopoietic stromal defect, in mice heterozygous for the Slj allele, during haemopoietic stress induced by treatment with bacterial lipopolysaccharides (LPS) or lethal total body irradiation (TBI) and boneâmarrow cell (BMC) reconstitution. Both treatments resulted in a comparable haemopoietic stem cell (CFUâs) proliferation in Slj/+ and +/+ haemopoietic organs. There was no difference in committed haemopoietic progenitor cell (BFUâe and CFUâG/M) kinetics after TBI and +/+ boneâmarrow transplantation in Slj/+ and +/+ mice. the Slj/+ mice were deficient in their ability to support macroscopic spleen colony formation (65% of +/+ controls) as measured at 7 and 10 days after BMC transplantation. However, the Slj/+ spleen colonies contained the same number of BFUâE and CFUâG/M as colonies from +/+ spleens, while their CFUâs content was increased. On day 10 postâtransplantation, the macroscopic âmissingâ colonies could be detected at the microscopic level. These small colonies contained far fewer CFUâs than the macroscopic detectable colonies. Analysis of CFUâs proliferationâinducing activities in control and postâLPS sera revealed that Slj/+ mice are normal in their ability to produce and to respond to humoral stemâcell regulators. We postulate that Slj/+ mice have a normal number of splenic stromal ânichesâ for colony formation. However, 35% of these niches is defective in its proliferative support. Copyrigh
The DNA damage response is developmentally regulated in the African trypanosome
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Genomes are affected by a wide range of damage, which has resulted in the evolution of a number of widely conserved DNA repair pathways. Most of these repair reactions have been described in the African trypanosome Trypanosoma brucei, which is a genetically tractable eukaryotic microbe and important human and animal parasite, but little work has considered how the DNA damage response operates throughout the T. brucei life cycle. Using quantitative PCR we have assessed damage induction and repair in both the nuclear and mitochondrial genomes of the parasite. We show differing kinetics of repair for three forms of DNA damage, and dramatic differences in repair between replicative life cycle forms found in the testse fly midgut and the mammal. We find that mammal-infective T. brucei cells repair oxidative and crosslink-induced DNA damage more efficiently than tsetse-infective cells and, moreover, very distinct patterns of induction and repair of DNA alkylating damage in the two life cycle forms. We also reveal robust repair of DNA lesions in the highly unusual T. brucei mitochondrial genome (the kinetoplast). By examining mutants we show that nuclear alkylation damage is repaired by the concerted action of two repair pathways, and that Rad51 acts in kinetoplast repair. Finally, we correlate repair with cell cycle arrest and cell growth, revealing that induced DNA damage has strikingly differing effects on the two life cycle stages, with distinct timing of alkylation-induced cell cycle arrest and higher levels of damage induced death in mammal-infective cells. Our data reveal that T. brucei regulates the DNA damage response during its life cycle, a capacity that may be shared by many microbial pathogens that exist in variant environments during growth and transmission
Two levels of the inspired oxygen fraction in propofol-anesthetized dogs with high intracranial pressure: cardiopulmonary function
- Author
- A.L.G. Souza
- ARMITAGE-CHAN E.A.
- BAGLEY R.S.
- BRISMAR B.
- E.A Belmonte
- FALCĂO A.L.E.
- FUJII Y.
- G.B. Pereira Neto
- GOLDFARB M.A.
- GREENE S.A.
- HARVEY R.C.
- HASKINS S.C.
- HASKINS S.C.
- HEDENSTIERNA G.
- HĂGGENDAL E.
- JOHNSTON W.E.
- JOSĂ A.
- KUPE T.J.
- L.G.G.G. Dias
- MAGNUSSON L.
- MARK J.B.
- MAZZAFERRO E.M.
- McCULLOCH T.J.
- MCKEAGE K.
- MILLER E.D.
- N. Nunes
- NUNES N.
- NUNES N.
- P.C. Ferro Lopes
- PASETTO A.
- PAULA D.P.
- PLĂCHL W.
- R. M. Almeida
- SHOEMAKER W.C.
