9 research outputs found
Branching of negative streamers in free flight
We recently have shown that a negative streamer in a sufficiently high
homogeneous field can branch spontaneously due to a Laplacian instability,
rather than approach a stationary mode of propagation with fixed radius. In our
previous simulations, the streamer started from a wide initial ionization seed
on the cathode. We here demonstrate in improved simulations that a streamer
emerging from a single electron branches in the same way. In fact, though the
evolving streamer is much more narrow, it branches after an even shorter
propagation distance.Comment: 4 pages, 3 figure
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Renal cell carcinoma(RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival
Nonperturbative Approach to the Description of Molecular Excitation by Ultrashort Laser Pulses
We study the problem of excitation of molecules by an ultrashort laser pulse sequence by the use of path-integral approach in energy states space. Using numerical calculations of path-integral we evaluate laser field parameters at which there are quantum resonances in rotational dynamics of dinitrogen isotopes. So we describe recent experimental results [Phys. Rev. Lett. 109, 043003 (2012)] theoretically
Satisfaction with the actual experience: Croatian lay judges on their experience in mixed tribunals
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival. Ricketts et al. find distinctive features of each RCC subtype, providing the foundation for development of subtype-specific therapeutic and management strategies. Somatic alteration of BAP1, PBRM1, and metabolic pathways correlates with subtype-specific decreased survival, while CDKN2A alteration, DNA hypermethylation, and Th2 immune signature correlate with decreased survival within all subtypes