Effect of Pancuronium on Plasma Free-Norepinephrine and Epinephrine in Adult Cardiac Surgical Patients

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65996/1/j.1399-6576.1978.tb01318.x.pd

Ketamine kinetics in unmedicated and diazepam‐premedicated subjects

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109775/1/cptclpt1984235.pd

Solid deuterium surface degradation at ultracold neutron sources

Solid deuterium (sD_2) is used as an efficient converter to produce ultracold neutrons (UCN). It is known that the sD_2 must be sufficiently cold, of high purity and mostly in its ortho-state in order to guarantee long lifetimes of UCN in the solid from which they are extracted into vacuum. Also the UCN transparency of the bulk sD_2 material must be high because crystal inhomogeneities limit the mean free path for elastic scattering and reduce the extraction efficiency. Observations at the UCN sources at Paul Scherrer Institute and at Los Alamos National Laboratory consistently show a decrease of the UCN yield with time of operation after initial preparation or later treatment (`conditioning') of the sD_2. We show that, in addition to the quality of the bulk sD_2, the quality of its surface is essential. Our observations and simulations support the view that the surface is deteriorating due to a build-up of D_2 frost-layers under pulsed operation which leads to strong albedo reflections of UCN and subsequent loss. We report results of UCN yield measurements, temperature and pressure behavior of deuterium during source operation and conditioning, and UCN transport simulations. This, together with optical observations of sD_2 frost formation on initially transparent sD_2 in offline studies with pulsed heat input at the North Carolina State University UCN source results in a consistent description of the UCN yield decrease.Comment: 15 pages, 22 figures, accepted by EPJ-

A highly stable atomic vector magnetometer based on free spin precession

We present a magnetometer based on optically pumped Cs atoms that measures the magnitude and direction of a 1 $\mu$T magnetic field. Multiple circularly polarized laser beams were used to probe the free spin precession of the Cs atoms. The design was optimized for long-time stability and achieves a scalar resolution better than 300 fT for integration times ranging from 80 ms to 1000 s. The best scalar resolution of less than 80 fT was reached with integration times of 1.6 to 6 s. We were able to measure the magnetic field direction with a resolution better than 10 $\mu$rad for integration times from 10 s up to 2000 s

The AtCRK5 Protein Kinase Is Required to Maintain the ROS NO Balance Affecting the PIN2-Mediated Root Gravitropic Response in Arabidopsis

The Arabidopsis AtCRK5 protein kinase is involved in the establishment of the proper auxin gradient in many developmental processes. Among others, the Atcrk5-1 mutant was reported to exhibit a delayed gravitropic response via compromised PIN2-mediated auxin transport at the root tip. Here, we report that this phenotype correlates with lower superoxide anion (O-2(center dot-)) and hydrogen peroxide (H2O2) levels but a higher nitric oxide (NO) content in the mutant root tips in comparison to the wild type (AtCol-0). The oxidative stress inducer paraquat (PQ) triggering formation of O-2(center dot-) (and consequently, H2O2) was able to rescue the gravitropic response of Atcrk5-1 roots. The direct application of H2O2 had the same effect. Under gravistimulation, correct auxin distribution was restored (at least partially) by PQ or H2O2 treatment in the mutant root tips. In agreement, the redistribution of the PIN2 auxin efflux carrier was similar in the gravistimulated PQ-treated mutant and untreated wild type roots. It was also found that PQ-treatment decreased the endogenous NO level at the root tip to normal levels. Furthermore, the mutant phenotype could be reverted by direct manipulation of the endogenous NO level using an NO scavenger (cPTIO). The potential involvement of AtCRK5 protein kinase in the control of auxin-ROS-NO-PIN2-auxin regulatory loop is discussed

Testing isotropy of the universe using the Ramsey resonance technique on ultracold neutron spins

Physics at the Planck scale could be revealed by looking for tiny violations of fundamental symmetries in low energy experiments. In 2008, a sensitive test of the isotropy of the Universe using has been performed with stored ultracold neutrons (UCN), this is the first clock-comparison experiment performed with free neutrons. During several days we monitored the Larmor frequency of neutron spins in a weak magnetic field using the Ramsey resonance technique. An non-zero cosmic axial field, violating rotational symmetry, would induce a daily variation of the precession frequency. Our null result constitutes one of the most stringent tests of Lorentz invariance to date.Comment: proceedings of the PNCMI2010 conferenc

An Improved Search for the Neutron Electric Dipole Moment

A permanent electric dipole moment of fundamental spin-1/2 particles violates both parity (P) and time re- versal (T) symmetry, and hence, also charge-parity (CP) symmetry since there is no sign of CPT-violation. The search for a neutron electric dipole moment (nEDM) probes CP violation within and beyond the Stan- dard Model. The experiment, set up at the Paul Scherrer Institute (PSI), an improved, upgraded version of the apparatus which provided the current best experimental limit, dn < 2.9E-26 ecm (90% C.L.), by the RAL/Sussex/ILL collaboration: Baker et al., Phys. Rev. Lett. 97, 131801 (2006). In the next two years we aim to improve the sensitivity of the apparatus to sigma(dn) = 2.6E-27 ecm corresponding to an upper limit of dn < 5E-27 ecm (95% C.L.), in case for a null result. In parallel the collaboration works on the design of a new apparatus to further increase the sensitivity to sigma(dn) = 2.6E-28 ecm.Comment: APS Division for particles and fields, Conference Proceedings, Two figure

An Improved Neutron Electric Dipole Moment Experiment

A new measurement of the neutron EDM, using Ramsey's method of separated oscillatory fields, is in preparation at the new high intensity source of ultra-cold neutrons (UCN) at the Paul Scherrer Institute, Villigen, Switzerland (PSI). The existence of a non-zero nEDM would violate both parity and time reversal symmetry and, given the CPT theorem, might lead to a discovery of new CP violating mechanisms. Already the current upper limit for the nEDM (|d_n|<2.9E-26 e.cm) constrains some extensions of the Standard Model. The new experiment aims at a two orders of magnitude reduction of the experimental uncertainty, to be achieved mainly by (1) the higher UCN flux provided by the new PSI source, (2) better magnetic field control with improved magnetometry and (3) a double chamber configuration with opposite electric field directions. The first stage of the experiment will use an upgrade of the RAL/Sussex/ILL group's apparatus (which has produced the current best result) moved from Institut Laue-Langevin to PSI. The final accuracy will be achieved in a further step with a new spectrometer, presently in the design phase.Comment: Flavor Physics & CP Violation Conference, Taipei, 200