- SPONHEIM S.
- STEINER L.A.
- STURGES B.K.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Aspects of Orchidaceae distribution in Costa Rica and northwestern South America: a study on similarity with emphasis on the Amazonian Region
- Author
- Ab'SĂĄber A.
- Amorim D.S.
- Amorim D.S.
- Atzingen N.V.
- Baldwin L.K.
- Blanco M.A.
- BogarĂn D.
- Bolker B.M.
- Braem R.
- Cardoso A.L.R.
- Chase M.W.
- Christenson E.A.
- Christenson E.A.
- Christenson E.A.
- Christenson E.A.
- Cracraft J.
- Daly D.C.
- Dick C.W.
- Dressler R.L.
- Dressler R.L.
- Dressler R.L.
- Dressler R.L.
- Franco-Rosselli P.
- Funk V.A.
- Garda A.A.
- Gentry A.H.
- Gentry A.H.
- Gutierrez R.G.
- Haffer J.
- Hall J.P.W.
- Hooghiemstra H.
- Iganci J.R.V.
- Koch A.K.
- Kovach W.L.
- Kury A.B.
- Legendre P.
- Legendre P.
- Leopardi C.
- Leopardi C.
- McCulloch C.E.
- Morrone J.J.
- Morrone J.J.
- Odum E.P.
- Pennington R.T.
- Pessoa E.
- Prance G.T.
- Pridgeon A.M.
- Pupulin F.
- Pupulin F.
- Quijano-Abril M.A.
- Ribeiro J.E.L.S.
- Silva J.M.C.
- Silveira E.C.
- Sneath P.H.
- Stehmann J.R.
- Ter Braak C.J.F.
- Trejo-Torres J.C.
- Van Der Pijl L.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol
- Author
- A.P. Souza
- A.V. Leite
- ADAMS W.M.
- ARMITAGE-CHAN E.A.
- BAGLEY R.S.
- BAZIN J.E.
- BRANSON K.R.
- C.T.D. Nishimori
- CHARLES E.S.
- CLARKE K.W.
- CORTOPASSI S.R.G.
- CRYSTAL G.J.
- D.P. Paula
- DENEUCHE A.
- DEWEY C.W.
- FANTONI D.T.
- FERRO P.C.
- FUJII Y.
- GLOWASKI M.M.
- HANOUZ J.L.
- HARVEY R.C.
- ITO H.
- LEITE A.V.
- LEWIS D.D.
- MAGELLA H.A.
- McCULLOCH T.J.
- MONKHOFF M.
- MUIR III W.W.
- N. Nunes
- NUNES N.
- OMOIGUI S.
- P.C.F. Lopes
- P.N. Henao Guerrero
- P.S.P. Santos
- PAULA D.P.
- PLOCHL W.
- QUANDT J.E.
- RAVUSSIN P.
- REZENDE M.L.
- SCHWENDER D.
- SHORT C.E.
- SIMON J.W.
- SMITH A.L.
- SPONHEIM S.
- STEINER L.A.
- WESTBROOK A.
- WHITWAM J.G.
