Re-examining the relationship between audiometric profile and tinnitus pitch

Objective: We explored the relationship between audiogram shape and tinnitus pitch to answer questions arising from neurophysiological models of tinnitus: ‘Is the dominant tinnitus pitch associated with the edge of hearing loss?’ and ‘Is such a relationship more robust in people with narrow tinnitus bandwidth or steep sloping hearing loss?’ Design: A broken-stick fitting objectively quantified slope, degree and edge of hearing loss up to 16 kHz. Tinnitus pitch was characterized up to 12 kHz. We used correlation and multiple regression analyses for examining relationships with many potentially predictive audiometric variables. Study Sample: 67 people with chronic bilateral tinnitus (43 men and 24 women, aged from 22 to 81 years). Results: In this ample of 67 subjects correlation failed to reveal any relationship between the tinnitus pitch and the edge frequency. The tinnitus pitch generally fell within the area of hearing loss. The pitch of the tinnitus in a subset of subjects with a narrow tinnitus bandwidth (n = 23) was associated with the audiometric edge. Conclusions: Our findings concerning subjects with narrow tinnitus bandwidth suggest that this can be used as an a priori inclusion criterion. A large group of such subjects should be tested to confirm these results

Ursinus College Alumni Journal, March 1954

President\u27s page • Dr. Gaylord P. Harnwell to speak at commencement • Ursinus confers honorary degree on Dr. James Wagner • William S. Pettit named Dean of Ursinus College • Prospective students entertained at Ursinus • May queen 1954 • Annual Messiah sung by largest chorus • Charles Roberts makes first 1954 loyalty fund report • Evelyn Glazier Henzel candidate for state legislature • Ursinus places nineteenth in mathematical competition • Lloyd Wood candidate for nomination of governor • Pre-meds enjoy hospital tours with Dr. Tornetta, \u2738 • Ursinus Women\u27s Club sets important spring dates • Watch for news of your Ursinus regional group spring meeting • Meeting of the Washington alumni on April 29 • Harrisburg-Hershey to organize • Berks Co. alumni dinner April 21 • Floyd Justice president of Philadelphia alumni • New York meeting on May 5 • Lehigh Valley dinner April 29 • Don\u27t miss Alumni Day - it\u27s May 29 • Be sure to vote for your alumni officers! • Watch for your ballot in April • Sports review • Mermaids open season with Drexel • Best football record in twenty years • Basketball belles take opener 51-21 • Coach Gurzynski reviews 1954 track prospects • Coach Spangler has hustling basketball squad • Basketball and hilarity at alumni-varsity game • Wrestling captain • Wrestling resume • Doc Baker reviews the 1953 soccer season • Hockey players Merrifield and Price honored • A day with the Dean of Women at Ursinus • News about ourselves • Ziegler awarded air medal • Engagements • Weddings • Births • Necrology • Carters enjoy life in Coloradohttps://digitalcommons.ursinus.edu/alumnijournal/1050/thumbnail.jp

Ursinus College Alumni Journal, November 1954

Two new preceptresses join administrative staff • Ursinus freshman honored by school group • Ursinus college evening school registration increases • Ursinus faculty member presents TV program • Three new members join the Ursinus faculty • Eight-week summer session at Ursinus • 1954-55 academic year opens with 685 students • Williams named dean at Buena Vista College • South Jersey alumni group holds annual dinner dance • Alumni booster group organizes • McKee named dean at New York University • Ursinus colony at University of Delaware • Dr. Robert McAllister directs polio tests • Bunny Harshaw Vosters \u2740 Middle States tennis champion • Dr. Cornelius Weygandt honored by Dr. Wm. J. Phillips • Christian education in India • College supply store under new management • Sports review • 1954 soccer prospects • Women\u27s varsity hockey • Ursinus women\u27s alumni hockey team plays Irish touring team • Ursinus 1954 football squad • Alumni give over $20,000 • Irene Heinly, class secretary explains the success of the class of 1911 • 1954 loyalty fund report • Mr. and Mrs. Kenneth Reinhart attribute the success of \u2749 to the aid of the vice chairmen • Report of 1954 loyalty fund campaign • Contributors for the 1954 loyalty fund campaign • UC Messiah chorus largest in history • Curtain Club plans fall production • News about ourselves • Engagements • Weddings • Births • Necrologyhttps://digitalcommons.ursinus.edu/alumnijournal/1051/thumbnail.jp

The Influence of Prednisolone (PRED) and Methotrexate (MTX) on the Cell and Connective Tissue Content of Subcutaneously Implanted Polyurethane Sponges in Rats

Findings indicate that prednislone and methotrexate have profound effects on the cellular events of acute and chronic inflammation, and influence the synthesis or degradation of connective tissue macromolecules at certain stages of the inflammatory process

