Constitutive Equations for Use in Design Analyses of Long-life Elevated Temperature Components

Design analysis needs and procedures relative to elevated temperature components in liquid metal fast breeder reactor (LMFBR) system were examined. The effects of the thermal transients on the pressure boundary components are enhanced by the excellent heat transfer properties of the liquid sodium coolant. Design criteria for high temperature nuclear reactor components recognize the potential occurrence of inelastic structural response. Specifically, criteria and limits were developed which reflect a recognition of this potential and employ design by analysis concepts that requires that inelastic (elastic-plastic and creep) analyses be performed. Constitutive equations to represent multiaxial time-dependent responses of LMFBR alloys are established. The development of equations applicable under cyclic loading conditions are outlined

In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury.

Microglia respond to damage and microenvironmental changes within the central nervous system by morphologically transforming and migrating to the lesion, but the real-time behavior of populations of these resident immune cells and the neurons they support have seldom been observed simultaneously. Here, we have used in vivo high-resolution optical coherence tomography (OCT) and scanning laser ophthalmoscopy with and without adaptive optics to quantify the 3D distribution and dynamics of microglia in the living retina before and after local damage to photoreceptors. Following photoreceptor injury, microglia migrated both laterally and vertically through the retina over many hours, forming a tight cluster within the area of visible damage that resolved over 2 wk. In vivo OCT optophysiological assessment revealed that the photoreceptors occupying the damaged region lost all light-driven signaling during the period of microglia recruitment. Remarkably, photoreceptors recovered function to near-baseline levels after the microglia had departed the injury locus. These results demonstrate the spatiotemporal dynamics of microglia engagement and restoration of neuronal function during tissue remodeling and highlight the need for mechanistic studies that consider the temporal and structural dynamics of neuron-microglia interactions in vivo

Properties of quasi-periodic pulsations in solar flares from a single active region

We investigate the properties of a set of solar flares originating from a single active region (AR) that exhibit QPPs, and look for signs of the QPP periods relating to AR properties. The AR studied, best known as NOAA 12192, was unusually long-lived and produced 181 flares. Data from the GOES, EVE, Fermi, Vernov and NoRH observatories were used to determine if QPPs were present in the flares. For the soft X-ray GOES and EVE data, the time derivative of the signal was used. Power spectra of the time series data (without any form of detrending) were inspected, and flares with a peak above the 95% confidence level in the spectrum were labelled as having candidate QPPs. The confidence levels were determined taking account of uncertainties and the possible presence of red noise. AR properties were determined using HMI line of sight magnetograms. A total of 37 flares (20% of the sample) show good evidence of having QPPs, and some of the pulsations can be seen in data from multiple instruments and in different wavebands. The QPP periods show a weak correlation with the flare amplitude and duration, but this may be due to an observational bias. A stronger correlation was found between the QPP period and duration of the QPP signal, which can be partially but not entirely explained by observational constraints. No correlations were found with the AR area, bipole separation, or average magnetic field strength. The fact that a substantial fraction of the flare sample showed evidence of QPPs using a strict detection method with minimal processing of the data demonstrates that these QPPs are a real phenomenon, which cannot be explained by the presence of red noise or the superposition of multiple unrelated flares. The lack of correlation between the QPP periods and AR properties implies that the small-scale structure of the AR is important, and/or that different QPP mechanisms act in different cases.Comment: 23 pages, 57 figures. Accepted for publication by Astronomy & Astrophysic

RGS9-1 is required for normal inactivation of mouse cone phototransduction

Purpose: To test the hypothesis that Regulator of G-protein Signaling 9 (RGS9-1) is necessary for the normal inactivation of retinal cones. Methods: Mice having the gene RGS9-1 inactivated in both alleles (RGS9-1 -/-) were tested between the ages 8-10 weeks with electroretinographic (ERG) protocols that isolate cone-driven responses. Immunohistochemistry was performed with a primary antibody against RGS9-1 (anti-RGS9-1c), with the secondary conjugated to fluorescein isothiocyanate, and with rhodamine-conjugated peanut agglutinin. Results: (1) Immunohistochemistry showed RGS9-1 to be strongly expressed in the cones of wildtype (WT is C57BL/6) mice, but absent from the cones of RGS9-1 mice. (2) Cone-driven b-wave responses of dark-adapted RGS9-1 -/- mice had saturating amplitudes and sensitivities in the midwave and UV regions of the spectrum equal to or slightly greater than those of WT (C57BL/6) mice. (3) Cone-driven b-wave and a-wave responses of RGS9-1 -/- mice recovered much more slowly than those of WT after a strong conditioning flash: for a flash estimated to isomerize 1.2% of the M-cone pigment and 0.9% of the UV-cone pigment, recovery of 50% saturating amplitude was approximately 60-fold slower than in WT. Conclusions: (1) The amplitudes and sensitivities of the cone-driven responses indicate that cones and cone-driven neurons in RGS9-1 -/- mice have normal generator currents. (2) The greatly retarded recovery of cone-driven responses of RGS9-1 -/- mice relative to those of WT mice establishes that RGS9-1 is required for normal inactivation of the cone phototransduction cascades of both UV- and M-cones

