1,273 research outputs found
Forage Data Hub – A Platform for Sharing Valuable Datasets for Resilience
In accord with the necessity to enhance ecosystem services and productivity in food systems, is the increase of data availability at multiple scales and over time. To help meet this need, we discuss the development of a National Forage Data Hub which will act as a platform to curate, share, and analyze data pertaining to forage systems. This centralized hub will leverage existing datasets by bridging multiple sources including forage crop—soil, water, and nutrient availability—yield (animal and crop) potential (and gaps)— climate—management systems at high spatial and temporal resolution enabling system interaction assessments through next-generation analytics. This novel approach to existing datasets will integrate Big Data at the soilwater- plant-animal-climate nexus to advance data storage technology systems for multiple trophic-level research projects
Spontaneous symmetry breaking in a two-lane model for bidirectional overtaking traffic
First we consider a unidirectional flux \omega_bar of vehicles each of which
is characterized by its `natural' velocity v drawn from a distribution P(v).
The traffic flow is modeled as a collection of straight `world lines' in the
time-space plane, with overtaking events represented by a fixed queuing time
tau imposed on the overtaking vehicle. This geometrical model exhibits platoon
formation and allows, among many other things, for the calculation of the
effective average velocity w=\phi(v) of a vehicle of natural velocity v.
Secondly, we extend the model to two opposite lanes, A and B. We argue that the
queuing time \tau in one lane is determined by the traffic density in the
opposite lane. On the basis of reasonable additional assumptions we establish a
set of equations that couple the two lanes and can be solved numerically. It
appears that above a critical value \omega_bar_c of the control parameter
\omega_bar the symmetry between the lanes is spontaneously broken: there is a
slow lane where long platoons form behind the slowest vehicles, and a fast lane
where overtaking is easy due to the wide spacing between the platoons in the
opposite direction. A variant of the model is studied in which the spatial
vehicle density \rho_bar rather than the flux \omega_bar is the control
parameter. Unequal fluxes \omega_bar_A and \omega_bar_B in the two lanes are
also considered. The symmetry breaking phenomenon exhibited by this model, even
though no doubt hard to observe in pure form in real-life traffic, nevertheless
indicates a tendency of such traffic.Comment: 50 pages, 16 figures; extra references adde
Nonhydrothermal Synthesis and Properties of Saponite-Like Materials
Abstract-Main features of nonhydrothermal synthesis of saponite-like materials containing Zn(II) and Mg(II) cations in octahedral networks were studied. Optimal conditions for the synthesis were determined. The influence exerted by the double-charged structure-forming cation on the rate of structure formation in the synthesized materials and also on their pore structure and thermal stability was studied
Manipulation of drugs to achieve the required dose is intrinsic to paediatric practice but is not supported by guidelines or evidence
Background: A lack of age-appropriate formulations can make it difficult to administer medicines to children. A manipulation of the dosage form may be required to achieve the required dose. This study aimed to describe medicines that are manipulated to achieve the required dose in paediatric practice.Method: A structured, undisguised observational study and postal survey. The observational study investigated drug manipulations occurring in clinical practice across three sites. The questionnaire, administered to a sample of paediatric nurses throughout the UK, surveyed manipulations conducted and nurses' experiences and views.Results: The observational study identified 310 manipulations, of which 62% involved tablets, 21% were intravenous drugs and 10% were sachets. Of the 54 observed manipulations 40 involved tablets with 65% of the tablets being cut and 30% dispersed to obtain a smaller dose. 188 manipulations were reported by questionnaire respondents, of these 46% involved tablets, 12% were intravenous drugs, and 12% were nebuliser solutions. Manipulations were predominantly, but not exclusively, identified in specialist clinical areas with more highly dependent patients. Questionnaire respondents were concerned about the accuracy of the dose achieved following manipulations and the lack of practice guidance.Conclusion: Manipulations to achieve the required dose occur throughout paediatric in-patient settings. The impact of manipulations on the efficacy of the drugs, the accuracy of the dose and any adverse effects on patients is not known. There is a need to develop evidence-based guidance for manipulations of medicines in children
De novo mutations in ARID1B associated with both syndromic and non-syndromic short stature
Frameshift mutations at the C-terminus of HIST1H1E result in a specific DNA hypomethylation signature
BACKGROUND: We previously associated HIST1H1E mutations causing Rahman syndrome with a specific genome-wide methylation pattern. RESULTS: Methylome analysis from peripheral blood samples of six affected subjects led us to identify a specific hypomethylated profile. This "episignature" was enriched for genes involved in neuronal system development and function. A computational classifier yielded full sensitivity and specificity in detecting subjects with Rahman syndrome. Applying this model to a cohort of undiagnosed probands allowed us to reach diagnosis in one subject. CONCLUSIONS: We demonstrate an epigenetic signature in subjects with Rahman syndrome that can be used to reach molecular diagnosis
The Localization Transition of the Two-Dimensional Lorentz Model
We investigate the dynamics of a single tracer particle performing Brownian
motion in a two-dimensional course of randomly distributed hard obstacles. At a
certain critical obstacle density, the motion of the tracer becomes anomalous
over many decades in time, which is rationalized in terms of an underlying
percolation transition of the void space. In the vicinity of this critical
density the dynamics follows the anomalous one up to a crossover time scale
where the motion becomes either diffusive or localized. We analyze the scaling
behavior of the time-dependent diffusion coefficient D(t) including corrections
to scaling. Away from the critical density, D(t) exhibits universal
hydrodynamic long-time tails both in the diffusive as well as in the localized
phase.Comment: 13 pages, 7 figures
Carrier Density Collapse and Colossal Magnetoresistance in Doped Manganites
A novel ferromagnetic transition, accompanied by carrier density collapse, is
found in doped charge-transfer insulators with strong electron-phonon coupling.