- WIDMER W.R.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The Tolbachik volcanic massif: A review of the petrology, volcanology and eruption history prior to the 2012â2013 eruption
- Author
- Alexeiev
- Almeev
- Almeev
- Alves
- Anoshin
- Anoshin
- Ariskin
- Auer
- B.N. Gordeychik
- B.R. Edwards
- Balesta
- Bazanova
- Belousov
- Belousov
- Bindeman
- Braitseva
- Braitseva
- Braitseva
- Braitseva
- Braitseva
- Braitseva
- Braitseva
- Brenguier
- Bryant
- Bryant
- Calkins
- Churikova
- Churikova
- Churikova
- Churikova
- Churikova
- Churikova
- Davaille
- DeMets
- DePaolo
- Dorendorf
- Dosseto
- Dosseto
- Dvigalo
- Dvigalo
- E.A. Zelenin
- Edwards
- Edwards
- Ermakov
- Ermakov
- Fedotov
- Fedotov
- Fedotov
- Fedotov
- Flerov
- Flerov
- Flerov
- Flerov
- Flerov
- Geist
- Gilichinsky
- Gorbach
- Gorbach
- Gorbatikov
- Gorbatov
- Gordeev
- Gorelchik
- Gorelchik
- Grapenthin
- Grishin
- Hochstaedter
- Hofmann
- Ionov
- Ishikawa
- Ivanov
- Ivanov
- Iwasaki
- Kayzar
- Kepezhinskas
- Kersting
- Kersting
- Kersting
- Kessel
- Khrenov
- Khubunaya
- Khubunaya
- Khubunaya
- Kirsanov
- Koloskov
- Konradi
- Konstantinovskaia
- Konstantinovskaia
- Koulakov
- Koulakov
- Krasheninnikov
- Kudo
- Kugaenko
- Kugaenko
- Kulakov
- Lander
- Le Maitre
- Levin
- Levin
- Lukanin
- Markhinin
- McCulloch
- Melekestsev
- Melekestsev
- Melekestsev
- Melekestsev
- Melekestsev
- Melekestsev
- Melekestsev
- Menyailov
- Mironov
- Mironov
- Miyashiro
- Muravyev
- MĂŒnker
- Naboko
- Nishizawa
- Ovsyannikov
- Ozerov
- Ozerov
- Park
- Petrov
- Pevzner
- Pevzner
- Piip
- Piip
- Piip
- Pineau
- Plank
- Ponomareva
- Ponomareva
- Ponomareva
- Ponomareva
- Ponomareva
- Ponomaryov
- Popkov
- Portnyagin
- Portnyagin
- Portnyagin
- Portnyagin
- Powell
- Pronin
- Romanchev
- Ruscitto
- Saxena
- Scholl
- Seliverstov
- Senyukov
- Senyukov
- Shantser
- Shapiro
- Shcherbakov
- Sirin
- Sirin
- Slavina
- Sun
- T.G. Churikova
- Taisne
- Taylor
- Telling
- Thelen
- Thompson
- Timerbaeva
- Tokarev
- Tokarev
- Turner
- Turner
- Turner
- Turner
- Uspensky
- V.V. Ponomareva
- van Keken
- Vergasova
- Vergasova
- Vlodavets
- Vlodavets
- Vlodavets
- Volynets
- Volynets
- Volynets
- Volynets
- Volynets
- Volynets
- Wells
- West
- Yogodzinski
- Zavaritsky
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The Physics of the B Factories
- Author
- Abachi S.
- Abashian A.
- Abe K.
- Abe N.
- Abe R.
- Abe T.
- Abrams G.S.
- Adachi I.
- Adam I.
- Adamczyk K.
- Adametz A.
- Adye T.
- Agarwal A.
- Ahmed H.
- Ahmed M.
- Ahmed S.
- Ahn B.S.
- Ahn H.S.
- Aihara H.
- Aitchison I.J.R.
- Akai K.
- Akar S.
- Akatsu M.
- Akemoto M.
- Akhmetshin R.
- Akre R.
- Alam M.S.
- Albert J.
- Albert J.N.
- Aleksan R.
- Alexander J.P.
- Alimonti G.
- Allen M.T.
- Allison J.
- Allmendinger T.
- Alsmiller J.R.G.
- Altenburg D.
- Alwyn K.E.
- An Q.
- Anderson J.
- Andreassen R.
- Andreotti D.
- Andreotti M.
- Andress J.C.
- Angelini C.
- Anipko D.
- Anjomshoaa A.
- Anthony P.L.
- Antillon E.A.
- Antonioli E.
- Anulli F.
- Aoki K.
- Arguin J.F.
- Arinstein K.
- Arisaka K.
- Arnaud N.
- Asai K.
- Asai M.
- Asano Y.
- Asgeirsson D.J.
- Asner D.M.
- Aso T.
- Aspinwall M.L.
- Aston D.
- Atmacan H.
- Aubert B.
- Aulchenko V.
- Aushev T.
