1,502 research outputs found
A low-noise CMOS front-end for TOF-PET
An analogue CMOS front-end for triggering and amplification of signals produced by a silicon photomultiplier (SiPM) coupled to a LYSO scintillator is proposed. The solution is intended for time-of-flight measurement in compact Positron Emission Tomography (TOF-PET) medical imaging equipments where excellent timing resolution is required (approximate to 100 ps). A CMOS 0.13 mu m technology was used to implement such front end, and the design includes preamplification, shaping, baseline holder and biasing circuitry, for a total silicon area of 500x90 mu m. Waveform sampling and time-over-threshold (ToT) techniques are under study and the front-end provides fast and shaped outputs for time and energy measurements. Post layout simulation results show that, for the trigger of a single photoelectron, the time jitter due to the pre-amplifier noise can be as low as 15 ps (FWHM), for a photodetector with a total capacitance of 70 pF. The very low input impedance of the pre-amplifier (approximate to 5 Omega) allows 1.8 ns of peaking time, at the cost of 10 mW of power consumption
Beam test results of the irradiated Silicon Drift Detector for ALICE
The Silicon Drift Detectors will equip two of the six cylindrical layers of
high precision position sensitive detectors in the ITS of the ALICE experiment
at LHC. In this paper we report the beam test results of a SDD irradiated with
1 GeV electrons. The aim of this test was to verify the radiation tolerance of
the device under an electron fluence equivalent to twice particle fluence
expected during 10 years of ALICE operation.Comment: 6 pages,6 figures, to appear in the proceedings of International
Workshop In high Multiplicity Environments (TIME'05), 3-7 October 2005,
Zurich,Switzerlan
A low-noise CMOS front-end for TOF-PET
An analogue CMOS front-end for triggering and amplification of signals produced by a silicon photomultiplier (SiPM) coupled to a LYSO scintillator is proposed. The solution is intended for time-of-flight measurement in compact Positron Emission Tomography (TOF-PET) medical imaging equipments where excellent timing resolution is required (approximate to 100 ps). A CMOS 0.13 mu m technology was used to implement such front end, and the design includes preamplification, shaping, baseline holder and biasing circuitry, for a total silicon area of 500x90 mu m. Waveform sampling and time-over-threshold (ToT) techniques are under study and the front-end provides fast and shaped outputs for time and energy measurements. Post layout simulation results show that, for the trigger of a single photoelectron, the time jitter due to the pre-amplifier noise can be as low as 15 ps (FWHM), for a photodetector with a total capacitance of 70 pF. The very low input impedance of the pre-amplifier (approximate to 5 Omega) allows 1.8 ns of peaking time, at the cost of 10 mW of power consumption
A low-noise CMOS front-end for TOF-PET
An analogue CMOS front-end for triggering and amplification of signals produced by a silicon photomultiplier (SiPM) coupled to a LYSO scintillator is proposed. The solution is intended for time-of-flight measurement in compact Positron Emission Tomography (TOF-PET) medical imaging equipments where excellent timing resolution is required (approximate to 100 ps). A CMOS 0.13 mu m technology was used to implement such front end, and the design includes preamplification, shaping, baseline holder and biasing circuitry, for a total silicon area of 500x90 mu m. Waveform sampling and time-over-threshold (ToT) techniques are under study and the front-end provides fast and shaped outputs for time and energy measurements. Post layout simulation results show that, for the trigger of a single photoelectron, the time jitter due to the pre-amplifier noise can be as low as 15 ps (FWHM), for a photodetector with a total capacitance of 70 pF. The very low input impedance of the pre-amplifier (approximate to 5 Omega) allows 1.8 ns of peaking time, at the cost of 10 mW of power consumption
A low-noise CMOS front-end for TOF-PET