Constitutive equations for meeting elevated-temperature-design needs

Constitutive equations for representing the inelastic behavior of structural alloys at temperatures in the creep regime are discussed from the viewpoint of advances made over the past decade. An emphasis is placed on the progress that has been made in meeting the needs of the program whose design process is based in part on a design-by-inelastic-analysis approach. In particular, the constitutive equations that have been put into place for current use in design analyses are discussed along with some material behavior background information. Equations representing short-term plastic and long-term creep behaviors are considered. Trends towards establishing improved equations for use in the future are also described. Progress relating to fundamentals of continuum mechanics, physical modeling, phenomenological modeling, and implementation is addressed

Sweet cherry production in South Patagonia

In South Patagonia, the total sweet cherry (Prunus avium L.) area has increased from 176 ha in 1997 to 507 ha in 2004, of which 232 ha are located in Los Antiguos (46°19¿ SL; 220 m elevation), 158 ha in the Lower Valley of Chubut River (LVCHR) (43°16¿ SL; 30 m elevation), 52 ha in Sarmiento (45°35¿ SL; 270 m elevation), 35 ha in Esquel (42°55¿ SL; 570 m elevation) and 30 ha in Comodoro Rivadavia (45°52¿ SL; 50 m elevation). The most common varieties are `Lapins¿, `Bing¿, `Newstar¿, `Sweetheart¿, `Stella¿, `Sunburst¿ and `Van¿ grafted on `Mahaleb¿, `Pontaleb¿, `SL 64¿, `Colt¿ or `Mazzard¿ rootstocks. Trees generally are drip-irrigated and planted at high densities, using training systems such as Tatura, central leader and modified vase (2700, 1100 and 1000 trees ha-1, respectively). Growers in Los Antiguos are more traditional, planting mainly as vase (400 to 1000 trees ha-1) or freestanding trees (280 trees ha-1) and irrigating by gravity (74% of the area). Only 4.4% of the area of Los Antiguos is frost protected, as growers rely strongly on the moderating effect of Lake Buenos Aires. Frost control systems are absent in Comodoro Rivadavia because the established orchards are located next to the sea, in an area with low risk of frost. The frost-protected area is 49% in Sarmiento, 35% in Esquel and 57% in LVCHR. Fruit are harvested from November (LVCHR) to the end of January (Los Antiguos and Esquel), and the harvest-only labour demand during the 2004/2005 season was 100,000 h. In that season, seven packinghouses exported 390 t (45% of the total production) to Europe. Most orchards have not yet reached their mature stage and new ones are being established. Therefore, fruit volumes will continue to increase and shortages of labour and packing facilities may become a constraint

Breaking quantum linearity: constraints from human perception and cosmological implications

Resolving the tension between quantum superpositions and the uniqueness of the classical world is a major open problem. One possibility, which is extensively explored both theoretically and experimentally, is that quantum linearity breaks above a given scale. Theoretically, this possibility is predicted by collapse models. They provide quantitative information on where violations of the superposition principle become manifest. Here we show that the lower bound on the collapse parameter lambda, coming from the analysis of the human visual process, is ~ 7 +/- 2 orders of magnitude stronger than the original bound, in agreement with more recent analysis. This implies that the collapse becomes effective with systems containing ~ 10^4 - 10^5 nucleons, and thus falls within the range of testability with present-day technology. We also compare the spectrum of the collapsing field with those of known cosmological fields, showing that a typical cosmological random field can yield an efficient wave function collapse.Comment: 13 pages, LaTeX, 3 figure

Crosslinking and composition influence the surface properties, mechanical stiffness and cell reactivity of collagen-based films.

This study focuses on determining the effect of varying the composition and crosslinking of collagen-based films on their physical properties and interaction with myoblasts. Films composed of collagen or gelatin and crosslinked with a carbodiimide were assessed for their surface roughness and stiffness. These samples are significant because they allow variation of physical properties as well as offering different recognition motifs for cell binding. Cell reactivity was determined by the ability of myoblastic C2C12 and C2C12-α2+ cell lines (with different integrin expression) to adhere to and spread on the films. Significantly, crosslinking reduced the cell reactivity of all films, irrespective of their initial composition, stiffness or roughness. Crosslinking resulted in a dramatic increase in the stiffness of the collagen film and also tended to reduce the roughness of the films (R(q) = 0.417 ± 0.035 μm, E = 31 ± 4.4 MPa). Gelatin films were generally smoother and more compliant than comparable collagen films (R(q) = 7.9 ± 1.5 nm, E = 15 ± 3.1 MPa). The adhesion of α2-positive cells was enhanced relative to the parental C2C12 cells on collagen compared with gelatin films. These results indicate that the detrimental effect of crosslinking on cell response may be due to the altered physical properties of the films as well as a reduction in the number of available cell binding sites. Hence, although crosslinking can be used to enhance the mechanical stiffness and reduce the roughness of films, it reduces their capacity to support cell activity and could potentially limit the effectiveness of the collagen-based films and scaffolds