- Ayad R.
- Azemoon T.
- Aziz T.
- Azzolini V.
- Azzopardi D.E.
- Baak M.A.
- Back J.J.
- Bagnasco S.
- Bahinipati S.
- Bailey D.S.
- Bailey S.
- Bailly P.
- Bakich A.M.
- Bala A.
- Balagura V.
- Baldini-Ferroli R.
- Ban Y.
- Banas E.
- Band H.R.
- Banerjee S.
- Banerjee S.
- Baracchini E.
- Barate R.
- Barberio E.
- Barbero M.
- Bard D.J.
- Barillari T.
- Barlow N.R.
- Barlow R.J.
- Barrett M.
- Bartel W.
- Bartelt J.
- Bartoldus R.
- Batignani G.
- Battaglia M.
- Bauer J.M.
- Bay A.
- Beaulieu M.
- Bechtle P.
- Beck T.W.
- Becker J.
- Becla J.
- Bedny I.
- Behari S.
- Behera P.K.
- Behn E.
- Behr L.
- Beigbeder C.
- Beiline D.
- Bell R.
- Bellini F.
- Bellis M.
- Bellodi G.
- Belous K.
- Ben-Haim E.
- Benayoun M.
- Beneke M.
- Benelli G.
- Benitez J.F.
- Benkebil M.
- Berger N.
- Beringer J.
- Bernabeu J.
- Bernard D.
- Bernet R.
- Bernlochner F.U.
- Berryhill J.W.
- Bertsche K.
- Besson P.
- Best D.S.
- Bettarini S.
- Bettoni D.
- Bevan A.J.
- Bhardwaj V.
- Bhimji W.
- Bhuyan B.
- Biagini M.E.
- Bianchi F.
- Biasini M.
- Biassoni P.
- Biesiada J.
- Bigi I.I.
- Bingham I.
- Bionta R.M.
- Bischofberger M.
- Bitenc U.
- Bizjak I.
- Blanc F.
- Blaylock G.
- Blinov V.E.
- Bloom E.
- Bloom P.C.
- Blount N.L.
- Blouw J.
- Bly M.
- Blyth S.
- Boeheim C.T.
- Bomben M.
- Bona M.
- Bondar A.
- Bondioli M.
- Bonneaud G.R.
- Bonvicini G.
- Booke M.
- Booth J.
- Borean C.
- Borgland A.W.
- Borsato E.
- Bosi F.
- Bosisio L.
- Botov A.A.
- Bougher J.
- Bouldin K.
- Bourgeois P.
- Boutigny D.
- Bowerman D.A.
- Boyarski A.M.
- Boyce R.F.
- Boyd J.T.
- Bozek A.
- Bozzi C.
- Brambilla N.
- Brandenburg G.
- Brandt T.
- Brau B.
- Brau J.
- BraÄko M.
- Breon A.B.
- Breton D.
- Brew C.
- Briand H.
- Bright-Thomas P.G.
- BrigljeviÄ V.
- Britton D.I.
- Brochard F.
- Brodzicka J.
- Broomer B.
- Brose J.
- Browder T.E.
- Brown C.L.
- Brown C.M.
- Brown D.N.
- Browne M.
- Bruinsma M.
- Brunet S.
- Bucci F.
- Buchanan C.
- Buchmueller O.L.
- Bugg W.
- Bukin A.D.
- Bula R.
- Bulten H.
- Burchat P.R.
- Burgess W.
- Burke J.P.
- Button-Shafer J.
- Buzykaev A.R.
- Buzzo A.
- BĂŒnger C.
- Cahn R.N.
- Cai Y.
- Calabrese R.
- Calcaterra A.
- Calderini G.
- Camanzi B.
- Campagna E.
- Campagnari C.
- Capra R.
- Carassiti V.
- Carpinelli M.
- Carroll M.
- Cartaro C.
- Casarosa G.
- Casey B.C.K.
- Cason N.M.
- Castelli G.
- Cavallo N.
- Cavoto G.
- Cecchi A.
- Cenci R.
