Application of NASAP to the design of communication circuits

Modifications to CDC 3600 NASAP for design of linear communication circuit

Size effect and the quadratic temperature dependence of the transverse magnetoresistivity in "size-effect" tungsten single crystals

The transverse magnetoresistivity of pure tungsten single crystals with a residual resistivity ratio ρ293K/ρ4.2K of about 75000 was measured from 4.2 to 20 K and in magnetic fields of up to 15 T. The size effect, i.e. the linear dependence of the magnetoconductivity on the inverse cross sample dimensions, was studied in detail at high fields. We show that the size effect can be used for the separation of the contributions from the electron-surface and the electron-phonon scattering mechanisms to the full conductivity. We demonstrate that the electron-phonon scattering leads to the exponential temperature dependence of the conductivity, and the interference between the electron-phonon and the electron-surface processes leads to a new scattering mechanism "electron-phonon-surface" with a quadratic temperature dependence of the magnetoconductivity. © Published under licence by IOP Publishing Ltd

Sub-Doppler UV spectroscopy by resonance-enhanced two-photon ionization: the structure of the benzene20,22Ne cluster

In this work it is demonstrated that mass selected multiphoton ionization is a powerful technique for high resolution spectroscopy, isotope cluster separation and investigation of the structure of van der Waals clusters. The rotationally resolved UV spectra of the benzene-20Ne and benzene-22Ne clusters are selectively measured in a natural isotopic mixture of benzene and benzene-Ne clusters in a cooled supersonic jet. The analysis of these spectra yields accurate values for the rotational constants of both species. From this data it is found that the Ne atom is located on the C6 rotational axis of the benzene ring at an average distance of 3.46 Å with a slight difference for the two isotopes. This distance decreases by 40 mÅ when benzene is electronically excited. The influence of the large amplitude van der Waals vibrations on the average bond length is discussed

The universal functorial equivariant Lefschetz invariant

We introduce the universal functorial equivariant Lefschetz invariant for endomorphisms of finite proper G-CW-complexes, where G is a discrete group. We use K_0 of the category of "phi-endomorphisms of finitely generated free RPi(G,X)-modules". We derive results about fixed points of equivariant endomorphisms of cocompact proper smooth G-manifolds.Comment: 33 pages; shortened version of the author's PhD thesis, supervised by Wolfgang Lueck, Westfaelische Wilhelms-Universitaet Muenster, 200

Developments in quantitative luminescence techniques

Developments in quantitative luminescence technique

1/f noise of Josephson-junction-embedded microwave resonators at single photon energies and millikelvin temperatures

We present measurements of 1/f frequency noise in both linear and Josephson-junction-embedded superconducting aluminum resonators in the low power, low temperature regime - typical operating conditions for superconducting qubits. The addition of the Josephson junction does not result in additional frequency noise, thereby placing an upper limit for fractional critical current fluctuations of $10^{-8}$ (Hz$^{-1/2}$) at 1 Hz for sub-micron, shadow evaporated junctions. These values imply a minimum dephasing time for a superconducting qubit due to critical current noise of 40 -- 1400 $\mu$s depending on qubit architecture. Occasionally, at temperatures above 50 mK, we observe the activation of individual fluctuators which increase the level of noise significantly and exhibit Lorentzian spectra

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

Targeted delivery represents a promising approach for the development of safer and more effective therapeutics for oncology applications. Although macromolecules accumulate nonspecifically in tumors through the enhanced permeability and retention (EPR) effect, previous studies using nanoparticles to deliver chemotherapeutics or siRNA demonstrated that attachment of cell-specific targeting ligands to the surface of nanoparticles leads to enhanced potency relative to nontargeted formulations. Here, we use positron emission tomography (PET) and bioluminescent imaging to quantify the in vivo biodistribution and function of nanoparticles formed with cyclodextrin-containing polycations and siRNA. Conjugation of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid to the 5' end of the siRNA molecules allows labeling with 64Cu for PET imaging. Bioluminescent imaging of mice bearing luciferase-expressing Neuro2A s.c. tumors before and after PET imaging enables correlation of functional efficacy with biodistribution data. Although both nontargeted and transferrin-targeted siRNA nanoparticles exhibit similar biodistribution and tumor localization by PET, transferrin-targeted siRNA nanoparticles reduce tumor luciferase activity by {approx}50% relative to nontargeted siRNA nanoparticles 1 d after injection. Compartmental modeling is used to show that the primary advantage of targeted nanoparticles is associated with processes involved in cellular uptake in tumor cells rather than overall tumor localization. Optimization of internalization may therefore be key for the development of effective nanoparticle-based targeted therapeutics

Quantum State Sensitivity of an Autoresonant Superconducting Circuit

When a frequency chirped excitation is applied to a classical high-Q nonlinear oscillator, its motion becomes dynamically synchronized to the drive and large oscillation amplitude is observed, provided the drive strength exceeds the critical threshold for autoresonance. We demonstrate that when such an oscillator is strongly coupled to a quantized superconducting qubit, both the effective nonlinearity and the threshold become a non-trivial function of the qubit-oscillator detuning. Moreover, the autoresonant threshold is sensitive to the quantum state of the qubit and may be used to realize a high fidelity, latching readout whose speed is not limited by the oscillator Q.Comment: 5 pages, 4 figure