An analogue CMOS front-end for triggering and amplification of signals produced by a silicon photomultiplier (SiPM) coupled to a LYSO scintillator is proposed. The solution is intended for time-of-flight measurement in compact Positron Emission Tomography (TOF-PET) medical imaging equipments where excellent timing resolution is required (approximate to 100 ps). A CMOS 0.13 mu m technology was used to implement such front end, and the design includes preamplification, shaping, baseline holder and biasing circuitry, for a total silicon area of 500x90 mu m. Waveform sampling and time-over-threshold (ToT) techniques are under study and the front-end provides fast and shaped outputs for time and energy measurements. Post layout simulation results show that, for the trigger of a single photoelectron, the time jitter due to the pre-amplifier noise can be as low as 15 ps (FWHM), for a photodetector with a total capacitance of 70 pF. The very low input impedance of the pre-amplifier (approximate to 5 Omega) allows 1.8 ns of peaking time, at the cost of 10 mW of power consumption
Mechanism of DNA flexibility enhancement by HMGB proteins
The mechanism by which sequence non-specific DNA-binding proteins enhance DNA flexibility is studied by examining complexes of double-stranded DNA with the high mobility group type B proteins HMGB2 (Box A) and HMGB1 (Box A+B) using atomic force microscopy. DNA end-to-end distances and local DNA bend angle distributions are analyzed for protein complexes deposited on a mica surface. For HMGB2 (Box A) binding we find a mean induced DNA bend angle of 78°, with a standard error of 1.3° and a SD of 23°, while HMGB1 (Box A+B) binding gives a mean bend angle of 67°, with a standard error of 1.3° and a SD of 21°. These results are consistent with analysis of the observed global persistence length changes derived from end-to-end distance measurements, and with results of DNA-stretching experiments. The moderately broad distributions of bend angles induced by both proteins are inconsistent with either a static kink model, or a purely flexible hinge model for DNA distortion by protein binding. Therefore, the mechanism by which HMGB proteins enhance the flexibility of DNA must differ from that of the Escherichia coli HU protein, which in previous studies showed a flat angle distribution consistent with a flexible hinge model
Reprogramming the diseased brain
Direct conversion of astrocytes to dopamine neurons in vivo offers fresh optimism for the development of improved Parkinson's therapie
A Cylindrical GEM Inner Tracker for the BESIII experiment at IHEP
The Beijing Electron Spectrometer III (BESIII) is a multipurpose detector
that collects data provided by the collision in the Beijing Electron Positron
Collider II (BEPCII), hosted at the Institute of High Energy Physics of
Beijing. Since the beginning of its operation, BESIII has collected the world
largest sample of J/{\psi} and {\psi}(2s). Due to the increase of the
luminosity up to its nominal value of 10^33 cm-2 s-1 and aging effect, the MDC
decreases its efficiency in the first layers up to 35% with respect to the
value in 2014. Since BESIII has to take data up to 2022 with the chance to
continue up to 2027, the Italian collaboration proposed to replace the inner
part of the MDC with three independent layers of Cylindrical triple-GEM (CGEM).
The CGEM-IT project will deploy several new features and innovation with
respect the other current GEM based detector: the {\mu}TPC and analog readout,
with time and charge measurements will allow to reach the 130 {\mu}m spatial
resolution in 1 T magnetic field requested by the BESIII collaboration. In this
proceeding, an update of the status of the project will be presented, with a
particular focus on the results with planar and cylindrical prototypes with
test beams data. These results are beyond the state of the art for GEM
technology in magnetic field
Theory of biopolymer stretching at high forces
We provide a unified theory for the high force elasticity of biopolymers
solely in terms of the persistence length, , and the monomer spacing,
. When the force f>\fh \sim k_BT\xi_p/a^2 the biopolymers behave as Freely
Jointed Chains (FJCs) while in the range \fl \sim k_BT/\xi_p < f < \fh the
Worm-like Chain (WLC) is a better model. We show that can be estimated
from the force extension curve (FEC) at the extension
(normalized by the contour length of the biopolymer). After validating the
theory using simulations, we provide a quantitative analysis of the FECs for a
diverse set of biopolymers (dsDNA, ssRNA, ssDNA, polysaccharides, and
unstructured PEVK domain of titin) for . The success of a specific
polymer model (FJC or WLC) to describe the FEC of a given biopolymer is
naturally explained by the theory. Only by probing the response of biopolymers
over a wide range of forces can the -dependent elasticity be fully
described.Comment: 20 pages, 4 figure
- …