- Cerizza G.
- Cervelli A.
- Ceseracciu A.
- Chai X.
- Chaisanguanthum K.S.
- Chang M.C.
- Chang P.
- Chang Y.H.
- Chang Y.W.
- Chao D.S.
- Chao M.
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- Charles E.
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- Chauveau J.
- Chavez C.A.
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- Chen A.
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- Chen W.T.
- Chen X.
- Chen X.R.
- Chen Y.Q.
- Cheng B.
- Cheng C.H.
- Cheng H.-Y.
- Cheon B.G.
- Chevalier N.
- Chia Y.M.
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- Chistiakova M.V.
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- Cho I.S.
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- Chobanova V.
- Choi H.H.F.
- Choi K.S.
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- Christ S.
- Chu P.H.
- Chun S.
- Chuvikov A.
- Cibinetto G.
- Cinabro D.
- Cizeron R.
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- Claus R.
- Claxton B.
- Clifton Z.C.
- Cochran J.
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- Colangelo P.
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- Cole S.
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- Condurache C.
- Contri R.
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- Convery M.R.
- Cooke P.
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- Cormack C.M.
- Corwin L.A.
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- Cote D.
- Cotta Ramusino A.
- Cottingham W.N.
- Couderc F.
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- Covarelli R.
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- Craddock W.W.
- Crane G.
- Crawley H.B.
- Cremaldi L.
- Crescente A.
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- Crnkovic J.
- Crosetti G.
- Cuhadar-Donszelmann T.
- Cunha A.
- Curry S.
- Dahlinger G.
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- Dal Corso F.
- Dallapiccola C.
- Dalseno J.
- Danielson N.
- Danilov M.
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- Dasu S.
- Datta M.
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- Dauncey P.D.
- David P.
- Davier M.
- Davies C.
- Davis C.L.
- Day C.T.
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- De Groot N.
- De la VaissiĂšre C.
- de la VaissiĂšre C.
- de Lesquen A.
- De Mori F.
- De Nardo G.
- de Sangro R.
- De Silva A.
- DeBarger S.
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- del Amo Sanchez P.
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- del Re D.
- Della Ricca G.
- Denig A.G.
- Derkach D.
- Derrington I.M.
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- Destree J.
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- Dittongo S.
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- Dorfan J.
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- Epifanov D.
- Erdos E.
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- Fernholz R.E.
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- Filippi A.
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- Flood K.T.
- Ford K.E.
- Ford W.T.
- Forster I.J.
- Forti A.C.
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- Foster B.
- Foulkes S.D.
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- Fujikawa M.
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- Fujiyama Y.
- Fukunaga C.
- Fukushima M.
- Fullwood J.
- Fulsom B.G.
- Funahashi Y.
- Funakoshi Y.
- Furano F.
- Furman M.
- Furukawa K.
- Futterschneider H.
- Gabareen A.M.
- Gabathuler E.
- Gabriel T.A.
- Gabyshev N.
- Gaede F.
- Gagliardi N.
- Gaidot A.
- Gaillard J.-M.
- Gaillard J.R.
- Galagedera S.
- Galeazzi F.
- Gallo F.
- Gamba D.
- Gambino P.
- Gamet R.
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- Gandini P.
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- Gaponenko I.
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- Garzia I.
- Gaspero M.
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- Gatto C.
- Gaur V.
- Gaz A.
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- Georgette Z.
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- Gill M.S.
- Gillard R.
- Gilman J.D.
- Gioi L.L.
- Giordano F.
- Giorgi M.A.
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- Publication venue
- Springer Verlag
- Publication date
- 29/01/2015
- Field of study
SHORT-TERM CULTURES OF MOUSE MARROW CELLS SEPARATED BY VELOCITY SEDIMENTATION
- Publication venue
- 'Wiley'
- Publication date
- Field of study
GRAFT SIZE CONSIDERATIONS IN THE KINETICS OF SPLEEN COLONY DEVELOPMENT
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Foetal Erythropoiesis in Steel Mutant Mice.
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
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