Mapping trabecular disconnection "hotspots" in aged human spine and hip

Trabecular bone disconnection is an independent factor in age-related skeletal failure where real termini (ReTm; rare in youth) may cause weakness disproportionate to tissue loss, yet their structural contribution at vulnerable locations remains uncertain. ReTm (previously recorded at the iliac crest) were mapped in "normal" aged vertebral bodies (T11-L5 autopsy; 20 females, 10 males) and corresponding proximal femora (autopsy; 10 females). Results were compared with biomechanically failed femora from orthopaedic subjects aged >. 58. yr (osteoporosis OP, 10 females; osteoarthritis OA, 10 females). A novel direct 2D/3D histological method was applied to large, thick (300. μm) slices superficially silver-stained to separate ReTm (unstained) from apparent termini (planar artefacts, brown). Light microscope field co-ordinates enabled ReTm mapping and statistical testing relative to i) sex, ii) tissue sector and iii) slicing plane. In men ReTm populations were small and random while in women they were large and sector-specific. In vertebrae they clustered anterior/superior being rare posterior/inferior; in the femoral head they concentrated distal/superior and also near the fovea, being fewer distal/inferior. A distribution polarity was evident with 100% more ReTm observed transversely (i.e., on tensile-related cross struts) than longitudinally (i.e., on compression-related vertical struts). Their numbers rose in OP (BV/TV. . 14%), remaining polarised and sector-specific in OP only. Comparative experimentation by marrow elution of an OP animal model demonstrated "floating segments" as a possible outcome. Conclusions were supported statistically that trabecular disconnection "hotspots" at vulnerable locations are sex- and sector-specific, mainly transaxial, and subject to disease modulation

Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo

The ability of 5-aminolaevulinic acid and some of its esterified derivatives to induce porphyrin accumulation has been examined in CaNT murine mammary carcinoma cells growing in culture and as tumours in vivo. Topical or intravenous administration of 5-aminolaevulinic acid-esters to mice bearing subcutaneous tumours produced lower porphyrin levels in the tumour than an equimolar dose of 5-aminolaevulinic acid. Reducing the dose of intravenous hexyl- or benzyl-ALA and topical hexyl-5-aminolaevulinic acid resulted in a dose-dependent reduction in porphyrin accumulation. A number of normal tissues accumulated higher concentrations of porphyrins than tumour tissue following intravenous administration of 5-aminolaevulinic acid-esters. Esterase activity in these normal tissues was greater than that in tumour tissue. In contrast to the situation in vivo, all of the 5-aminolaevulinic acid-esters examined were at least as effective as 5-aminolaevulinic acid when applied to cloned CaNT cells in vitro, with the drug concentration required for maximum porphyrin accumulation varying with ester chain-length. Tumour cells growing in culture released esterase activity into the medium. These findings suggest that the efficacy of 5-aminolaevulinic esters may vary depending on the esterase activity of the target tissue, and suggest caution when interpreting the findings of in vitro studies using these and similar prodrugs

Temporomandibular Joint Disorder Complaints in Tinnitus: Further Hints for a Putative Tinnitus Subtype

OBJECTIVE: Tinnitus is considered to be highly heterogeneous with respect to its etiology, its comorbidities and the response to specific interventions. Subtyping is recommended, but it remains to be determined which criteria are useful, since it has not yet been clearly demonstrated whether and to which extent etiologic factors, comorbid states and interventional response are related to each other and are thus applicable for subtyping tinnitus. Analyzing the Tinnitus Research Initiative Database we differentiated patients according to presence or absence of comorbid temporomandibular joint (TMJ) disorder complaints and compared the two groups with respect to etiologic factors. METHODS: 1204 Tinnitus patients from the Tinnitus Research Initiative (TRI) Database with and without subjective TMJ complaints were compared with respect to demographic, tinnitus and audiological characteristics, questionnaires, and numeric ratings. Data were analysed according to a predefined statistical analysis plan. RESULTS: Tinnitus patients with TMJ complaints (22% of the whole group) were significantly younger, had a lower age at tinnitus onset, and were more frequently female. They could modulate or mask their tinnitus more frequently by somatic maneuvers and by music or sound stimulation. Groups did not significantly differ for tinnitus duration, type of onset (gradual/abrupt), onset related events (whiplash etc.), character (pulsatile or not), hyperacusis, hearing impairment, tinnitus distress, depression, quality of life and subjective ratings (loudness etc.). CONCLUSION: Replicating previous work in tinnitus patients with TMJ complaints, classical risk factors for tinnitus like older age and male gender are less relevant in tinnitus patients with TMJ complaints. By demonstrating group differences for modulation of tinnitus by movements and sounds our data further support the notion that tinnitus with TMJ complaints represents a subgroup of tinnitus with clinical features that are highly relevant for specific therapeutic management

International home economics

The conference was planned to serve the interests of those who wish to work in home economics programs abroad and those who are concerned with the education of international students in the universities and colleges of the United States. Approximately 165 home economists from other states and from foreign countries I including the African and Latin American countries I participated in the conference.https://lib.dr.iastate.edu/card_reports/1026/thumbnail.jp