The transition is driven by an exchange interaction of polaronic carriers
with localized spins; the strength of the interaction determines whether the
transition is first or second order. A giant drop in the number of current
carriers during the transition, which is a consequence of bound pairs formation
in the paramagnetic phase close to the transition, is extremely sensitive to an
external magnetic field. This carrier density collapse describes the
resistivity peak and the colossal magnetoresistance of doped manganites.Comment: 5 pages, REVTeX 3.0, 3 EPS-figures embedded via epsf. Added - inset
in Fig. 2; Ref.[32]; footnotes [29], [30], [33
Competition of Zener and polaron phases in doped CMR manganites
Inspired by the strong experimental evidence for the coexistence of localized
and itinerant charge carriers close to the metal-insulator transition in the
ferromagnetic phase of colossal magnetoresistive manganese perovskites, for a
theoretical description of the CMR transition we propose a two-phase scenario
with percolative characteristics between equal-density polaron and Zener
band-electron states. We find that the subtle balance between these two states
with distinctly different electronic properties can be readily influenced by
varying physical parameters, producing various ``colossal'' effects, such as
the large magnetization and conductivity changes in the vicinity of the
transition temperature.Comment: 8 pages, 5 figure
In vivo and in vitro expression of steroid-converting enzymes in human breast tumours: associations with interleukin-6
Enzymes modulating local steroid availability play an important role in the progression of human breast cancer. These include isoforms of 17β-hydroxysteroid dehydrogenase (17-HSD), aromatase and steroid sulphatase (STS). The aim of this study was to investigate the expression, by reverse transcription polymerase chain reaction, of 17-HSD types I–IV, aromatase and steroid STS in a series of 51 human breast tumour biopsies and 22 primary cultures of epithelial and stromal cells derived from these tumours, giving a profile of the steroid-regulating network for individual tumours. Correlations between enzyme expression profiles and expression of the interleukin (IL)-6 gene were also sought. All except one tumour expressed at least one isoform of 17-HSD, either alone or in combination with aromatase and STS. Expression of 17-HSD isoforms I–IV were observed in nine tumours. Of the 15 tumours which expressed three isoforms, a combination of 17-HSD II, III and IV was most common (6/15 samples). The majority of tumours (n = 17) expressed two isoforms of 17-HSD with combinations of 17-HSD II and IV predominant (7/17 samples). Eight tumours expressed a single isoform and of these, 17-HSD I was in the majority (5/8 samples). In primary epithelial cultures, enzyme expression was ranked: HSD I (86%) > STS (77%) > HSD II (59%) > HSD IV (50%) = aromatase (50%) > HSD III (32%). Incidence of enzyme expression was generally reduced in stromal cultures which were ranked: HSD I (68%) > STS (67%) > aromatase (48%) > HSD II (43%) > HSD IV (28%) > HSD III (19%). Expression of IL-6 was associated with tumours that expressed ≥ 3 steroid-converting enzymes. These tumours were of higher grade and tended to come from patients with family history of breast cancer. In conclusion, we propose that these enzymes work in tandem with cytokines thereby providing sufficient quantities of bioactive oestrogen from less active precursors which stimulates tumour growth. © 1999 Cancer Research Campaig
- …